Rudin, Charles

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CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors. Nature. 2024 Academic Article GET IT
Correction: SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing. 2024 GET IT
ATR inhibition activates cancer cell cGAS/STING-interferon signaling and promotes antitumor immunity in small-cell lung cancer. Science advances. 2024 Academic Article GET IT
Detection of SEZ6, a therapeutic target, in medullary thyroid carcinoma. The Journal of clinical endocrinology and metabolism. 2024 Academic Article GET IT
A Phase I/II Study of Valemetostat (DS-3201b), an EZH1/2 Inhibitor, in Combination with Irinotecan in Patients with Recurrent Small-Cell Lung Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2024 Academic Article GET IT
Combination of MDM2 and Targeted Kinase Inhibitors Results in Prolonged Tumor Control in Lung Adenocarcinomas With Oncogenic Tyrosine Kinase Drivers and MDM2 Amplification. JCO precision oncology. 2024 Academic Article GET IT
Early Circulating Tumor DNA Shedding Kinetics for Prediction of Platinum Sensitivity in Patients With Small Cell Lung Cancer. JCO precision oncology. 2024 Academic Article GET IT
TGF-β and RAS jointly unmask primed enhancers to drive metastasis. Cell. 2024 Academic Article GET IT
Chromothripsis-mediated small cell lung carcinoma. Cancer discovery. 2024 Academic Article GET IT
Small cell lung cancer profiling: an updated synthesis of subtypes, vulnerabilities, and plasticity. Trends in cancer. 2024 Review GET IT
Optimal systemic treatment and real-world clinical application of ctDNA in patients with metastatic HER2-mutant lung cancer. European journal of cancer. 2024 Academic Article GET IT
SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing. Journal of hematology & oncology. 2024 Academic Article GET IT
CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation. Signal transduction and targeted therapy. 2024 Academic Article GET IT
Intratumoral Escherichia Is Associated With Improved Survival to Single-Agent Immune Checkpoint Inhibition in Patients With Advanced Non-Small-Cell Lung Cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2024 Academic Article GET IT
Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies. Cancer cell. 2024 Academic Article GET IT
Times cited: 3
Antibiotics are associated with worse outcomes in lung cancer patients treated with chemotherapy and immunotherapy. NPJ precision oncology. 2024 Academic Article GET IT
Imaging with [⁸⁹Zr]Zr-DFO-SC16.56 anti-DLL3 antibody in patients with high-grade neuroendocrine tumours of the lung and prostate: a phase 1/2, first-in-human trial. The Lancet. Oncology. 2024 Academic Article GET IT
Times cited: 3
Molecular classification and biomarkers of outcome with immunotherapy in extensive-stage small-cell lung cancer: analyses of the CASPIAN phase 3 study. Molecular cancer. 2024 Academic Article GET IT
Biomarkers associated with pulmonary exacerbations in a randomized trial of nintedanib for radiation pneumonitis. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2024 Academic Article GET IT
RESILIENT Part 2: A Randomized, Open-Label Phase III Study of Liposomal Irinotecan Versus Topotecan in Adults With Relapsed Small Cell Lung Cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2024 Academic Article GET IT
Molecular phenotyping of small cell lung cancer using targeted cfDNA profiling of transcriptional regulatory regions. Science advances. 2024 Academic Article GET IT
Prognostic Implications of Small Cell Lung Cancer Transcriptional Subtyping for CNS Metastases. JCO precision oncology. 2024 Academic Article GET IT
Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer. Science advances. 2024 Academic Article GET IT
Times cited: 12
Role of CD38 in anti-tumor immunity of small cell lung cancer. Frontiers in immunology. 2024 Academic Article GET IT
A Lung Cancer Mouse Model Database. 2024 GET IT
Functional Characterisation of the ATOH1 Molecular Subtype Indicates a Pro-Metastatic Role in Small Cell Lung Cancer. 2024 GET IT
Immune heterogeneity in small-cell lung cancer and vulnerability to immune checkpoint blockade. Cancer cell. 2024 Academic Article GET IT
First-in-human imaging with [⁸⁹Zr]Zr-DFO-SC16.56 anti-DLL3 antibody in patients with high-grade neuroendocrine tumors of the lung and prostate. 2024 GET IT
