Fouda, Genevieve

Publications

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Co-Author Network

selected publications

Characterization of Early Viral Populations in Infants Acquiring HIV Through Perinatal and Breastmilk Transmission: A Review of what is Currently Known and the Gaps that Need to be Addressed to Guide Passive HIV Immunization of Breastfeeding Infants. Current HIV research. 2025 Academic Article GET IT
Pediatric T cell and B cell responses to SARS-CoV-2 infection. JCI insight. 2025 Academic Article GET IT
Integration of Preclinical and Clinical Vaccine Safety and Immunogenicity Testing for Development of a Pediatric HIV Vaccine to Achieve Protective HIV Immunity Prior to Adolescence. Current HIV research. 2025 Academic Article GET IT
Negative Control Outcome Adjustment in Early-Phase Randomized Trials: Estimating Vaccine Effects on Immune Responses in HIV Exposed Uninfected Infants. Statistics in medicine. 2025 Academic Article GET IT
Germline-targeting HIV Envelope SOSIP immunization more frequently elicits broadly-neutralizing antibody precursor responses in infant compared to juvenile rhesus macaques. 2025 GET IT
Cost-effectiveness of broadly neutralizing antibodies for HIV prophylaxis for infants born in settings with high HIV burdens. PloS one. 2025 Academic Article GET IT
In utero human cytomegalovirus infection expands NK-like FcγRIII+ CD8+ T cells that mediate Fc antibody functions. The Journal of clinical investigation. 2024 Academic Article GET IT
A novel HIV triple broadly neutralizing antibody (bNAb) combination-based passive immunization of infant rhesus macaques achieves durable protective plasma neutralization levels and mediates anti-viral effector functions. PloS one. 2024 Academic Article GET IT
Assessing the impact of autologous virus neutralizing antibodies on viral rebound time in postnatally SHIV-infected ART-treated infant rhesus macaques. Epidemics. 2024 Academic Article GET IT
Assessing the impact of autologous neutralizing antibodies on rebound dynamics in postnatally SHIV-infected ART-treated infant rhesus macaques. 2024 GET IT
Comparative analysis of within-host dynamics of acute infection and viral rebound dynamics in postnatally SHIV-infected ART-treated infant rhesus macaques. 2024 GET IT
Immunogenicity of Monovalent mRNA-1273 and BNT162b2 Vaccines in Children Less Than 5 Years of Age. Pediatrics. 2024 Academic Article GET IT
Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques. NPJ vaccines. 2023 Academic Article GET IT
Cost-effectiveness of broadly neutralizing antibodies for infant HIV prophylaxis in settings with high HIV burdens: a simulation modeling study. 2023 GET IT
Assessing the impact of autologous neutralizing antibodies on viral rebound in postnatally SHIV-infected ART-treated infant rhesus macaques. 2023 GET IT
In utero human cytomegalovirus infection expands NK cell-like FcγRIII-expressing CD8+ T cells that mediate antibody-dependent functions. 2023 GET IT
Delta variant neutralizing antibody response following maternal COVID-19 vaccination. American journal of infection control. 2023 Academic Article GET IT
Times cited: 1
Cost-effectiveness of broadly neutralizing antibody prophylaxis for HIV-exposed infants in sub-Saharan African settings. Journal of the International AIDS Society. 2023 Academic Article GET IT
Times cited: 13
Infant rhesus macaques immunized against SARS-CoV-2 are protected against heterologous virus challenge one year later. Science translational medicine. 2022 Academic Article GET IT
Characterization of the primary antibody response to Plasmodium falciparum antigens in infants living in a malaria-endemic area. Malaria journal. 2022 Academic Article GET IT
Times cited: 5
Self-assembling peptide nanofiber HIV vaccine elicits robust vaccine-induced antibody functions and modulates Fc glycosylation. Science advances. 2022 Academic Article GET IT
Times cited: 12
Maternal Fc-mediated non-neutralizing antibody responses correlate with protection against congenital human cytomegalovirus infection. The Journal of clinical investigation. 2022 Academic Article GET IT
Times cited: 41
Challenges and Opportunities of Therapies Targeting Early Life Immunity for Pediatric HIV Cure. Frontiers in immunology. 2022 Review GET IT
Kinetics of pneumococcal antibodies among HIV-exposed, uninfected infants in Botswana. Vaccine. 2022 Academic Article GET IT
Times cited: 3
Vertical HIV-1 Transmission in the Setting of Maternal Broad and Potent Antibody Responses. Journal of virology. 2022 Academic Article GET IT
