Toth, Miklos

Publications

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selected publications

Acquisition and extinction of drug-context memories are linked to distinct epigenetic and transcriptional mechanisms in the mouse dentate gyrus. bioRxiv : the preprint server for biology. 2026 Article GET IT
Large-scale reorganization of DNA methylation and upregulation of extracellular matrix genes in the dorsal dentate gyrus following cocaine taking. bioRxiv : the preprint server for biology. 2026 Article GET IT
A transposase-derived gene required for human brain development. Science advances. 2026 Academic Article GET IT
Times cited: 1
Maternal postpartum sedentary life exacerbates the metabolic impact of moderately fat-rich diet in male mice. npj metabolic health and disease. 2025 Academic Article GET IT
Adverse gestational environment configures a subpopulation of ventral dentate granule cells for recruitment to drive innate anxiety. Cell reports. 2025 Academic Article GET IT
A transposase-derived gene required for human brain development. bioRxiv : the preprint server for biology. 2024 Article GET IT
The chemokine XCL1 functions as a pregnancy hormone to program offspring innate anxiety. Brain, behavior, and immunity. 2024 Academic Article GET IT
Times cited: 3
Single cell transcriptomic representation of social dominance in prefrontal cortex and the influence of preweaning maternal and postweaning social environment. Scientific reports. 2024 Academic Article GET IT
Times cited: 4
Editorial: Prosocial and hypersocial behavior: From genes to circuits and behavior. Frontiers in behavioral neuroscience. 2022 Editorial Article GET IT
Times cited: 1
Serotonin-1A receptor, a psychiatric disease risk factor, influences offspring immunity via sex-dependent genetic nurture. iScience. 2022 Academic Article GET IT
Times cited: 4
Epigenetic Neuropharmacology: Drugs Affecting the Epigenome in the Brain. Annual review of pharmacology and toxicology. 2020 Information Resource GET IT
Times cited: 23
Maternal Programming of Social Dominance via Milk Cytokines. iScience. 2020 Academic Article GET IT
Times cited: 12
Epigenomically Bistable Regions across Neuron-Specific Genes Govern Neuron Eligibility to a Coding Ensemble in the Hippocampus. Cell reports. 2020 Academic Article GET IT
Times cited: 12
Regulation of embryonic and adult neurogenesis by Ars2. Development (Cambridge, England). 2020 Academic Article GET IT
Times cited: 10
UPF2 leads to degradation of dendritically targeted mRNAs to regulate synaptic plasticity and cognitive function. Molecular psychiatry. 2019 Academic Article GET IT
Times cited: 28
The other side of the coin: Hypersociability. Genes, brain, and behavior. 2018 Information Resource GET IT
Times cited: 19
Maternal Brain TNF-α Programs Innate Fear in the Offspring. Current biology : CB. 2017 Academic Article GET IT
Times cited: 13
FOXO protects against age-progressive axonal degeneration. Aging cell. 2017 Academic Article GET IT
Times cited: 56
Programming social behavior by the maternal fragile X protein. Genes, brain, and behavior. 2016 Academic Article GET IT
Times cited: 11
Behavioural traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanisms. Nature communications. 2016 Academic Article GET IT
Times cited: 32
Principles Governing DNA Methylation during Neuronal Lineage and Subtype Specification. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2016 Academic Article GET IT
Times cited: 43
Mechanisms of non-genetic inheritance and psychiatric disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2014 Information Resource GET IT
Times cited: 57
KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability. Science signaling. 2014 Academic Article GET IT
Times cited: 62
Maternal hematopoietic TNF, via milk chemokines, programs hippocampal development and memory. Nature neuroscience. 2013 Academic Article GET IT
Times cited: 55
Establishing brain functional laterality in adult mice through unilateral gene manipulation in the embryonic cortex. Cell research. 2013 Article GET IT
Times cited: 22
