Lee, Francis S

Publications

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selected publications

Understanding the development of a functional brain circuit: reward processing as an illustration. Translational psychiatry. 2025 Review GET IT
Elevating levels of the endocannabinoid 2-arachidonoylglycerol blunts opioid reward but not analgesia. Science advances. 2024 Academic Article GET IT
A sexually dimorphic signature of activity-dependent BDNF signaling on the intrinsic excitability of pyramidal neurons in the prefrontal cortex. Frontiers in cellular neuroscience. 2024 Academic Article GET IT
Molecular and functional alterations in the cerebral microvasculature in an optimized mouse model of sepsis-associated cognitive dysfunction. eNeuro. 2024 Academic Article GET IT
Efficacy of a Mobile App-Based Intervention for Young Adults With Anxiety Disorders: A Randomized Clinical Trial. JAMA network open. 2024 Academic Article GET IT
Molecular and functional alterations in the cerebral microvasculature in an optimized mouse model of sepsis-associated cognitive dysfunction. 2024 GET IT
Elevating levels of the endocannabinoid 2-arachidonoylglycerol blunts opioid reward but not analgesia. 2024 GET IT
Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk. Cell reports. 2023 Academic Article GET IT
Times cited: 6
Immune activation of the p75 neurotrophin receptor: implications in neuroinflammation. Frontiers in molecular neuroscience. 2023 Academic Article GET IT
The role of neurotrophic factors in novel, rapid psychiatric treatments. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023 Review GET IT
Developmental age and fatty acid amide hydrolase genetic variation converge to mediate fear regulation in female mice. Developmental psychobiology. 2023 Academic Article GET IT
Synaptic plasticity via receptor tyrosine kinase/G protein-coupled receptor crosstalk. 2023 GET IT
Intermixed safety cues facilitate extinction retention in adult and adolescent mice. Physiology & behavior. 2023 Academic Article GET IT
Towards a youth mental health paradigm: a perspective and roadmap. Molecular psychiatry. 2023 Review GET IT
Translating Developmental Neuroscience to Understand Risk for Psychiatric Disorders. The American journal of psychiatry. 2023 Review GET IT
Regulation of social interaction in mice by a frontostriatal circuit modulated by established hierarchical relationships. Nature communications. 2023 Academic Article GET IT
Times cited: 407
A genetic variant of fatty acid amide hydrolase (FAAH) exacerbates hormone-mediated orexigenic feeding in mice. eLife. 2023 Academic Article GET IT
Neurotransmission-related gene expression in the frontal pole is altered in subjects with bipolar disorder and schizophrenia. Translational psychiatry. 2023 Review GET IT
Times cited: 3
Control of Gα_q signaling dynamics and GPCR cross-talk by GRKs. Science advances. 2022 Academic Article GET IT
Human immunomodulatory ligand B7-1 mediates synaptic remodeling via the p75 neurotrophin receptor. The Journal of clinical investigation. 2022 Academic Article GET IT
Large Common Mitochondrial DNA Deletions Are Associated with a Mitochondrial SNP T14798C Near the 3' Breakpoints. Complex psychiatry. 2022 Academic Article GET IT
Mitochondria DNA copy number, mitochondria DNA total somatic deletions, Complex I activity, synapse number, and synaptic mitochondria number are altered in schizophrenia and bipolar disorder. Translational psychiatry. 2022 Academic Article GET IT
The role of BDNF in mediating the prophylactic effects of (R,S)-ketamine on fear generalization and extinction. Translational psychiatry. 2022 Academic Article GET IT
Acute stress induces an aberrant increase of presynaptic release of glutamate and cellular activation in the hippocampus of BDNF^Val/Met mice. Journal of cellular physiology. 2022 Academic Article GET IT
Enhancing exposure therapy for posttraumatic stress disorder (PTSD): a randomized clinical trial of virtual reality and imaginal exposure with a cognitive enhancer. Translational psychiatry. 2022 Academic Article GET IT
A Common Human Brain-Derived Neurotrophic Factor Polymorphism Leads to Prolonged Depression of Excitatory Synaptic Transmission by Isoflurane in Hippocampal Cultures. Frontiers in molecular neuroscience. 2022 Academic Article GET IT
Identification of potential blood biomarkers associated with suicide in major depressive disorder. Translational psychiatry. 2022 Academic Article GET IT
Rare coding variants in ten genes confer substantial risk for schizophrenia. Nature. 2022 Academic Article GET IT
Corticosterone induces discrete epigenetic signatures in the dorsal and ventral hippocampus that depend upon sex and genotype: focus on methylated Nr3c1 gene. Translational psychiatry. 2022 Academic Article GET IT
The Added Value of Crosstalk Between Developmental Circuit Neuroscience and Clinical Practice to Inform the Treatment of Adolescent Anxiety. Biological psychiatry global open science. 2022 Review GET IT
Times cited: 11
The α₂-adrenergic receptor pathway modulating depression influences the risk of arterial thrombosis associated with BDNFVal66Met polymorphism. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Academic Article GET IT
