Christini, David J.

Publications

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selected publications

Resolving Artifacts in Voltage-Clamp Experiments with Computational Modeling: An Application to Fast Sodium Current Recordings. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2025 Academic Article GET IT
Resolving artefacts in voltage-clamp experiments with computational modelling: an application to fast sodium current recordings. bioRxiv : the preprint server for biology. 2024 Article GET IT
Single-cell ionic current phenotyping elucidates non-canonical features and predictive potential of cardiomyocytes during automated drug experiments. The Journal of physiology. 2024 Academic Article GET IT
Times cited: 1
Stem cell-derived cardiomyocyte heterogeneity confounds electrophysiological insights. The Journal of physiology. 2024 Information Resource GET IT
Times cited: 7
Single-cell ionic current phenotyping explains stem cell-derived cardiomyocyte action potential morphology. American journal of physiology. Heart and circulatory physiology. 2024 Academic Article GET IT
Times cited: 6
Optimization of a cardiomyocyte model illuminates role of increased I_Na,L in repolarization reserve. American journal of physiology. Heart and circulatory physiology. 2023 Academic Article GET IT
Times cited: 2
Rapid ionic current phenotyping (RICP) identifies mechanistic underpinnings of iPSC-CM AP heterogeneity. bioRxiv : the preprint server for biology. 2023 Article GET IT
Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2023 Article GET IT
Times cited: 5
An in silico-in vitro pipeline for drug cardiotoxicity screening identifies ionic pro-arrhythmia mechanisms. British journal of pharmacology. 2022 Academic Article GET IT
Times cited: 20
A dual SHOX2:GFP; MYH6:mCherry knockin hESC reporter line for derivation of human SAN-like cells. iScience. 2022 Academic Article GET IT
Times cited: 5
Validation of quantitative measure of repolarization reserve as a novel marker of drug induced proarrhythmia. Journal of molecular and cellular cardiology. 2020 Academic Article GET IT
Times cited: 14
A human embryonic stem cell reporter line for monitoring chemical-induced cardiotoxicity. Cardiovascular research. 2020 Academic Article GET IT
Times cited: 17
Calibration of ionic and cellular cardiac electrophysiology models. Wiley interdisciplinary reviews. Systems biology and medicine. 2020 Information Resource GET IT
Times cited: 87
Light-Activated Dynamic Clamp Using iPSC-Derived Cardiomyocytes. Biophysical journal. 2018 Academic Article GET IT
Times cited: 28
Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing. Frontiers in physiology. 2018 Information Resource GET IT
Times cited: 21
Overexpression of Map3k7 activates sinoatrial node-like differentiation in mouse ES-derived cardiomyocytes. PloS one. 2017 Academic Article GET IT
Times cited: 10
Global Optimization of Ventricular Myocyte Model to Multi-Variable Objective Improves Predictions of Drug-Induced Torsades de Pointes. Frontiers in physiology. 2017 Academic Article GET IT
Times cited: 33
Slow [Na⁺]_i dynamics impacts arrhythmogenesis and spiral wave reentry in cardiac myocyte ionic model. Chaos (Woodbury, N.Y.). 2017 Academic Article GET IT
Times cited: 14
Hard real-time closed-loop electrophysiology with the Real-Time eXperiment Interface (RTXI). PLoS computational biology. 2017 Academic Article GET IT
Times cited: 53
Differential roles of two delayed rectifier potassium currents in regulation of ventricular action potential duration and arrhythmia susceptibility. The Journal of physiology. 2016 Academic Article GET IT
Times cited: 35
Illuminating Myocyte-Fibroblast Homotypic and Heterotypic Gap Junction Dynamics Using Dynamic Clamp. Biophysical journal. 2016 Academic Article GET IT
Times cited: 17
Improving cardiomyocyte model fidelity and utility via dynamic electrophysiology protocols and optimization algorithms. The Journal of physiology. 2016 Information Resource GET IT
Times cited: 34
Computational Approaches to Understanding the Role of Fibroblast-Myocyte Interactions in Cardiac Arrhythmogenesis. BioMed research international. 2015 Information Resource GET IT
Times cited: 17