Prevalence and Therapeutic Targeting of High Level ERBB2 Amplification in Non-Small Cell Lung Cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2024 Academic Article GET IT
Immune-related colitis is associated with fecal microbial dysbiosis and can be mitigated by fecal microbiota transplantation. Cancer immunology research. 2023 Academic Article GET IT
Standard-of-care systemic therapy with or without stereotactic body radiotherapy in patients with oligoprogressive breast cancer or non-small-cell lung cancer (Consolidative Use of Radiotherapy to Block [CURB] oligoprogression): an open-label, randomised, controlled, phase 2 study. Lancet (London, England). 2023 Academic Article GET IT
SKYSCRAPER-02: Tiragolumab in Combination With Atezolizumab Plus Chemotherapy in Untreated Extensive-Stage Small-Cell Lung Cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2023 Academic Article GET IT
Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma. Cancer discovery. 2023 Academic Article GET IT
KEAP1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance. Cell reports. 2023 Academic Article GET IT
Microsatellite instability and mismatch repair deficiency define a distinct subset of lung cancers characterized by smoking exposure, high tumor mutational burden and recurrent somatic MLH1 inactivation. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2023 Academic Article GET IT
Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma. 2023 GET IT
ctDNA-based detection of molecular residual disease in stage I-III non-small cell lung cancer patients treated with definitive radiotherapy. Frontiers in oncology. 2023 Academic Article GET IT
Patient-Reported Health-Related Quality of Life in KEYNOTE-604: Pembrolizumab or Placebo Added to Etoposide and Platinum as First-Line Therapy for Extensive-Stage SCLC. JTO clinical and research reports. 2023 Academic Article GET IT
Breathing room - focusing on the 'other' lung cancer. Nature cancer. 2023 Academic Article GET IT
De Novo and Histologically Transformed Small-Cell Lung Cancer Is Sensitive to Lurbinectedin Treatment Through the Modulation of EMT and NOTCH Signaling Pathways. Clinical cancer research : an official journal of the American Association for Cancer Research. 2023 Academic Article GET IT
Outcomes of Combination Platinum-Doublet Chemotherapy and Anti-PD(L)-1 Blockade in KRASG12C-Mutant Non-Small Cell Lung Cancer. The oncologist. 2023 Academic Article GET IT
Phase I Study of Entinostat, Atezolizumab, Carboplatin, and Etoposide in Previously Untreated Extensive-Stage Small Cell Lung Cancer, ETCTN 10399. The oncologist. 2023 Academic Article GET IT
Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 down-regulation in lung and prostate cancers. Science translational medicine. 2023 Academic Article GET IT
Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growth. 2023 GET IT
Clinical and molecular features of long-term response to immune checkpoint inhibitors in patients with advanced non-small cell lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2023 Academic Article GET IT
Efficacy of PD-(L)1 blockade monotherapy compared with PD-(L)1 blockade plus chemotherapy in first-line PD-L1-positive advanced lung adenocarcinomas: a cohort study. Journal for immunotherapy of cancer. 2023 Academic Article GET IT
Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer. 2023 GET IT
Emerging therapies targeting the delta-like ligand 3 (DLL3) in small cell lung cancer. Journal of hematology & oncology. 2023 Review GET IT
Clinical Benefit From Immunotherapy in Patients With SCLC Is Associated With Tumor Capacity for Antigen Presentation. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2023 Academic Article GET IT
Times cited: 35
CRACD loss promotes small cell lung cancer tumorigenesis via EZH2-mediated immune evasion. 2023 GET IT
Combination Therapy With MDM2 and MEK Inhibitors Is Effective in Patient-Derived Models of Lung Adenocarcinoma With Concurrent Oncogenic Drivers and MDM2 Amplification. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2023 Academic Article GET IT
Times cited: 6
Conserved transcriptional connectivity of regulatory T cells in the tumor microenvironment informs new combination cancer therapy strategies. Nature immunology. 2023 Academic Article GET IT
