Lee, Guinevere Q.

Publications

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selected publications

Development and validation of HIV SMRTcap for the characterization of HIV-1 reservoirs across tissues and subtypes. 2025 GET IT
Differences in HIV-1 reservoir size, landscape characteristics, and decay dynamics in acute and chronic treated HIV-1 Clade C infection. eLife. 2025 Academic Article GET IT
Subtypes A1 and D, and recombinant HIV-1 natural polymorphisms associated with lenacapavir drug resistance in Uganda. The Journal of antimicrobial chemotherapy. 2025 Academic Article GET IT
HIV-1 subtype A1, D, and recombinant proviral genome landscapes during long-term suppressive therapy. Nature communications. 2024 Academic Article GET IT
Differences in HIV-1 reservoir size, landscape characteristics and decay dynamics in acute and chronic treated HIV-1 Clade C infection. 2024 GET IT
HIV reservoirs are dominated by genetically younger and clonally enriched proviruses. mBio. 2023 Academic Article GET IT
SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8⁺ T-cells. Nature communications. 2022 Academic Article GET IT
Times cited: 22
Attenuated HIV-1 Nef But Not Vpu Function in a Cohort of Rwandan Long-Term Survivors. Frontiers in virology. 2022 Academic Article GET IT
Times cited: 22
Near-Full-Length Single-Genome HIV-1 DNA Sequencing. Methods in molecular biology (Clifton, N.J.). 2022 Academic Article GET IT
Times cited: 7
Chemistry and Bioinformatics Considerations in Using Next-Generation Sequencing Technologies to Inferring HIV Proviral DNA Genome-Intactness. Viruses. 2021 Academic Article GET IT
Times cited: 8
Pre-treatment integrase inhibitor resistance is uncommon in antiretroviral therapy-naive individuals with HIV-1 subtype A1 and D infections in Uganda. AIDS (London, England). 2021 Academic Article GET IT
Times cited: 13
HIV-specific T cell responses reflect substantive in vivo interactions with antigen despite long-term therapy. JCI insight. 2021 Academic Article GET IT
Times cited: 49
HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA). Nature communications. 2021 Academic Article GET IT
Times cited: 73
Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5. PLoS pathogens. 2020 Academic Article GET IT
Times cited: 26
Blood and Lymph Node Dissemination of Clonal Genome-Intact Human Immunodeficiency Virus 1 DNA Sequences During Suppressive Antiretroviral Therapy. The Journal of infectious diseases. 2020 Academic Article GET IT
Times cited: 24
Differential Vpu-Mediated CD4 and Tetherin Downregulation Functions among Major HIV-1 Group M Subtypes. Journal of virology. 2020 Academic Article GET IT
Times cited: 7
Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection. PLoS pathogens. 2020 Academic Article GET IT
Times cited: 30
HIV-1 DNA sequence diversity and evolution during acute subtype C infection. Nature communications. 2019 Academic Article GET IT
Times cited: 56
Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. The Journal of clinical investigation. 2019 Academic Article GET IT
Times cited: 212
Genotypic and Mechanistic Characterization of Subtype-Specific HIV Adaptation to Host Cellular Immunity. Journal of virology. 2018 Academic Article GET IT
Times cited: 18
HLA-C downregulation by HIV-1 adapts to host HLA genotype. PLoS pathogens. 2018 Academic Article GET IT
Times cited: 22
HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers. The Journal of clinical investigation. 2018 Academic Article GET IT
Times cited: 64
Increasing Prevalence of HIV Pretreatment Drug Resistance in Women But Not Men in Rural Uganda During 2005-2013. AIDS patient care and STDs. 2018 Academic Article GET IT
Times cited: 12
Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4⁺ T Cells. Immunity. 2018 Academic Article GET IT
Times cited: 106
Distribution and reduction magnitude of HIV-DNA burden in CD4+ T cell subsets depend on art initiation timing. AIDS (London, England). 2018 Academic Article GET IT
Times cited: 3
Dolutegravir reshapes the genetic diversity of HIV-1 reservoirs. The Journal of antimicrobial chemotherapy. 2018 Academic Article GET IT
Times cited: 7
Effect of analytical treatment interruption and reinitiation of antiretroviral therapy on HIV reservoirs and immunologic parameters in infected individuals. PLoS pathogens. 2018 Academic Article GET IT
Times cited: 82
Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A case study. 2017 GET IT
Times cited: 41
Prevalence and clinical impacts of HIV-1 intersubtype recombinants in Uganda revealed by near-full-genome population and deep sequencing approaches. AIDS (London, England). 2017 Academic Article GET IT
