selected publications
- Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model. Neuron. 2024 Academic Article GET IT
- Fostering Academia-Industry Partnerships to Facilitate Therapeutic Discoveries in Neurology: The Role of ANA as a Catalyst. Annals of neurology. 2024 Academic Article GET IT
- Selenium abandons selenoproteins to inhibit ferroptosis rapidly. Nature metabolism. 2024 Academic Article GET IT
- 2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer's resilience. Neuron. 2023 Academic Article GET IT
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Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.
Nature neuroscience.
2023
Academic Article
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Times cited: 32 -
Parkin coregulates glutathione metabolism in adult mammalian brain.
Acta neuropathologica communications.
2023
Academic Article
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Times cited: 4 - Targeting oxidative distress to treat chemobrain: Go with the choroid plexus-cerebrospinal fluid flow. Neuron. 2022 Comment GET IT
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A STING agonist preconditions against ischaemic stroke via an adaptive antiviral Type 1 interferon response.
Brain communications.
2022
Academic Article
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Times cited: 10 -
Hemin-Induced Death Models Hemorrhagic Stroke and Is a Variant of Classical Neuronal Ferroptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2022
Academic Article
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Times cited: 26 -
HIF1α stabilization in hypoxia is not oxidant-initiated.
eLife.
2021
Academic Article
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Times cited: 16 -
Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery.
PloS one.
2021
Academic Article
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Times cited: 4 -
Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage.
Science immunology.
2021
Academic Article
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Times cited: 32 -
Machine intelligence identifies soluble TNFa as a therapeutic target for spinal cord injury.
Scientific reports.
2021
Academic Article
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Times cited: 12 -
Epigenetic regulators of neuronal ferroptosis identify novel therapeutics for neurological diseases: HDACs, transglutaminases, and HIF prolyl hydroxylases.
Neurobiology of disease.
2020
Review
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Times cited: 24 -
Manipulating Adult Neural Stem and Progenitor Cells with G-Quadruplex Ligands.
ACS chemical neuroscience.
2020
Academic Article
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Times cited: 7 -
The Chemical Biology of Ferroptosis in the Central Nervous System.
Cell chemical biology.
2020
Review
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Times cited: 114 -
The drug adaptaquin blocks ATF4/CHOP-dependent pro-death Trib3 induction and protects in cellular and mouse models of Parkinson's disease.
Neurobiology of disease.
2020
Academic Article
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Times cited: 37 -
Paired Associative Stimulation as a Tool to Assess Plasticity Enhancers in Chronic Stroke.
Frontiers in neuroscience.
2019
Academic Article
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Times cited: 1 -
Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke.
Cell.
2019
Academic Article
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Times cited: 149 -
Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors.
eNeuro.
2019
Academic Article
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Times cited: 64 -
Lactate is an antidepressant that mediates resilience to stress by modulating the hippocampal levels and activity of histone deacetylases.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2019
Academic Article
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Times cited: 91 -
Protecting and repairing the brain: central and peripheral strategies define the New Rehabilitation following traumatic brain injury.
Current opinion in neurology.
2018
Editorial Article
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Times cited: 1 -
N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice.
Annals of neurology.
2018
Academic Article
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Times cited: 214 -
Arginase overexpression in neurons and its effect on traumatic brain injury.
Molecular genetics and metabolism.
2018
Academic Article
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Times cited: 24 - The interferon response as a common final pathway for many preconditioning stimuli: unexpected crosstalk between hypoxic adaptation and antiviral defense. Conditioning medicine. 2018 Academic Article GET IT
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Designing Dual Transglutaminase 2/Histone Deacetylase Inhibitors Effective at Halting Neuronal Death.
ChemMedChem.
2018
Academic Article
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Times cited: 10 -
Activation of Nrf2 and Hypoxic Adaptive Response Contribute to Neuroprotection Elicited by Phenylhydroxamic Acid Selective HDAC6 Inhibitors.
