selected publications
- A Transcriptional Signature of Induced Neurons Differentiates Virologically Suppressed People Living With HIV from People Without HIV. 2024 GET IT
- A T cell receptor specific for an HLA-A*03:01-restricted epitope in the endogenous retrovirus ERV-K-Env exhibits limited recognition of its cognate epitope. Mobile DNA. 2024 Academic Article GET IT
- People Living With HIV Have More Intact HIV DNA in Circulating CD4+ T Cells if They Have History of Pulmonary Tuberculosis. Pathogens & immunity. 2024 Academic Article GET IT
- Transcription of HIV-1 at sites of intact latent provirus integration. The Journal of experimental medicine. 2024 Academic Article GET IT
- The HIV latency reversing agent HODHBt inhibits the phosphatases PTPN1 and PTPN2. JCI insight. 2024 Academic Article GET IT
- HIV-1 subtype A1, D, and recombinant proviral genome landscapes during long-term suppressive therapy. Nature communications. 2024 Academic Article GET IT
- Limited Immunogenicity of an HLA-A*03:01-restricted Epitope of Erv-k-env in Non-hiv-1 Settings: Implications for Adoptive Cell Therapy in Cancer. 2024 GET IT
- Transcription of HIV-1 at sites of intact latent provirus integration. 2024 GET IT
- Evaluation of HIV-1 DNA levels among adolescents living with perinatally acquired HIV-1 in Yaounde, Cameroon: A contribution to paediatric HIV cure research in Sub-Saharan Africa. Journal of virus eradication. 2024 Academic Article GET IT
- Persistence of a Skewed Repertoire of NK Cells in People with HIV-1 on Long-Term Antiretroviral Therapy. Journal of immunology (Baltimore, Md. : 1950). 2024 Academic Article GET IT
- Circulating CD4+ T cells in people with HIV and history of pulmonary tuberculosis have more intact HIV DNA. 2024 GET IT
- Advancing HIV cure research in low- and middle-income countries requires empowerment of the next generation of scientists. Journal of virus eradication. 2024 Academic Article GET IT
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The latency-reversing agent HODHBt synergizes with IL-15 to enhance cytotoxic function of HIV-specific T cells.
JCI insight.
2023
Academic Article
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Times cited: 6 - Immunogenicity of COVID-19 vaccines and their effect on HIV reservoir in older people with HIV. iScience. 2023 Academic Article GET IT
- Whack-a-virus: HIV-specific T cells play an exhausting game. Cell host & microbe. 2023 Academic Article GET IT
- Impact of a TLR9 agonist and broadly neutralizing antibodies on HIV-1 persistence: the randomized phase 2a TITAN trial. Nature medicine. 2023 Academic Article GET IT
- Aminobisphosphonates reactivate the latent reservoir in people living with HIV-1. Frontiers in immunology. 2023 Academic Article GET IT
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Epigenetic memory of coronavirus infection in innate immune cells and their progenitors.
Cell.
2023
Academic Article
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Times cited: 2 - Nanodepots Encapsulating a Latency Reversing Agent and Broadly Neutralizing Antibody Enhance Natural Killer Cell Cytotoxicity Against an in vitro Model of Latent HIV. International journal of nanomedicine. 2023 Academic Article GET IT
- Immunogenicity of COVID-19 vaccines and their effect on the HIV reservoir in older people with HIV. 2023 GET IT
- Current HIV/SIV Reservoir Assays for Preclinical and Clinical Applications: Recommendations from the Experts 2022 NIAID Workshop Summary. AIDS research and human retroviruses. 2023 Academic Article GET IT
- CD8+ T cells promote HIV latency by remodeling CD4+ T cell metabolism to enhance their survival, quiescence, and stemness. Immunity. 2023 Academic Article GET IT
- Highlights from the Tenth International Workshop on HIV Persistence during Therapy, December 13-16, 2022, Miami, Florida-USA. Journal of virus eradication. 2023 Academic Article GET IT
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Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity.
Nature communications.
2022
Academic Article
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Times cited: 26 -
Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial.
Nature medicine.
2022
Academic Article
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Times cited: 45 - Inhibition of major histocompatibility complex-I antigen presentation by sarbecovirus ORF7a proteins. Proceedings of the National Academy of Sciences of the United States of America. 2022 Academic Article GET IT
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SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells.
Nature communications.
2022
Academic Article
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Times cited: 20 - Potential multi-modal effects of provirus integration on HIV-1 persistence: lessons from other viruses. Trends in immunology. 2022 Review GET IT
- No evidence that circulating HIV-specific immune responses contribute to persistent inflammation and immune activation in persons on long-term ART. AIDS (London, England). 2022 Academic Article GET IT
- Natural Killer Cell Receptors and Ligands Are Associated With Markers of HIV-1 Persistence in Chronically Infected ART Suppressed Patients. Frontiers in cellular and infection microbiology. 2022 Academic Article GET IT
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Effect of 3BNC117 and romidepsin on the HIV-1 reservoir in people taking suppressive antiretroviral therapy (ROADMAP): a randomised, open-label, phase 2A trial.
