Duran Molina, Maria Angeles

Publications

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selected publications

Opposing regulation of the STING pathway in hepatic stellate cells by NBR1 and p62 determines the progression of hepatocellular carcinoma. Molecular cell. 2024 Academic Article GET IT
Protocol to characterize mouse intestinal epithelial cell lineage using Opal multiplex immunofluorescence. STAR protocols. 2024 Academic Article GET IT
Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation. Developmental cell. 2024 Academic Article GET IT
Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis. Nature communications. 2023 Academic Article GET IT
THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer. Nature communications. 2023 Academic Article GET IT
Whole-mount staining of mouse colorectal cancer organoids and fibroblast-organoid co-cultures. STAR protocols. 2023 Academic Article GET IT
Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer. Cancer cell. 2022 Academic Article GET IT
Air-liquid organotypic assays to investigate cellular crosstalk in the tumor microenvironment of cancer cells. STAR protocols. 2022 Academic Article GET IT
The lactate-NAD⁺ axis activates cancer-associated fibroblasts by downregulating p62. Cell reports. 2022 Academic Article GET IT
Protein kinase Cλ/ι in cancer: a contextual balance of time and signals. Trends in cell biology. 2022 Review GET IT
PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis. Molecular cell. 2021 Academic Article GET IT
Times cited: 14
NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ. Nature communications. 2021 Academic Article GET IT
Mouse model of colorectal cancer: orthotopic co-implantation of tumor and stroma cells in cecum and rectum. STAR protocols. 2021 Academic Article GET IT
An Orthotopic Implantation Mouse Model of Hepatocellular Carcinoma with Underlying Liver Steatosis. STAR protocols. 2020 Academic Article GET IT
Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population. Developmental cell. 2020 Academic Article GET IT
Times cited: 63
PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression. Cancer cell. 2020 Academic Article GET IT
Times cited: 94
NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly. Journal of hepatology. 2020 Academic Article GET IT
Times cited: 73
Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer. Cancer cell. 2019 Academic Article GET IT
Times cited: 141
Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance. Immunity. 2018 Academic Article GET IT
Times cited: 38
The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer. Cell reports. 2018 Academic Article GET IT
Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor. Cancer cell. 2018 Academic Article GET IT
Times cited: 85
ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma. Cell metabolism. 2017 Academic Article GET IT
Times cited: 81
p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer. Cancer cell. 2016 Academic Article GET IT
Times cited: 194
p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells. Cancer cell. 2016 Academic Article GET IT
Times cited: 360
Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade. Cell reports. 2015 Academic Article GET IT
Times cited: 97
Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ. Cell reports. 2015 Academic Article GET IT
Times cited: 71
p62 is required for stem cell/progenitor retention through inhibition of IKK/NF-κB/Ccl4 signaling at the bone marrow macrophage-osteoblast niche. Cell reports. 2014 Academic Article GET IT
Times cited: 54
A macrophage NBR1-MEKK3 complex triggers JNK-mediated adipose tissue inflammation in obesity. Cell metabolism. 2014 Academic Article GET IT
Times cited: 37
Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis. Cancer cell. 2014 Academic Article GET IT
Times cited: 253
K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells. Molecular cell. 2013 Academic Article GET IT
Times cited: 207
Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis. Cell. 2013 Academic Article GET IT
Times cited: 154
p62 is a key regulator of nutrient sensing in the mTORC1 pathway. Molecular cell. 2011 Academic Article GET IT
Times cited: 420
Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formation. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 44
A functional role for the p62-ERK1 axis in the control of energy homeostasis and adipogenesis. EMBO reports. 2010 Academic Article GET IT
Times cited: 76
Loss of PKC lambda/iota impairs Th2 establishment and allergic airway inflammation in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 35
Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo. Molecular and cellular biology. 2008 Academic Article GET IT
Times cited: 69
Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis. The EMBO journal. 2008 Academic Article GET IT
Times cited: 69
The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis. Cancer cell. 2008 Academic Article GET IT
Times cited: 405
Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. Cell metabolism. 2006 Academic Article GET IT
Times cited: 232
Tumour-suppression activity of the proapoptotic regulator Par4. EMBO reports. 2005 Academic Article GET IT
Times cited: 92
Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis. The EMBO journal. 2004 Academic Article GET IT
Times cited: 45
The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Developmental cell. 2004 Academic Article GET IT
Times cited: 251
Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation. The EMBO journal. 2003 Academic Article GET IT
Times cited: 278
Role of zeta PKC in B-cell signaling and function. The EMBO journal. 2002 Academic Article GET IT
Times cited: 120
Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway. Molecular cell. 2001 Academic Article GET IT
Times cited: 319

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Research

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Funding awarded

Dissecting the in vivo stromal metabolic and inflammatory crosstalk in colorectal cancer awarded by National Cancer Institute Principal Investigator 2022 - 2027
missing activity Principal Investigator 2023 - 2023

Cholesterol Metabolism in Mesenchymal Colorectal Cancer awarded by National Cancer Institute Co-Investigator 2022 - 2027
Interferon regulation by NBR1-driven chaperone-mediated autophagy in stellate cells in liver cancer awarded by National Cancer Institute Co-Investigator 2021 - 2026
Molecular mechanisms driving mesenchymal colorectal cancer awarded by National Cancer Institute Co-Investigator 2021 - 2026

Novel Pathways in the Control of Lineage Plasticity in Neuroendocrine Prostate Cancer awarded by National Cancer Institute Co-Principal Investigator 2020 - 2025
missing activity Co-Principal Investigator 2020 - 2022

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Background

education and training

Ph.D., Autonomous University of Madrid (Spain) 2006
B.S., University of Granada (Spain) 2000

Contact

full name

Angeles Duran Molina

primary email

mdu4003@med.cornell.edu

VIVO Weill Cornell Medical College

Angeles Duran Molina Assistant Professor of Research in Pathology and Laboratory Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email