Differential gene body methylation and reduced expression of cell adhesion and neurotransmitter receptor genes in adverse maternal environment. Translational psychiatry. 2013 Academic Article GET IT
Times cited: 44
The central nervous system is a target of acute graft versus host disease in mice. Blood. 2013 Academic Article GET IT
Times cited: 54
Acute 5-HT₁A autoreceptor knockdown increases antidepressant responses and serotonin release in stressful conditions. Psychopharmacology. 2012 Academic Article GET IT
Times cited: 65
New antidepressant strategy based on acute siRNA silencing of 5-HT1A autoreceptors. Molecular psychiatry. 2012 Academic Article GET IT
Times cited: 15
Fmr-1 as an offspring genetic and a maternal environmental factor in neurodevelopmental disease. Results and problems in cell differentiation. 2012 Academic Article GET IT
Times cited: 3
Behavioral characterization of cereblon forebrain-specific conditional null mice: a model for human non-syndromic intellectual disability. Behavioural brain research. 2011 Academic Article GET IT
Times cited: 42
Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects. Molecular psychiatry. 2011 Academic Article GET IT
Times cited: 103
Maternal genetic mutations as gestational and early life influences in producing psychiatric disease-like phenotypes in mice. Frontiers in psychiatry. 2011 Academic Article GET IT
Times cited: 10
Characterization of 5-HT(1A/1B)-/- mice: an animal model sensitive to anxiolytic treatments. Neuropharmacology. 2011 Academic Article GET IT
Times cited: 38
Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs. Molecular therapy : the journal of the American Society of Gene Therapy. 2011 Academic Article GET IT
Times cited: 60
Role of maternal 5-HT(1A) receptor in programming offspring emotional and physical development. Genes, brain, and behavior. 2010 Academic Article GET IT
Times cited: 18
The serotonin1A receptor gene as a genetic and prenatal maternal environmental factor in anxiety. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 55
Dopamine release induced by atypical antipsychotics in prefrontal cortex requires 5-HT(1A) receptors but not 5-HT(2A) receptors. The international journal of neuropsychopharmacology. 2010 Academic Article GET IT
Times cited: 81
Serotonin(1A)-receptor-dependent signaling proteins in mouse hippocampus. Neuropharmacology. 2009 Academic Article GET IT
Times cited: 3
Paradoxical anxiogenic response of juvenile mice to fluoxetine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2009 Academic Article GET IT
Times cited: 70
Transcription factor Lmo4 defines the shape of functional areas in developing cortices and regulates sensorimotor control. Developmental biology. 2008 Academic Article GET IT
Times cited: 30
TRH-receptor-type-2-deficient mice are euthyroid and exhibit increased depression and reduced anxiety phenotypes. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2008 Academic Article GET IT
Times cited: 43
Inactivation of the maternal fragile X gene results in sensitization of GABAB receptor function in the offspring. The Journal of pharmacology and experimental therapeutics. 2008 Academic Article GET IT
Times cited: 18
Validation and use of a computer-assisted counting procedure to quantify BrdU-labeled proliferating cells in the early postnatal mouse hippocampus. Journal of neuroscience methods. 2008 Academic Article GET IT
Times cited: 5
Wild-type male offspring of fmr-1+/- mothers exhibit characteristics of the fragile X phenotype. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2008 Academic Article GET IT
Times cited: 27
Substance P neurokinin 1 receptor activation within the dorsal raphe nucleus controls serotonin release in the mouse frontal cortex. Molecular pharmacology. 2007 Academic Article GET IT
Times cited: 39
Association between Chlamydia trachomatis and abnormal uterine bleeding. American journal of reproductive immunology (New York, N.Y. : 1989). 2007 Academic Article GET IT
Times cited: 37
In vivo actions of aripiprazole on serotonergic and dopaminergic systems in rodent brain. Psychopharmacology. 2007 Academic Article GET IT
Times cited: 100