The Lancet. Microbe.
2022
Academic Article
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Times cited: 2 -
Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021.
Nature medicine.
2021
Review
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Times cited: 27 - T cell receptor-targeted immunotherapeutics drive selective in vivo HIV- and CMV-specific T cell expansion in humanized mice. The Journal of clinical investigation. 2021 Academic Article GET IT
- Characterizing the Relationship Between Neutralization Sensitivity and env Gene Diversity During ART Suppression. Frontiers in immunology. 2021 Academic Article GET IT
- Selective BCL-XL Antagonists Eliminate Infected Cells from a Primary-Cell Model of HIV Latency but Not from Ex Vivo Reservoirs. Journal of virology. 2021 Academic Article GET IT
- A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies. The Journal of experimental medicine. 2021 Academic Article GET IT
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HIV-specific T cell responses reflect substantive in vivo interactions with antigen despite long-term therapy.
JCI insight.
2021
Academic Article
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Times cited: 39 -
The Intact Non-Inducible Latent HIV-1 Reservoir is Established In an In Vitro Primary TCM Cell Model of Latency.
Journal of virology.
2021
Academic Article
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Times cited: 13 -
HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA).
Nature communications.
2021
Academic Article
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Times cited: 59 - Editorial: On two fronts: synergies and costs at the interface of responses to two global viral pandemics. Current opinion in HIV and AIDS. 2021 Editorial Article GET IT
- Relationships between Neutralization, Binding, and ADCC of Broadly Neutralizing Antibodies against Reservoir HIV. Journal of virology. 2020 Article GET IT
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SARS-CoV-2-specific T cells are rapidly expanded for therapeutic use and target conserved regions of the membrane protein.
Blood.
2020
Academic Article
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Times cited: 99 -
Human splice factors contribute to latent HIV infection in primary cell models and blood CD4+ T cells from ART-treated individuals.
PLoS pathogens.
2020
Academic Article
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Times cited: 21 -
Immunological approaches to HIV cure.
Seminars in immunology.
2020
Information Resource
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Times cited: 6 -
Engineered Antigen-Specific T Cells Secreting Broadly Neutralizing Antibodies: Combining Innate and Adaptive Immune Response against HIV.
Molecular therapy. Methods & clinical development.
2020
Academic Article
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Times cited: 10 -
Suboptimal Biological Sampling as a Probable Cause of False-Negative COVID-19 Diagnostic Test Results.
The Journal of infectious diseases.
2020
Academic Article
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Times cited: 70 -
Structure-Activity Relationship Analysis of Benzotriazine Analogues as HIV-1 Latency-Reversing Agents.
Antimicrobial agents and chemotherapy.
2020
Academic Article
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Times cited: 5 -
CTL Clonotypes with Higher TCR Affinity Have Better Ability to Reduce the HIV Latent Reservoir.
Journal of immunology (Baltimore, Md. : 1950).
2020
Academic Article
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Times cited: 3 -
BCL-2 antagonism sensitizes cytotoxic T cell-resistant HIV reservoirs to elimination ex vivo.
The Journal of clinical investigation.
2020
Academic Article
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Times cited: 75 -
Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection.
PLoS pathogens.
2020
Academic Article
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Times cited: 29 -
Integrated Assessment of Viral Transcription, Antigen Presentation, and CD8+ T Cell Function Reveals Multiple Limitations of Class I-Selective Histone Deacetylase Inhibitors during HIV-1 Latency Reversal.
Journal of virology.
2020
Academic Article
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Times cited: 17 -
Differences in inducibility of the latent HIV reservoir in perinatal and adult infection.
JCI insight.
2020
Academic Article
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Times cited: 22 -
PLGA nanodepots co-encapsulating prostratin and anti-CD25 enhance primary natural killer cell antiviral and antitumor function.
Nano research.
2020
Academic Article
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Times cited: 16 -
Inhibition of HIV Replication by Apolipoprotein A-I Binding Protein Targeting the Lipid Rafts.
mBio.
2020
Academic Article
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Times cited: 32 -
T cells with high PD-1 expression are associated with lower HIV-specific immune responses despite long-term antiretroviral therapy.
AIDS (London, England).
2020
Academic Article
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Times cited: 24 -
HIV-Specific T Cells Can Be Generated against Non-escaped T Cell Epitopes with a GMP-Compliant Manufacturing Platform.
Molecular therapy. Methods & clinical development.
2019
Academic Article
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Times cited: 17 -
Transcriptomic analysis of human endogenous retroviruses in systemic lupus erythematosus.
