selected publications
- Thrombotic, Cardiovascular, and Microvascular Complications of Myeloproliferative Neoplasms and Clonal Hematopoiesis (CHIP): A Narrative Review. Journal of clinical medicine. 2024 Review GET IT
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The pathobiology of thrombosis, microvascular disease, and hemorrhage in the myeloproliferative neoplasms.
Blood.
2021
Information Resource
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Times cited: 1 - Thrombotic, Vascular, and Bleeding Complications of the Myeloproliferative Neoplasms. Hematology/oncology clinics of North America. 2021 Information Resource GET IT
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Incremental Utility of Right Ventricular Dysfunction in Patients With Myeloproliferative Neoplasm-Associated Pulmonary Hypertension.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.
2019
Academic Article
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Times cited: 14 - Current Education of Physicians: Lost in Translation?. JACC. Basic to translational science. 2019 Editorial Article GET IT
- PRESIDENT'S ADDRESS FROM BUDAPEST TO VIENNA AND BACK. Transactions of the American Clinical and Climatological Association. 2018 http://purl.obolibrary.org/obo/ I A O_0000030 GET IT
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In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs.
Mayo Clinic proceedings.
2015
Article
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Times cited: 129 -
Stalled cerebral capillary blood flow in mouse models of essential thrombocythemia and polycythemia vera revealed by in vivo two-photon imaging.
Journal of thrombosis and haemostasis : JTH.
2014
Academic Article
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Times cited: 22 -
In vivo two-photon excited fluorescence microscopy reveals cardiac- and respiration-dependent pulsatile blood flow in cortical blood vessels in mice.
American journal of physiology. Heart and circulatory physiology.
2012
Academic Article
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Times cited: 107 -
Hyperhomocysteinemia impairs endothelium-derived hyperpolarizing factor-mediated vasorelaxation in transgenic cystathionine beta synthase-deficient mice.
Blood.
2011
Academic Article
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Times cited: 56 -
Regulation of homocysteine metabolism and methylation in human and mouse tissues.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2010
Academic Article
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Times cited: 135 -
Hyperhomocysteinemia promotes inflammatory monocyte generation and accelerates atherosclerosis in transgenic cystathionine beta-synthase-deficient mice.
Circulation.
2009
Academic Article
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Times cited: 119 -
The cyclic GMP modulators YC-1 and zaprinast reduce vessel remodeling through antiproliferative and proapoptotic effects.
Journal of cardiovascular pharmacology and therapeutics.
2009
Academic Article
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Times cited: 8 - The academic job offer: what to expect and how to negotiate. Hematology. American Society of Hematology. Education Program. 2009 Academic Article GET IT
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Inhibition of plasminogen activator inhibitor-1 expression in vascular smooth muscle cells by protoporphyrins through a heme oxygenase-independent mechanism.
Molecular and cellular biochemistry.
2008
Academic Article
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Times cited: 2 -
Hemin upregulates Egr-1 expression in vascular smooth muscle cells via reactive oxygen species ERK-1/2-Elk-1 and NF-kappaB.
Circulation research.
2007
Academic Article
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Times cited: 101 -
Differential regulation of homocysteine transport in vascular endothelial and smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology.
2007
Academic Article
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Times cited: 31 -
Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene.
Blood.
2007
Academic Article
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Times cited: 122 -
Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance.
Circulation research.
2006
Academic Article
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Times cited: 165 -
Molecular basis of the diagnosis and treatment of polycythemia vera and essential thrombocythemia.
Blood.
2006
Information Resource
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Times cited: 118 -
Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation.
Arteriosclerosis, thrombosis, and vascular biology.
2005
Academic Article
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Times cited: 138 -
Local administration of carbon monoxide inhibits neointima formation in balloon injured rat carotid arteries.
Cellular and molecular biology (Noisy-le-Grand, France).
2005
Academic Article
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Times cited: 31 - Crafting an effective strategic plan for a department of medicine. The American journal of medicine. 2005 Academic Article GET IT
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Endoplasmic reticulum stress stimulates heme oxygenase-1 gene expression in vascular smooth muscle. Role in cell survival.