Times cited: 5
Early Post-Vaccination Gene Signatures Correlate With the Magnitude and Function of Vaccine-Induced HIV Envelope-Specific Plasma Antibodies in Infant Rhesus Macaques. Frontiers in immunology. 2022 Academic Article GET IT
Times cited: 1
Congenital Human Cytomegalovirus Infection Is Associated With Decreased Transplacental IgG Transfer Efficiency Due to Maternal Hypergammaglobulinemia. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2022 Academic Article GET IT
Times cited: 5
Vaccine-Induced, High-Magnitude HIV Env-Specific Antibodies with Fc-Mediated Effector Functions Are Insufficient to Protect Infant Rhesus Macaques against Oral SHIV Infection. mSphere. 2022 Academic Article GET IT
Times cited: 2
Different adjuvanted pediatric HIV envelope vaccines induced distinct plasma antibody responses despite similar B cell receptor repertoires in infant rhesus macaques. PloS one. 2021 Academic Article GET IT
Times cited: 1
Frequent development of broadly neutralizing antibodies in early life in a large cohort of children living with HIV. The Journal of infectious diseases. 2021 Academic Article GET IT
Dynamics and origin of rebound viremia in SHIV-infected infant macaques following interruption of long-term ART. JCI insight. 2021 Academic Article GET IT
Times cited: 14
Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents. JCI insight. 2021 Academic Article GET IT
Times cited: 41
HIV envelope antigen valency on peptide nanofibers modulates antibody magnitude and binding breadth. Scientific reports. 2021 Academic Article GET IT
Times cited: 11
SARS-CoV-2 vaccines elicit durable immune responses in infant rhesus macaques. Science immunology. 2021 Academic Article GET IT
Times cited: 38
Maternal Intervention to Prevent Mother-to-Child Transmission of HIV: Moving Beyond Antiretroviral Therapy. The Pediatric infectious disease journal. 2021 Review GET IT
Times cited: 8
Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents. 2021 GET IT
Safety of Breastfeeding by Mothers With COVID-19: New Evidence From Israel. Pediatrics. 2021 Comment GET IT
Times cited: 1
SARS-CoV-2 Vaccines Elicit Durable Immune Responses in Infant Rhesus Macaques. 2021 GET IT
Understanding Early-Life Adaptive Immunity to Guide Interventions for Pediatric Health. Frontiers in immunology. 2021 Review GET IT
Times cited: 94
Systematic Assessment of Antiviral Potency, Breadth, and Synergy of Triple Broadly Neutralizing Antibody Combinations against Simian-Human Immunodeficiency Viruses. Journal of virology. 2021 Academic Article GET IT
Times cited: 6
Simian-Human Immunodeficiency Virus SHIV.C.CH505 Persistence in ART-Suppressed Infant Macaques Is Characterized by Elevated SHIV RNA in the Gut and a High Abundance of Intact SHIV DNA in Naive CD4⁺ T Cells. Journal of virology. 2020 Academic Article GET IT
Times cited: 27
Harnessing early life immunity to develop a pediatric HIV vaccine that can protect through adolescence. PLoS pathogens. 2020 Academic Article GET IT
Times cited: 6
Lessons From COVID-19 in Children: Key Hypotheses to Guide Preventative and Therapeutic Strategies. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2020 Review GET IT
Times cited: 34
Therapeutic vaccination of SIV-infected, ART-treated infant rhesus macaques using Ad48/MVA in combination with TLR-7 stimulation. PLoS pathogens. 2020 Academic Article GET IT
Times cited: 24
Advances in nanomaterial vaccine strategies to address infectious diseases impacting global health. Nature nanotechnology. 2020 Review GET IT
Times cited: 173
Induction of Neutralizing Responses against Autologous Virus in Maternal HIV Vaccine Trials. mSphere. 2020 Academic Article GET IT
Times cited: 3
Pediatric HIV: the Potential of Immune Therapeutics to Achieve Viral Remission and Functional Cure. Current HIV/AIDS reports. 2020 Review GET IT
Times cited: 14
Efficiency of placental transfer of vaccine-elicited antibodies relative to prenatal Tdap vaccination status. Vaccine. 2020 Academic Article GET IT
Times cited: 20
Shortening HIV vaccine regimens to achieve high coverage. The lancet. HIV. 2020 Comment GET IT
Times cited: 1
Immunological mechanisms of inducing HIV immunity in infants. Vaccine. 2019 Review GET IT
Times cited: 12
Maternal Humoral Immune Responses Do Not Predict Postnatal HIV-1 Transmission Risk in Antiretroviral-Treated Mothers from the IMPAACT PROMISE Study. mSphere. 2019 Academic Article GET IT
Times cited: 5
Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women. Cell. 2019 Academic Article GET IT
Times cited: 98