ACS chemical neuroscience.
2018
Academic Article
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Times cited: 29 -
Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models.
Journal of Huntington's disease.
2018
Academic Article
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Times cited: 15 - Building on NeuroNEXT: Next generation clinics to cure chronic neurological disability. Annals of neurology. 2017 Editorial Article GET IT
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Rehabilitation following hemorrhagic stroke: building the case for stroke-subtype specific recovery therapies.
F1000Research.
2017
Review
GET IT
Times cited: 27 -
Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis.
Stroke.
2017
Academic Article
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Times cited: 404 -
Early recovery of T-cell function predicts improved survival after T-cell depleted allogeneic transplant.
Leukemia & lymphoma.
2017
Academic Article
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Times cited: 50 -
Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinson's Disease.
Aging and disease.
2016
Academic Article
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Times cited: 20 -
Hematopoietic Cell Transplantation Comorbidity Index Predicts Outcomes in Patients with Acute Myeloid Leukemia and Myelodysplastic Syndromes Receiving CD34+ Selected Grafts for Allogeneic Hematopoietic Cell Transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2016
Academic Article
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Times cited: 22 -
Oxidative Stress and Huntington's Disease: The Good, The Bad, and The Ugly.
Journal of Huntington's disease.
2016
Information Resource
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Times cited: 158 - Nature and nurture meet at the epigenome to modulate disorders of the nervous system. Neuroscience letters. 2016 Editorial Article GET IT
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Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2016
Academic Article
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Times cited: 160 -
Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate.
eLife.
2016
Academic Article
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Times cited: 506 -
Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis.
Cell death & disease.
2016
Academic Article
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Times cited: 39 -
Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.
Science translational medicine.
2016
Academic Article
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Times cited: 116 -
Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?.
Neuroscience letters.
2016
Information Resource
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Times cited: 424 -
Hypoxic Adaptation in the Nervous System: Promise for Novel Therapeutics for Acute and Chronic Neurodegeneration.
Advances in experimental medicine and biology.
2016
Article
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Times cited: 7 -
Daidzein Augments Cholesterol Homeostasis via ApoE to Promote Functional Recovery in Chronic Stroke.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2015
Academic Article
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Times cited: 47 -
Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase-independent catalase-like mechanism.
Chemistry & biology.
2015
Academic Article
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Times cited: 36 -
Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin.
Antioxidants & redox signaling.
2015
Academic Article
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Times cited: 18 -
Recent advances in hydrogen peroxide imaging for biological applications.
Cell & bioscience.
2014
Information Resource
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Times cited: 92 -
Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2014
Academic Article
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Times cited: 27 -
cAMP-responsive element-binding protein (CREB) and cAMP co-regulate activator protein 1 (AP1)-dependent regeneration-associated gene expression and neurite growth.
The Journal of biological chemistry.
2014
Academic Article
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Times cited: 37 -
A selective phenelzine analogue inhibitor of histone demethylase LSD1.
ACS chemical biology.
2014
Academic Article
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Times cited: 85 -
The interplay between microRNAs and histone deacetylases in neurological diseases.
Neurochemistry international.
2014
Information Resource
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Times cited: 32 -
Transcriptional dysregulation in Huntington's disease: a failure of adaptive transcriptional homeostasis.
Drug discovery today.
2014
Information Resource
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Times cited: 47 -
An adaptive role for BDNF Val66Met polymorphism in motor recovery in chronic stroke.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2014
Academic Article
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Times cited: 82 -
Spatial, temporal, and quantitative manipulation of intracellular hydrogen peroxide in cultured cells.
Methods in enzymology.
2014
Article
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Times cited: 10 -
Looking above but not beyond the genome for therapeutics in neurology and psychiatry: epigenetic proteins and RNAs find a new focus.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.
2013
Editorial Article
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Times cited: 3 -
The epigenetics of stroke recovery and rehabilitation: from polycomb to histone deacetylases.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.