Cell-specific cardiac electrophysiology models. PLoS computational biology. 2015 Academic Article GET IT
Times cited: 92
Voltage and calcium dynamics both underlie cellular alternans in cardiac myocytes. Biophysical journal. 2014 Academic Article GET IT
Times cited: 26
Dependence of phase-2 reentry and repolarization dispersion on epicardial and transmural ionic heterogeneity: a simulation study. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2014 Academic Article GET IT
Times cited: 23
Kcne2 deletion creates a multisystem syndrome predisposing to sudden cardiac death. Circulation. Cardiovascular genetics. 2014 Academic Article GET IT
Times cited: 43
Dynamic clamp in cardiac and neuronal systems using RTXI. Methods in molecular biology (Clifton, N.J.). 2014 Academic Article GET IT
Times cited: 21
NHE isoform switching and KChIP2 upregulation in aging porcine atria. PloS one. 2013 Academic Article GET IT
Times cited: 4
The relative influences of phosphometabolites and pH on action potential morphology during myocardial reperfusion: a simulation study. PloS one. 2012 Academic Article GET IT
Times cited: 9
Rapid genetic algorithm optimization of a mouse computational model: benefits for anthropomorphization of neonatal mouse cardiomyocytes. Frontiers in physiology. 2012 Academic Article GET IT
Times cited: 35
Non-linear dynamics of cardiac alternans: subcellular to tissue-level mechanisms of arrhythmia. Frontiers in physiology. 2012 Academic Article GET IT
Times cited: 27
Transcriptomic analysis reveals atrial KCNE1 down-regulation following lung lobectomy. Journal of molecular and cellular cardiology. 2012 Academic Article GET IT
Times cited: 13
Nonlinear dynamics in cardiology. Annual review of biomedical engineering. 2012 Information Resource GET IT
Times cited: 52
Exploiting mathematical models to illuminate electrophysiological variability between individuals. The Journal of physiology. 2012 Information Resource GET IT
Times cited: 121
A class of Monte-Carlo-based statistical algorithms for efficient detection of repolarization alternans. IEEE transactions on bio-medical engineering. 2012 Academic Article GET IT
Times cited: 9
Effects of electrical and structural remodeling on atrial fibrillation maintenance: a simulation study. PLoS computational biology. 2012 Academic Article GET IT
Times cited: 79
NHE inhibition does not improve Na(+) or Ca(2+) overload during reperfusion: using modeling to illuminate the mechanisms underlying a therapeutic failure. PLoS computational biology. 2011 Academic Article GET IT
Times cited: 21
A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms. Science translational medicine. 2011 Academic Article GET IT
Times cited: 194
Control of action potential duration alternans in canine cardiac ventricular tissue. IEEE transactions on bio-medical engineering. 2010 Academic Article GET IT
Times cited: 19
Feedback-control induced pattern formation in cardiac myocytes: a mathematical modeling study. Journal of theoretical biology. 2010 Academic Article GET IT
Times cited: 21
Action potential voltage alternans: an indicator of calcium handling dysfunction during heart failure?. Heart rhythm. 2010 Editorial Article GET IT
Times cited: 2
Off-site control of repolarization alternans in cardiac fibers. Physical review. E, Statistical, nonlinear, and soft matter physics. 2010 Academic Article GET IT
Times cited: 19
Control of action potential duration alternans in canine ventricular tissue. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2010 Academic Article GET IT
Times cited: 3
Real-time experiment interface for biological control applications. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2010 Academic Article GET IT
Times cited: 44
Anthropomorphizing the mouse cardiac action potential via a novel dynamic clamp method. Biophysical journal. 2009 Academic Article GET IT
Times cited: 18
Pacing-induced spatiotemporal dynamics can be exploited to improve reentry termination efficacy. Physical review. E, Statistical, nonlinear, and soft matter physics. 2009 Academic Article GET IT
Times cited: 4
Dynamical mechanism for subcellular alternans in cardiac myocytes. Circulation research. 2009 Academic Article GET IT
Times cited: 57