Times cited: 19
IL-18-secreting CAR T cells targeting DLL3 are highly effective in small cell lung cancer models. The Journal of clinical investigation. 2023 Academic Article GET IT
Times cited: 53
Tarlatamab: New Star on the Horizon for Small-Cell Lung Cancer?. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2023 Editorial Article GET IT
In vivo metabolomics identifies CD38 as an emergent vulnerability in LKB1 -mutant lung cancer. 2023 GET IT
Genomic mapping of metastatic organotropism in lung adenocarcinoma. Cancer cell. 2023 Academic Article GET IT
Lineage tracing reveals clonal progenitors and long-term persistence of tumor-specific T cells during immune checkpoint blockade. Cancer cell. 2023 Academic Article GET IT
Inference of single cell profiles from histology stains with the Single-Cell omics from Histology Analysis Framework (SCHAF). 2023 GET IT
Randomized Phase 2 Placebo-Controlled Trial of Nintedanib for the Treatment of Radiation Pneumonitis. International journal of radiation oncology, biology, physics. 2023 Academic Article GET IT
Times cited: 1
Safety and clinical activity of atezolizumab plus erlotinib in patients with non-small-cell lung cancer. ESMO open. 2023 Academic Article GET IT
Times cited: 6
Phase 1, open-label, dose-escalation study on the safety, pharmacokinetics, and preliminary efficacy of intravenous Coxsackievirus A21 (V937), with or without pembrolizumab, in patients with advanced solid tumors. Journal for immunotherapy of cancer. 2023 Academic Article GET IT
Times cited: 18
The ectonucleotidase CD39 identifies tumor-reactive CD8⁺ T cells predictive of immune checkpoint blockade efficacy in human lung cancer. Immunity. 2022 Academic Article GET IT
Molecular Biomarkers of Disease Outcomes and Mechanisms of Acquired Resistance to First-Line Osimertinib in Advanced EGFR-Mutant Lung Cancers. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2022 Academic Article GET IT
Times cited: 48
Genomic and transcriptomic analysis of a diffuse pleural mesothelioma patient-derived xenograft library. Genome medicine. 2022 Academic Article GET IT
Times cited: 2
Overall survival with circulating tumor DNA-guided therapy in advanced non-small-cell lung cancer. Nature medicine. 2022 Academic Article GET IT
Times cited: 71
Rb Tumor Suppressor in Small Cell Lung Cancer: Combined Genomic and IHC Analysis with a Description of a Distinct Rb-Proficient Subset. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 Editorial Article GET IT
Times cited: 39
Neuroendocrine neoplasms of the lung and gastrointestinal system: convergent biology and a path to better therapies. Nature reviews. Clinical oncology. 2022 Review GET IT
Times cited: 2
Protocol to dissociate, process, and analyze the human lung tissue using single-cell RNA-seq. STAR protocols. 2022 Academic Article GET IT
Targeting NFE2L2/KEAP1 Mutations in Advanced NSCLC With the TORC1/2 Inhibitor TAK-228. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2022 Academic Article GET IT
Times cited: 15
APOBEC mutagenesis, kataegis, chromothripsis in EGFR-mutant osimertinib-resistant lung adenocarcinomas. Annals of oncology : official journal of the European Society for Medical Oncology. 2022 Academic Article GET IT
Times cited: 26
Systemic and Oligo-Acquired Resistance to PD-(L)1 Blockade in Lung Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 Academic Article GET IT
Times cited: 26
BMS-986012, an Anti-Fucosyl-GM1 Monoclonal Antibody as Monotherapy or in Combination With Nivolumab in Relapsed/Refractory SCLC: Results From a First-in-Human Phase 1/2 Study. JTO clinical and research reports. 2022 Academic Article GET IT
Regulation of neuroendocrine plasticity by the RNA-binding protein ZFP36L1. Nature communications. 2022 Academic Article GET IT
Times cited: 14
cfDNA methylome profiling for detection and subtyping of small cell lung cancers. Nature cancer. 2022 Academic Article GET IT
Times cited: 58
PRC2 Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1 Targeted Therapy via Enhanced Viral Mimicry. Cancer discovery. 2022 Academic Article GET IT
Ultrasmall Nanoparticle Delivery of Doxorubicin Improves Therapeutic Index for High-Grade Glioma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 Academic Article GET IT
Times cited: 10