2013
Information Resource
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Times cited: 17 -
Two-photon fluorescence imaging of intracellular hydrogen peroxide with chemoselective fluorescent probes.
Journal of biomedical optics.
2013
Academic Article
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Times cited: 16 -
Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2013
Academic Article
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Times cited: 84 -
Transglutaminase is a therapeutic target for oxidative stress, excitotoxicity and stroke: a new epigenetic kid on the CNS block.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2013
Information Resource
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Times cited: 31 -
Derivation of multivariate syndromic outcome metrics for consistent testing across multiple models of cervical spinal cord injury in rats.
PloS one.
2013
Academic Article
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Times cited: 58 -
In vitro ischemia suppresses hypoxic induction of hypoxia-inducible factor-1α by inhibition of synthesis and not enhanced degradation.
Journal of neuroscience research.
2013
Academic Article
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Times cited: 14 -
Epigenetic regulation of cholinergic receptor M1 (CHRM1) by histone H3K9me3 impairs Ca(2+) signaling in Huntington's disease.
Acta neuropathologica.
2013
Academic Article
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Times cited: 41 -
Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by "antioxidant" metal chelators: From ferroptosis to stroke.
Free radical biology & medicine.
2013
Information Resource
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Times cited: 121 -
Epigenetics and the environment: in search of the "toleroasome" vital to execution of ischemic preconditioning.
Translational stroke research.
2013
Information Resource
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Times cited: 11 -
15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) protects neurons from oxidative death via an Nrf2 astrocyte-specific mechanism independent of PPARγ.
Journal of neurochemistry.
2013
Academic Article
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Times cited: 28 - Advances in Doppler OCT. Chinese optics letters : COL. 2013 Academic Article GET IT
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Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke.
Annals of neurology.
2012
Academic Article
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Times cited: 95 -
Catalytic mechanism and substrate specificity of HIF prolyl hydroxylases.
Biochemistry. Biokhimiia.
2012
Review
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Times cited: 21 -
T cell-depleted stem cell transplantation for adults with high-risk acute lymphoblastic leukemia: long-term survival for patients in first complete remission with a decreased risk of graft-versus-host disease.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2012
Academic Article
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Times cited: 37 -
A screen for inducers of p21(waf1/cip1) identifies HIF prolyl hydroxylase inhibitors as neuroprotective agents with antitumor properties.
Neurobiology of disease.
2012
Academic Article
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Times cited: 32 -
Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease.
Antioxidants & redox signaling.
2012
Academic Article
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Times cited: 138 -
miR-886-3p levels are elevated in Friedreich ataxia.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2012
Academic Article
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Times cited: 35 -
Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes.
Diabetologia.
2012
Academic Article
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Times cited: 113 -
Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2012
Academic Article
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Times cited: 53 -
CD36 is involved in astrocyte activation and astroglial scar formation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2012
Academic Article
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Times cited: 90 -
Lysophosphatidic acid differentially regulates axonal mRNA translation through 5'UTR elements.
Molecular and cellular neurosciences.
2012
Academic Article
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Times cited: 30 -
Higher Blood Glucose within the Normal Range Is Associated with More Severe Strokes.
Stroke research and treatment.
2012
Academic Article
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Times cited: 6 -
Hypoxia-inducible factor prolyl hydroxylase inhibition: robust new target or another big bust for stroke therapeutics?.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2012
Information Resource
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Times cited: 84 -
Activation of endoplasmic reticulum stress by hyperglycemia is essential for Müller cell-derived inflammatory cytokine production in diabetes.
Diabetes.
2012
Academic Article
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Times cited: 154 - Improving precision in therapeutics for brain recovery: throwing out the bath water and not the baby. Current opinion in neurology. 2011 Editorial Article GET IT
- Histone Deacetylase Inhibitors and Mithramycin A Impact a Similar Neuroprotective Pathway at a Crossroad between Cancer and Neurodegeneration. Pharmaceuticals (Basel, Switzerland). 2011 Academic Article GET IT
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Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators.
