I am currently an Associate Professor in the Division of Hematopathology at Weill Cornell Medical College/NewYork-Presbyterian Hospital, where I also serve as Director of the Multiparametric In Situ Imaging (MISI) Laboratory within the Department of Pathology. My research activities broadly center on the application of multi-omics approaches to human tissue, with an emphasis on spatial profiling of intact cellular microenvironments, in order to identify prognostic and predictive biomarkers in hematolymphoid neoplasia. To date, my most significant contributions have been in the areas of NPM1-mutated acute myeloid leukemias and related pre-leukemic myeloid neoplasms, the spatial architecture of human hematopoiesis, and in classic Hodgkin lymphoma. Several high-impact first/senior-author publications, and meritorious awards, have resulted from these studies. 

Select Publications:
1. Sarachakov A, Varlamova A, Svelolkin V, Polyakova M, Valencia I, Unkenholz C, Pannellini T, Galkin I, Ovcharov P, Tabakov D, Postovalova E, Shin N, Sethi I, Bagaev A, Itkin T, Crane GM, Kluk MJ, Geyer JT, Inghirami GG, Patel SS. Spatial Mapping of Human Hematopoiesis at Single Cell Resolution Reveals Aging-Associated Topographic Remodeling. Blood. 2023 Sep 29; PubMed PMID: 37774374.
2. Patel SS, Weirather JL, Lipschitz M, Lako A, Chen PH, Griffin GK, Armand P, Shipp MA, Rodig SJ. The microenvironmental niche in classic Hodgkin lymphoma is enriched for CTLA-4-positive T cells that are PD-1-negative. Blood. 2019 Dec 5;134(23):2059-2069. PubMed Central PMCID: PMC7218752.
3. Patel SS, Ho C, Ptashkin RN, Sadigh S, Bagg A, Geyer JT, Xu ML, Prebet T, Mason EF, Seegmiller AC, Morgan EA, Steensma DP, Winer ES, Wong WJ, Hasserjian RP, Weinberg OK. Clinicopathologic and genetic characterization of nonacute NPM1-mutated myeloid neoplasms. Blood Adv. 2019 May 14;3(9):1540-1545. PubMed Central PMCID: PMC6517660.
4. Patel SS, Kuo FC, Gibson CJ, Steensma DP, Soiffer RJ, Alyea EP 3rd, Chen YA, Fathi AT, Graubert TA, Brunner AM, Wadleigh M, Stone RM, DeAngelo DJ, Nardi V, Hasserjian RP, Weinberg OK. High NPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML. Blood. 2018 Jun 21;131(25):2816-2825. PubMed Central PMCID: PMC6265642.