Genomic modules and intramodular network concordance in susceptible and resilient male mice across models of stress. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2021 Academic Article GET IT
Genetic Variants of Fatty Acid Amide Hydrolase Modulate Acute Inflammatory Responses to Colitis in Adult Male Mice. Frontiers in cellular neuroscience. 2021 Academic Article GET IT
Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors. JCI insight. 2021 Academic Article GET IT
Times cited: 15
SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts. Nature communications. 2021 Academic Article GET IT
TrkB deubiquitylation by USP8 regulates receptor levels and BDNF-dependent neuronal differentiation. Journal of cell science. 2020 Academic Article GET IT
Times cited: 8
mGreenLantern: a bright monomeric fluorescent protein with rapid expression and cell filling properties for neuronal imaging. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 90
Pre-adolescent stress disrupts adult, but not adolescent, safety learning. Behavioural brain research. 2020 Academic Article GET IT
Times cited: 20
An Adolescent Sensitive Period for Threat Responding: Impacts of Stress and Sex. Biological psychiatry. 2020 Information Resource GET IT
Times cited: 41
Zinc induced structural changes in the intrinsically disordered BDNF Met prodomain confer synaptic elimination. Metallomics : integrated biometal science. 2020 Academic Article GET IT
Times cited: 1
Insulin receptor substrate in brain-enriched exosomes in subjects with major depression: on the path of creation of biosignatures of central insulin resistance. Molecular psychiatry. 2020 Academic Article GET IT
Times cited: 80
Impact of BDNF Val66Met Polymorphism on Myocardial Infarction: Exploring the Macrophage Phenotype. Cells. 2020 Academic Article GET IT
Times cited: 18
Endocannabinoid genetic variation enhances vulnerability to THC reward in adolescent female mice. Science advances. 2020 Academic Article GET IT
Times cited: 19
SorCS2 is required for social memory and trafficking of the NMDA receptor. Molecular psychiatry. 2020 Academic Article GET IT
Times cited: 3
Endocannabinoid Signaling Collapse Mediates Stress-Induced Amygdalo-Cortical Strengthening. Neuron. 2020 Academic Article GET IT
Times cited: 71
Ventral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humans. Proceedings of the National Academy of Sciences of the United States of America. 2019 Academic Article GET IT
Times cited: 85
D3 dopamine receptors and a missense mutation of fatty acid amide hydrolase linked in mouse and men: implication for addiction. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2019 Academic Article GET IT
Times cited: 15
Enhanced exposure therapy for combat-related Posttraumatic Stress Disorder (PTSD): Study protocol for a randomized controlled trial. Contemporary clinical trials. 2019 Academic Article GET IT
Times cited: 2
The microbiota regulate neuronal function and fear extinction learning. Nature. 2019 Academic Article GET IT
Times cited: 328
Electrophysiological evaluation of extracellular spermine and alkaline pH on synaptic human GABA_A receptors. Translational psychiatry. 2019 Academic Article GET IT
Times cited: 9
Physical Exercise Affects Adipose Tissue Profile and Prevents Arterial Thrombosis in BDNF Val66Met Mice. Cells. 2019 Academic Article GET IT
Times cited: 18
The Endocannabinoid System: A New Treatment Target for Obsessive Compulsive Disorder?. Cannabis and cannabinoid research. 2019 Information Resource GET IT
Times cited: 26
Splice-Break: exploiting an RNA-seq splice junction algorithm to discover mitochondrial DNA deletion breakpoints and analyses of psychiatric disorders. Nucleic acids research. 2019 Academic Article GET IT
Times cited: 26
Diminished Fear Extinction in Adolescents Is Associated With an Altered Somatostatin Interneuron-Mediated Inhibition in the Infralimbic Cortex. Biological psychiatry. 2019 Academic Article GET IT
Times cited: 30
Role of BDNF in the development of an OFC-amygdala circuit regulating sociability in mouse and human. Molecular psychiatry. 2019 Academic Article GET IT
Times cited: 35
Translating Developmental Neuroscience to Understand Risk for Psychiatric Disorders. The American journal of psychiatry. 2019 Information Resource GET IT
Times cited: 22
Using a Developmental Ecology Framework to Align Fear Neurobiology Across Species. Annual review of clinical psychology. 2019 Review GET IT
Times cited: 67
Exploring Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Extinction Learning-Based Treatment Outcome in Obsessive-Compulsive Disorder: A Pilot Study. Journal of clinical psychopharmacology. 2019 Article GET IT
Times cited: 3
Global epigenetic analysis of BDNF Val66Met mice hippocampus reveals changes in dendrite and spine remodeling genes. Hippocampus. 2018 Academic Article GET IT
Times cited: 8
Epigenetic intersection of BDNF Val66Met genotype with premenstrual dysphoric disorder transcriptome in a cross-species model of estradiol add-back. Molecular psychiatry. 2018 Academic Article GET IT
Times cited: 27
Sub-Chronic Stress Exacerbates the Pro-Thrombotic Phenotype in BDNF^Val/Met Mice: Gene-Environment Interaction in the Modulation of Arterial Thrombosis. International journal of molecular sciences. 2018 Academic Article GET IT
Times cited: 22
