Antibody-catalyzed degradation of cocaine. Academic Article uri icon

Overview

abstract

  • Immunization with a phosphonate monoester transition-state analog of cocaine provided monoclonal antibodies capable of catalyzing the hydrolysis of the cocaine benzoyl ester group. An assay for the degradation of radiolabeled cocaine identified active enzymes. Benzoyl esterolysis yields ecgonine methyl ester and benzoic acid, fragments devoid of cocaine's stimulant activity. Passive immunization with such an artificial enzyme could provide a treatment for dependence by blunting reinforcement.

publication date

  • March 26, 1993

Research

keywords

  • Antibodies, Catalytic
  • Antibodies, Monoclonal
  • Cocaine

Identity

Scopus Document Identifier

  • 0027193032

PubMed ID

  • 8456315

Additional Document Info

volume

  • 259

issue

  • 5103