selected publications
- Chalkophore mediated respiratory oxidase flexibility controls M. tuberculosis virulence. 2024 GET IT
- Microbial cancer immunotherapy reprograms hematopoietic stem cells to enhance anti-tumor immunity. 2024 GET IT
- Structure of the M. tuberculosis DnaK-GrpE complex reveals how key DnaK roles are controlled. Nature communications. 2024 Academic Article GET IT
- Commensal antimicrobial resistance mediates microbiome resilience to antibiotic disruption. Science translational medicine. 2024 Academic Article GET IT
- The Rip1 intramembrane protease contributes to iron and zinc homeostasis in Mycobacterium tuberculosis. mSphere. 2023 Academic Article GET IT
- Roles for mycobacterial DinB2 in frameshift and substitution mutagenesis. eLife. 2023 Academic Article GET IT
- The C-Terminal Acid Phosphatase Module of the RNase HI Enzyme RnhC Controls Rifampin Sensitivity and Light-Dependent Colony Pigmentation of Mycobacterium smegmatis. Journal of bacteriology. 2023 Academic Article GET IT
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Mycobacterial helicase Lhr abets resistance to DNA crosslinking agents mitomycin C and cisplatin.
Nucleic acids research.
2023
Academic Article
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Times cited: 1 -
Diisonitrile Lipopeptides Mediate Resistance to Copper Starvation in Pathogenic Mycobacteria.
mBio.
2022
Academic Article
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Times cited: 8 -
BCG-Induced Tumor Immunity Requires Tumor-Intrinsic CIITA Independent of MHC-II.
Cancer immunology research.
2022
Academic Article
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Times cited: 3 -
Distinctive roles of translesion polymerases DinB1 and DnaE2 in diversification of the mycobacterial genome through substitution and frameshift mutagenesis.
Nature communications.
2022
Academic Article
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Times cited: 6 - Single-Cell Transcriptional Profiling Reveals Signatures of Helper, Effector, and Regulatory MAIT Cells during Homeostasis and Activation. Journal of immunology (Baltimore, Md. : 1950). 2022 Academic Article GET IT
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Division of labor between SOS and PafBC in mycobacterial DNA repair and mutagenesis.
Nucleic acids research.
2021
Academic Article
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Times cited: 12 -
Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system.
Cell reports.
2021
Academic Article
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Times cited: 15 -
Integrated sensing of host stresses by inhibition of a cytoplasmic two-component system controls M. tuberculosis acute lung infection.
eLife.
2021
Academic Article
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Times cited: 15 -
The DnaK Chaperone System Buffers the Fitness Cost of Antibiotic Resistance Mutations in Mycobacteria.
mBio.
2021
Academic Article
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Times cited: 18 -
Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis.
Nature communications.
2021
Academic Article
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Times cited: 30 -
Efficient 5-OP-RU-Induced Enrichment of Mucosa-Associated Invariant T Cells in the Murine Lung Does Not Enhance Control of Aerosol Mycobacterium tuberculosis Infection.
Infection and immunity.
2020
Academic Article
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Times cited: 22 -
A multilayered repair system protects the mycobacterial chromosome from endogenous and antibiotic-induced oxidative damage.
Proceedings of the National Academy of Sciences of the United States of America.
2020
Academic Article
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Times cited: 17 -
Bacterial immunotherapy for cancer induces CD4-dependent tumor-specific immunity through tumor-intrinsic interferon-γ signaling.
Proceedings of the National Academy of Sciences of the United States of America.
2020
Academic Article
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Times cited: 70 -
Determinants of COVID-19 disease severity in patients with cancer.
Nature medicine.
2020
Academic Article
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Times cited: 473 -
Editorial overview: Attrition warfare: host cell weapons against intracellular pathogens, and how the pathogens fight back.
Current opinion in immunology.
2019
Editorial Article
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Times cited: 1 -
Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in Mycobacteria.
mBio.
2019
Academic Article
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Times cited: 31 -
TOX is a critical regulator of tumour-specific T cell differentiation.
Nature.
2019
Academic Article
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Times cited: 706 -
Viral oncolytic immunotherapy in the war on cancer: Infection control considerations.
Infection control and hospital epidemiology.