New Roles for an Ancient Factor. Trends in neurosciences. 2018 Article GET IT
Protective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice. Molecular psychiatry. 2018 Academic Article GET IT
Times cited: 37
Acetyl-l-carnitine deficiency in patients with major depressive disorder. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 110
Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 35
The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior. Neuron. 2018 Academic Article GET IT
Times cited: 47
Connective Tissue Growth Factor Is a Novel Prodepressant. Biological psychiatry. 2018 Academic Article GET IT
Times cited: 17
The relationship between posttraumatic and depressive symptoms during virtual reality exposure therapy with a cognitive enhancer. Journal of anxiety disorders. 2018 Academic Article GET IT
Times cited: 15
Effects of Rapastinel (Formerly GLYX-13) on Serum Brain-Derived Neurotrophic Factor in Obsessive-Compulsive Disorder. The Journal of clinical psychiatry. 2018 Article GET IT
Times cited: 6
Quantitative validation of immunofluorescence and lectin staining using reduced CLARITY acrylamide formulations. Brain structure & function. 2017 Academic Article GET IT
Times cited: 8
Mitochondrial Complex I Deficiency in Schizophrenia and Bipolar Disorder and Medication Influence. Molecular neuropsychiatry. 2017 Academic Article GET IT
Effect of Early-Life Fluoxetine on Anxiety-Like Behaviors in BDNF Val66Met Mice. The American journal of psychiatry. 2017 Academic Article GET IT
Times cited: 23
Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress. Neuron. 2017 Academic Article GET IT
Times cited: 51
A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met mice. Nature communications. 2017 Academic Article GET IT
Times cited: 52
Variant BDNF-Val66Met Polymorphism is Associated with Layer-Specific Alterations in GABAergic Innervation of Pyramidal Neurons, Elevated Anxiety and Reduced Vulnerability of Adolescent Male Mice to Activity-Based Anorexia. Cerebral cortex (New York, N.Y. : 1991). 2017 Academic Article GET IT
Times cited: 22
Blockade of alcohol escalation and "relapse" drinking by pharmacological FAAH inhibition in male and female C57BL/6J mice. Psychopharmacology. 2017 Academic Article GET IT
Times cited: 43
The Role of the Endocannabinoid System and Genetic Variation in Adolescent Brain Development. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2017 Information Resource GET IT
Times cited: 154
BDNFVal66met polymorphism: a potential bridge between depression and thrombosis. European heart journal. 2017 Academic Article GET IT
Times cited: 66
D-Cycloserine Augmentation of Exposure-Based Cognitive Behavior Therapy for Anxiety, Obsessive-Compulsive, and Posttraumatic Stress Disorders: A Systematic Review and Meta-analysis of Individual Participant Data. JAMA psychiatry. 2017 Review GET IT
Times cited: 127
Pilot Study of a Telehealth-Delivered Medication-Augmented Exposure Therapy Protocol for PTSD. The Journal of nervous and mental disease. 2017 Academic Article GET IT
Times cited: 19
Rare Synaptogenesis-Impairing Mutations in SLITRK5 Are Associated with Obsessive Compulsive Disorder. PloS one. 2017 Academic Article GET IT
Times cited: 32
Translational profiling of stress-induced neuroplasticity in the CA3 pyramidal neurons of BDNF Val66Met mice. Molecular psychiatry. 2016 Academic Article GET IT
Times cited: 29
The Role of BDNF in the Development of Fear Learning. Depression and anxiety. 2016 Information Resource GET IT
Times cited: 72
Brain-Derived Neurotrophic Factor Val66Met Human Polymorphism Impairs the Beneficial Exercise-Induced Neurobiological Changes in Mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2016 Academic Article GET IT
Times cited: 83
New Insights into the Biology of the BDNF Transcriptional 'Code'. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2016 Article GET IT
The BDNF Val66Met polymorphism enhances glutamatergic transmission but diminishes activity-dependent synaptic plasticity in the dorsolateral striatum. Neuropharmacology. 2016 Academic Article GET IT
Times cited: 24
Differential effects of BDNF and neurotrophin 4 (NT4) on endocytic sorting of TrkB receptors. Journal of neurochemistry. 2016 Academic Article GET IT
Times cited: 55
Dynamic changes in neural circuitry during adolescence are associated with persistent attenuation of fear memories. Nature communications. 2016 Academic Article GET IT
Times cited: 139
Endocannabinoids and Stress Resilience: Is Deficiency Sufficient to Promote Vulnerability?. Biological psychiatry. 2016 Article GET IT
Times cited: 13
Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 80
Involvement of Endocannabinoids in Alcohol "Binge" Drinking: Studies of Mice with Human Fatty Acid Amide Hydrolase Genetic Variation and After CB1 Receptor Antagonists. Alcoholism, clinical and experimental research. 2016 Academic Article GET IT
Times cited: 41
Developmental regulation of fear learning and anxiety behavior by endocannabinoids. Genes, brain, and behavior. 2015 Information Resource GET IT
Times cited: 54
Expression and Dendritic Trafficking of BDNF-6 Splice Variant are Impaired in Knock-In Mice Carrying Human BDNF Val66Met Polymorphism. The international journal of neuropsychopharmacology. 2015 Academic Article GET IT
