Sanjay Patel   Assistant Professor of Pathology and Laboratory Medicine

Phone
  • +1 212 746 2442

I am currently an assistant professor in the Division of Hematopathology at Weill Cornell Medical College/NewYork-Presbyterian Hospital, where I also serve as Director of the Multiparametric In Situ Imaging (MISI) Laboratory within the Department of Pathology. Prior to my current role(s), I completed my residency in anatomic and clinical pathology at the University of Wisconsin Hospital and Clinics, followed by fellowship training in clinical hematopathology at the Brigham & Women’s Hospital/Dana-Farber Cancer Institute (BWH/DFCI). In conjunction with my clinical hematopathology training, I also obtained post-doctoral research research training as the first Geraldine S. Pinkus Fellow in Translational Research in Hematopathology (Ruth L. Kirschstein T32 Award) at BWH/DFCI.

My extensive background in basic science and clinical medicine has driven me toward a career as a clinician-scientist, and my research goals broadly center on the application of multi-omics approaches to human tissue, with an emphasis on spatial profiling of intact cellular microenvironments, in order to identify prognostic and predictive biomarkers in hematolymphoid neoplasia. To date, my most significant contributions have been in the areas of NPM1-mutated acute myeloid leukemias and related pre-leukemic myeloid neoplasms, and in classic Hodgkin lymphoma. Several high-impact first-author publications, and meritorious awards, have resulted from these studies. At present, my translational research activities center on continued application of highly multiplexed in situ imaging techniques to 1) study intact tumor microenvironments in Hodgkin and non-Hodgkin lymphomas, 2) dissect the bone marrow microenvironment in NPM1-mutated myeloid neoplasms in order to identify biomarkers associated with and predictive of measurable residual disease, and 3) map the spatial features of human hematopoiesis in health, aging, and malignant bone marrow states.

Select Publications:
1. Sarachakov A, Varlamova A, Svelolkin V, Polyakova M, Valencia I, Unkenholz C, Pannellini T, Galkin I, Ovcharov P, Tabakov D, Postovalova E, Shin N, Sethi I, Bagaev A, Itkin T, Crane GM, Kluk MJ, Geyer JT, Inghirami GG, Patel SS. Spatial Mapping of Human Hematopoiesis at Single Cell Resolution Reveals Aging-Associated Topographic Remodeling. Blood. 2023 Sep 29; PubMed PMID: 37774374.
2. Patel SS, Weirather JL, Lipschitz M, Lako A, Chen PH, Griffin GK, Armand P, Shipp MA, Rodig SJ. The microenvironmental niche in classic Hodgkin lymphoma is enriched for CTLA-4-positive T cells that are PD-1-negative. Blood. 2019 Dec 5;134(23):2059-2069. PubMed Central PMCID: PMC7218752.
3. Patel SS, Ho C, Ptashkin RN, Sadigh S, Bagg A, Geyer JT, Xu ML, Prebet T, Mason EF, Seegmiller AC, Morgan EA, Steensma DP, Winer ES, Wong WJ, Hasserjian RP, Weinberg OK. Clinicopathologic and genetic characterization of nonacute NPM1-mutated myeloid neoplasms. Blood Adv. 2019 May 14;3(9):1540-1545. PubMed Central PMCID: PMC6517660.
4. Patel SS, Kuo FC, Gibson CJ, Steensma DP, Soiffer RJ, Alyea EP 3rd, Chen YA, Fathi AT, Graubert TA, Brunner AM, Wadleigh M, Stone RM, DeAngelo DJ, Nardi V, Hasserjian RP, Weinberg OK. High NPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML. Blood. 2018 Jun 21;131(25):2816-2825. PubMed Central PMCID: PMC6265642.



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full name

  • Sanjay Patel

primary email

  • sap9151@med.cornell.edu