Proceedings of the National Academy of Sciences of the United States of America.
2019
Letter
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Times cited: 10 -
Telescope: Characterization of the retrotranscriptome by accurate estimation of transposable element expression.
PLoS computational biology.
2019
Academic Article
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Times cited: 87 -
HTLV-1 as a Model for Virus and Host Coordinated Immunoediting.
Frontiers in immunology.
2019
Academic Article
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Times cited: 8 -
Have Cells Harboring the HIV Reservoir Been Immunoedited?.
Frontiers in immunology.
2019
Academic Article
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Times cited: 15 -
Modeling HIV-1 Latency Using Primary CD4+ T Cells from Virally Suppressed HIV-1-Infected Individuals on Antiretroviral Therapy.
Journal of virology.
2019
Academic Article
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Times cited: 11 -
HIV Controllers Exhibit Effective CD8+ T Cell Recognition of HIV-1-Infected Non-activated CD4+ T Cells.
Cell reports.
2019
Academic Article
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Times cited: 23 -
Establishment of a Novel Humanized Mouse Model To Investigate In Vivo Activation and Depletion of Patient-Derived HIV Latent Reservoirs.
Journal of virology.
2019
Academic Article
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Times cited: 24 -
Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion.
Nature communications.
2019
Academic Article
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Times cited: 131 -
Susceptibility to Neutralization by Broadly Neutralizing Antibodies Generally Correlates with Infected Cell Binding for a Panel of Clade B HIV Reactivated from Latent Reservoirs.
Journal of virology.
2018
Academic Article
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Times cited: 20 -
Short Communication: Expression of Host Restriction Factors by Memory CD4+ T Cells Differs Between Healthy Donors and HIV-1-Infected Individuals with Effective Antiretroviral Therapy.
AIDS research and human retroviruses.
2018
Academic Article
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Times cited: 4 -
Dual TLR2 and TLR7 agonists as HIV latency-reversing agents.
JCI insight.
2018
Academic Article
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Times cited: 68 -
Evidence that CD32a does not mark the HIV-1 latent reservoir.
Nature.
2018
Academic Article
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Times cited: 40 -
HLA-C downregulation by HIV-1 adapts to host HLA genotype.
PLoS pathogens.
2018
Academic Article
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Times cited: 21 -
Influence of Biological Sex, Age, and HIV Status in an In Vitro Primary Cell Model of HIV Latency Using a CXCR4 Tropic Virus.
AIDS research and human retroviruses.
2018
Academic Article
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Times cited: 20 -
Diverse Impacts of HIV Latency-Reversing Agents on CD8+ T-Cell Function: Implications for HIV Cure.
Frontiers in immunology.
2018
Information Resource
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Times cited: 26 -
HIV-Specific T Cells Generated from Naive T Cells Suppress HIV In Vitro and Recognize Wide Epitope Breadths.
Molecular therapy : the journal of the American Society of Gene Therapy.
2018
Academic Article
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Times cited: 15 -
The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles.
Blood advances.
2018
Academic Article
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Times cited: 64 -
Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells.
The Journal of clinical investigation.
2018
Academic Article
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Times cited: 148 -
T-cell responses targeting HIV Nef uniquely correlate with infected cell frequencies after long-term antiretroviral therapy.
PLoS pathogens.
2017
Academic Article
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Times cited: 39 -
Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape.
Cell host & microbe.
2017
Academic Article
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Times cited: 259 -
IFITM1 targets HIV-1 latently infected cells for antibody-dependent cytolysis.
JCI insight.
2017
Academic Article
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Times cited: 10 -
Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells.
Biomaterials.
2016
Academic Article
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Times cited: 59 -
Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion.
Immunity.
2016
Academic Article
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Times cited: 55 -
T-cell therapies for HIV: Preclinical successes and current clinical strategies.
Cytotherapy.
2016
Information Resource
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Times cited: 33 -
A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes.
PLoS pathogens.
2016
Academic Article
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Times cited: 129 -
HIV-specific CD8⁺ T cells and HIV eradication.
The Journal of clinical investigation.
2016
Information Resource
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Times cited: 108 -
A robust and scalable TCR-based reporter cell assay to measure HIV-1 Nef-mediated T cell immune evasion.
Journal of immunological methods.
2015
Academic Article
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Times cited: 15 -
Diminished humoral responses against and reduced gene expression levels of human endogenous retrovirus-K (HERV-K) in psoriasis.
Journal of translational medicine.
2014
Academic Article
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Times cited: 16 -
Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes.
PLoS pathogens.
2014
Academic Article
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Times cited: 169 -
Vaccination against endogenous retrotransposable element consensus sequences does not protect rhesus macaques from SIVsmE660 infection and replication.
PloS one.