Delta-like ligand 3-targeted radioimmunotherapy for neuroendocrine prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. 2022 Academic Article GET IT
Times cited: 22
POU2F3 in SCLC: Clinicopathologic and Genomic Analysis With a Focus on Its Diagnostic Utility in Neuroendocrine-Low SCLC. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2022 Academic Article GET IT
Times cited: 43
Targeting Lysine-Specific Demethylase 1 Rescues Major Histocompatibility Complex Class I Antigen Presentation and Overcomes Programmed Death-Ligand 1 Blockade Resistance in SCLC. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2022 Academic Article GET IT
Selpercatinib-Induced Hypothyroidism Through Off-Target Inhibition of Type 2 Iodothyronine Deiodinase. JCO precision oncology. 2022 Academic Article GET IT
ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1. Molecular cell. 2022 Academic Article GET IT
Times cited: 12
WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC. Cell reports. 2022 Academic Article GET IT
Times cited: 61
Rationale and Design of the Phase 3 KEYLYNK-013 Study of Pembrolizumab With Concurrent Chemoradiotherapy Followed by Pembrolizumab With or Without Olaparib for Limited-Stage Small-Cell Lung Cancer. Clinical lung cancer. 2022 Academic Article GET IT
Times cited: 3
Germline Pathogenic Variants Impact Clinicopathology of Advanced Lung Cancer. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2022 Academic Article GET IT
Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenografts. Nature communications. 2022 Academic Article GET IT
Times cited: 27
Radioimmunotherapy Targeting Delta-like Ligand 3 in Small Cell Lung Cancer Exhibits Antitumor Efficacy with Low Toxicity. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 Academic Article GET IT
Times cited: 27
Inferring gene expression from cell-free DNA fragmentation profiles. Nature biotechnology. 2022 Academic Article GET IT
Times cited: 3
Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients. Cell. 2022 Academic Article GET IT
Molecular Imaging of Neuroendocrine Prostate Cancer by Targeting Delta-Like Ligand 3. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2022 Academic Article GET IT
Times cited: 22
Immune biomarkers and response to checkpoint inhibition of BRAF^V600 and BRAF non-V600 altered lung cancers. British journal of cancer. 2021 Academic Article GET IT
Times cited: 17
Multiomic Analysis of Lung Tumors Defines Pathways Activated in Neuroendocrine Transformation. Cancer discovery. 2021 Academic Article GET IT
Times cited: 85
Rlf-Mycl Gene Fusion Drives Tumorigenesis and Metastasis in a Mouse Model of Small Cell Lung Cancer. Cancer discovery. 2021 Academic Article GET IT
Times cited: 25
Inhibition of XPO1 Sensitizes Small Cell Lung Cancer to First- and Second-Line Chemotherapy. Cancer research. 2021 Academic Article GET IT
Times cited: 25
Phase 1 Clinical Trial of Trametinib and Ponatinib in Patients With NSCLC Harboring KRAS Mutations. JTO clinical and research reports. 2021 Academic Article GET IT
Times cited: 8
A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry. Viruses. 2021 Academic Article GET IT
Times cited: 10
Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation. Journal of hematology & oncology. 2021 Academic Article GET IT
Times cited: 37
Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer. Cancer cell. 2021 Academic Article GET IT
Times cited: 197
MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer. iScience. 2021 Academic Article GET IT
Times cited: 14
Smarca4 Inactivation Promotes Lineage-Specific Transformation and Early Metastatic Features in the Lung. Cancer discovery. 2021 Academic Article GET IT
Times cited: 59
Co-targeting TGF-β and PD-L1 with radiation therapy: The Goldilocks principle. Cell reports. Medicine. 2021 Comment GET IT
Times cited: 2
Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis. Cancer cell. 2021 Academic Article GET IT
Times cited: 76
Clinical utility of next-generation sequencing-based ctDNA testing for common and novel ALK fusions. Lung cancer (Amsterdam, Netherlands). 2021 Academic Article GET IT
Times cited: 18
Quantitative In Vivo Analyses Reveal a Complex Pharmacogenomic Landscape in Lung Adenocarcinoma. Cancer research. 2021 Academic Article GET IT
Times cited: 11
Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS. Nature communications. 2021 Academic Article GET IT