2019
Review
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Times cited: 11 -
Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.
Nature communications.
2018
Academic Article
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Times cited: 56 -
Mucosal-associated invariant and γδ T cell subsets respond to initial Mycobacterium tuberculosis infection.
JCI insight.
2018
Academic Article
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Times cited: 53 -
Mycobacterial Mutagenesis and Drug Resistance Are Controlled by Phosphorylation- and Cardiolipin-Mediated Inhibition of the RecA Coprotease.
Molecular cell.
2018
Academic Article
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Times cited: 18 -
Challenges for the MD Physician-Scientist Upon Entering the Lab: From the Grand to the Practical.
The Journal of infectious diseases.
2018
Academic Article
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Times cited: 5 -
Blood transcriptomic markers of Mycobacterium tuberculosis load in sputum.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
2018
Academic Article
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Times cited: 9 -
The Canonical Wnt Pathway Drives Macropinocytosis in Cancer.
Cancer research.
2018
Academic Article
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Times cited: 68 -
Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU).
PloS one.
2018
Academic Article
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Times cited: 28 -
Control of biotin biosynthesis in mycobacteria by a pyruvate carboxylase dependent metabolic signal.
Molecular microbiology.
2017
Academic Article
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Times cited: 11 -
Antibiotic treatment for Tuberculosis induces a profound dysbiosis of the microbiome that persists long after therapy is completed.
Scientific reports.
2017
Academic Article
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Times cited: 143 -
Nontuberculous Mycobacterial Infections After Silicone Breast Implant Reconstruction Emphasize a Diversity of Infecting Mycobacteria.
Open forum infectious diseases.
2017
Academic Article
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Times cited: 9 -
Longitudinal profiling reveals a persistent intestinal dysbiosis triggered by conventional anti-tuberculosis therapy.
Microbiome.
2017
Academic Article
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Times cited: 118 -
Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA.
eLife.
2017
Academic Article
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Times cited: 93 -
Mycobacterium tuberculosis protease MarP activates a peptidoglycan hydrolase during acid stress.
The EMBO journal.
2017
Academic Article
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Times cited: 42 -
Homologous recombination mediated by the mycobacterial AdnAB helicase without end resection by the AdnAB nucleases.
Nucleic acids research.
2016
Academic Article
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Times cited: 15 -
Division of labor among Mycobacterium smegmatis RNase H enzymes: RNase H1 activity of RnhA or RnhC is essential for growth whereas RnhB and RnhA guard against killing by hydrogen peroxide in stationary phase.
Nucleic acids research.
2016
Academic Article
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Times cited: 19 -
Reconstitution of a Mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK.
Proceedings of the National Academy of Sciences of the United States of America.
2016
Academic Article
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Times cited: 40 -
Adding Insult to Injury: Exacerbating TB Risk with Smoking.
Cell host & microbe.
2016
Comment
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Times cited: 5 -
Control of T cell antigen reactivity via programmed TCR downregulation.
Nature immunology.
2016
Academic Article
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Times cited: 64 -
Clinical and radiographic differentiation of lung nodules caused by mycobacteria and lung cancer: a case-control study.
BMC infectious diseases.
2015
Academic Article
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Times cited: 4 -
RecF and RecR Play Critical Roles in the Homologous Recombination and Single-Strand Annealing Pathways of Mycobacteria.
Journal of bacteriology.
2015
Academic Article
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Times cited: 16 - Genome-Wide Mapping of the Distribution of CarD, RNAP σA, and RNAP β on the Mycobacterium smegmatis Chromosome using Chromatin Immunoprecipitation Sequencing. Genomics data. 2014 Academic Article GET IT
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Novel imidazoline antimicrobial scaffold that inhibits DNA replication with activity against mycobacteria and drug resistant Gram-positive cocci.
ACS chemical biology.
2014
Academic Article
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Times cited: 17 -
RecO protein initiates DNA recombination and strand annealing through two alternative DNA binding mechanisms.
The Journal of biological chemistry.
2014
Academic Article
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Times cited: 12 -
An essential nonredundant role for mycobacterial DnaK in native protein folding.
PLoS genetics.
2014
Academic Article
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Times cited: 55 -
DNA ligase C1 mediates the LigD-independent nonhomologous end-joining pathway of Mycobacterium smegmatis.