Chemistry & biology.
2011
Academic Article
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Times cited: 97 -
Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2011
Academic Article
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Times cited: 112 -
Genetic variant of BDNF (Val66Met) polymorphism attenuates stroke-induced angiogenic responses by enhancing anti-angiogenic mediator CD36 expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2011
Academic Article
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Times cited: 69 -
Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington's disease mice.
Acta neuropathologica.
2010
Academic Article
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Times cited: 135 -
Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway.
Proceedings of the National Academy of Sciences of the United States of America.
2010
Academic Article
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Times cited: 126 -
Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease.
EMBO molecular medicine.
2010
Academic Article
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Times cited: 119 -
Utilization of an in vivo reporter for high throughput identification of branched small molecule regulators of hypoxic adaptation.
Chemistry & biology.
2010
Academic Article
GET IT
Times cited: 73 -
HIF prolyl hydroxylase inhibitors prevent neuronal death induced by mitochondrial toxins: therapeutic implications for Huntington's disease and Alzheimer's disease.
Antioxidants & redox signaling.
2010
Academic Article
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Times cited: 55 -
Histone deacetylase inhibitors de-repress tyrosine hydroxylase expression in the olfactory bulb and rostral migratory stream.
Biochemical and biophysical research communications.
2010
Academic Article
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Times cited: 12 -
A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2010
Academic Article
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Times cited: 77 -
HDAC6 is a target for protection and regeneration following injury in the nervous system.
Proceedings of the National Academy of Sciences of the United States of America.
2009
Academic Article
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Times cited: 275 -
Epigenetics and the nervous system: epiphenomenon or missing piece of the neurotherapeutic puzzle?.
The Lancet. Neurology.
2009
Letter
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Times cited: 11 -
Cause and consequence: mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases.
Biochimica et biophysica acta.
2009
Information Resource
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Times cited: 215 -
Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson disease.
The Journal of biological chemistry.
2009
Academic Article
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Times cited: 92 -
Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2009
Academic Article
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Times cited: 113 -
Putting the 'HAT' back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions.
Expert opinion on investigational drugs.
2009
Review
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Times cited: 70 -
A nonradioactive dot blot assay for transglutaminase activity.
Analytical biochemistry.
2009
Academic Article
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Times cited: 8 -
Antioxidants, HIF prolyl hydroxylase inhibitors or short interfering RNAs to BNIP3 or PUMA, can prevent prodeath effects of the transcriptional activator, HIF-1alpha, in a mouse hippocampal neuronal line.
Antioxidants & redox signaling.
2008
Academic Article
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Times cited: 42 -
ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo.
The Journal of experimental medicine.
2008
Academic Article
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Times cited: 224 -
Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2008
Academic Article
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Times cited: 132 -
Prolyl 4-hydroxylase activity-responsive transcription factors: from hydroxylation to gene expression and neuroprotection.
Frontiers in bioscience : a journal and virtual library.
2008
Review
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Times cited: 42 -
Harnessing hypoxic adaptation to prevent, treat, and repair stroke.
Journal of molecular medicine (Berlin, Germany).
2007
Information Resource
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Times cited: 79 -
CD81, a cell cycle regulator, is a novel target for histone deacetylase inhibition in glioma cells.
Neurobiology of disease.
2007
Academic Article
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Times cited: 20 -
Hypoxia inducible factor prolyl 4-hydroxylase enzymes: center stage in the battle against hypoxia, metabolic compromise and oxidative stress.
Neurochemical research.