Improving the utility of T-wave alternans by quantifying its relationship to underlying action-potential duration alternans. Heart rhythm. 2009 Editorial Article GET IT
Times cited: 1
Instability in action potential morphology underlies phase 2 reentry: a mathematical modeling study. Heart rhythm. 2009 Academic Article GET IT
Times cited: 33
Re-evaluating the efficacy of beta-adrenergic agonists and antagonists in long QT-3 syndrome through computational modelling. Cardiovascular research. 2009 Academic Article GET IT
Times cited: 29
MinK-dependent internalization of the IKs potassium channel. Cardiovascular research. 2009 Academic Article GET IT
Times cited: 42
Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f). FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2008 Academic Article GET IT
Times cited: 102
Resetting and termination of reentry in a loop-and-tail cardiac model. Physical review. E, Statistical, nonlinear, and soft matter physics. 2008 Academic Article GET IT
Times cited: 6
A KCNE2 mutation in a patient with cardiac arrhythmia induced by auditory stimuli and serum electrolyte imbalance. Cardiovascular research. 2007 Academic Article GET IT
Times cited: 38
Optical mapping system with real-time control capability. American journal of physiology. Heart and circulatory physiology. 2007 Academic Article GET IT
Times cited: 9
Characterizing the contribution of voltage- and calcium-dependent coupling to action potential stability: implications for repolarization alternans. American journal of physiology. Heart and circulatory physiology. 2007 Academic Article GET IT
Times cited: 44
Mechanism underlying initiation of paroxysmal atrial flutter/atrial fibrillation by ectopic foci: a simulation study. Circulation. 2007 Academic Article GET IT
Times cited: 94
Action potential duration dispersion and alternans in simulated heterogeneous cardiac tissue with a structural barrier. Biophysical journal. 2006 Academic Article GET IT
Times cited: 24
Implantable cardioverter-defibrillator detection of repolarization alternans: uncovering a marker of electrical instability. Heart rhythm. 2006 Editorial Article GET IT
Times cited: 2
Control of electrical alternans in canine cardiac purkinje fibers. Physical review letters. 2006 Academic Article GET IT
Times cited: 114
Structural barrier increases QT-peak dispersion in swine left ventricle in vivo. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2006 Academic Article GET IT
Action potential morphology influences intracellular calcium handling stability and the occurrence of alternans. Biophysical journal. 2005 Academic Article GET IT
Times cited: 30
Detection of repolarization alternans with an implantable cardioverter defibrillator lead in a porcine model. IEEE transactions on bio-medical engineering. 2005 Academic Article GET IT
Times cited: 11
Therapies for ventricular cardiac arrhythmias. Critical reviews in biomedical engineering. 2005 Information Resource GET IT
Times cited: 16
Time course and predictors of autonomic dysfunction after ablation of the slow atrioventricular nodal pathway. Pacing and clinical electrophysiology : PACE. 2004 Academic Article GET IT
Times cited: 8
Adaptive diastolic interval control of cardiac action potential duration alternans. Journal of cardiovascular electrophysiology. 2004 Academic Article GET IT
Times cited: 40
Determining the effects of memory and action potential duration alternans on cardiac restitution using a constant-memory restitution protocol. Physiological measurement. 2004 Academic Article GET IT
Times cited: 13
Effect of beta-adrenergic blockade on dynamic electrical restitution in vivo. American journal of physiology. Heart and circulatory physiology. 2004 Academic Article GET IT
Times cited: 27
MinK-related peptide 2 modulates Kv2.1 and Kv3.1 potassium channels in mammalian brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003 Academic Article GET IT
Times cited: 87
Endocardial detection of repolarization alternans. IEEE transactions on bio-medical engineering. 2003 Academic Article GET IT
Times cited: 18
Antispiral waves in reaction-diffusion systems. Physical review letters. 2003 Academic Article GET IT
Times cited: 14