5-hydroxytryptamine induces mast cell adhesion and migration. Journal of immunology (Baltimore, Md. : 1950). 2006 Academic Article GET IT
Times cited: 132
Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science (New York, N.Y.). 2006 Academic Article GET IT
Times cited: 1205
Effects of genetic background and null mutation of 5-HT1A receptors on basal and stress-induced body temperature: modulation by serotonergic and GABAA-ergic drugs. European journal of pharmacology. 2006 Academic Article GET IT
Times cited: 29
The anxiety-like phenotype of 5-HT receptor null mice is associated with genetic background-specific perturbations in the prefrontal cortex GABA-glutamate system. Journal of neurochemistry. 2006 Academic Article GET IT
Times cited: 32
Fmrp is required for the establishment of the startle response during the critical period of auditory development. Brain research. 2006 Academic Article GET IT
Times cited: 36
Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science (New York, N.Y.). 2006 Academic Article GET IT
Times cited: 377
Blockade of 5-HT1A receptors by (+/-)-pindolol potentiates cortical 5-HT outflow, but not antidepressant-like activity of paroxetine: microdialysis and behavioral approaches in 5-HT1A receptor knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2006 Academic Article GET IT
Times cited: 60
Involvement of 5-HT1A receptors in prefrontal cortex in the modulation of dopaminergic activity: role in atypical antipsychotic action. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Academic Article GET IT
Times cited: 275
Variability in the benzodiazepine response of serotonin 5-HT1A receptor null mice displaying anxiety-like phenotype: evidence for genetic modifiers in the 5-HT-mediated regulation of GABA(A) receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Academic Article GET IT
Times cited: 32
Co-expression and in vivo interaction of serotonin1A and serotonin2A receptors in pyramidal neurons of prefrontal cortex. Cerebral cortex (New York, N.Y. : 1991). 2004 Academic Article GET IT
Times cited: 324
In vivo efflux of serotonin in the dorsal raphe nucleus of 5-HT1A receptor knockout mice. Journal of neurochemistry. 2004 Academic Article GET IT
Times cited: 72
The RNA binding domain of Jerky consists of tandemly arranged helix-turn-helix/homeodomain-like motifs and binds specific sets of mRNAs. Molecular and cellular biology. 2003 Academic Article GET IT
Times cited: 25
5-HT1A receptor knockout mouse as a genetic model of anxiety. European journal of pharmacology. 2003 Information Resource GET IT
Times cited: 154
The fragile X mental retardation protein binds and regulates a novel class of mRNAs containing U rich target sequences. Neuroscience. 2003 Academic Article GET IT
Times cited: 139
Jerky, a protein deficient in a mouse epilepsy model, is associated with translationally inactive mRNA in neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002 Academic Article GET IT
Times cited: 25
The 5-HT(1A) receptor knockout mouse and anxiety. Behavioural pharmacology. 2001 Information Resource GET IT
Times cited: 87
Differential effects of 5-HT1A receptor deletion upon basal and fluoxetine-evoked 5-HT concentrations as revealed by in vivo microdialysis. Brain research. 2001 Academic Article GET IT
Times cited: 47
Fragile X mice develop sensory hyperreactivity to auditory stimuli. Neuroscience. 2001 Academic Article GET IT
Times cited: 295
Molecular pathways of anxiety revealed by knockout mice. Molecular neurobiology. 2001 Information Resource GET IT
Times cited: 34
Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors. Proceedings of the National Academy of Sciences of the United States of America. 2000 Academic Article GET IT
Times cited: 357
Genetic inactivation of the Serotonin(1A) receptor in mice results in downregulation of major GABA(A) receptor alpha subunits, reduction of GABA(A) receptor binding, and benzodiazepine-resistant anxiety. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2000 Academic Article GET IT
Times cited: 184