Bridging Vaccine-Induced HIV-1 Neutralizing and Effector Antibody Responses in Rabbit and Rhesus Macaque Animal Models. Journal of virology. 2019 Academic Article GET IT
Times cited: 21
Determinants of Tenascin-C and HIV-1 envelope binding and neutralization. Mucosal immunology. 2019 Academic Article GET IT
Times cited: 23
Rare Detection of Antiviral Functions of Polyclonal IgA Isolated from Plasma and Breast Milk Compartments in Women Chronically Infected with HIV-1. Journal of virology. 2019 Academic Article GET IT
Times cited: 17
Mercury Exposure and Poor Nutritional Status Reduce Response to Six Expanded Program on Immunization Vaccines in Children: An Observational Cohort Study of Communities Affected by Gold Mining in the Peruvian Amazon. International journal of environmental research and public health. 2019 Academic Article GET IT
Times cited: 19
Coadministration of CH31 Broadly Neutralizing Antibody Does Not Affect Development of Vaccine-Induced Anti-HIV-1 Envelope Antibody Responses in Infant Rhesus Macaques. Journal of virology. 2019 Academic Article GET IT
Times cited: 18
Pediatric HIV-1 Acquisition and Lifelong Consequences of Infant Infection. Current immunology reviews. 2019 Academic Article GET IT
Times cited: 2
Adjuvant-Dependent Enhancement of HIV Env-Specific Antibody Responses in Infant Rhesus Macaques. Journal of virology. 2018 Academic Article GET IT
Times cited: 39
Noncanonical placental Fc receptors: What is their role in modulating transplacental transfer of maternal IgG?. PLoS pathogens. 2018 Academic Article GET IT
Times cited: 36
Development and application of a multiplex assay for the simultaneous measurement of antibody responses elicited by common childhood vaccines. Vaccine. 2018 Academic Article GET IT
Times cited: 24
Infant transmitted/founder HIV-1 viruses from peripartum transmission are neutralization resistant to paired maternal plasma. PLoS pathogens. 2018 Academic Article GET IT
Times cited: 25
Maternal HIV-1 Env Vaccination for Systemic and Breast Milk Immunity To Prevent Oral SHIV Acquisition in Infant Macaques. mSphere. 2018 Academic Article GET IT
Times cited: 15
Increased Susceptibility to Plasmodium falciparum in Infants is associated with Low, not High, Placental Malaria Parasitemia. Scientific reports. 2018 Academic Article GET IT
Times cited: 11
The Impact of IgG transplacental transfer on early life immunity. ImmunoHorizons. 2018 Academic Article GET IT
Times cited: 173
HIV-Exposed Infants Vaccinated with an MF59/Recombinant gp120 Vaccine Have Higher-Magnitude Anti-V1V2 IgG Responses than Adults Immunized with the Same Vaccine. Journal of virology. 2017 Academic Article GET IT
Times cited: 27
Impact of Poxvirus Vector Priming, Protein Coadministration, and Vaccine Intervals on HIV gp120 Vaccine-Elicited Antibody Magnitude and Function in Infant Macaques. Clinical and vaccine immunology : CVI. 2017 Academic Article GET IT
Times cited: 27
Maternal Humoral Immune Correlates of Peripartum Transmission of Clade C HIV-1 in the Setting of Peripartum Antiretrovirals. Clinical and vaccine immunology : CVI. 2017 Academic Article GET IT
Times cited: 11
Lessons learned from human HIV vaccine trials. Current opinion in HIV and AIDS. 2017 Review GET IT
Times cited: 27
Maternal Binding and Neutralizing IgG Responses Targeting the C-Terminal Region of the V3 Loop Are Predictive of Reduced Peripartum HIV-1 Transmission Risk. Journal of virology. 2017 Academic Article GET IT
Times cited: 23
Characterization of Simian Immunodeficiency Virus Variants Anatomically Compartmentalized in Plasma and Milk in Chronically Infected African Green Monkeys. Journal of virology. 2016 Academic Article GET IT
Times cited: 2
The Presence and Anti-HIV-1 Function of Tenascin C in Breast Milk and Genital Fluids. PloS one. 2016 Academic Article GET IT
Times cited: 16
Combined HIV-1 Envelope Systemic and Mucosal Immunization of Lactating Rhesus Monkeys Induces a Robust Immunoglobulin A Isotype B Cell Response in Breast Milk. Journal of virology. 2016 Academic Article GET IT
Times cited: 26
Systemic administration of an HIV-1 broadly neutralizing dimeric IgA yields mucosal secretory IgA and virus neutralization. Mucosal immunology. 2016 Academic Article GET IT
Times cited: 32
Contrasting Adult and Infant Immune Responses to HIV Infection and Vaccination. Clinical and vaccine immunology : CVI. 2015 Review GET IT
Times cited: 39
Breast Milk of HIV-Positive Mothers Has Potent and Species-Specific In Vivo HIV-Inhibitory Activity. Journal of virology. 2015 Academic Article GET IT
Times cited: 24