Times cited: 91
Tim-4⁺ cavity-resident macrophages impair anti-tumor CD8⁺ T cell immunity. Cancer cell. 2021 Academic Article GET IT
Times cited: 115
Protein neddylation as a therapeutic target in pulmonary and extrapulmonary small cell carcinomas. Genes & development. 2021 Academic Article GET IT
Times cited: 5
ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer. Nature cancer. 2021 Academic Article GET IT
Times cited: 84
N-Linked Glycosylation on Anthrax Toxin Receptor 1 Is Essential for Seneca Valley Virus Infection. Viruses. 2021 Academic Article GET IT
Times cited: 6
Small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up^☆. Annals of oncology : official journal of the European Society for Medical Oncology. 2021 Guideline GET IT
Times cited: 293
Synthesis and Comparative In Vivo Evaluation of Site-Specifically Labeled Radioimmunoconjugates for DLL3-Targeted ImmunoPET. Bioconjugate chemistry. 2021 Academic Article GET IT
Times cited: 10
Advances in Small-Cell Lung Cancer (SCLC) Translational Research. Cold Spring Harbor perspectives in medicine. 2021 Review GET IT
Times cited: 32
Ribociclib and everolimus in well-differentiated foregut neuroendocrine tumors. Endocrine-related cancer. 2021 Academic Article GET IT
Times cited: 5
Response to Standard Therapies and Comprehensive Genomic Analysis for Patients with Lung Adenocarcinoma with EGFR Exon 20 Insertions. Clinical cancer research : an official journal of the American Association for Cancer Research. 2021 Academic Article GET IT
Times cited: 50
KRAS ^G12C Mutation Is Associated with Increased Risk of Recurrence in Surgically Resected Lung Adenocarcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2021 Academic Article GET IT
Times cited: 25
Treatment Outcomes and Clinical Characteristics of Patients with KRAS-G12C-Mutant Non-Small Cell Lung Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2021 Academic Article GET IT
Times cited: 76
Correction: Combined Inhibition of NEDD8-activating Enzyme and mTOR Suppresses NF2 Loss-driven Tumorigenesis. 2021 GET IT
Small-cell lung cancer. Nature reviews. Disease primers. 2021 Review GET IT
Times cited: 747
A Call to Action: Dismantling Racial Injustices in Preclinical Research and Clinical Care of Black Patients Living with Small Cell Lung Cancer. Cancer discovery. 2020 Academic Article GET IT
Times cited: 10
TMEM41B Is a Pan-flavivirus Host Factor. Cell. 2020 Academic Article GET IT
Times cited: 118
Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer. Cell reports. 2020 Academic Article GET IT
Times cited: 146
MET Exon 14-altered Lung Cancers and MET Inhibitor Resistance. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 Academic Article GET IT
Times cited: 41
Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties. Journal of medicinal chemistry. 2020 Academic Article GET IT
Times cited: 57
TMEM41B is a pan-flavivirus host factor. 2020 GET IT
SCLC Subtypes Defined by ASCL1, NEUROD1, POU2F3, and YAP1: A Comprehensive Immunohistochemical and Histopathologic Characterization. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2020 Academic Article GET IT
Times cited: 299
Inherited Rare, Deleterious Variants in ATM Increase Lung Adenocarcinoma Risk. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2020 Academic Article GET IT
Times cited: 1
Concurrent Targeting of Potential Cancer Stem Cells Regulating Pathways Sensitizes Lung Adenocarcinoma to Standard Chemotherapy. Molecular cancer therapeutics. 2020 Academic Article GET IT
Times cited: 8
Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. Cell. 2020 Academic Article GET IT
Times cited: 784
CRISPR Gene Therapy: Applications, Limitations, and Implications for the Future. Frontiers in oncology. 2020 Review GET IT
Times cited: 287
Molecular Engineering of Ultrasmall Silica Nanoparticle-Drug Conjugates as Lung Cancer Therapeutics. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 Academic Article GET IT
Times cited: 19
CNS Metastases in Patients With MET Exon 14-Altered Lung Cancers and Outcomes With Crizotinib. JCO precision oncology. 2020 Academic Article GET IT
Times cited: 20
The Genomic Landscape of SMARCA4 Alterations and Associations with Outcomes in Patients with Lung Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 Academic Article GET IT
