Slitrks as emerging candidate genes involved in neuropsychiatric disorders. Review uri icon

Overview

abstract

  • Slitrks are a family of structurally related transmembrane proteins belonging to the leucine-rich repeat (LRR) superfamily. Six family members exist (Slitrk1-6) and all are highly expressed in the central nervous system (CNS). Slitrks have been implicated in mediating basic neuronal processes, ranging from neurite outgrowth and dendritic elaboration to neuronal survival. Recent studies in humans and genetic mouse models have led to the identification of Slitrks as candidate genes that might be involved in the development of neuropsychiatric conditions, such as obsessive compulsive spectrum disorders and schizophrenia. Although these system-level approaches have suggested that Slitrks play prominent roles in CNS development, key questions remain regarding the molecular mechanisms through which they mediate neuronal signaling and connectivity.

publication date

  • March 1, 2011

Research

keywords

  • Genetic Predisposition to Disease
  • Membrane Proteins
  • Mental Disorders
  • Multigene Family
  • Nerve Tissue Proteins

Identity

PubMed Central ID

  • PMC3051006

Scopus Document Identifier

  • 79952252418

Digital Object Identifier (DOI)

  • 10.1016/j.tins.2011.01.001

PubMed ID

  • 21315458

Additional Document Info

volume

  • 34

issue

  • 3