The Journal of biological chemistry.
2004
Academic Article
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Times cited: 110 -
Cyclic strain stimulates L-proline transport in vascular smooth muscle cells.
American journal of hypertension.
2004
Academic Article
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Times cited: 11 -
Thrombocytosis.
The New England journal of medicine.
2004
Information Resource
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Times cited: 292 -
Platelet-derived growth factor stimulates LAT1 gene expression in vascular smooth muscle: role in cell growth.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2004
Academic Article
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Times cited: 62 -
Genetic and acquired determinants of individual variability of response to antiplatelet drugs.
Circulation.
2003
Editorial Article
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Times cited: 31 -
Optimizing initial therapy of acute venous thromboembolism.
Thrombosis and haemostasis.
2003
Editorial Article
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Times cited: 1 -
The research community now and in the future: APM's recommendations for NIH priorities.
The American journal of medicine.
2003
Academic Article
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Times cited: 2 -
Physiologic cyclic stretch inhibits apoptosis in vascular endothelium.
FEBS letters.
2003
Academic Article
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Times cited: 63 -
Warfarin for venous thromboembolism - walking the dosing tightrope.
The New England journal of medicine.
2003
Editorial Article
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Times cited: 13 -
Thrombotic disorders: diagnosis and treatment.
Hematology. American Society of Hematology. Education Program.
2003
Information Resource
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Times cited: 61 -
Hyperhomocysteinemia accelerates atherosclerosis in cystathionine beta-synthase and apolipoprotein E double knock-out mice with and without dietary perturbation.
Blood.
2002
Academic Article
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Times cited: 147 -
Carbon monoxide inhibits apoptosis in vascular smooth muscle cells.
Cardiovascular research.
2002
Academic Article
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Times cited: 151 -
Heme oxygenase-1-derived carbon monoxide is an autocrine inhibitor of vascular smooth muscle cell growth.
Blood.
2002
Academic Article
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Times cited: 136 -
YC-1-mediated vascular protection through inhibition of smooth muscle cell proliferation and platelet function.
Biochemical and biophysical research communications.
2002
Academic Article
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Times cited: 47 -
Cyclin A transcriptional suppression is the major mechanism mediating homocysteine-induced endothelial cell growth inhibition.
Blood.
2002
Academic Article
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Times cited: 57 -
The fault lines of academic medicine.
Perspectives in biology and medicine.
2002
Information Resource
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Times cited: 8 -
Thrombocytosis: too much of a good thing?.
Transactions of the American Clinical and Climatological Association.
2002
Information Resource
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Times cited: 9 -
Transforming growth factor-beta 1 stimulates vascular smooth muscle cell L-proline transport by inducing system A amino acid transporter 2 (SAT2) gene expression.
The Biochemical journal.
2001
Academic Article
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Times cited: 16 -
Adenovirus-mediated heme oxygenase-1 gene delivery inhibits injury-induced vascular neointima formation.
Circulation.
2001
Academic Article
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Times cited: 153 - Genetic polymorphisms in arterial thrombosis and vascular disease. Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists. 2001 Article GET IT
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Antithrombotic therapy in patients with acute coronary syndromes.
Archives of internal medicine.
2001
Information Resource
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Times cited: 29 -
Heme oxygenase-1 attenuates vascular remodeling following balloon injury in rat carotid arteries.
Atherosclerosis.
2001
Academic Article
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Times cited: 125 -
Transforming growth factor-beta(1) stimulates L-arginine transport and metabolism in vascular smooth muscle cells: role in polyamine and collagen synthesis.
Circulation.
2001
Academic Article
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Times cited: 113 -
YC-1, a benzyl indazole derivative, stimulates vascular cGMP and inhibits neointima formation.
Biochemical and biophysical research communications.
2000
Academic Article
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Times cited: 41 -
Physiological cyclic stretch directs L-arginine transport and metabolism to collagen synthesis in vascular smooth muscle.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2000
Academic Article
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Times cited: 61 -
Physiological cyclic stretch causes cell cycle arrest in cultured vascular smooth muscle cells.
