selected publications
- Protocol for analysis of intracellular conversion of artezomib molecules into new proteasome inhibitors in Plasmodium falciparum parasites. STAR protocols. 2024 Academic Article GET IT
- Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors. Nature communications. 2023 Academic Article GET IT
- Covalent Macrocyclic Proteasome Inhibitors Mitigate Resistance in Plasmodium falciparum. ACS infectious diseases. 2023 Academic Article GET IT
- Dual-pharmacophore artezomibs hijack the Plasmodium ubiquitin-proteasome system to kill malaria parasites while overcoming drug resistance. Cell chemical biology. 2023 Academic Article GET IT
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High-Throughput/High Content Imaging Screen Identifies Novel Small Molecule Inhibitors and Immunoproteasomes as Therapeutic Targets for Chordoma.
Pharmaceutics.
2023
Academic Article
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Times cited: 2 - Structure of the human UBR5 E3 ubiquitin ligase. Structure (London, England : 1993). 2023 Academic Article GET IT
- Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome. Cell chemical biology. 2023 Academic Article GET IT
- A Study on Origin Traceability of White Tea (White Peony) Based on Near-Infrared Spectroscopy and Machine Learning Algorithms. Foods (Basel, Switzerland). 2023 Academic Article GET IT
- Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors─Part II. Journal of medicinal chemistry. 2023 Academic Article GET IT
- Discovery of Highly Selective Inhibitors of the Human Constitutive Proteasome β5c Chymotryptic Subunit. Journal of medicinal chemistry. 2023 Academic Article GET IT
- Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors. Antimicrobial agents and chemotherapy. 2022 Academic Article GET IT
- Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors. Journal of medicinal chemistry. 2022 Academic Article GET IT
- Microbial proteasomes as drug targets. PLoS pathogens. 2021 Review GET IT
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Macrocyclic Peptides that Selectively Inhibit the Mycobacterium tuberculosis Proteasome.
Journal of medicinal chemistry.
2021
Academic Article
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Times cited: 10 -
Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti-malaria Activity in Humanized Mice.
Angewandte Chemie (International ed. in English).
2021
Academic Article
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Times cited: 22 - Noncytotoxic Inhibition of the Immunoproteasome Regulates Human Immune Cells In Vitro and Suppresses Cutaneous Inflammation in the Mouse. Journal of immunology (Baltimore, Md. : 1950). 2021 Academic Article GET IT
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Structure-Activity Relationships of Noncovalent Immunoproteasome β5i-Selective Dipeptides.
Journal of medicinal chemistry.
2020
Academic Article
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Times cited: 10 -
Activity of Epigenetic Inhibitors against Plasmodium falciparum Asexual and Sexual Blood Stages.
Antimicrobial agents and chemotherapy.
2020
Academic Article
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Times cited: 22 -
Immunoproteasome inhibitor DPLG3 attenuates experimental colitis by restraining NF-κB activation.
Biochemical pharmacology.
2020
Academic Article
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Times cited: 3 -
Selective Phenylimidazole-Based Inhibitors of the Mycobacterium tuberculosis Proteasome.
Journal of medicinal chemistry.
2019
Academic Article
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Times cited: 15 -
Improvement of Asparagine Ethylenediamines as Anti-malarial Plasmodium-Selective Proteasome Inhibitors.
Journal of medicinal chemistry.
2019
Academic Article
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Times cited: 28 -
Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes.
Nature communications.
2017
Academic Article
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Times cited: 44 -
The immunoproteasome: An old player with a novel and emerging role in alloimmunity.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2017
Review
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Times cited: 19 -
Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome.
Biochemistry.
2016
Academic Article
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Times cited: 14 -
Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice.
Proceedings of the National Academy of Sciences of the United States of America.
2016
Academic Article
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Times cited: 57 -
Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome.
ACS infectious diseases.
2016
Academic Article
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Times cited: 21 -
Immunoproteasome β5i-Selective Dipeptidomimetic Inhibitors.
ChemMedChem.
2016
Academic Article
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Times cited: 27 -
Identification and characterization of a constitutively expressed Ctenopharyngodon idella ADAR1 splicing isoform (CiADAR1a).
Developmental and comparative immunology.
2016
Academic Article
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Times cited: 2 -
Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells.
Cell host & microbe.
2015
Academic Article
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Times cited: 80 -
Ctenopharyngodon idella IRF2 plays an antagonistic role to IRF1 in transcriptional regulation of IFN and ISG genes.
Developmental and comparative immunology.
2014
Academic Article
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Times cited: 28 -
Oxathiazolones Selectively Inhibit the Human Immunoproteasome over the Constitutive Proteasome.
ACS medicinal chemistry letters.
2014
Academic Article
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Times cited: 43 -
N,C-Capped dipeptides with selectivity for mycobacterial proteasome over human proteasomes: role of S3 and S1 binding pockets.
Journal of the American Chemical Society.
2013
Academic Article
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Times cited: 48 -
Crossover inhibition as an indicator of convergent evolution of enzyme mechanisms: a β-lactamase and a N-terminal nucleophile hydrolase.
FEBS letters.
2012
Academic Article
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Times cited: 8 -
Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome.
Archives of biochemistry and biophysics.
2010
Academic Article
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Times cited: 54 -
Structural basis for the assembly and gate closure mechanisms of the Mycobacterium tuberculosis 20S proteasome.
The EMBO journal.
2010
Academic Article
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Times cited: 36 -
Structural insights on the Mycobacterium tuberculosis proteasomal ATPase Mpa.
Structure (London, England : 1993).
2009
Academic Article
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Times cited: 67 -
Nitazoxanide kills replicating and nonreplicating Mycobacterium tuberculosis and evades resistance.
Journal of medicinal chemistry.
2009
Academic Article
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Times cited: 107 -
Inhibitors selective for mycobacterial versus human proteasomes.
Nature.
2009
Academic Article
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Times cited: 191 -
Distinct specificities of Mycobacterium tuberculosis and mammalian proteasomes for N-acetyl tripeptide substrates.
The Journal of biological chemistry.
2008
Academic Article
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Times cited: 47 -
A philosophy of anti-infectives as a guide in the search for new drugs for tuberculosis.
Tuberculosis (Edinburgh, Scotland).
2008
Review
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Times cited: 51 -
Selective killing of nonreplicating mycobacteria.
Cell host & microbe.
2008
Academic Article
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Times cited: 159 -
Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity.
Molecular microbiology.
2006
Academic Article
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Times cited: 90 -
Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate.
Molecular microbiology.
2006
Academic Article
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Times cited: 108 -
Characterization of a Mycobacterium tuberculosis proteasomal ATPase homologue.
Molecular microbiology.
2005
Academic Article
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Times cited: 104