Faraco, Giuseppe

Publications

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selected publications

Early life high fructose impairs microglial phagocytosis and neurodevelopment. Nature. 2025 Academic Article GET IT
Neutrophil stalling does not mediate the increase in tau phosphorylation and the cognitive impairment associated with high salt diet. 2025 GET IT
Molecular and functional alterations in the cerebral microvasculature in an optimized mouse model of sepsis-associated cognitive dysfunction. eNeuro. 2024 Academic Article GET IT
Molecular and functional alterations in the cerebral microvasculature in an optimized mouse model of sepsis-associated cognitive dysfunction. 2024 GET IT
Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension. Nature neuroscience. 2023 Academic Article GET IT
Essential Role of Endothelial Sphingolipid Biosynthesis in Cerebrovascular Homeostasis. Circulation research. 2023 Academic Article GET IT
Early life high fructose exposure disrupts microglia function and impedes neurodevelopment. 2023 GET IT
Expanding the horizon of research into the pathogenesis of the white matter diseases: Proceedings of the 2021 Annual Workshop of the Albert Research Institute for White Matter and Cognition. GeroScience. 2021 Academic Article GET IT
Endothelial S1P₁ Signaling Counteracts Infarct Expansion in Ischemic Stroke. Circulation research. 2020 Academic Article GET IT
Times cited: 96
Endothelium-Macrophage Crosstalk Mediates Blood-Brain Barrier Dysfunction in Hypertension. Hypertension (Dallas, Tex. : 1979). 2020 Academic Article GET IT
Times cited: 136
Dietary salt promotes cognitive impairment through tau phosphorylation. Nature. 2019 Academic Article GET IT
Times cited: 179
Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response. Nature neuroscience. 2018 Academic Article GET IT
Times cited: 268
Brain perivascular macrophages: characterization and functional roles in health and disease. Journal of molecular medicine (Berlin, Germany). 2017 Information Resource GET IT
Times cited: 157
Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 169
Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension. The Journal of clinical investigation. 2016 Academic Article GET IT
Times cited: 272
Spatio-temporal profile, phenotypic diversity, and fate of recruited monocytes into the post-ischemic brain. Journal of neuroinflammation. 2016 Academic Article GET IT
Times cited: 92
Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells. Nature medicine. 2016 Academic Article GET IT
Times cited: 867
Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2016 Academic Article GET IT
Times cited: 144
Dichotomous effects of chronic intermittent hypoxia on focal cerebral ischemic injury. Stroke. 2014 Academic Article GET IT
Times cited: 41
Water deprivation induces neurovascular and cognitive dysfunction through vasopressin-induced oxidative stress. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2014 Academic Article GET IT
Times cited: 53
Hypertension: a harbinger of stroke and dementia. Hypertension (Dallas, Tex. : 1979). 2013 Information Resource GET IT
Times cited: 312
Circulating endothelin-1 alters critical mechanisms regulating cerebral microcirculation. Hypertension (Dallas, Tex. : 1979). 2013 Academic Article GET IT
Times cited: 49
Angiotensin II slow-pressor hypertension enhances NMDA currents and NOX2-dependent superoxide production in hypothalamic paraventricular neurons. American journal of physiology. Regulatory, integrative and comparative physiology. 2013 Academic Article GET IT
Times cited: 55
Membrane trafficking of NADPH oxidase p47(phox) in paraventricular hypothalamic neurons parallels local free radical production in angiotensin II slow-pressor hypertension. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Academic Article GET IT
Times cited: 38
Endothelin 1-dependent neurovascular dysfunction in chronic intermittent hypoxia. Hypertension (Dallas, Tex. : 1979). 2012 Academic Article GET IT
Times cited: 62
Central cardiovascular circuits contribute to the neurovascular dysfunction in angiotensin II hypertension. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Academic Article GET IT
Times cited: 87
The acetylation of RelA in Lys310 dictates the NF-κB-dependent response in post-ischemic injury. Cell death & disease. 2010 Academic Article GET IT
Times cited: 88
The cerebrovascular dysfunction induced by slow pressor doses of angiotensin II precedes the development of hypertension. American journal of physiology. Heart and circulatory physiology. 2010 Academic Article GET IT
Times cited: 107
Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 165
Cyclooxygenase 1-derived prostaglandin E2 and EP1 receptors are required for the cerebrovascular dysfunction induced by angiotensin II. Hypertension (Dallas, Tex. : 1979). 2010 Academic Article GET IT
Times cited: 57
Brain ischemic preconditioning does not require PARP-1. Stroke. 2009 Academic Article GET IT
Times cited: 8
Histone deacetylase (HDAC) inhibitors reduce the glial inflammatory response in vitro and in vivo. Neurobiology of disease. 2009 Academic Article GET IT
Times cited: 99
Leptin is induced in the ischemic cerebral cortex and exerts neuroprotection through NF-kappaB/c-Rel-dependent transcription. Stroke. 2008 Academic Article GET IT
Times cited: 79
High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo. Journal of neurochemistry. 2007 Academic Article GET IT
Times cited: 183
Carboxymethyl beta-glucan binds to corneal epithelial cells and increases cell adhesion to laminin and resistance to oxidative stress. Cornea. 2007 Academic Article GET IT
Times cited: 5
Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brain. Molecular pharmacology. 2006 Academic Article GET IT
Times cited: 195
Poly(ADP-ribose) accumulation and enhancement of postischemic brain damage in 110-kDa poly(ADP-ribose) glycohydrolase null mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2006 Academic Article GET IT
Times cited: 58

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Research

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Funding awarded

Gut Immunity, Neurovascular dysregulation and Cognitive Impairment awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2022 - 2027

Dietary sodium, neurovascular dysfunction and cerebrovascular risk awarded by National Institute of Neurological Disorders & Stroke Co-Investigator 2021 - 2026
Hypertension, tau and neurodegeneration awarded by Cure Alzheimer’s Fund Co-Investigator 2024 - 2025
Endothelial Sphingolipid Signaling in Post-Sepsis Cognitive Impairment. awarded by National Institute of Neurological Disorders & Stroke Co-Investigator 2022 - 2025

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Background

education and training

Ph.D., University of Florence Faculty of Medicine and Surgery (Italy) 2011
M.D., University of Florence Faculty of Medicine and Surgery (Italy) 2004

Contact

full name

Giuseppe Faraco

primary email

gif2004@med.cornell.edu

VIVO Weill Cornell Medical College

Giuseppe Faraco Assistant Professor of Neuroscience

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email