Times cited: 156
Emergence of a High-Plasticity Cell State during Lung Cancer Evolution. Cancer cell. 2020 Academic Article GET IT
Times cited: 199
Role of mTOR As an Essential Kinase in SCLC. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2020 Academic Article GET IT
Times cited: 14
COVID-19 in patients with lung cancer. Annals of oncology : official journal of the European Society for Medical Oncology. 2020 Academic Article GET IT
Times cited: 200
Publisher Correction: Lineage plasticity in cancer: a shared pathway of therapeutic resistance. 2020 GET IT
Times cited: 1
Pembrolizumab or Placebo Plus Etoposide and Platinum as First-Line Therapy for Extensive-Stage Small-Cell Lung Cancer: Randomized, Double-Blind, Phase III KEYNOTE-604 Study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2020 Academic Article GET IT
Times cited: 493
Targeted Therapies and Biomarkers in Small Cell Lung Cancer. Frontiers in oncology. 2020 Review GET IT
Times cited: 68
SC-002 in patients with relapsed or refractory small cell lung cancer and large cell neuroendocrine carcinoma: Phase 1 study. Lung cancer (Amsterdam, Netherlands). 2020 Academic Article GET IT
Times cited: 20
Protein-altering germline mutations implicate novel genes related to lung cancer development. Nature communications. 2020 Academic Article GET IT
Times cited: 30
Clinical outcomes, local-regional control and the role for metastasis-directed therapies in stage III non-small cell lung cancers treated with chemoradiation and durvalumab. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2020 Academic Article GET IT
Times cited: 47
HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers. Cancer discovery. 2020 Academic Article GET IT
Times cited: 185
Direct genome editing of patient-derived xenografts using CRISPR-Cas9 enables rapid in vivo functional genomics. Nature cancer. 2020 Academic Article GET IT
Times cited: 26
Lineage plasticity in cancer: a shared pathway of therapeutic resistance. Nature reviews. Clinical oncology. 2020 Review GET IT
Times cited: 290
Epigenetic therapy inhibits metastases by disrupting premetastatic niches. Nature. 2020 Academic Article GET IT
Times cited: 235
Circulating Tumor DNA Analysis to Assess Risk of Progression after Long-term Response to PD-(L)1 Blockade in NSCLC. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 Academic Article GET IT
Times cited: 88
Regenerative lineages and immune-mediated pruning in lung cancer metastasis. Nature medicine. 2020 Academic Article GET IT
Times cited: 245
Clinical and molecular correlates of PD-L1 expression in patients with lung adenocarcinomas. Annals of oncology : official journal of the European Society for Medical Oncology. 2020 Academic Article GET IT
Times cited: 220
New Approaches to SCLC Therapy: From the Laboratory to the Clinic. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2020 Review GET IT
Times cited: 120
A Phase II Trial of Albumin-Bound Paclitaxel and Gemcitabine in Patients with Newly Diagnosed Stage IV Squamous Cell Lung Cancers. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 Academic Article GET IT
Times cited: 9
Utilization and factors precluding the initiation of consolidative durvalumab in unresectable stage III non-small cell lung cancer. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2019 Academic Article GET IT
Times cited: 20
High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants. Nature medicine. 2019 Academic Article GET IT
Times cited: 494
SMARCA4-Deficient Thoracic Sarcomatoid Tumors Represent Primarily Smoking-Related Undifferentiated Carcinomas Rather Than Primary Thoracic Sarcomas. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2019 Academic Article GET IT
Times cited: 200
Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis. Nature cell biology. 2019 Academic Article GET IT
Times cited: 284
Epigenetic targeting of DNA repair in lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 2019 Article GET IT
Times cited: 3
Eosinophilic Fasciitis Following Checkpoint Inhibitor Therapy: Four Cases and a Review of Literature. The oncologist. 2019 Review GET IT
Times cited: 41
Phase II randomised discontinuation trial of brivanib in patients with advanced solid tumours. European journal of cancer. 2019 Academic Article GET IT
Times cited: 25