2007
Review
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Times cited: 101 -
Role of cyclooxygenase-2 induction by transcription factor Sp1 and Sp3 in neuronal oxidative and DNA damage response.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2006
Academic Article
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Times cited: 51 -
Arginase 1 regulation of nitric oxide production is key to survival of trophic factor-deprived motor neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2006
Academic Article
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Times cited: 50 -
Oxygen-sensitive reset of hypoxia-inducible factor transactivation response: prolyl hydroxylases tune the biological normoxic set point.
Free radical biology & medicine.
2006
Academic Article
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Times cited: 53 -
The histone deacetylase inhibitor sodium butyrate protects against cisplatin-induced hearing loss in guinea pigs.
The Laryngoscope.
2006
Academic Article
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Times cited: 39 -
The metabolic coupling of arginine metabolism to nitric oxide generation by astrocytes.
Antioxidants & redox signaling.
2006
Review
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Times cited: 19 -
Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system.
The Journal of biological chemistry.
2005
Academic Article
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Times cited: 278 -
Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival.
The Journal of biological chemistry.
2005
Academic Article
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Times cited: 184 -
Antioxidants modulate mitochondrial PKA and increase CREB binding to D-loop DNA of the mitochondrial genome in neurons.
Proceedings of the National Academy of Sciences of the United States of America.
2005
Academic Article
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Times cited: 143 -
Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2005
Academic Article
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Times cited: 47 -
Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis.
Journal of neuroimmunology.
2005
Academic Article
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Times cited: 250 -
Transglutaminase activity is present in highly purified nonsynaptosomal mouse brain and liver mitochondria.
Biochemistry.
2005
Academic Article
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Times cited: 48 -
Proteasome inhibition protects HT22 neuronal cells from oxidative glutamate toxicity.
Journal of neurochemistry.
2005
Academic Article
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Times cited: 55 -
Remodeling chromatin and stress resistance in the central nervous system: histone deacetylase inhibitors as novel and broadly effective neuroprotective agents.
Current drug targets. CNS and neurological disorders.
2005
Information Resource
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Times cited: 140 -
Prosurvival and prodeath effects of hypoxia-inducible factor-1alpha stabilization in a murine hippocampal cell line.
The Journal of biological chemistry.
2004
Academic Article
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Times cited: 95 -
Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2004
Academic Article
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Times cited: 173 -
cAMP response element binding protein family transcription factors: the Holy Grail of neurological therapeutics?.
Annals of neurology.
2004
Editorial Article
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Times cited: 5 -
Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease.
The Journal of biological chemistry.
2004
Academic Article
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Times cited: 367 -
The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism.
Journal of neurochemistry.
2004
Academic Article
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Times cited: 77 -
The role of iron neurotoxicity in ischemic stroke.
Ageing research reviews.
2004
Review
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Times cited: 112 -
Novel changes in gene expression following axotomy of a sympathetic ganglion: a microarray analysis.
Journal of neurobiology.
2004
Academic Article
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Times cited: 100 -
Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2003
Academic Article
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Times cited: 623 -
Mining genome databases for therapeutic gold: SIM2 is a novel target for treatment of solid tumors.
Trends in pharmacological sciences.
2003
Academic Article
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Times cited: 1 -
Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration.
The Journal of biological chemistry.
2003
Academic Article
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Times cited: 261 -
Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway.
Proceedings of the National Academy of Sciences of the United States of America.
2003
Academic Article
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Times cited: 898 -
Sp1 and Sp3 are oxidative stress-inducible, antideath transcription factors in cortical neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2003
Academic Article
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Times cited: 206 -
"Silent" strokes and dementia.
The New England journal of medicine.
2003
Editorial Article
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Times cited: 11 -
Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox.
Proceedings of the National Academy of Sciences of the United States of America.
2003
Academic Article
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Times cited: 311 -
Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway.
Proceedings of the National Academy of Sciences of the United States of America.
2003
Academic Article
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Times cited: 236 -
New perspectives on developing acute stroke therapy.
Annals of neurology.