Times cited: 38
Treating the Developing versus Developed Brain: Translating Preclinical Mouse and Human Studies. Neuron. 2015 Information Resource GET IT
Times cited: 90
Slitrk5 Mediates BDNF-Dependent TrkB Receptor Trafficking and Signaling. Developmental cell. 2015 Academic Article GET IT
Times cited: 71
Bex3 Dimerization Regulates NGF-Dependent Neuronal Survival and Differentiation by Enhancing trkA Gene Transcription. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015 Academic Article GET IT
Times cited: 29
Alteration of the Centromedial Amygdala Glutamatergic Synapses by the BDNF Val66Met Polymorphism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2015 Academic Article GET IT
Times cited: 16
Effects of the BDNF Val66Met Polymorphism on Anxiety-Like Behavior Following Nicotine Withdrawal in Mice. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2015 Academic Article GET IT
Times cited: 13
FAAH genetic variation enhances fronto-amygdala function in mouse and human. Nature communications. 2015 Academic Article GET IT
Times cited: 247
Common Polymorphisms in the Age of Research Domain Criteria (RDoC): Integration and Translation. Biological psychiatry. 2015 Information Resource GET IT
Times cited: 19
Mental health. Adolescent mental health--opportunity and obligation. Science (New York, N.Y.). 2014 Academic Article GET IT
Times cited: 387
Sensitive periods in affective development: nonlinear maturation of fear learning. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2014 Information Resource GET IT
Times cited: 72
BDNF modulates contextual fear learning during adolescence. Developmental neuroscience. 2014 Academic Article GET IT
Times cited: 27
proBDNF negatively regulates neuronal remodeling, synaptic transmission, and synaptic plasticity in hippocampus. Cell reports. 2014 Academic Article GET IT
Times cited: 261
An adaptive role for BDNF Val66Met polymorphism in motor recovery in chronic stroke. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Academic Article GET IT
Times cited: 85
D-cycloserine augmentation of exposure therapy for post-traumatic stress disorder: a pilot randomized clinical trial. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2013 Academic Article GET IT
Times cited: 186
DSM-5 and RDoC: progress in psychiatry research?. Nature reviews. Neuroscience. 2013 Information Resource GET IT
Times cited: 273
Early-life stress has persistent effects on amygdala function and development in mice and humans. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 247
Fear and anxiety from principle to practice: implications for when to treat youth with anxiety disorders. Biological psychiatry. 2013 Article GET IT
Times cited: 41
Fear learning and memory across adolescent development: Hormones and Behavior Special Issue: Puberty and Adolescence. Hormones and behavior. 2013 Information Resource GET IT
Times cited: 59
"Altered Fear in Mice and Humans". Current directions in psychological science. 2013 Academic Article GET IT
Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction. Nature communications. 2013 Academic Article GET IT
Times cited: 189
Treating the developing brain: implications from human imaging and mouse genetics. Annual review of medicine. 2012 Information Resource GET IT
Times cited: 26
Altered fear learning across development in both mouse and human. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 331
Brain-derived neurotrophic factor genotype impacts the prenatal cocaine-induced mouse phenotype. Developmental neuroscience. 2012 Academic Article GET IT
Times cited: 13
Variant brain-derived neurotrophic factor (Valine66Methionine) polymorphism contributes to developmental and estrous stage-specific expression of anxiety-like behavior in female mice. Biological psychiatry. 2012 Academic Article GET IT
Times cited: 87
Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Academic Article GET IT
Times cited: 246
Enhanced extinction of cocaine seeking in brain-derived neurotrophic factor Val66Met knock-in mice. The European journal of neuroscience. 2012 Academic Article GET IT
Times cited: 18
The BDNF Val66Met polymorphism impairs synaptic transmission and plasticity in the infralimbic medial prefrontal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Academic Article GET IT
Times cited: 138
BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 214
BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2012 Academic Article GET IT
Times cited: 148
Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex. Biological psychiatry. 2011 Academic Article GET IT
Times cited: 348
Effect of brain-derived neurotrophic factor haploinsufficiency on stress-induced remodeling of hippocampal neurons. Hippocampus. 2011 Academic Article GET IT
Times cited: 207
Slitrks as emerging candidate genes involved in neuropsychiatric disorders. Trends in neurosciences. 2011 Information Resource GET IT
Times cited: 86
Region-specific involvement of BDNF secretion and synthesis in conditioned taste aversion memory formation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Academic Article GET IT
Times cited: 55
Genetic variant of BDNF (Val66Met) polymorphism attenuates stroke-induced angiogenic responses by enhancing anti-angiogenic mediator CD36 expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Academic Article GET IT