American journal of physiology. Heart and circulatory physiology.
2000
Academic Article
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Times cited: 83 -
My doctor recently recommended that I take low-dose aspirin to minimize the risk of a heart attack or stroke. I routinely take ibuprofen for arthritis pain. Do I need both, and is it safe to combine the two?.
Health news (Waltham, Mass.).
2000
Academic Article
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Times cited: 2 -
Platelet-derived growth factor stimulates heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology.
1999
Academic Article
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Times cited: 54 -
Venous thrombosis as a chronic disease.
The New England journal of medicine.
1999
Editorial Article
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Times cited: 43 -
A perspective on the potential problems with aspirin as an antithrombotic agent: a comparison of studies in an animal model with clinical trials.
Journal of the American College of Cardiology.
1999
Information Resource
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Times cited: 54 -
Carbon monoxide and vascular cell function (review).
International journal of molecular medicine.
1998
Information Resource
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Times cited: 100 -
Thrombin stimulates vascular smooth muscle cell polyamine synthesis by inducing cationic amino acid transporter and ornithine decarboxylase gene expression.
Circulation research.
1998
Academic Article
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Times cited: 32 -
Lysophosphatidylcholine regulates cationic amino acid transport and metabolism in vascular smooth muscle cells. Role in polyamine biosynthesis.
The Journal of biological chemistry.
1997
Academic Article
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Times cited: 43 -
Hemodynamic forces induce the expression of heme oxygenase in cultured vascular smooth muscle cells.
The Journal of clinical investigation.
1997
Academic Article
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Times cited: 176 -
cAMP induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle.
The American journal of physiology.
1997
Academic Article
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Times cited: 80 -
Nitric oxide induces heme oxygenase-1 gene expression and carbon monoxide production in vascular smooth muscle cells.
Circulation research.
1997
Academic Article
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Times cited: 276 -
Vascular endothelium: in defense of blood fluidity.
The Journal of clinical investigation.
1997
Editorial Article
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Times cited: 21 -
Low-molecular-weight heparin for venous thromboembolism.
Hospital practice (1995).
1997
Information Resource
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Times cited: 1 -
Management of thrombocythemia.
Current opinion in hematology.
1996
Information Resource
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Times cited: 10 -
Platelets and shear stress.
Blood.
1996
Information Resource
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Times cited: 756 -
Selective induction of a cationic amino acid transporter by tumor necrosis factor-alpha in vascular endothelium.
Proceedings of the Association of American Physicians.
1996
Academic Article
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Times cited: 17 -
Differential regulation of L-arginine transport and nitric oxide production by vascular smooth muscle and endothelium.
Circulation research.
1996
Academic Article
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Times cited: 64 -
Platelet-derived growth factor regulates vascular smooth muscle cell proliferation by inducing cationic amino acid transporter gene expression.
The Journal of biological chemistry.
1996
Academic Article
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Times cited: 39 -
Epinephrine and shear stress synergistically induce platelet aggregation via a mechanism that partially bypasses VWF-GP IB interactions.
Biorheology.
1996
Academic Article
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Times cited: 20 -
Regulation of interleukin-1-beta-stimulated inducible nitric oxide synthase expression in cultured vascular smooth muscle cells by hemostatic proteins.
Biochemical pharmacology.
1996
Academic Article
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Times cited: 15 -
Low-molecular-weight heparin--an opportunity for home treatment of venous thrombosis.
The New England journal of medicine.
1996
Editorial Article
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Times cited: 62 -
Antiplatelet effects of fibrinolytic agents: a potential contributor to the hemostatic defect after thrombolysis.
Coronary artery disease.
1995
Information Resource
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Times cited: 2 -
The role of thrombin and thrombin inhibitors in coronary angioplasty.
Chest.
1995
Information Resource
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Times cited: 10 -
Fibrinolysis inhibits shear stress-induced platelet aggregation.
Circulation.
1995
Academic Article
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Times cited: 20 -
Deployment of academic subspecialists in the emerging era of primary care.
