Effects of nonsteroidal antiinflammatory drugs on platelet function and systemic hemostasis. Review uri icon

Overview

abstract

  • Aspirin and nonaspirin nonsteroidal antiinflammatory drugs (NSAIDs) inhibit platelet cyclooxygenase, thereby blocking the formation of thromboxane A2. These drugs produce a systemic bleeding tendency by impairing thromboxane-dependent platelet aggregation and consequently prolonging the bleeding time. Aspirin exerts these effects by irreversibly blocking cyclooxygenase and, therefore, its actions persist for the circulating lifetime of the platelet. Nonaspirin NSAIDs inhibit cyclooxygenase reversibly and, therefore, the duration of their action depends on specific drug dose, serum level, and half-life. The clinical risks of bleeding with aspirin or nonaspirin NSAIDs are enhanced by the concomitant use of alcohol or anticoagulants and by associated conditions, including advanced age, liver disease, and other coexisting coagulopathies.

publication date

  • March 1, 1995

Research

keywords

  • Anti-Inflammatory Agents, Non-Steroidal
  • Blood Platelets
  • Hemostasis

Identity

Scopus Document Identifier

  • 0028922825

PubMed ID

  • 7608308

Additional Document Info

volume

  • 35

issue

  • 3