Times cited: 71
Selective early-acquired fear memories undergo temporary suppression during adolescence. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 134
Long-distance control of synapse assembly by target-derived NGF. Neuron. 2010 Academic Article GET IT
Times cited: 107
The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 Academic Article GET IT
Times cited: 159
Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice. Nature medicine. 2010 Academic Article GET IT
Times cited: 284
The serotonin1A receptor gene as a genetic and prenatal maternal environmental factor in anxiety. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 53
Neurotrophic factor control of adult SVZ neurogenesis. Developmental neurobiology. 2010 Information Resource GET IT
Times cited: 95
BDNF variant Val66Met interacts with estrous cycle in the control of hippocampal function. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 62
A genetic variant BDNF polymorphism alters extinction learning in both mouse and human. Science (New York, N.Y.). 2010 Academic Article GET IT
Times cited: 513
Treatments for common psychiatric conditions among adults during acute, rehabilitation, and reintegration phases. International review of psychiatry (Abingdon, England). 2009 Information Resource GET IT
Times cited: 17
CCM2 mediates death signaling by the TrkA receptor tyrosine kinase. Neuron. 2009 Academic Article GET IT
Times cited: 45
Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 194
Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development. Neuroscience. 2009 Review GET IT
Times cited: 125
Variant BDNF Val66Met polymorphism affects extinction of conditioned aversive memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Academic Article GET IT
Times cited: 131
Endogenous truncated TrkB.T1 receptor regulates neuronal complexity and TrkB kinase receptor function in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Academic Article GET IT
Quantitative intact specimen magnetic resonance microscopy at 3.0 T. Magnetic resonance imaging. 2009 Academic Article GET IT
Times cited: 6
Neuronal release of proBDNF. Nature neuroscience. 2009 Academic Article GET IT
Times cited: 377
High-level expression of a phage display-derived scFv in Pichia pastoris. Methods in molecular biology (Clifton, N.J.). 2009 Academic Article GET IT
Times cited: 8
Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Academic Article GET IT
Times cited: 141
Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell. 2007 Academic Article GET IT
Times cited: 1310
Single-cell characterization of retrograde signaling by brain-derived neurotrophic factor. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 Academic Article GET IT
Times cited: 62
Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science (New York, N.Y.). 2006 Academic Article GET IT
Times cited: 1178
Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination. Neuron. 2006 Academic Article GET IT
Times cited: 154
Variant BDNF (Val66Met) impact on brain structure and function. Cognitive, affective & behavioral neuroscience. 2006 Information Resource GET IT
Times cited: 238
Neurotrophin signalling in health and disease. Clinical science (London, England : 1979). 2006 Information Resource GET IT
Times cited: 476
A novel endocytic recycling signal distinguishes biological responses of Trk neurotrophin receptors. Molecular biology of the cell. 2005 Academic Article GET IT
Times cited: 91
Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Academic Article GET IT
Times cited: 359
ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Academic Article GET IT
Times cited: 875
Neurotrophin survival signaling mechanisms. Journal of Alzheimer's disease : JAD. 2004 Academic Article GET IT
Times cited: 22
Transactivation of Trk neurotrophin receptors by G-protein-coupled receptor ligands occurs on intracellular membranes. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Academic Article GET IT
Times cited: 230
Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Academic Article GET IT
Times cited: 783
Novel crosstalk between G protein-coupled receptors and NMDA receptors. Experimental neurology. 2003 Article GET IT
Times cited: 3
Activation of Trk neurotrophin receptor signaling by pituitary adenylate cyclase-activating polypeptides. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 177
Activation of Trk neurotrophin receptors in the absence of neurotrophins. Proceedings of the National Academy of Sciences of the United States of America. 2001 Academic Article GET IT
Times cited: 448
GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways. Molecular biology of the cell. 2001 Academic Article GET IT
Times cited: 135
Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001 Academic Article GET IT
Times cited: 164
Synaptic vesicle glutamate uptake in epileptic (EL) mice. Neurochemistry international. 1997 Academic Article GET IT
Times cited: 16
A protein factor that inhibits ATP-dependent glutamate and gamma-aminobutyric acid accumulation into synaptic vesicles: purification and initial characterization. Proceedings of the National Academy of Sciences of the United States of America. 1997 Academic Article GET IT
Times cited: 41