2003
Review
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Times cited: 83 -
Therapeutic effects of cystamine in a murine model of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2002
Academic Article
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Times cited: 298 -
Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro.
Neuron.
2002
Academic Article
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Times cited: 285 -
In vitro model of oxidative stress in cortical neurons.
Methods in enzymology.
2002
Academic Article
GET IT
Times cited: 19 -
Sequence-selective DNA binding drugs mithramycin A and chromomycin A3 are potent inhibitors of neuronal apoptosis induced by oxidative stress and DNA damage in cortical neurons.
Annals of neurology.
2001
Academic Article
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Times cited: 119 -
Epidermal growth factor receptor induced apoptosis: potentiation by inhibition of Ras signaling.
FEBS letters.
2001
Academic Article
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Times cited: 34 -
L-buthionine sulfoximine potentiates the antitumor effect of 4-hydroperoxycyclophosphamide when administered locally in a rat glioma model.
Neurosurgery.
2001
Academic Article
GET IT
Times cited: 22 -
The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome.
The Journal of biological chemistry.
2000
Academic Article
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Times cited: 107 -
Ironing-out mechanisms of neuronal injury under hypoxic-ischemic conditions and potential role of iron chelators as neuroprotective agents.
Antioxidants & redox signaling.
2000
Review
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Times cited: 43 -
p53-independent inhibition of proliferation and p21(WAF1/Cip1)-modulated induction of cell death by the antioxidants N-acetylcysteine and vitamin E.
Neoplasia (New York, N.Y.).
1999
Academic Article
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Times cited: 33 -
Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1999
Academic Article
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Times cited: 309 -
Decreased intracellular superoxide levels activate Sindbis virus-induced apoptosis.
The Journal of biological chemistry.
1999
Academic Article
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Times cited: 32 -
Elevated extracellular calcium can prevent apoptosis via the calcium-sensing receptor.
Biochemical and biophysical research communications.
1998
Academic Article
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Times cited: 93 -
Inhibition versus induction of apoptosis by proteasome inhibitors depends on concentration.
Cell death and differentiation.
1998
Academic Article
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Times cited: 72 -
Suppression of steady-state, but not stimulus-induced NF-kappaB activity inhibits alphavirus-induced apoptosis.
The Journal of cell biology.
1998
Academic Article
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Times cited: 83 -
Purification of a multipotent antideath activity from bovine liver and its identification as arginase: nitric oxide-independent inhibition of neuronal apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1998
Academic Article
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Times cited: 72 -
The epidermal growth factor receptor associates with and recruits phosphatidylinositol 3-kinase to the platelet-derived growth factor beta receptor.
The Journal of biological chemistry.
1998
Academic Article
GET IT
Times cited: 41 -
Neuronal (type I) nitric oxide synthase regulates nuclear factor kappaB activity and immunologic (type II) nitric oxide synthase expression.
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Neurochemistry international.
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Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B.
The Journal of cell biology.
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Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
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Basilar artery occlusion in a young patient with Wegener's granulomatosis.
1994
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Oxidative stress induces apoptosis in embryonic cortical neurons.
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Long-lasting and rapid calcium changes during mitosis.
The Journal of cell biology.
1988
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Altered response of fibroblasts from aged and Alzheimer donors to drugs that elevate cytosolic free calcium.
Neurobiology of aging.
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The use of microinjection and video microscopy for the study of calmodulin and calcium in living cells.
Methods in enzymology.
1987
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Cytosolic free calcium and cell spreading decrease in fibroblasts from aged and Alzheimer donors.
Proceedings of the National Academy of Sciences of the United States of America.
1986
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Transition from metaphase to anaphase is accompanied by local changes in cytoplasmic free calcium in Pt K2 kidney epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America.
1986
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Calcium and calmodulin in the regulation of the microtubular cytoskeleton.
Annals of the New York Academy of Sciences.
1986
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Local cytoplasmic calcium gradients in living mitotic cells.
Nature.
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