2014
Academic Article
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Times cited: 9 -
LINE-1 retrotransposable element DNA accumulates in HIV-1-infected cells.
Journal of virology.
2013
Academic Article
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Times cited: 49 -
Human endogenous retrovirus K(HML-2) Gag and Env specific T-cell responses are not detected in HTLV-I-infected subjects using standard peptide screening methods.
Journal of negative results in biomedicine.
2013
Academic Article
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Times cited: 14 -
High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control.
Blood.
2012
Academic Article
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Times cited: 55 -
HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates.
The Journal of clinical investigation.
2012
Academic Article
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Times cited: 72 -
Short communication: HIV type 1 accumulates in influenza-specific T cells in subjects receiving seasonal vaccination in the context of effective antiretroviral therapy.
AIDS research and human retroviruses.
2012
Academic Article
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Times cited: 12 -
Human endogenous retrovirus expression is inversely associated with chronic immune activation in HIV-1 infection.
PloS one.
2012
Academic Article
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Times cited: 21 -
Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection.
PloS one.
2012
Academic Article
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Times cited: 73 -
Vaccination with cancer- and HIV infection-associated endogenous retrotransposable elements is safe and immunogenic.
Journal of immunology (Baltimore, Md. : 1950).
2012
Academic Article
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Times cited: 44 -
Pandemic H1N1 Influenza Infection and Vaccination in Humans Induces Cross-Protective Antibodies that Target the Hemagglutinin Stem.
Frontiers in immunology.
2012
Academic Article
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Times cited: 103 -
Antigen-independent induction of Tim-3 expression on human T cells by the common γ-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway.
Journal of immunology (Baltimore, Md. : 1950).
2012
Academic Article
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Times cited: 51 -
Mucosal correlates of isolated HIV semen shedding during effective antiretroviral therapy.
Mucosal immunology.
2012
Academic Article
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Times cited: 24 -
Human endogenous retrovirus K(HML-2) Gag- and Env-specific T-cell responses are infrequently detected in HIV-1-infected subjects using standard peptide matrix-based screening.
Clinical and vaccine immunology : CVI.
2011
Academic Article
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Times cited: 11 -
Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection.
The Journal of experimental medicine.
2011
Academic Article
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Times cited: 57 -
Strong human endogenous retrovirus-specific T cell responses are associated with control of HIV-1 in chronic infection.
Journal of virology.
2011
Academic Article
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Times cited: 52 -
HTLV-1 tax specific CD8+ T cells express low levels of Tim-3 in HTLV-1 infection: implications for progression to neurological complications.
PLoS neglected tropical diseases.
2011
Academic Article
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Times cited: 22 -
HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression.
European journal of immunology.
2010
Academic Article
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Times cited: 74 -
A synthetic globotriaosylceramide analogue inhibits HIV-1 infection in vitro by two mechanisms.
Glycoconjugate journal.
2010
Academic Article
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Times cited: 24 -
The impact of CCL3L1 copy number in an HIV-1-infected white population.
AIDS (London, England).
2010
Academic Article
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Times cited: 4 -
HIV-specific IL-21 producing CD4+ T cells are induced in acute and chronic progressive HIV infection and are associated with relative viral control.
Journal of immunology (Baltimore, Md. : 1950).
2010
Academic Article
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Times cited: 83 -
Rapid progressing allele HLA-B35 Px restricted anti-HIV-1 CD8+ T cells recognize vestigial CTL epitopes.
PloS one.
2010
Academic Article
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Times cited: 16 -
Persistent HIV RNA shedding in semen despite effective antiretroviral therapy.
AIDS (London, England).
2009
Academic Article
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Times cited: 105 -
Human immunodeficiency virus type 1 escapes from interleukin-2-producing CD4+ T-cell responses without high-frequency fixation of mutations.
Journal of virology.
2009
Academic Article
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Times cited: 18 -
Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection.
The Journal of experimental medicine.
2008
Academic Article
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Times cited: 623 -
HIV-specific T-cells accumulate in the liver in HCV/HIV co-infection.
PloS one.
2008
Academic Article
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Times cited: 27 -
CD40L expressed from the canarypox vector, ALVAC, can boost immunogenicity of HIV-1 canarypox vaccine in mice and enhance the in vitro expansion of viral specific CD8+ T cell memory responses from HIV-1-infected and HIV-1-uninfected individuals.
Vaccine.
2008
Academic Article
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Times cited: 46 -
Nucleoside analogue reverse transcriptase inhibitors differentially inhibit human LINE-1 retrotransposition.
PloS one.
2008
Academic Article
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Times cited: 77 -
T cell responses to human endogenous retroviruses in HIV-1 infection.
PLoS pathogens.
2007
Academic Article
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Times cited: 107 -
Advances in celiac disease.
Current opinion in gastroenterology.
2006
Information Resource
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Times cited: 16