Ultrasmall Core-Shell Silica Nanoparticles for Precision Drug Delivery in a High-Grade Malignant Brain Tumor Model. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Academic Article GET IT
Times cited: 63
Efficacy and Safety of Rovalpituzumab Tesirine in Third-Line and Beyond Patients with DLL3-Expressing, Relapsed/Refractory Small-Cell Lung Cancer: Results From the Phase II TRINITY Study. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Academic Article GET IT
Times cited: 221
Frequency and outcomes of brain metastases in patients with HER2-mutant lung cancers. Cancer. 2019 Academic Article GET IT
Times cited: 59
Lessons learned from routine, targeted assessment of liquid biopsies for EGFR T790M resistance mutation in patients with EGFR mutant lung cancers. Acta oncologica (Stockholm, Sweden). 2019 Academic Article GET IT
Times cited: 8
Circulating Tumor DNA Profiling in Small-Cell Lung Cancer Identifies Potentially Targetable Alterations. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Academic Article GET IT
Times cited: 38
Analyzing the Thin Tail: Searching for Biomarkers of Exceptional Survival in SCLC. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2019 Editorial Article GET IT
Author Correction: Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. 2019 GET IT
Times cited: 16
Concurrent RB1 and TP53 Alterations Define a Subset of EGFR-Mutant Lung Cancers at risk for Histologic Transformation and Inferior Clinical Outcomes. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2019 Academic Article GET IT
Times cited: 253
Positron-Emission Tomographic Imaging of a Fluorine 18-Radiolabeled Poly(ADP-Ribose) Polymerase 1 Inhibitor Monitors the Therapeutic Efficacy of Talazoparib in SCLC Patient-Derived Xenografts. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2019 Academic Article GET IT
Times cited: 16
A Prospective Study of Circulating Tumor DNA to Guide Matched Targeted Therapy in Lung Cancers. Journal of the National Cancer Institute. 2019 Academic Article GET IT
Times cited: 98
Spread Through Air Spaces (STAS) Is Prognostic in Atypical Carcinoid, Large Cell Neuroendocrine Carcinoma, and Small Cell Carcinoma of the Lung. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2019 Academic Article GET IT
Times cited: 67
Immunophenotype and Response to Immunotherapy of RET-Rearranged Lung Cancers. JCO precision oncology. 2019 Academic Article GET IT
Times cited: 115
Acquired MET Exon 14 Alteration Drives Secondary Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in EGFR-Mutated Lung Cancer. JCO precision oncology. 2019 Academic Article GET IT
Times cited: 51
Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. Nature reviews. Cancer. 2019 Review GET IT
Times cited: 749
High Yield of RNA Sequencing for Targetable Kinase Fusions in Lung Adenocarcinomas with No Mitogenic Driver Alteration Detected by DNA Sequencing and Low Tumor Mutation Burden. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Academic Article GET IT
Times cited: 331
Phase Ib study of the MEK inhibitor cobimetinib (GDC-0973) in combination with the PI3K inhibitor pictilisib (GDC-0941) in patients with advanced solid tumors. Investigational new drugs. 2019 Academic Article GET IT
Times cited: 39
Ultra-deep next-generation sequencing of plasma cell-free DNA in patients with advanced lung cancers: results from the Actionable Genome Consortium. Annals of oncology : official journal of the European Society for Medical Oncology. 2019 Academic Article GET IT
Times cited: 121
Harnessing Clinical Sequencing Data for Survival Stratification of Patients with Metastatic Lung Adenocarcinomas. JCO precision oncology. 2019 Academic Article GET IT
Times cited: 32
Stage IV lung carcinoids: spectrum and evolution of proliferation rate, focusing on variants with elevated proliferation indices. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2019 Academic Article GET IT
Times cited: 62
Acquired BRAF Rearrangements Induce Secondary Resistance to EGFR therapy in EGFR-Mutated Lung Cancers. 2019 GET IT
Times cited: 63
Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition. Science signaling. 2019 Academic Article GET IT
Times cited: 147
Afatinib in patients with metastatic or recurrent HER2-mutant lung cancers: a retrospective international multicentre study. European journal of cancer. 2019 Academic Article GET IT
