Fine, Howard Alan

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selected publications

Bridging the gap between tumor and disease: Innovating cancer and glioma models. The Journal of experimental medicine. 2024 Review GET IT
Positron Emission Tomography and Magnetic Resonance Imaging Findings in the Diagnosis of Stroke-Like Migraine Attacks after Radiation Therapy Syndrome: A Case Report. 2024 GET IT
DOTATATE PET/MR Imaging Differentiates Secondary-Progressive from de Novo World Health Organization Grade 3 Meningiomas. AJNR. American journal of neuroradiology. 2024 Academic Article GET IT
Glioblastoma: Not Just Another Cancer. Cancer discovery. 2024 Academic Article GET IT
Shifting the landscape: The role of IDH inhibitors in glioma cell fate. Cancer cell. 2024 Academic Article GET IT
Chronic hypoxia remodels the tumor microenvironment to support glioma stem cell growth. Acta neuropathologica communications. 2024 Academic Article GET IT
Stem cell modeling of nervous system tumors. Disease models & mechanisms. 2024 Review GET IT
Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling. Cancer cell. 2023 Academic Article GET IT
A multicenter, phase 1, dose escalation clinical trial (G-FORCE-1) of XRT, RRx-001 and temozolomide followed by temozolomide +/- RRx-001 in newly diagnosed glioblastoma. Frontiers in oncology. 2023 Academic Article GET IT
Times cited: 7
Microenvironment-driven dynamic chromatin changes in glioblastoma recapitulate early neural development at single-cell resolution. Cancer research. 2023 Academic Article GET IT
Concurrent immunotherapy and re-irradiation utilizing stereotactic body radiotherapy for recurrent high-grade gliomas. Cancer reports (Hoboken, N.J.). 2023 Academic Article GET IT
Innovations in Neuro-Oncology. World neurosurgery. 2021 Academic Article GET IT
Outcomes following upfront radiation versus monitoring in atypical meningiomas: 16-year experience at a tertiary medical center. Neuro-oncology advances. 2021 Academic Article GET IT
Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate. Proceedings of the National Academy of Sciences of the United States of America. 2021 Academic Article GET IT
Times cited: 129
Diffuse Glioma Heterogeneity and Its Therapeutic Implications. Cancer discovery. 2021 Information Resource GET IT
Times cited: 3
Incorporating genomic signatures into surgical and medical decision-making for elderly glioblastoma patients. Neurosurgical focus. 2020 Academic Article GET IT
Times cited: 1
The Prognostic Value of MRI Subventricular Zone Involvement and Tumor Genetics in Lower Grade Gliomas. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2020 Academic Article GET IT
Generating Patient-Derived Gliomas within Cerebral Organoids. STAR protocols. 2020 Academic Article GET IT
Tumor Microenvironment Is Critical for the Maintenance of Cellular States Found in Primary Glioblastomas. Cancer discovery. 2020 Academic Article GET IT
Times cited: 30
Integrative Molecular Analysis of Patients With Advanced and Metastatic Cancer. JCO precision oncology. 2019 Academic Article GET IT
Times cited: 33
Grading meningiomas utilizing multiparametric MRI with inclusion of susceptibility weighted imaging and quantitative susceptibility mapping. Journal of neuroradiology = Journal de neuroradiologie. 2019 Academic Article GET IT
Times cited: 18
Pilot Trial of Adoptive Transfer of Chimeric Antigen Receptor-transduced T Cells Targeting EGFRvIII in Patients With Glioblastoma. Journal of immunotherapy (Hagerstown, Md. : 1997). 2019 Academic Article GET IT
Times cited: 275
Modeling Patient-Derived Glioblastoma with Cerebral Organoids. Cell reports. 2019 Academic Article GET IT
Times cited: 298
Integrated PET-MRI for Glioma Surveillance: Perfusion-Metabolism Discordance Rate and Association With Molecular Profiling. AJR. American journal of roentgenology. 2019 Academic Article GET IT
Times cited: 6
MRI Features Associated with TERT Promoter Mutation Status in Glioblastoma. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2019 Academic Article GET IT
Times cited: 9
Texture analysis on conventional MRI images accurately predicts early malignant transformation of low-grade gliomas. European radiology. 2019 Academic Article GET IT
Times cited: 6
MRI based texture analysis to classify low grade gliomas into astrocytoma and 1p/19q codeleted oligodendroglioma. Magnetic resonance imaging. 2018 Academic Article GET IT
Times cited: 9
Tubular brain tumor biopsy improves diagnostic yield for subcortical lesions. Journal of neuro-oncology. 2018 Academic Article GET IT
Times cited: 8
The REMBRANDT study, a large collection of genomic data from brain cancer patients. Scientific data. 2018 Academic Article GET IT
Times cited: 123