Journal of bacteriology.
2014
Academic Article
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Times cited: 14 -
Deficiency of double-strand DNA break repair does not impair Mycobacterium tuberculosis virulence in multiple animal models of infection.
Infection and immunity.
2014
Academic Article
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Times cited: 15 -
The Rip1 protease of Mycobacterium tuberculosis controls the SigD regulon.
Journal of bacteriology.
2014
Academic Article
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Times cited: 22 -
The mechanism of action of BCG therapy for bladder cancer--a current perspective.
Nature reviews. Urology.
2014
Review
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Times cited: 333 -
Function of site-2 proteases in bacteria and bacterial pathogens.
Biochimica et biophysica acta.
2013
Information Resource
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Times cited: 35 -
Essential yet limited role for CCR2⁺ inflammatory monocytes during Mycobacterium tuberculosis-specific T cell priming.
eLife.
2013
Academic Article
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Times cited: 116 -
Site-2 protease substrate specificity and coupling in trans by a PDZ-substrate adapter protein.
Proceedings of the National Academy of Sciences of the United States of America.
2013
Academic Article
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Times cited: 12 -
M.tuberculosis mutants lacking oxygenated mycolates show increased immunogenicity and protective efficacy as compared to M. bovis BCG vaccine in an experimental mouse model.
PloS one.
2013
Academic Article
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Times cited: 6 -
Structure and function of CarD, an essential mycobacterial transcription factor.
Proceedings of the National Academy of Sciences of the United States of America.
2013
Academic Article
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Times cited: 76 -
Oncogenic activation of Pak1-dependent pathway of macropinocytosis determines BCG entry into bladder cancer cells.
Cancer research.
2013
Academic Article
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Times cited: 83 -
A dual role for mycobacterial RecO in RecA-dependent homologous recombination and RecA-independent single-strand annealing.
Nucleic acids research.
2013
Academic Article
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Times cited: 28 -
Characterization of Mycobacterium smegmatis PolD2 and PolD1 as RNA/DNA polymerases homologous to the POL domain of bacterial DNA ligase D.
Biochemistry.
2012
Academic Article
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Times cited: 22 -
Interaction of CarD with RNA polymerase mediates Mycobacterium tuberculosis viability, rifampin resistance, and pathogenesis.
Journal of bacteriology.
2012
Academic Article
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Times cited: 56 -
Inhibition of mycobacterial infection by the tumor suppressor PTEN.
The Journal of biological chemistry.
2012
Academic Article
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Times cited: 36 -
Mycobacterium tuberculosis lacking all mycolic acid cyclopropanation is viable but highly attenuated and hyperinflammatory in mice.
Infection and immunity.
2012
Academic Article
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Times cited: 71 -
Catalytic and non-catalytic roles for the mono-ADP-ribosyltransferase Arr in the mycobacterial DNA damage response.
PloS one.
2011
Academic Article
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Times cited: 14 -
A gamma interferon independent mechanism of CD4 T cell mediated control of M. tuberculosis infection in vivo.
PLoS pathogens.
2011
Academic Article
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Times cited: 169 -
CarD: a new RNA polymerase modulator in mycobacteria.
Transcription.
2011
Information Resource
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Times cited: 12 -
Mycobacteria exploit three genetically distinct DNA double-strand break repair pathways.
Molecular microbiology.
2010
Academic Article
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Times cited: 86 -
An improved counterselectable marker system for mycobacterial recombination using galK and 2-deoxy-galactose.
Gene.
2010
Academic Article
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Times cited: 39 -
M. tuberculosis intramembrane protease Rip1 controls transcription through three anti-sigma factor substrates.
Molecular microbiology.
2010
Academic Article
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Times cited: 51 -
Redundant function of cmaA2 and mmaA2 in Mycobacterium tuberculosis cis cyclopropanation of oxygenated mycolates.
Journal of bacteriology.
2010
Academic Article
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Times cited: 45 -
CarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistence.
Cell.
2009
Academic Article
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Times cited: 192 -
Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis.
Chemistry & biology.
2009
Academic Article
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Times cited: 101 -
AdnAB: a new DSB-resecting motor-nuclease from mycobacteria.