Times cited: 71
ONECUT2 is a driver of neuroendocrine prostate cancer. Nature communications. 2019 Academic Article GET IT
Times cited: 167
Peptide-based PET quantifies target engagement of PD-L1 therapeutics. The Journal of clinical investigation. 2019 Academic Article GET IT
Times cited: 105
NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination. Science (New York, N.Y.). 2018 Academic Article GET IT
Times cited: 273
Activation of KRAS Mediates Resistance to Targeted Therapy in MET Exon 14-mutant Non-small Cell Lung Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018 Academic Article GET IT
Times cited: 91
PD-L1 expression, tumor mutational burden, and response to immunotherapy in patients with MET exon 14 altered lung cancers. Annals of oncology : official journal of the European Society for Medical Oncology. 2018 Academic Article GET IT
Times cited: 247
Acquired ALK and RET Gene Fusions as Mechanisms of Resistance to Osimertinib in EGFR-Mutant Lung Cancers. JCO precision oncology. 2018 Academic Article GET IT
Times cited: 91
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A phase I study of STEALTH cisplatin (SPI-77) and vinorelbine in patients with advanced non small-cell lung cancer. Clinical lung cancer. 2000 Academic Article GET IT
Cell line dependence of Bcl-2-induced alteration of glutathione handling. Oncogene. 2000 Academic Article GET IT
Times cited: 34
Early release of mitochondrial cytochrome c and expression of mitochondrial epitope 7A6 with a porphyrin-derived photosensitizer: Bcl-2 and Bcl-xL overexpression do not prevent early mitochondrial events but still depress caspase activity. Laboratory investigation; a journal of technical methods and pathology. 1999 Academic Article GET IT
Times cited: 71
Bcl-xL and Bcl-2 expression in squamous cell carcinoma of the head and neck. Cancer. 1999 Academic Article GET IT
Times cited: 102
B-cell development and maturation. Seminars in oncology. 1998 Information Resource GET IT
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Bcl-xL is phosphorylated in malignant cells following microtubule disruption. Cancer research. 1998 Article GET IT
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A Bcl-xL transgene promotes malignant conversion of chemically initiated skin papillomas. Cancer research. 1998 Academic Article GET IT
Times cited: 61
Apoptosis and disease: regulation and clinical relevance of programmed cell death. Annual review of medicine. 1997 Information Resource GET IT
Times cited: 308
Apoptotic signaling in lymphocytes. Current opinion in hematology. 1996 Information Resource GET IT
Times cited: 9
Expression of bcl-xL can confer a multidrug resistance phenotype. Blood. 1995 Academic Article GET IT
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Two conserved essential motifs of the murine immunoglobulin lambda enhancers bind B-cell-specific factors. Molecular and cellular biology. 1992 Academic Article GET IT
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Identification and localization of an enhancer for the human lambda L chain Ig gene complex. Journal of immunology (Baltimore, Md. : 1950). 1991 Academic Article GET IT
Times cited: 25
Precursors of both conventional and Ly-1 B cells can escape feedback inhibition of Ig gene rearrangement. Journal of immunology (Baltimore, Md. : 1950). 1991 Academic Article GET IT
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Differential splicing of thymosin beta 4 mRNA. Journal of immunology (Baltimore, Md. : 1950). 1990 Academic Article GET IT
Times cited: 23
A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B. Genes & development. 1990 Academic Article GET IT
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Inhibition of immunoglobulin gene rearrangement by the expression of a lambda 2 transgene. The Journal of experimental medicine. 1989 Academic Article GET IT
Times cited: 47

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Background

education and training

Ph.D., University of Chicago Pritzker School of Medicine 91
M.D., University of Chicago Pritzker School of Medicine 1993
B.S., University of Wisconsin, Milwaukee 1986

Contact

full name

Charles Rudin

VIVO Weill Cornell Medical College

Charles Rudin Professor of Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email