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Research

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Co-investigator Network

Funding awarded

MTA with MeiraGTx, LLC awarded by MeiraGTx, LLC Principal Investigator 2025 - 2026
A Molecular Framework to Define Slitrk5 Function Related to OCD awarded by New Venture Fund Principal Investigator 2023 - 2026
Impact of BDNF on the Development of Social Behavior Circuits awarded by National Institute of Mental Health Principal Investigator 2020 - 2026

missing activity Co-Investigator 2019 - 2025
A Non-Inferiority Randomized Controlled Clinical Trial Comparing Interpersonal Therapy to Exposure Therapy for PTSD Consequent to MST in Male and Female Military Personnel and Veterans awarded by United States Department of Defense Co-Investigator 2018 - 2025

missing activity Co-Principal Investigator 2022 - 2027
Immunomodulatory Ligand B7-1 Targets p75 Neurotrophin Receptor in Neurodegeneration awarded by National Institute on Aging Co-Principal Investigator 2023 - 2026

Circuit and Synaptic Mechanisms of Endocannabinoid-Opioid Crosstalk awarded by National Institute on Drug Abuse Principal Investigator Subaward 2024 - 2027

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Background

education and training

M.D., Ph.D., University of Michigan Medical School 96
B.A., Princeton University 1987

Contact

full name

Francis S Lee

primary email

fslee@med.cornell.edu

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Francis S Lee Chair of Psychiatry

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

webpage