Detailed longitudinal sampling of glioma stem cells in situ reveals Chr7 gain and Chr10 loss as repeated events in primary tumor formation and recurrence. International journal of cancer. 2017 Academic Article GET IT
Times cited: 18
A Core Regulatory Circuit in Glioblastoma Stem Cells Links MAPK Activation to a Transcriptional Program of Neural Stem Cell Identity. Scientific reports. 2017 Academic Article GET IT
Times cited: 20
Prioritization schema for immunotherapy clinical trials in glioblastoma. Oncoimmunology. 2016 Information Resource GET IT
Times cited: 13
A Phase II trial of tandutinib (MLN 518) in combination with bevacizumab for patients with recurrent glioblastoma. CNS oncology. 2016 Academic Article GET IT
Times cited: 23
Concurrent functional and metabolic assessment of brain tumors using hybrid PET/MR imaging. Journal of neuro-oncology. 2016 Academic Article GET IT
Times cited: 16
A phase II trial of enzastaurin (LY317615) in combination with bevacizumab in adults with recurrent malignant gliomas. Journal of neuro-oncology. 2015 Academic Article GET IT
Times cited: 22
A phase II trial of tamoxifen and bortezomib in patients with recurrent malignant gliomas. Journal of neuro-oncology. 2015 Academic Article GET IT
Times cited: 26
Glioma Angiogenesis and Perfusion Imaging: Understanding the Relationship between Tumor Blood Volume and Leakiness with Increasing Glioma Grade. AJNR. American journal of neuroradiology. 2015 Academic Article GET IT
Times cited: 39
A Phase 2 Study of Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid for Patients With Glioblastoma. International journal of radiation oncology, biology, physics. 2015 Academic Article GET IT
Times cited: 162
An in silico screen links gene expression signatures to drug response in glioblastoma stem cells. The pharmacogenomics journal. 2014 Academic Article GET IT
Times cited: 1
Identification of molecular pathways facilitating glioma cell invasion in situ. PloS one. 2014 Academic Article GET IT
Times cited: 36
Master regulators, regulatory networks, and pathways of glioblastoma subtypes. Cancer informatics. 2014 Academic Article GET IT
Times cited: 12
Timing (and biology) are everything. Neuro-oncology. 2014 Editorial Article GET IT
Times cited: 1
Report of the Jumpstarting Brain Tumor Drug Development Coalition and FDA clinical trials neuroimaging endpoint workshop (January 30, 2014, Bethesda MD). Neuro-oncology. 2014 Academic Article GET IT
Times cited: 43
Multiple chimeric antigen receptors successfully target chondroitin sulfate proteoglycan 4 in several different cancer histologies and cancer stem cells. Journal for immunotherapy of cancer. 2014 Academic Article GET IT
Times cited: 120
Bevacizumab-related toxicities in the National Cancer Institute malignant glioma trial cohort. Journal of neuro-oncology. 2014 Academic Article GET IT
Times cited: 11
How to get from here to there: tracking down invasive glioma cells. Journal of the National Cancer Institute. 2014 Editorial Article GET IT
Times cited: 1
Micro-environment causes reversible changes in DNA methylation and mRNA expression profiles in patient-derived glioma stem cells. PloS one. 2014 Academic Article GET IT
Times cited: 36
Bevacizumab in glioblastoma--still much to learn. The New England journal of medicine. 2014 Editorial Article GET IT
Times cited: 32
ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state. Cell reports. 2014 Academic Article GET IT
Times cited: 100
A novel uHPLC-MS/MS method for the quantitation of AZD7451 (AZ12607092) in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2013 Academic Article GET IT
Times cited: 1
Chemoirradiation for glioblastoma multiforme: the national cancer institute experience. PloS one. 2013 Academic Article GET IT
Times cited: 17
Age-specific signatures of glioblastoma at the genomic, genetic, and epigenetic levels. PloS one. 2013 Academic Article GET IT
Times cited: 52
Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization. PloS one. 2012 Academic Article GET IT
Times cited: 96
G-cimp status prediction of glioblastoma samples using mRNA expression data. PloS one. 2012 Academic Article GET IT
Times cited: 32
A phase I/II trial of vandetanib for patients with recurrent malignant glioma. Neuro-oncology. 2012 Academic Article GET IT
Times cited: 77
A phase II study of conventional radiation therapy and thalidomide for supratentorial, newly-diagnosed glioblastoma (RTOG 9806). Journal of neuro-oncology. 2012 Academic Article GET IT
Times cited: 14
Continuous daily sunitinib for recurrent glioblastoma. Journal of neuro-oncology. 2012 Academic Article GET IT
Times cited: 65
Recognition of glioma stem cells by genetically modified T cells targeting EGFRvIII and development of adoptive cell therapy for glioma. Human gene therapy. 2012 Academic Article GET IT
