Betel, Doron

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selected publications

Enhanced yield and subtype identity of hPSC-derived midbrain dopamine neuron by modulation of WNT and FGF18 signaling. 2025 GET IT
Machine learning analysis of population-wide plasma proteins identifies hormonal biomarkers of Parkinson's Disease. 2024 GET IT
Multi-Omic Atlas reveals cytotoxic phenotype and ROS-linked metabolic quiescence as key features of CTL-resistant HIV-infected CD4 ⁺ T-cells. 2024 GET IT
Cross-species single-cell RNA-seq analysis reveals disparate and conserved cardiac and extracardiac inflammatory responses upon heart injury. Communications biology. 2024 Academic Article GET IT
An IFN-STAT1-CYBB Axis Defines Protective Plasmacytoid DC to Neutrophil Crosstalk During Aspergillus fumigatus Infection. 2024 GET IT
Selenocysteine tRNA methylation promotes oxidative stress resistance in melanoma metastasis. Nature cancer. 2024 Academic Article GET IT
Correction: SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing. 2024 GET IT
SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing. Journal of hematology & oncology. 2024 Academic Article GET IT
A classical epithelial state drives acute resistance to KRAS inhibition in pancreas cancer. Cancer discovery. 2024 Academic Article GET IT
Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration. Cell stem cell. 2024 Academic Article GET IT
Intratumoral immune triads are required for immunotherapy-mediated elimination of solid tumors. Cancer cell. 2024 Academic Article GET IT
TNF-NF-κB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons. Cell. 2024 Academic Article GET IT
CAR-engineered lymphocyte persistence is governed by a FAS ligand/FAS auto-regulatory circuit. 2024 GET IT
A reversible epigenetic memory of inflammatory injury controls lineage plasticity and tumor initiation in the mouse pancreas. Developmental cell. 2023 Academic Article GET IT
The latency-reversing agent HODHBt synergizes with IL-15 to enhance cytotoxic function of HIV-specific T cells. JCI insight. 2023 Academic Article GET IT
Times cited: 6
Hallmarks of CD8⁺ T cell dysfunction are established within hours of tumor antigen encounter before cell division. Nature immunology. 2023 Academic Article GET IT
TCF12 Deficiency Impairs the Proliferation of Glioblastoma Tumor Cells and Improves Survival. Cancers. 2023 Academic Article GET IT
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes. Nature cell biology. 2023 Academic Article GET IT
Cross-species single-cell comparison of systemic and cardiac inflammatory responses after cardiac injury. 2023 GET IT
hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung's disease. Cell stem cell. 2023 Academic Article GET IT
Epsilon toxin-producing Clostridium perfringens colonize the MS gut and epsilon toxin overcomes immune privilege. The Journal of clinical investigation. 2023 Academic Article GET IT
Activation of MAP2K signaling by genetic engineering or HF-rTMS promotes corticospinal axon sprouting and functional regeneration. Science translational medicine. 2023 Academic Article GET IT
Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration. Nature communications. 2022 Academic Article GET IT
Increased Primary Bile Acids with Ileocolonic Resection Impact Ileal Inflammation and Gut Microbiota in Inflammatory Bowel Disease. Journal of Crohn's & colitis. 2022 Academic Article GET IT
SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8⁺ T-cells. Nature communications. 2022 Academic Article GET IT
Times cited: 20
Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA. Nature medicine. 2022 Academic Article GET IT
TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion. The Journal of experimental medicine. 2021 Academic Article GET IT
An autoimmune stem-like CD8 T cell population drives type 1 diabetes. Nature. 2021 Academic Article GET IT
Inducible and reversible inhibition of miRNA-mediated gene repression in vivo. eLife. 2021 Academic Article GET IT
Hippocampal Transcriptome Changes After Subarachnoid Hemorrhage in Mice. Frontiers in neurology. 2021 Academic Article GET IT
Selective BCL-X_L Antagonists Eliminate Infected Cells from a Primary-Cell Model of HIV Latency but Not from Ex Vivo Reservoirs. Journal of virology. 2021 Academic Article GET IT
Impact of Use of Antibiotics on Response to Immune Checkpoint Inhibitors and Tumor Microenvironment. American journal of clinical oncology. 2021 Academic Article GET IT
Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer's disease. Nature neuroscience. 2021 Academic Article GET IT
Times cited: 125
Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use. Cell stem cell. 2021 Academic Article GET IT
Times cited: 118
Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531. eLife. 2020 Academic Article GET IT
Times cited: 5
Multicenter Phase II Study of Cabazitaxel in Advanced Gastroesophageal Cancer: Association of HER2 Expression and M2-Like Tumor-Associated Macrophages with Patient Outcome. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 Academic Article GET IT
Times cited: 9
A Multiplex Human Pluripotent Stem Cell Platform Defines Molecular and Functional Subclasses of Autism-Related Genes. Cell stem cell. 2020 Academic Article GET IT
Times cited: 49
A Novel JAK1 Mutant Breast Implant-Associated Anaplastic Large Cell Lymphoma Patient-Derived Xenograft Fostering Pre-Clinical Discoveries. Cancers. 2020 Academic Article GET IT
High-Resolution In Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down. Molecular cell. 2020 Academic Article GET IT
Times cited: 25
Microtubule Engagement with Taxane Is Altered in Taxane-Resistant Gastric Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 Academic Article GET IT
Times cited: 24
TOX is a critical regulator of tumour-specific T cell differentiation. Nature. 2019 Academic Article GET IT
Times cited: 724
Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs. Cell stem cell. 2019 Academic Article GET IT
Times cited: 91
Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation. Nature genetics. 2019 Academic Article GET IT