The function and affinity maturation of HIV-1 gp120-specific monoclonal antibodies derived from colostral B cells. Mucosal immunology. 2015 Academic Article GET IT
Times cited: 14
Association of HIV-1 Envelope-Specific Breast Milk IgA Responses with Reduced Risk of Postnatal Mother-to-Child Transmission of HIV-1. Journal of virology. 2015 Academic Article GET IT
Times cited: 52
Maternal HIV-1 envelope-specific antibody responses and reduced risk of perinatal transmission. The Journal of clinical investigation. 2015 Academic Article GET IT
Times cited: 63
Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates. Journal of virology. 2015 Academic Article GET IT
Times cited: 39
Antibodies for prevention of mother-to-child transmission of HIV-1. Current opinion in HIV and AIDS. 2015 Review GET IT
Times cited: 8
Infant HIV-1 vaccines: supplementing strategies to reduce maternal-child transmission. JAMA. 2015 Academic Article GET IT
Times cited: 7
Infant HIV type 1 gp120 vaccination elicits robust and durable anti-V1V2 immunoglobulin G responses and only rare envelope-specific immunoglobulin A responses. The Journal of infectious diseases. 2014 Academic Article GET IT
Times cited: 52
Restricted isotype, distinct variable gene usage, and high rate of gp120 specificity of HIV-1 envelope-specific B cells in colostrum compared with those in blood of HIV-1-infected, lactating African women. Mucosal immunology. 2014 Academic Article GET IT
Times cited: 17
Immune-based interventions to prevent postnatal HIV-1 transmission. Trends in microbiology. 2014 Academic Article GET IT
Times cited: 4
Tenascin-C is an innate broad-spectrum, HIV-1-neutralizing protein in breast milk. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 72
Lack of B cell dysfunction is associated with functional, gp120-dominant antibody responses in breast milk of simian immunodeficiency virus-infected African green monkeys. Journal of virology. 2013 Academic Article GET IT
Times cited: 13
Mucosal immunization of lactating female rhesus monkeys with a transmitted/founder HIV-1 envelope induces strong Env-specific IgA antibody responses in breast milk. Journal of virology. 2013 Academic Article GET IT
Times cited: 38
Short communication: HIV type 1 subtype C variants transmitted through the bottleneck of breastfeeding are sensitive to new generation broadly neutralizing antibodies directed against quaternary and CD4-binding site epitopes. AIDS research and human retroviruses. 2013 Academic Article GET IT
Times cited: 16
Postnatally-transmitted HIV-1 Envelope variants have similar neutralization-sensitivity and function to that of nontransmitted breast milk variants. Retrovirology. 2013 Academic Article GET IT
Times cited: 34
Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum. PloS one. 2012 Academic Article GET IT
Times cited: 25
Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies. Journal of virology. 2011 Academic Article GET IT
Times cited: 79
HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies. Journal of virology. 2011 Academic Article GET IT
Times cited: 83
Origin and evolution of HIV-1 in breast milk determined by single-genome amplification and sequencing. Journal of virology. 2010 Academic Article GET IT
Times cited: 53
Longitudinal studies of Plasmodium falciparum malaria in pregnant women living in a rural Cameroonian village with high perennial transmission. The American journal of tropical medicine and hygiene. 2010 Academic Article GET IT
Times cited: 30
Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia. Journal of virology. 2008 Academic Article GET IT
Times cited: 522
Multiplex assay for simultaneous measurement of antibodies to multiple Plasmodium falciparum antigens. Clinical and vaccine immunology : CVI. 2006 Academic Article GET IT
Times cited: 72
Lack of an association between antibodies to Plasmodium falciparum glycosylphosphatidylinositols and malaria-associated placental changes in Cameroonian women with preterm and full-term deliveries. Infection and immunity. 2004 Academic Article GET IT
Times cited: 20
Plasmodium falciparum-infected erythrocytes adhere both in the intervillous space and on the villous surface of human placenta by binding to the low-sulfated chondroitin sulfate proteoglycan receptor. The American journal of pathology. 2004 Academic Article GET IT
Times cited: 74
Changes in the levels of chemokines and cytokines in the placentas of women with Plasmodium falciparum malaria. The Journal of infectious diseases. 2003 Academic Article GET IT
Times cited: 136