The American journal of medicine.
1995
Academic Article
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Times cited: 5 -
Ethanol potentiates interleukin-1 beta-stimulated inducible nitric oxide synthase expression in cultured vascular smooth muscle cells.
The Biochemical journal.
1995
Academic Article
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Times cited: 41 -
Vascular smooth muscle cell heme oxygenases generate guanylyl cyclase-stimulatory carbon monoxide.
Circulation.
1995
Academic Article
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Times cited: 231 -
Comparative real-time effects on platelet adhesion and aggregation under flowing conditions of in vivo aspirin, heparin, and monoclonal antibody fragment against glycoprotein IIb-IIIa.
Circulation.
1995
Academic Article
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Times cited: 76 -
Differential regulation of L-arginine transport and inducible NOS in cultured vascular smooth muscle cells.
The American journal of physiology.
1995
Academic Article
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Times cited: 57 -
Effects of nonsteroidal antiinflammatory drugs on platelet function and systemic hemostasis.
Journal of clinical pharmacology.
1995
Information Resource
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Times cited: 272 -
Shear-induced platelet aggregation is inhibited by in vivo infusion of an anti-glycoprotein IIb/IIIa antibody fragment, c7E3 Fab, in patients undergoing coronary angioplasty.
Circulation.
1995
Academic Article
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Times cited: 83 -
Effects of low-dose aspirin on in vitro platelet aggregation in the early minutes after ingestion in normal subjects.
The American journal of cardiology.
1994
Academic Article
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Times cited: 48 -
Cyclic nucleotide regulation of interleukin-1 beta induced nitric oxide synthase expression in vascular smooth muscle cells.
Thrombosis research.
1994
Academic Article
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Times cited: 17 -
Platelets inhibit the induction of nitric oxide synthesis by interleukin-1 beta in vascular smooth muscle cells.
Blood.
1994
Academic Article
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Times cited: 22 -
Acquired platelet storage pool deficiency due to severe valvular disease corrected by prosthetic valve replacement.
American journal of hematology.
1994
Article
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Times cited: 3 -
Protein kinase C is activated in platelets subjected to pathological shear stress.
The Journal of biological chemistry.
1993
Academic Article
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Times cited: 86 -
Plasmin potentiates induction of nitric oxide synthesis by interleukin-1 beta in vascular smooth muscle cells.
The American journal of physiology.
1993
Academic Article
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Times cited: 49 -
Thrombin inhibits induction of nitric oxide synthase in vascular smooth muscle cells.
The American journal of physiology.
1993
Academic Article
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Times cited: 29 - Endothelium-derived Relaxing Factor Inhibits Shear Stress-induced Platelet Aggregation. Platelets. 1993 Academic Article GET IT
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Nonatheromatous arterial thrombosis.
Annual review of medicine.
1993
Information Resource
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Times cited: 23 -
Monoclonal antibody AG-1 initiates platelet activation by a pathway dependent on glycoprotein IIb-IIIa and extracellular calcium.
Biochimica et biophysica acta.
1992
Academic Article
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Times cited: 15 -
Effects on platelet aggregation and fibrinolytic activity during upright posture and exercise in healthy men.
The American journal of cardiology.
1992
Academic Article
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Times cited: 77 -
The induction of nitric oxide synthase activity is inhibited by TGF-beta 1, PDGFAB and PDGFBB in vascular smooth muscle cells.
European journal of pharmacology.
1992
Academic Article
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Times cited: 98 -
Platelet alpha 2 adrenoceptor characteristics during the morning increase in platelet aggregability.
European heart journal.
1992
Academic Article
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Times cited: 15 -
Endothelium-derived relaxing factor inhibits thrombin-induced platelet aggregation by inhibiting platelet phospholipase C.
Blood.
1992
Academic Article
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Times cited: 65 -
Platelet inhibition by an L-arginine-derived substance released by IL-1 beta-treated vascular smooth muscle cells.
The American journal of physiology.