Times cited: 265
Gliomagenesis arising from Pten- and Ink4a/Arf-deficient neural progenitor cells is mediated by the p53-Fbxw7/Cdc4 pathway, which controls c-Myc. Cancer research. 2012 Academic Article GET IT
Times cited: 26
SnapShot: glioblastoma multiforme. Cancer cell. 2012 Article GET IT
Times cited: 23
Differential sensitivity of glioma- versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors. Cancer discovery. 2012 Academic Article GET IT
Times cited: 279
Refining endpoints in brain tumor clinical trials. Journal of neuro-oncology. 2012 Academic Article GET IT
Times cited: 35
Spinal cord glioneuronal tumor with neuropil-like islands with 1p/19q deletion in an adult with low-grade cerebral oligodendroglioma. Journal of neuro-oncology. 2011 Academic Article GET IT
Times cited: 10
Qualitative network modeling of the Myc-p53 control system of cell proliferation and differentiation. Biophysical journal. 2011 Academic Article GET IT
Times cited: 22
A phase II trial of single-agent bevacizumab in patients with recurrent anaplastic glioma. Neuro-oncology. 2011 Academic Article GET IT
Times cited: 99
Effect of brain- and tumor-derived connective tissue growth factor on glioma invasion. Journal of the National Cancer Institute. 2011 Academic Article GET IT
Times cited: 112
Integration and analysis of genome-scale data from gliomas. Nature reviews. Neurology. 2011 Information Resource GET IT
Times cited: 93
Ischemic stroke and intracranial hemorrhage in glioma patients on antiangiogenic therapy. Journal of neuro-oncology. 2011 Academic Article GET IT
Times cited: 73
A phase I/II trial of the histone deacetylase inhibitor romidepsin for adults with recurrent malignant glioma: North American Brain Tumor Consortium Study 03-03. Neuro-oncology. 2011 Academic Article GET IT
Times cited: 94
Prediction of Associations between microRNAs and Gene Expression in Glioma Biology. PloS one. 2011 Academic Article GET IT
Times cited: 70
Neuromuscular junction toxicity with tandutinib induces a myasthenic-like syndrome. Neurology. 2011 Academic Article GET IT
Times cited: 19
Selected human leukocyte antigen class II polymorphisms and risk of adult glioma. Journal of neuroimmunology. 2010 Academic Article GET IT
Times cited: 7
Predicting in vitro drug sensitivity using Random Forests. Bioinformatics (Oxford, England). 2010 Academic Article GET IT
Times cited: 136
Malignant gliomas: new translational therapies. The Mount Sinai journal of medicine, New York. 2010 Information Resource GET IT
Times cited: 15
A phase I trial of tipifarnib with radiation therapy, with and without temozolomide, for patients with newly diagnosed glioblastoma. International journal of radiation oncology, biology, physics. 2010 Academic Article GET IT
Times cited: 28
Gene pathways and subnetworks distinguish between major glioma subtypes and elucidate potential underlying biology. Journal of biomedical informatics. 2010 Academic Article GET IT
Times cited: 10
Scale to predict survival after surgery for recurrent glioblastoma multiforme. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2010 Academic Article GET IT
Times cited: 283
GliomaPredict: a clinically useful tool for assigning glioma patients to specific molecular subtypes. BMC medical informatics and decision making. 2010 Academic Article GET IT
Times cited: 14
FastMEDUSA: a parallelized tool to infer gene regulatory networks. Bioinformatics (Oxford, England). 2010 Academic Article GET IT
Times cited: 16
Risk of meningioma and common variation in genes related to innate immunity. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2010 Academic Article GET IT
Times cited: 42
CNAReporter: a GenePattern pipeline for the generation of clinical reports of genomic alterations. BMC medical genomics. 2010 Academic Article GET IT
Times cited: 3
Phase 2 trial of talampanel, a glutamate receptor inhibitor, for adults with recurrent malignant gliomas. Cancer. 2010 Academic Article GET IT
Times cited: 105
Phase II trial of pazopanib (GW786034), an oral multi-targeted angiogenesis inhibitor, for adults with recurrent glioblastoma (North American Brain Tumor Consortium Study 06-02). Neuro-oncology. 2010 Academic Article GET IT
Times cited: 178
Bevacizumab for malignant gliomas. Archives of neurology. 2010 Information Resource GET IT
Times cited: 44
Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2010 Academic Article GET IT
Times cited: 428
A phase I/II trial of enzastaurin in patients with recurrent high-grade gliomas. Neuro-oncology. 2010 Academic Article GET IT
Times cited: 91
A phase I trial of erlotinib in patients with nonprogressive glioblastoma multiforme postradiation therapy, and recurrent malignant gliomas and meningiomas. Neuro-oncology. 2009 Academic Article GET IT
Times cited: 41
A phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy. Neuro-oncology. 2009 Academic Article GET IT
Times cited: 235
DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma. Neuro-oncology. 2009 Academic Article GET IT
Times cited: 112
The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Academic Article GET IT
Times cited: 193
Phase II study of imatinib mesylate for recurrent meningiomas (North American Brain Tumor Consortium study 01-08). Neuro-oncology. 2009 Academic Article GET IT
Times cited: 131
Talampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma: a multicenter phase II trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2009 Academic Article GET IT
Times cited: 142
Phase II trials of erlotinib or gefitinib in patients with recurrent meningioma. Journal of neuro-oncology. 2009 Academic Article GET IT
Times cited: 163
SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma. Cell stem cell. 2009 Academic Article GET IT
Times cited: 566
A phase I trial of enzastaurin in patients with recurrent gliomas. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 Academic Article GET IT
Times cited: 47
Common variation in genes related to innate immunity and risk of adult glioma. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2009 Academic Article GET IT
Times cited: 57
Unsupervised analysis of transcriptomic profiles reveals six glioma subtypes. Cancer research. 2009 Academic Article GET IT
Times cited: 182
Occupational exposure to magnetic fields and the risk of brain tumors. Neuro-oncology. 2009 Academic Article GET IT
Times cited: 35
Rembrandt: helping personalized medicine become a reality through integrative translational research. Molecular cancer research : MCR. 2009 Academic Article GET IT
Times cited: 355
Correlation analysis between single-nucleotide polymorphism and expression arrays in gliomas identifies potentially relevant target genes. Cancer research. 2009 Academic Article GET IT
Times cited: 29
Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2008 Academic Article GET IT
Times cited: 1378
Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-kappaB, and glucose regulation. Cancer research. 2008 Academic Article GET IT
Times cited: 231
Oxidative response gene polymorphisms and risk of adult brain tumors. Neuro-oncology. 2008 Academic Article GET IT
Times cited: 98
Invasion suppressor cystatin E/M (CST6): high-level cell type-specific expression in normal brain and epigenetic silencing in gliomas. Laboratory investigation; a journal of technical methods and pathology. 2008 Academic Article GET IT
Times cited: 55
Genetic variation in insulin-like growth factors and brain tumor risk. Neuro-oncology. 2008 Academic Article GET IT
Times cited: 26
Neurooncology clinical trial design for targeted therapies: lessons learned from the North American Brain Tumor Consortium. Neuro-oncology. 2008 Review GET IT
Times cited: 32
microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma. Cancer research. 2008 Academic Article GET IT
Times cited: 601
Notch-1 regulates transcription of the epidermal growth factor receptor through p53. Carcinogenesis. 2008 Academic Article GET IT
Times cited: 110
Progression-free survival: an important end point in evaluating therapy for recurrent high-grade gliomas. Neuro-oncology. 2008 Academic Article GET IT
Times cited: 368
FK506 binding protein mediates glioma cell growth and sensitivity to rapamycin treatment by regulating NF-kappaB signaling pathway. Neoplasia (New York, N.Y.). 2008 Academic Article GET IT
Times cited: 80
Genomic changes and gene expression profiles reveal that established glioma cell lines are poorly representative of primary human gliomas. Molecular cancer research : MCR. 2008 Academic Article GET IT
Times cited: 172
Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer cell. 2008 Academic Article GET IT
Times cited: 369
A phase I trial of lenalidomide in patients with recurrent primary central nervous system tumors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2007 Academic Article GET IT
Times cited: 58
Phase I study of temozolomide and irinotecan for recurrent malignant gliomas in patients receiving enzyme-inducing antiepileptic drugs: a north american brain tumor consortium study. Clinical cancer research : an official journal of the American Association for Cancer Research. 2007 Academic Article GET IT
Times cited: 20
Promising new therapies for malignant gliomas. Cancer journal (Sudbury, Mass.). 2007 Information Resource GET IT
Times cited: 16
Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma. Carcinogenesis. 2007 Academic Article GET IT
Times cited: 46
Polymorphisms in apoptosis and cell cycle control genes and risk of brain tumors in adults. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2007 Academic Article GET IT