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Research

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Co-investigator Network

Funding awarded

Leveraging novel pediatric SHIVs to identify biomarkers of prophylactic efficacy of bnAb against breast milk HIV transmission awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2025 - 2029
Defining and modeling HIV-1-specific antibody function in HIV-1-exposed Infants passively Infused with broadly neutralizing antibodies in the IMPAACT P1112 trial. awarded by National Institute of Child Health & Human Development Principal Investigator 2025 - 2027
Clinical and Translational Science Center - TL1 awarded by National Center for Advancing Translational Sciences Principal Investigator 2022 - 2027
Early life B cell responses and inflammation following SARS-CoV-2 infection awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2022 - 2026
Neutralizing and non-neutralizing antibody effector functions in HIV infected children awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2023 - 2025

Early Life Vaccination to Prevent HIV Acquisition During Adolescence awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2021 - 2026

Translating germline-targeting HIV Env SOSIP immunization of infants: targeting bnAbs in early life awarded by National Institute of Allergy & Infectious Diseases Co-Principal Investigator 2025 - 2030
missing activity Co-Principal Investigator 2023 - 2028
Pediatric Adolescent Virus Eradiation (PAVE) Martin Delaney Collaboratory awarded by National Institute of Allergy & Infectious Diseases Co-Principal Investigator 2021 - 2026

Translating germline-targeting HIV Env SOSIP immunization of infants: targeting bnAbs in early life awarded by National Institute of Allergy & Infectious Diseases Key Personnel 2025 - 2030

Impact of Early-life Exposure to Semi-Volatile Organic Compounds (SV)Cs) on Neonatal and Early Childhood Immune Function awarded by National Institute of Allergy & Infectious Diseases Principal Investigator Subaward 2022 - 2027
Sublingual Supromolecular Vaccines and Immunotherapies awarded by National Institute of Allergy & Infectious Diseases Principal Investigator Subaward 2023 - 2025
Supramolecular pediatric HIV vaccine design awarded by National Institute of Allergy & Infectious Diseases Principal Investigator Subaward 2022 - 2025

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Background

education and training

Ph.D., Georgetown University 2006
M.D., University of Yaounde, Faculty of Medicine and Biomedical Sciences (Cameroon) 2002

VIVO Weill Cornell Medical College

Genevieve Fouda Professor of Pediatrics

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email