CD4+ and CD8+ T cells are not major effectors of mouse hepatitis virus A59-induced demyelinating disease. Academic Article uri icon

Overview

abstract

  • We examined murine hepatitis virus strain A59 (MHV-A59)-induced demyelinating disease in C57BL/6 mice which had previously been thymectomized at 25 days of age. Demyelination was observed in 51-96% of spinal cord quadrants examined 30 or 60 days post infection (dpi), indicating that neither an intact thymus nor thymic infection is a prerequisite to demyelination. Depletion of CD4+ or CD8+ T cells at 5, 7 or 10 dpi did not influence the extent of demyelination indicating that neither T cell subset is a major effector of demyelination. However, these findings do not exclude the possibility that T cells are involved in initiating demyelinating disease very early in infection.

publication date

  • June 1, 1997

Research

keywords

  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Coronavirus Infections
  • Demyelinating Diseases
  • Murine hepatitis virus

Identity

Scopus Document Identifier

  • 0030844558

PubMed ID

  • 9200070

Additional Document Info

volume

  • 3

issue

  • 3