Times cited: 91
The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. Journal of the National Cancer Institute. 2007 Academic Article GET IT
Times cited: 43
Lead, genetic susceptibility, and risk of adult brain tumors. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2006 Academic Article GET IT
Times cited: 59
Personal hair dye use and risks of glioma, meningioma, and acoustic neuroma among adults. American journal of epidemiology. 2006 Academic Article GET IT
Times cited: 16
Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006 Academic Article GET IT
Times cited: 329
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer cell. 2006 Academic Article GET IT
Times cited: 1646
Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. Cancer cell. 2006 Academic Article GET IT
Times cited: 579
A phase 2 trial of irinotecan (CPT-11) in patients with recurrent malignant glioma: a North American Brain Tumor Consortium study. Neuro-oncology. 2006 Academic Article GET IT
Times cited: 181
Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors. Neuro-oncology. 2006 Academic Article GET IT
Times cited: 26
Evaluation of (76)Br-FBAU as a PET reporter probe for HSV1-tk gene expression imaging using mouse models of human glioma. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2005 Academic Article GET IT
Times cited: 19
Monocytes form a vascular barrier and participate in vessel repair after brain injury. Blood. 2005 Academic Article GET IT
Times cited: 48
Delta-aminolevulinic acid dehydratase polymorphism and risk of brain tumors in adults. Environmental health perspectives. 2005 Academic Article GET IT
Times cited: 24
Radiotherapy plus adjuvant temozolomide for the treatment of glioblastoma--a paradigm shift. Nature clinical practice. Oncology. 2005 Academic Article GET IT
Reproductive and hormonal factors and risk of brain tumors in adult females. International journal of cancer. 2005 Academic Article GET IT
Times cited: 104
Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid. International journal of cancer. 2005 Academic Article GET IT
Times cited: 175
Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation. Cancer research. 2005 Academic Article GET IT
Times cited: 451
Self-reported electrical appliance use and risk of adult brain tumors. American journal of epidemiology. 2005 Academic Article GET IT
Times cited: 23
Agents with selective estrogen receptor (ER) modulator activity induce apoptosis in vitro and in vivo in ER-negative glioma cells. Cancer research. 2004 Academic Article GET IT
Times cited: 61
Determination of CC-5013, an analogue of thalidomide, in human plasma by liquid chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Academic Article GET IT
Antiangiogenic therapy for primary and metastatic brain tumors. Hematology/oncology clinics of North America. 2004 Information Resource GET IT
Times cited: 21
Meningioma and schwannoma risk in adults in relation to family history of cancer. Neuro-oncology. 2004 Academic Article GET IT
Times cited: 14
Toward a glioblastoma vaccine: promise and potential pitfalls. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2004 Editorial Article GET IT
Times cited: 7
Noninvasive MR imaging of magnetically labeled stem cells to directly identify neovasculature in a glioma model. Blood. 2004 Academic Article GET IT
Times cited: 228
Season of birth and risk of brain tumors in adults. Neurology. 2004 Academic Article GET IT
Times cited: 57
Determination of SU5416, a novel angiogenesis inhibitor, in human plasma by liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Academic Article GET IT
Times cited: 18
Proteasome-mediated destruction of the cyclin a/cyclin-dependent kinase 2 complex suppresses tumor cell growth in vitro and in vivo. Cancer research. 2004 Academic Article GET IT
Times cited: 57
Neuronally expressed stem cell factor induces neural stem cell migration to areas of brain injury. The Journal of clinical investigation. 2004 Academic Article GET IT
Times cited: 242
Occupation and risk of meningioma and acoustic neuroma in the United States. American journal of industrial medicine. 2004 Academic Article GET IT
Times cited: 26
Phase II study of neoadjuvant 1, 3-bis (2-chloroethyl)-1-nitrosourea and temozolomide for newly diagnosed anaplastic glioma: a North American Brain Tumor Consortium Trial. Cancer. 2004 Academic Article GET IT
Times cited: 42
Phase 1 trial of irinotecan (CPT-11) in patients with recurrent malignant glioma: a North American Brain Tumor Consortium study. Neuro-oncology. 2004 Academic Article GET IT
Times cited: 77
Phase 2 study of BCNU and temozolomide for recurrent glioblastoma multiforme: North American Brain Tumor Consortium study. Neuro-oncology. 2004 Academic Article GET IT
Times cited: 65