Times cited: 25
Brief Report: Should Abacavir Be a First-Line Alternative for Adults With HIV in Sub-Saharan Africa?. Journal of acquired immune deficiency syndromes (1999). 2017 Academic Article GET IT
Times cited: 3
Potential for immune-driven viral polymorphisms to compromise antiretroviral-based preexposure prophylaxis for prevention of HIV-1 infection. AIDS (London, England). 2017 Academic Article GET IT
Times cited: 6
Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells. The Journal of clinical investigation. 2017 Academic Article GET IT
Times cited: 233
Subtype-Specific Differences in Gag-Protease-Driven Replication Capacity Are Consistent with Intersubtype Differences in HIV-1 Disease Progression. Journal of virology. 2017 Academic Article GET IT
Times cited: 42
In vitro functional assessment of natural HIV-1 group M Vpu sequences using a universal priming approach. Journal of virological methods. 2016 Academic Article GET IT
Times cited: 4
Non-R5-tropic HIV-1 in subtype A1 and D infections were associated with lower pretherapy CD4+ cell count but not with PI/(N)NRTI therapy outcomes in Mbarara, Uganda. AIDS (London, England). 2016 Academic Article GET IT
Times cited: 3
Diversity of HIV-1 reservoirs in CD4+ T-cell subpopulations. Current opinion in HIV and AIDS. 2016 Review GET IT
Times cited: 57
HIV drug resistance testing by high-multiplex "wide" sequencing on the MiSeq instrument. Antimicrobial agents and chemotherapy. 2015 Academic Article GET IT
Times cited: 54
Highly frequent HIV-1 minority resistant variants at baseline of the ANRS 139 TRIO trial had a limited impact on virological response. The Journal of antimicrobial chemotherapy. 2015 Academic Article GET IT
Times cited: 22
Reliable genotypic tropism tests for the major HIV-1 subtypes. Scientific reports. 2015 Academic Article GET IT
Times cited: 37
Prevalence and virologic consequences of transmitted HIV-1 drug resistance in Uganda. AIDS research and human retroviruses. 2014 Academic Article GET IT
Times cited: 28
Limited evolution of inferred HIV-1 tropism while viremia is undetectable during standard HAART therapy. PloS one. 2014 Academic Article GET IT
Times cited: 4
Theoretical and experimental assessment of degenerate primer tagging in ultra-deep applications of next-generation sequencing. Nucleic acids research. 2014 Academic Article GET IT
Times cited: 28
Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes. Retrovirology. 2013 Academic Article GET IT
Times cited: 72
Comparison of population and 454 "deep" sequence analysis for HIV type 1 tropism versus the original trofile assay in non-B subtypes. AIDS research and human retroviruses. 2013 Academic Article GET IT
Times cited: 16
Prolonged and substantial discordance in prevalence of raltegravir-resistant HIV-1 in plasma versus PBMC samples revealed by 454 "deep" sequencing. PloS one. 2012 Academic Article GET IT
Times cited: 20
Convergence of Ser/Thr and two-component signaling to coordinate expression of the dormancy regulon in Mycobacterium tuberculosis. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 96

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Research

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Co-investigator Network

Funding awarded

Patterns of HIV archival drug resistance in intact versus defective proviral DNA genomes awarded by Merck & Co., Inc. Principal Investigator 2025 - 2026
Characterization of Non-subtype B HIV-1 Reservoirs and its Association with Longitudinal Clinical Outcomes awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2021 - 2026

REACH: Research Enterprise to Advance a Cure for HIV awarded by National Institute of Allergy & Infectious Diseases Co-Principal Investigator 2021 - 2026

Impact of Neonatal ART and Broadly Neutralizing Antibodies on HIV-1 Reservoirs in Infants: Towards ART-free Remission awarded by National Institute of Allergy & Infectious Diseases Principal Investigator Subaward 2024 - 2029
missing activity Principal Investigator Subaward 2023 - 2024
missing activity Principal Investigator Subaward 2023 - 2024

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Background

education and training

Ph.D., University of British Columbia (Canada) 2015
M.Sc., University of British Columbia (Canada) 2008
B.Sc., University of British Columbia (Canada) 2004

Contact

full name

Guinevere Q. Lee

primary email

gul4001@med.cornell.edu

VIVO Weill Cornell Medical College

Guinevere Q. Lee Assistant Professor of Virology in Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email