1991
Academic Article
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Times cited: 30 -
von Willebrand factor binding to platelet GpIb initiates signals for platelet activation.
The Journal of clinical investigation.
1991
Academic Article
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Times cited: 252 -
Regulation of the phosphoinositide cycle by Na+/H+ exchange and intracellular pH in human platelets.
Biochimica et biophysica acta.
1991
Academic Article
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Times cited: 12 -
Platelet interaction with vascular smooth muscle in synthesis of prostacyclin.
The American journal of physiology.
1991
Academic Article
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Times cited: 14 -
The effect of enteric-coated aspirin on the morning increase in platelet activity.
American heart journal.
1991
Academic Article
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Times cited: 15 -
Essential thrombocythemia.
Progress in hemostasis and thrombosis.
1991
Information Resource
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Times cited: 46 -
Streptokinase inhibits acute platelet thrombus formation in stenosed dog coronary arteries.
Platelets.
1991
Academic Article
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Times cited: 6 -
Enhancement of thrombin- and ionomycin-stimulated prostacyclin and platelet-activating factor production in cultured endothelial cells by a tumor-promoting phorbol ester.
Journal of cellular physiology.
1990
Academic Article
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Times cited: 24 -
Hemostatic complications in young patients with essential thrombocythemia.
The American journal of medicine.
1990
Academic Article
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Times cited: 65 -
Thrombocytosis and thrombocythemia.
Hematology/oncology clinics of North America.
1990
Information Resource
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Times cited: 73 -
Biochemical mechanisms of platelet activation.
Blood.
1989
Information Resource
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Times cited: 316 -
Inhibition of vascular endothelial cell prostacyclin synthesis by plasmin.
Blood.
1989
Academic Article
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Times cited: 16 -
IL-1 and related cytokines enhance thrombin-stimulated PGI2 production in cultured endothelial cells without affecting thrombin-stimulated von Willebrand factor secretion or platelet-activating factor biosynthesis.
Journal of immunology (Baltimore, Md. : 1950).
1989
Academic Article
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Times cited: 60 -
Second messenger function of phosphatidic acid in platelet activation.
Journal of cellular physiology.
1989
Academic Article
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Times cited: 55 -
PGE1 accelerates thrombolysis by tissue plasminogen activator.
Blood.
1989
Academic Article
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Times cited: 63 -
Turnover of eicosanoid precursor fatty acids among phospholipid classes and subclasses of cultured human umbilical vein endothelial cells.
The Biochemical journal.
1989
Academic Article
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Times cited: 27 -
Morning increase in platelet aggregability. Association with assumption of the upright posture.
Circulation.
1988
Academic Article
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Times cited: 246 -
Control of platelet protein kinase C activation by cyclic AMP.
Biochimica et biophysica acta.
1988
Academic Article
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Times cited: 22 -
Preferential incorporation of eicosanoid precursor fatty acids into human umbilical vein endothelial cell phospholipids.
Biochimica et biophysica acta.
1987
Academic Article
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Times cited: 12 -
Effects of recombinant human granulocyte and macrophage colony-stimulating factors on signal transduction pathways in human granulocytes.
Journal of immunology (Baltimore, Md. : 1950).
1987
Academic Article
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Times cited: 103 - Concurrent morning increase in platelet aggregability and the risk of myocardial infarction and sudden cardiac death. The New England journal of medicine. 1987 Academic Article GET IT
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Synergistic inhibition of platelet activation by plasmin and prostaglandin I2.
Blood.
1987
Academic Article
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Times cited: 25 -
Vascular lipoxygenase activity: synthesis of 15-hydroxyeicosatetraenoic acid from arachidonic acid by blood vessels and cultured vascular endothelial cells.
Thrombosis research.
1987
Academic Article
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Times cited: 39 -
Focussing of the clot: normal and pathologic mechanisms.
Annual review of medicine.
1987
Information Resource
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Times cited: 13 -
Effect of alternate-day regular and enteric-coated aspirin on platelet aggregation, bleeding time, and thromboxane A2 levels in bleeding-time blood.
The American journal of medicine.