Genetically engineered biologically based hemostatic bioassay. Annals of biomedical engineering. 2003 Academic Article GET IT
Times cited: 4
Muscle sympathetic nerve traffic during spontaneous- versus adenosine-mediated termination of idiopathic right ventricular outflow tract tachycardia. The American journal of cardiology. 2003 Academic Article GET IT
Times cited: 2
Termination of reentry in an inhomogeneous ring of model cardiac cells. Physical review. E, Statistical, nonlinear, and soft matter physics. 2002 Academic Article GET IT
Times cited: 22
Critical role of inhomogeneities in pacing termination of cardiac reentry. Chaos (Woodbury, N.Y.). 2002 Academic Article GET IT
Times cited: 32
Introduction: Mapping and control of complex cardiac arrhythmias. Chaos (Woodbury, N.Y.). 2002 Academic Article GET IT
Times cited: 63
Enhanced myocyte-based biosensing of the blood-borne signals regulating chronotropy. Journal of applied physiology (Bethesda, Md. : 1985). 2002 Academic Article GET IT
Times cited: 9
Real-Time linux dynamic clamp: a fast and flexible way to construct virtual ion channels in living cells. Annals of biomedical engineering. 2001 Academic Article GET IT
Times cited: 133
Complex AV nodal dynamics during ventricular-triggered atrial pacing in humans. American journal of physiology. Heart and circulatory physiology. 2001 Academic Article GET IT
Times cited: 7
Direct biologically based biosensing of dynamic physiological function. American journal of physiology. Heart and circulatory physiology. 2001 Academic Article GET IT
Times cited: 9
Nonlinear-dynamical arrhythmia control in humans. Proceedings of the National Academy of Sciences of the United States of America. 2001 Academic Article GET IT
Times cited: 102
Restricted feedback control of one-dimensional maps. Physical review. E, Statistical, nonlinear, and soft matter physics. 2001 Academic Article GET IT
Times cited: 24
Adaptive estimation and control method for unstable periodic dynamics in spike trains. Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics. 2000 Academic Article GET IT
Times cited: 15
Biomedical Engineering Society 2000 Annual Fall Meeting. 12-14 October 2000. Abstracts. Annals of biomedical engineering. 2000 Conference Paper GET IT
Practical real-time computing system for biomedical experiment interface. Annals of biomedical engineering. 1999 Academic Article GET IT
Times cited: 31
The role of nonlinear dynamics in cardiac arrhythmia control. Heart disease (Hagerstown, Md.). 1999 Academic Article GET IT
Times cited: 17
Control of chaos in excitable physiological systems: A geometric analysis. Chaos (Woodbury, N.Y.). 1997 Academic Article GET IT
Times cited: 23
Experimental control of high-dimensional chaos: The driven double pendulum. Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics. 1996 Academic Article GET IT
Times cited: 44
Using chaos control and tracking to suppress a pathological nonchaotic rhythm in a cardiac model. Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics. 1996 Academic Article GET IT
Times cited: 95
Using noise and chaos control to control nonchaotic systems. Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics. 1995 Academic Article GET IT
Times cited: 35
Controlling nonchaotic neuronal noise using chaos control techniques. Physical review letters. 1995 Academic Article GET IT
Times cited: 101
Application of linear and nonlinear time series modeling to heart rate dynamics analysis. IEEE transactions on bio-medical engineering. 1995 Academic Article GET IT
Times cited: 49
Influence of autoregressive model parameter uncertainty on spectral estimates of heart rate dynamics. Annals of biomedical engineering. 1995 Academic Article GET IT
Times cited: 14

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Background

education and training

Ph.D., Boston University 1997
M.S., Boston University 1993
B.S., Pennsylvania State University 1991

Contact

full name

David J. Christini

VIVO Weill Cornell Medical College

David J. Christini Adjunct Professor of Systems and Computational Biomedicine

Publications

selected publications

Background

education and training

Contact

full name

Phone

Publications

selected publications

Background

education and training

Contact

full name