Times cited: 84
A Comparison of Homogenization vs. Enzymatic Lysis for Microbiome Profiling in Clinical Endoscopic Biopsy Tissue Samples. Frontiers in microbiology. 2019 Academic Article GET IT
Times cited: 6
Extracellular vesicles in DLBCL provide abundant clues to aberrant transcriptional programming and genomic alterations. Blood. 2018 Academic Article GET IT
Times cited: 27
"Same difference": comprehensive evaluation of four DNA methylation measurement platforms. Epigenetics & chromatin. 2018 Academic Article GET IT
Times cited: 19
Unifying cancer and normal RNA sequencing data from different sources. Scientific data. 2018 Academic Article GET IT
Times cited: 124
Early-onset Colorectal Cancer is Distinct From Traditional Colorectal Cancer. Clinical colorectal cancer. 2017 Academic Article GET IT
Times cited: 40
CryoPause: A New Method to Immediately Initiate Experiments after Cryopreservation of Pluripotent Stem Cells. Stem cell reports. 2017 Academic Article GET IT
Times cited: 19
The Gastric Microbiome and Its Influence on Gastric Carcinogenesis: Current Knowledge and Ongoing Research. Hematology/oncology clinics of North America. 2017 Information Resource GET IT
Times cited: 21
Encoding of contextual fear memory requires de novo proteins in the prelimbic cortex. Biological psychiatry. Cognitive neuroscience and neuroimaging. 2017 Academic Article GET IT
Times cited: 27
Circulating Plasma Levels of MicroRNA-21 and MicroRNA-221 Are Potential Diagnostic Markers for Primary Intrahepatic Cholangiocarcinoma. PloS one. 2016 Academic Article GET IT
Times cited: 56
Identification of low abundance microbiome in clinical samples using whole genome sequencing. Genome biology. 2015 Academic Article GET IT
Times cited: 70
Response to Zhou and Robinson. Genome biology. 2015 Article GET IT
Multiplexing of ChIP-Seq Samples in an Optimized Experimental Condition Has Minimal Impact on Peak Detection. PloS one. 2015 Academic Article GET IT
An allelic series of miR-17 ∼ 92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron. Nature genetics. 2015 Academic Article GET IT
Times cited: 97
Enhanced reduced representation bisulfite sequencing for assessment of DNA methylation at base pair resolution. Journal of visualized experiments : JoVE. 2015 Academic Article GET IT
Times cited: 82
Comprehensive evaluation of differential gene expression analysis methods for RNA-seq data. Genome biology. 2013 Academic Article GET IT
Times cited: 529
Genome-wide identification of miRNA targets by PAR-CLIP. Methods (San Diego, Calif.). 2012 Academic Article GET IT
Times cited: 88
Neurophysiological defects and neuronal gene deregulation in Drosophila mir-124 mutants. PLoS genetics. 2012 Academic Article GET IT
Times cited: 49
Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response. Genes & development. 2011 Academic Article GET IT
Times cited: 163
Widespread regulatory activity of vertebrate microRNA* species. RNA (New York, N.Y.). 2010 Academic Article GET IT
Times cited: 295
Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites. Genome biology. 2010 Academic Article GET IT
Times cited: 1342
Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas. Genes & development. 2009 Academic Article GET IT
Times cited: 429
Characterization of small RNAs in Aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB. Neuron. 2009 Academic Article GET IT
Times cited: 366
Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs. Nature biotechnology. 2009 Academic Article GET IT
Times cited: 441
The microRNA.org resource: targets and expression. Nucleic acids research. 2007 Academic Article GET IT
Times cited: 2186
Computational analysis of mouse piRNA sequence and biogenesis. PLoS computational biology. 2007 Academic Article GET IT
Times cited: 82
Structure-templated predictions of novel protein interactions from sequence information. PLoS computational biology. 2007 Academic Article GET IT
Times cited: 35
The Biomolecular Interaction Network Database and related tools 2005 update. Nucleic acids research. 2005 Academic Article GET IT
Times cited: 494
SeqHound: biological sequence and structure database as a platform for bioinformatics research. BMC bioinformatics. 2002 Academic Article GET IT
Times cited: 38
Kangaroo--a pattern-matching program for biological sequences. BMC bioinformatics. 2002 Academic Article GET IT
Times cited: 12
Mutation profiling of mismatch repair-deficient colorectal cncers using an in silico genome scan to identify coding microsatellites. Cancer research. 2002 Academic Article GET IT
Times cited: 49
Cloning and expression of a novel UDP-GlcNAc:alpha-D-mannoside beta1,2-N-acetylglucosaminyltransferase homologous to UDP-GlcNAc:alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I. The Biochemical journal. 2002 Academic Article GET IT
Times cited: 62

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Research

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Funding awarded

Mechanisms of CTL Resistance in HIV Reservoirs awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2022 - 2026
REACH: Research Enterprise to Advance a Cure for HIV awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2021 - 2026

Autoimmune Stem-like CD8 T cells in Type I Diabetes awarded by National Cancer Institute Principal Investigator Subaward 2023 - 2028
TOX-driven CD8 T cell differentiation and dysfunction in tumors awarded by National Cancer Institute Principal Investigator Subaward 2023 - 2028
Directing Fate, Subtype Identity And Survival In Human Pluripotent-Derived Midbrain Dopamine Neurons Principal Investigator Subaward 2021 - 2026

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Background

education and training

Ph.D., University of Toronto (Canada) 2005
B.Sc., York University (Canada) 1998

Contact

full name

Doron Betel

primary email

dob2014@med.cornell.edu

VIVO Weill Cornell Medical College

Doron Betel Associate Professor of Computational Biomedicine in Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email