Detection of chlamydial antigenic material in ovarian, prostatic, ectopic pregnancy and semen samples of culture-negative subjects. American journal of reproductive immunology (New York, N.Y. : 1989). 2000 Academic Article GET IT
Times cited: 37
Adaptive changes in postsynaptic dopamine receptors despite unaltered dopamine dynamics in mice lacking monoamine oxidase B. Journal of neurochemistry. 1999 Academic Article GET IT
Times cited: 26
Transgenic approaches to epilepsy. Advances in neurology. 1999 Information Resource GET IT
Times cited: 9
Increased anxiety of mice lacking the serotonin1A receptor. Proceedings of the National Academy of Sciences of the United States of America. 1998 Academic Article GET IT
Times cited: 620
Antisense inhibition of 5-hydroxytryptamine2a receptor induces an antidepressant-like effect in mice. Molecular pharmacology. 1997 Academic Article GET IT
Times cited: 67
Increased stress response and beta-phenylethylamine in MAOB-deficient mice. Nature genetics. 1997 Academic Article GET IT
Times cited: 232
Induction of messenger RNA for the 70 kDa heat shock protein in HeLa cells and the human endocervix following exposure to semen: implications for antisperm antibody production and susceptibility to sexually transmitted infections. Human reproduction (Oxford, England). 1997 Academic Article GET IT
Times cited: 17
Sensitivity to jerky gene dosage underlies epileptic seizures in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1997 Academic Article GET IT
Times cited: 28
Immune recognition of the 60kD heat shock protein: implications for subsequent fertility. Infectious diseases in obstetrics and gynecology. 1996 Academic Article GET IT
Times cited: 38
Transcriptional regulation of the 5-HT2A receptor. Behavioural brain research. 1996 Information Resource GET IT
Times cited: 15
Epileptic seizures caused by inactivation of a novel gene, jerky, related to centromere binding protein-B in transgenic mice. Nature genetics. 1995 Academic Article GET IT
Times cited: 82
Differentiation is induced in three-dimensional cultures of brain cells immortalized by the LAP mammalian regulatory system. Journal of neuroscience research. 1995 Academic Article GET IT
Times cited: 4
The 5' flanking region of the serotonin 2 receptor gene directs brain specific expression in transgenic animals. Brain research. Molecular brain research. 1994 Academic Article GET IT
Times cited: 9
Proliferative response to conserved epitopes of the Chlamydia trachomatis and human 60-kilodalton heat-shock proteins by lymphocytes from women with salpingitis. American journal of obstetrics and gynecology. 1994 Academic Article GET IT
Times cited: 57
Antagonist-mediated down-regulation of 5-hydroxytryptamine type 2 receptor gene expression: modulation of transcription. Molecular pharmacology. 1994 Academic Article GET IT
Times cited: 50
Glial cell-specific expression of the serotonin 2 receptor gene: selective reactivation of a repressed promoter. Brain research. Molecular brain research. 1993 Academic Article GET IT
Times cited: 41
Cell-mediated immune response to the recombinant 57-kDa heat-shock protein of Chlamydia trachomatis in women with salpingitis. The Journal of infectious diseases. 1993 Academic Article GET IT
Times cited: 65
Detection of Chlamydia trachomatis by the polymerase chain reaction in the cervices of women with acute salpingitis. American journal of obstetrics and gynecology. 1993 Academic Article GET IT
Times cited: 28
Pregnancy outcome following pelvic infection. Infectious diseases in obstetrics and gynecology. 1993 Academic Article GET IT
Times cited: 10
Adenovirus DNA replication facilitates binding of the MLTF/USF transcription factor to the viral major late promoter within infected cells. Nucleic acids research. 1992 Academic Article GET IT
Times cited: 11
In vivo tumor necrosis factor production in women with salpingitis. Surgery, gynecology & obstetrics. 1992 Academic Article GET IT
Times cited: 41
Increased inducibility of inflammatory mediators from peripheral blood mononuclear cells of women with salpingitis. American journal of obstetrics and gynecology. 1991 Academic Article GET IT
Times cited: 12