Progress report on the potential of angiogenesis inhibitors for neuro-oncology. Cancer investigation. 2004 Information Resource GET IT
Times cited: 17
Cellular and genetic characterization of human adult bone marrow-derived neural stem-like cells: a potential antiglioma cellular vector. Cancer research. 2003 Academic Article GET IT
Times cited: 94
Cancer in first-degree relatives and risk of glioma in adults. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2003 Academic Article GET IT
Times cited: 27
Phase II evaluation of temozolomide and 13-cis-retinoic acid for the treatment of recurrent and progressive malignant glioma: a North American Brain Tumor Consortium study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2003 Academic Article GET IT
Times cited: 133
Phase II trial of thalidomide and carmustine for patients with recurrent high-grade gliomas. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2003 Academic Article GET IT
Times cited: 153
A randomized, double-blind, placebo-controlled, phase 2 study of RMP-7 in combination with carboplatin administered intravenously for the treatment of recurrent malignant glioma. Neuro-oncology. 2003 Academic Article GET IT
Times cited: 183
Bone marrow-derived, endothelial progenitor-like cells as angiogenesis-selective gene-targeting vectors. Gene therapy. 2003 Academic Article GET IT
Times cited: 80
Sociodemographic indicators and risk of brain tumours. International journal of epidemiology. 2003 Academic Article GET IT
Times cited: 73
Handedness and risk of brain tumors in adults. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2003 Academic Article GET IT
Times cited: 17
Laterality of brain tumors. Neuroepidemiology. 2003 Academic Article GET IT
Times cited: 7
Occupation and the risk of adult glioma in the United States. Cancer causes & control : CCC. 2003 Academic Article GET IT
Times cited: 54
Polio vaccination and risk of brain tumors in adults: no apparent association. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2003 Academic Article GET IT
Times cited: 9
Genetic polymorphisms in GSTM1, -P1, -T1, and CYP2E1 and the risk of adult brain tumors. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2003 Academic Article GET IT
Times cited: 74
Primary central nervous system lymphoma: time to ask the question. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2002 Editorial Article GET IT
Antitumor activity and prolonged expression from a TRAIL-expressing adenoviral vector. Neoplasia (New York, N.Y.). 2002 Academic Article GET IT
Times cited: 66
History of allergies and autoimmune diseases and risk of brain tumors in adults. International journal of cancer. 2002 Academic Article GET IT
Times cited: 180
Cancer Molecular Analysis Project: weaving a rich cancer research tapestry. Cancer cell. 2002 Information Resource GET IT
Times cited: 21
Polyomavirus and medulloblastoma: a smoking gun or guilt by association?. Journal of the National Cancer Institute. 2002 Editorial Article GET IT
Times cited: 8
CI-980 for the treatment of recurrent or progressive malignant gliomas: national central nervous system consortium phase I-II evaluation of CI-980. Cancer investigation. 2002 Academic Article GET IT
Times cited: 5
Therapeutic effects of viral vector-mediated antiangiogenic gene transfer in malignant ascites. Human gene therapy. 2001 Academic Article GET IT
Times cited: 36
Cellular-telephone use and brain tumors. The New England journal of medicine. 2001 Academic Article GET IT
Times cited: 373
Phase II trial of the antiangiogenic agent thalidomide in patients with recurrent high-grade gliomas. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2000 Academic Article GET IT
Times cited: 394
Primary CNS lymphoma. Seminars in oncology. 1999 Information Resource GET IT
Times cited: 76
Treatment of patients with primary glioblastoma multiforme with standard postoperative radiotherapy and radiosurgical boost: prognostic factors and long-term outcome. Journal of neurosurgery. 1999 Academic Article GET IT
Times cited: 191
Viral vector-targeted antiangiogenic gene therapy utilizing an angiostatin complementary DNA. Cancer research. 1998 Academic Article GET IT
Times cited: 158
Immune parameters affecting adenoviral vector gene therapy in the brain. Journal of neurovirology. 1998 Academic Article GET IT
Times cited: 31
NCCN adult brain tumor practice guidelines. Oncology (Williston Park, N.Y.). 1997 Academic Article GET IT
Times cited: 13
Tumor-selective transgene expression in vivo mediated by an E2F-responsive adenoviral vector. Nature medicine. 1997 Academic Article GET IT
Times cited: 143
Viral vector-mediated transduction of a modified platelet factor 4 cDNA inhibits angiogenesis and tumor growth. Nature medicine. 1997 Academic Article GET IT