Genes & development.
2009
Academic Article
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Times cited: 75 -
Mutational analysis of Mycobacterium UvrD1 identifies functional groups required for ATP hydrolysis, DNA unwinding, and chemomechanical coupling.
Biochemistry.
2009
Academic Article
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Times cited: 29 -
Use of sloppy molecular beacon probes for identification of mycobacterial species.
Journal of clinical microbiology.
2009
Academic Article
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Times cited: 43 -
Mycobacterium haemophilum infection after alemtuzumab treatment.
Emerging infectious diseases.
2008
Article
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Times cited: 21 -
Delayed protection by ESAT-6-specific effector CD4+ T cells after airborne M. tuberculosis infection.
The Journal of experimental medicine.
2008
Academic Article
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Times cited: 159 -
Domain requirements for DNA unwinding by mycobacterial UvrD2, an essential DNA helicase.
Biochemistry.
2008
Academic Article
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Times cited: 43 -
The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends.
Genes & development.
2008
Academic Article
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Times cited: 100 -
Bacterial DNA repair by non-homologous end joining.
Nature reviews. Microbiology.
2007
Information Resource
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Times cited: 184 -
Leprosy as immune reconstitution inflammatory syndrome in HIV-positive persons.
Emerging infectious diseases.
2007
Article
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Times cited: 22 -
Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cells.
PLoS pathogens.
2007
Academic Article
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Times cited: 258 -
Mycobacterial nonhomologous end joining mediates mutagenic repair of chromosomal double-strand DNA breaks.
Journal of bacteriology.
2007
Academic Article
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Times cited: 80 -
Mycobacterial UvrD1 is a Ku-dependent DNA helicase that plays a role in multiple DNA repair events, including double-strand break repair.
The Journal of biological chemistry.
2007
Academic Article
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Times cited: 55 -
Trans-cyclopropanation of mycolic acids on trehalose dimycolate suppresses Mycobacterium tuberculosis -induced inflammation and virulence.
The Journal of clinical investigation.
2006
Academic Article
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Times cited: 164 -
Crystal structure and nonhomologous end-joining function of the ligase component of Mycobacterium DNA ligase D.
The Journal of biological chemistry.
2006
Academic Article
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Times cited: 53 -
Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D.
Proceedings of the National Academy of Sciences of the United States of America.
2006
Academic Article
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Times cited: 60 -
Regulation of Mycobacterium tuberculosis cell envelope composition and virulence by intramembrane proteolysis.
Nature.
2005
Academic Article
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Times cited: 94 -
Mechanism of nonhomologous end-joining in mycobacteria: a low-fidelity repair system driven by Ku, ligase D and ligase C.
Nature structural & molecular biology.
2005
Academic Article
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Times cited: 153 -
Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule.
The Journal of experimental medicine.
2005
Academic Article
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Times cited: 206 -
Biochemical and genetic analysis of the four DNA ligases of mycobacteria.
The Journal of biological chemistry.
2004
Academic Article
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Times cited: 115 -
Efficient allelic exchange and transposon mutagenesis in Mycobacterium avium by specialized transduction.
Applied and environmental microbiology.
2003
Academic Article
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Times cited: 17 -
The mmaA2 gene of Mycobacterium tuberculosis encodes the distal cyclopropane synthase of the alpha-mycolic acid.
The Journal of biological chemistry.
2002
Academic Article
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Times cited: 64 -
Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis.
The Journal of biological chemistry.
2001
Academic Article
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Times cited: 152 -
Microbial pathogenesis of Mycobacterium tuberculosis: dawn of a discipline.
Cell.
2001
Information Resource
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Times cited: 221 -
The Mycobacterium tuberculosis cmaA2 gene encodes a mycolic acid trans-cyclopropane synthetase.
The Journal of biological chemistry.
2000
Academic Article
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Times cited: 110 -
A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis.
Molecular cell.
2000
Academic Article
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Times cited: 504 -
Acute epiglottitis due to Pasteurella multocida in an adult without animal exposure.
Emerging infectious diseases.
1997
Article
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Times cited: 21 -
Antibody-catalyzed degradation of cocaine.
Science (New York, N.Y.).
1993
Academic Article
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Times cited: 234