Lyu, Mengze

Publications

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Identification of antigen-presenting cell-T cell interactions driving immune responses to food. Science (New York, N.Y.). 2024 Academic Article GET IT
CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation. Nature. 2024 Academic Article GET IT
The emerging family of RORγt⁺ antigen-presenting cells. Nature reviews. Immunology. 2023 Review GET IT
Times cited: 523
Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection. Cell. 2022 Academic Article GET IT
Times cited: 64
ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut. Nature. 2022 Academic Article GET IT
Group 3 innate lymphoid cells produce the growth factor HB-EGF to protect the intestine from TNF-mediated inflammation. Nature immunology. 2022 Academic Article GET IT
Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer. Cell. 2021 Academic Article GET IT
Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy. Cell research. 2020 Academic Article GET IT
Times cited: 509
Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses. Immunity. 2018 Academic Article GET IT
Times cited: 151

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Co-investigator Network

Defining novel mechanisms of microbiota in regulating anti-tumor responses awarded by National Cancer Institute Principal Investigator 2024 - 2026
Defining mechanisms of immune tolerance to the intestinal microbiota Principal Investigator 2023 - 2025

Innate immune regulation of neuroinflammation awarded by National Institute of Allergy & Infectious Diseases Key Personnel 2021 - 2026