Times cited: 186
A phase I trial of a new recombinant human beta-interferon (BG9015) for the treatment of patients with recurrent gliomas. Clinical cancer research : an official journal of the American Association for Cancer Research. 1997 Academic Article GET IT
Times cited: 36
Selective transgene expression for detection and elimination of contaminating carcinoma cells in hematopoietic stem cell sources. The Journal of clinical investigation. 1996 Academic Article GET IT
Times cited: 59
Gene therapy for malignant gliomas using replication incompetent retroviral and adenoviral vectors encoding the cytochrome P450 2B1 gene together with cyclophosphamide. Gene therapy. 1996 Academic Article GET IT
Times cited: 50
Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo. Nature medicine. 1996 Academic Article GET IT
Times cited: 105
In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizes glioma cells to 5-fluorocytosine. Human gene therapy. 1996 Academic Article GET IT
Times cited: 79
Selective effects of DNA damaging agents on HIV long terminal repeat activation and virus replication in vitro. Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association. 1996 Academic Article GET IT
Times cited: 5
Breast cancer selective gene expression and therapy mediated by recombinant adenoviruses containing the DF3/MUC1 promoter. The Journal of clinical investigation. 1995 Academic Article GET IT
Times cited: 124
High-grade astrocytomas. Neurologic clinics. 1995 Information Resource GET IT
Times cited: 28
Novel biologic therapies for malignant gliomas. Antiangiogenesis, immunotherapy, and gene therapy. Neurologic clinics. 1995 Information Resource GET IT
Times cited: 28
Treatment of primary central nervous system lymphoma: still more questions than answers. Blood. 1995 Editorial Article GET IT
Times cited: 32
Monocyte chemoattractant protein-1 (MCP-1) gene transduction: an effective tumor vaccine strategy for non-intracranial tumors. Cancer immunology, immunotherapy : CII. 1995 Academic Article GET IT
Times cited: 53
Radiosurgery for Intracranial Malignancies. Seminars in radiation oncology. 1995 Academic Article GET IT
Comparison of stereotactic radiosurgery and brachytherapy in the treatment of recurrent glioblastoma multiforme. Neurosurgery. 1995 Academic Article GET IT
Times cited: 247
Stereotactic radiosurgery for the definitive, noninvasive treatment of brain metastases. Journal of the National Cancer Institute. 1995 Academic Article GET IT
Times cited: 475
Enhancer sequences of the DF3 gene regulate expression of the herpes simplex virus thymidine kinase gene and confer sensitivity of human breast cancer cells to ganciclovir. Cancer research. 1994 Academic Article GET IT
Times cited: 84
Brain tumor chemotherapy trials: slow start, but quickly gaining. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1994 Editorial Article GET IT
Times cited: 2
Long term results of stereotactic brachytherapy used in the initial treatment of patients with glioblastomas. Cancer. 1994 Academic Article GET IT
Times cited: 107
Distinguishing central nervous system lymphoma from Toxoplasma encephalitis. Annals of internal medicine. 1994 Article GET IT
Times cited: 3
Primary central nervous system lymphoma. Annals of internal medicine. 1993 Information Resource GET IT
Times cited: 375
Complications of therapy for venous thromboembolic disease in patients with brain tumors. Neurology. 1993 Academic Article GET IT
Times cited: 130
Early response gene induction following DNA damage in astrocytoma cell lines. Biochemical pharmacology. 1993 Academic Article GET IT
Times cited: 27
Effect of Bcl-2 on ionizing radiation and 1-beta-D-arabinofuranosylcytosine-induced internucleosomal DNA fragmentation and cell survival in human myeloid leukemia cells. Oncology research. 1993 Academic Article GET IT
Times cited: 25
Use of stereotactic radiosurgery in the treatment of malignant glioma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1993 Article GET IT
High-dose chemotherapy with autologous bone marrow transplantation in the treatment of high grade astrocytomas in adults: therapeutic rationale and clinical experience. Bone marrow transplantation. 1992 Information Resource GET IT
Times cited: 27
Radiosurgery as part of the initial management of patients with malignant gliomas. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1992 Academic Article GET IT
Times cited: 214
Results of stereotactic brachytherapy used in the initial management of patients with glioblastoma. Journal of the National Cancer Institute. 1990 Academic Article GET IT
Times cited: 104
The treatment of recurrent brain metastases with stereotactic radiosurgery. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1990 Academic Article GET IT
Times cited: 236