Establishment of de novo DNA methylation patterns. Transcription factor binding and deoxycytidine methylation at CpG and non-CpG sequences in an integrated adenovirus promoter. Journal of molecular biology. 1990 Academic Article GET IT
Times cited: 114
Eukaryotic DNA methylation: facts and problems. FEBS letters. 1990 Information Resource GET IT
Times cited: 54
Prostaglandins E and F in cervical mucus of pregnant women. American journal of perinatology. 1989 Academic Article GET IT
Times cited: 26
Difference in the production of human interferon-alpha and -beta in mouse cells. The Journal of general virology. 1988 Academic Article GET IT
Times cited: 1
Activation of the major late promoter in adenovirus transformed cells by 5-azacytidine. Virology. 1988 Academic Article GET IT
Times cited: 3
The role of infection in the etiology of preterm birth. Obstetrics and gynecology. 1988 Academic Article GET IT
Times cited: 85
Adenovirus 2 VA RNAI synthesized in SP6 system. Nucleic acids research. 1988 Academic Article GET IT
Interferon induction by adenovirus type 12: stimulatory function of early region 1A. Journal of virology. 1987 Academic Article GET IT
Times cited: 7
Nonintervention in premature rupture of the amniotic membranes. Surgery, gynecology & obstetrics. 1986 Academic Article GET IT
Times cited: 16
The structure of adenovirus chromatin in infected cells. The Journal of general virology. 1985 Academic Article GET IT
Times cited: 39
Human interferons alpha and beta have more potent priming activities than interferon gamma. The Journal of general virology. 1985 Academic Article GET IT
Times cited: 5
Production of high titre human interferon-gamma in primed leukocyte cultures. Acta microbiologica Hungarica. 1985 Academic Article GET IT
Nuclease sensitivity of adenovirus type 2 chromatin in lytic infection. The Journal of general virology. 1984 Academic Article GET IT
Times cited: 1
Prostaglandin F2 alpha, oxytocin, and uterine activation in hypertonic saline-induced abortions. American journal of obstetrics and gynecology. 1984 Academic Article GET IT
Times cited: 4
Semi-crude human leukocyte interferon production in a simple medium. Acta microbiologica Hungarica. 1984 Academic Article GET IT
Times cited: 2
The left part of the viral genome is sufficient for interferon induction by adenovirus type 12. Archives of virology. 1984 Academic Article GET IT
Times cited: 2
Different interferon-inducing ability of human adenovirus types in chick embryo cells. Acta virologica. 1983 Academic Article GET IT
Times cited: 8
Preparative separation of intact incomplete and empty adenovirus type 2 particles. Acta virologica. 1982 Academic Article GET IT
Times cited: 10
Characterization of a parvovirus strain isolated from human adenovirus type 12. Acta microbiologica Academiae Scientiarum Hungaricae. 1981 Academic Article GET IT
Interferon production by leucocytes of dialysed chronic uraemic patients. Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association. 1981 Academic Article GET IT
Times cited: 2
Differential effect of interferon on the production on virus- and mitogen-induced leukocyte inhibitory factors in human leukocyte cultures. Acta virologica. 1980 Academic Article GET IT
Times cited: 4
Modulation of lymphokine production by interferon. Journal of interferon research. 1980 Academic Article GET IT
Times cited: 7
Parvovirus contamination of a human type 12 adenovirus strain. Acta virologica. 1980 Academic Article GET IT
Times cited: 1

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Research

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Funding awarded

The role of rapid estrogen signaling in alcohol drinking behavior awarded by National Institute on Alcohol Abuse & Alcoholism Co-Investigator 2024 - 2029

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Background

education and training

Ph.D., Hungarian Academy of Sciences (Hungary) 1985
M.D., Albert Szent-Gyorgyi Medical School (Hungary) 1977

Contact

full name

Miklos Toth

primary email

mtoth@med.cornell.edu

VIVO Weill Cornell Medical College

Miklos Toth Professor of Pharmacology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email