1986
Academic Article
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Times cited: 35 - Platelet protein phosphorylation, elevation of cytosolic calcium, and inositol phospholipid breakdown in platelet activation induced by plasmin. The Journal of clinical investigation. 1986 Academic Article GET IT
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Incorporation of platelet and leukocyte lipoxygenase metabolites by cultured vascular cells.
Blood.
1986
Academic Article
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Times cited: 19 -
Refractoriness of platelets to prostaglandins after infusion in rabbits.
The Journal of laboratory and clinical medicine.
1985
Academic Article
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Times cited: 4 -
Long-term efficacy of deferoxamine iron chelation therapy in adults with acquired transfusional iron overload.
Archives of internal medicine.
1985
Academic Article
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Times cited: 32 -
The hypercoagulable states.
Annals of internal medicine.
1985
Information Resource
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Times cited: 373 -
Hemodialysis-associated platelet activation and thrombocytopenia.
The American journal of medicine.
1985
Academic Article
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Times cited: 138 -
Plasmin inhibition of platelet function and of arachidonic acid metabolism.
The Journal of clinical investigation.
1985
Academic Article
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Times cited: 132 -
Leukotriene B4 stimulates polymorphonuclear leukocyte adhesion to cultured vascular endothelial cells.
The Journal of clinical investigation.
1984
Academic Article
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Times cited: 164 -
Bleeding and thrombosis in the myeloproliferative disorders.
Blood.
1984
Information Resource
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Times cited: 377 -
Heterogeneity of heparin lots associated with thrombocytopenia and thromboembolism.
The American journal of medicine.
1984
Academic Article
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Times cited: 28 -
Unidirectional transfer of prostaglandin endoperoxides between platelets and endothelial cells.
The Journal of clinical investigation.
1984
Academic Article
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Times cited: 77 -
Arachidonic acid stimulates mucin secretion in prairie dog gallbladder.
The American journal of physiology.
1983
Academic Article
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Times cited: 68 -
Platelet lipoxygenase-dependent oxygen burst. Evidence for differential activation of lipoxygenase in intact and disrupted human platelets.
Biochimica et biophysica acta.
1982
Academic Article
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Times cited: 9 -
Deficiency of platelet lipoxygenase activity in myeloproliferative disorders.
The New England journal of medicine.
1982
Academic Article
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Times cited: 108 -
Prostacyclin and beta-adrenergic catecholamines inhibit arachidonate release and PGI2 synthesis by vascular endothelium.
Blood.
1981
Academic Article
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Times cited: 39 -
Teratogenic effects of antileukemic chemotherapy.
Archives of internal medicine.
1981
Academic Article
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Times cited: 59 - Clinical consequences of acquired transfusional iron overload in adults. The New England journal of medicine. 1981 Academic Article GET IT
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Regulation of platelet arachidonic acid oxygenation by cyclic AMP.
Blood.
1980
Academic Article
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Times cited: 9 -
Endothelial cell adenylate cyclase: activation by catecholamines and prostaglandin I2+.
Biochemical and biophysical research communications.
1980
Academic Article
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Times cited: 46 -
Inhibition of platelet function by organic nitrate vasodilators.
Blood.
1980
Academic Article
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Times cited: 142 -
Identification of platelet receptors for prostaglandin I2 and D2.
The Journal of biological chemistry.
1979
Academic Article
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Times cited: 137 -
Desensitization of prostaglandin-activated platelet adenylate cyclase.
Prostaglandins.
1979
Academic Article
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Times cited: 15 -
Association of IgA multiple myeloma with pre-existing disease.
British journal of haematology.
1979
Academic Article
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Times cited: 23 -
The influence of chemotherapy on response of patients with hematologic malignancies to influenza vaccine.
Cancer.
1979
Academic Article
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Times cited: 40 -
Platelet resistance to prostaglandin D2 in patients with myeloproliferative disorders.
Blood.
1978
Academic Article
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Times cited: 65 -
Hairy cell leukemia: diagnosis and management.
The American journal of the medical sciences.
1978
Academic Article
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Times cited: 5