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Research

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Co-investigator Network

Funding awarded

missing activity Principal Investigator 2022 - 2023

Ultra-High Performance Brain-dedicated PET scanner for Neurology and Neuro-oncology imaging awarded by National Cancer Institute Co-Investigator 2023 - 2028
Elucidating single cell changes in neurogenic brain regions during HIV and cannabinoid exposure awarded by National Institute on Drug Abuse Co-Investigator 2023 - 2028

Identifying and targeting 3D regulatory nodes that maintain glioblastoma programs. awarded by National Institute of Neurological Disorders & Stroke Co-Principal Investigator 2024 - 2029
Elucidating single cell changes in neurogenic brain regions during HIV and cannabinoid exposure awarded by National Institute on Drug Abuse Co-Principal Investigator 2023 - 2028
Development of Brain Organoids to Study the Impact of HIV-1, Drugs of Abuse and Aging on Cognitive Impairment awarded by National Institute on Drug Abuse Co-Principal Investigator 2020 - 2025

Targeting cysteine susceptibility in glioblastoma awarded by National Institute of Neurological Disorders & Stroke Key Personnel 2022 - 2027

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Background

education and training

M.D., Mount Sinai School of Medicine 1984
B.A., University of Pennsylvania 1980

Contact

full name

Howard Alan Fine

webpage

Clinical Profile

VIVO Weill Cornell Medical College

Howard Alan Fine Professor of Neurology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

webpage

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

webpage