Reck-Peterson, Samara

Publications

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selected publications

Selectivity profiles and substrate recognition of Rab-phosphorylating kinases. The Biochemical journal. 2025 Academic Article GET IT
Cryo-EM captures early intermediate steps in dynein activation by LIS1. Nature communications. 2025 Academic Article GET IT
Type-II kinase inhibitors that target Parkinson's Disease-associated LRRK2. 2025 GET IT
Cryo-EM visualizes multiple steps of dynein's activation pathway. 2024 GET IT
A designed ankyrin-repeat protein that targets Parkinson's disease-associated LRRK2. The Journal of biological chemistry. 2024 Academic Article GET IT
Cell biology is…. Cell. 2024 Comment GET IT
Times cited: 1
Lis1 slows force-induced detachment of cytoplasmic dynein from microtubules. Nature chemical biology. 2023 Academic Article GET IT
Structure of LRRK1 and mechanisms of autoinhibition and activation. Nature structural & molecular biology. 2023 Academic Article GET IT
Times cited: 8
Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge. Nature structural & molecular biology. 2023 Academic Article GET IT
Times cited: 14
RNA recoding in cephalopods tailors microtubule motor protein function. Cell. 2023 Academic Article GET IT
Times cited: 33
Woronin body hitchhiking on early endosomes is dispensable for septal localization in Aspergillus nidulans. Molecular biology of the cell. 2023 Academic Article GET IT
Times cited: 4
Structures of human dynein in complex with the lissencephaly 1 protein, LIS1. eLife. 2023 Academic Article GET IT
Times cited: 14
Woronin bodies move dynamically and bidirectionally by hitchhiking on early endosomes in Aspergillus nidulans. 2023 GET IT
Structural basis for Parkinson's disease-linked LRRK2's binding to microtubules. Nature structural & molecular biology. 2022 Academic Article GET IT
Times cited: 32
Antiviral function and viral antagonism of the rapidly evolving dynein activating adaptor NINL. eLife. 2022 Academic Article GET IT
Times cited: 8
Hitchhiking Across Kingdoms: Cotransport of Cargos in Fungal, Animal, and Plant Cells. Annual review of cell and developmental biology. 2022 Review GET IT
Times cited: 17
Structural basis for cytoplasmic dynein-1 regulation by Lis1. eLife. 2022 Academic Article GET IT
Times cited: 28
Cytoplasmic dynein-1 cargo diversity is mediated by the combinatorial assembly of FTS-Hook-FHIP complexes. eLife. 2021 Academic Article GET IT
Times cited: 27
Optimizing microtubule arrangements for rapid cargo capture. Biophysical journal. 2021 Academic Article GET IT
Times cited: 8
Structural Biology of LRRK2 and its Interaction with Microtubules. Movement disorders : official journal of the Movement Disorder Society. 2021 Review GET IT
Times cited: 12
PxdA interacts with the DipA phosphatase to regulate peroxisome hitchhiking on early endosomes. Molecular biology of the cell. 2021 Academic Article GET IT
Times cited: 17
Self-repair protects microtubules from destruction by molecular motors. Nature materials. 2021 Academic Article GET IT
Times cited: 64
Structure of LRRK2 in Parkinson's disease and model for microtubule interaction. Nature. 2020 Academic Article GET IT
Times cited: 163
LIS1 promotes the formation of activated cytoplasmic dynein-1 complexes. Nature cell biology. 2020 Academic Article GET IT
Times cited: 76
Hitching a Ride: Mechanics of Transport Initiation through Linker-Mediated Hitchhiking. Biophysical journal. 2020 Academic Article GET IT
Times cited: 19
A minimal computational model for three-dimensional cell migration. Journal of the Royal Society, Interface. 2019 Academic Article GET IT
Times cited: 19
Hook3 is a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein-1 and KIF1C. The Journal of cell biology. 2019 Academic Article GET IT
Times cited: 51
Publisher Correction: The cytoplasmic dynein transport machinery and its many cargoes. 2018 GET IT
Times cited: 12
The cytoplasmic dynein transport machinery and its many cargoes. Nature reviews. Molecular cell biology. 2018 Review GET IT
Times cited: 469
Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein. Cell. 2017 Academic Article GET IT
Times cited: 62
The human cytoplasmic dynein interactome reveals novel activators of motility. eLife. 2017 Academic Article GET IT
Times cited: 102
Angular measurements of the dynein ring reveal a stepping mechanism dependent on a flexible stalk. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 33
Hitchhiking: A Non-Canonical Mode of Microtubule-Based Transport. Trends in cell biology. 2016 Review GET IT
Times cited: 84
Peroxisomes move by hitchhiking on early endosomes using the novel linker protein PxdA. The Journal of cell biology. 2016 Academic Article GET IT
Times cited: 78
Mechanism and regulation of cytoplasmic dynein. Annual review of cell and developmental biology. 2015 Review GET IT
Times cited: 196
Dynactin revealed. Nature structural & molecular biology. 2015 Academic Article GET IT
Cytoplasmic dynein is required for the spatial organization of protein aggregates in filamentous fungi. Cell reports. 2015 Academic Article GET IT
Times cited: 18
Lis1 regulates dynein by sterically blocking its mechanochemical cycle. eLife. 2014 Academic Article GET IT
Times cited: 78
Characterization of the mutagenic spectrum of 4-nitroquinoline 1-oxide (4-NQO) in Aspergillus nidulans by whole genome sequencing. G3 (Bethesda, Md.). 2014 Academic Article GET IT
Times cited: 39
Molecular motors: Shifting gears with light. Nature nanotechnology. 2014 Comment GET IT
Reconstitution of dynein transport to the microtubule plus end by kinesin. eLife. 2014 Academic Article GET IT
Times cited: 74
Human CFEOM1 mutations attenuate KIF21A autoinhibition and cause oculomotor axon stalling. Neuron. 2014 Academic Article GET IT
Times cited: 102
A microscopy-based screen employing multiplex genome sequencing identifies cargo-specific requirements for dynein velocity. Molecular biology of the cell. 2014 Academic Article GET IT
Times cited: 23
Engineering defined motor ensembles with DNA origami. Methods in enzymology. 2014 Review GET IT
Times cited: 11
Teaming up: from motors to people. Molecular biology of the cell. 2013 Academic Article GET IT
Samara Reck-Peterson: dynein defies expectations. Interview by Caitlin Sedwick. The Journal of cell biology. 2013 Article GET IT
Microtubule-based transport in filamentous fungi. Current opinion in microbiology. 2012 Review GET IT
Times cited: 78
Engineered, harnessed, and hijacked: synthetic uses for cytoskeletal systems. Trends in cell biology. 2012 Review GET IT
Times cited: 22
Lis1 acts as a "clutch" between the ATPase and microtubule-binding domains of the dynein motor. Cell. 2012 Academic Article GET IT
Times cited: 185
Lis1 is an initiation factor for dynein-driven organelle transport. The Journal of cell biology. 2012 Academic Article GET IT
Times cited: 147
Cortical dynein controls microtubule dynamics to generate pulling forces that position microtubule asters. Cell. 2012 Academic Article GET IT
Times cited: 309
Dynein achieves processive motion using both stochastic and coordinated stepping. Nature structural & molecular biology. 2012 Academic Article GET IT
Times cited: 161
Aspergillus myosin-V supports polarized growth in the absence of microtubule-based transport. PloS one. 2011 Academic Article GET IT
Times cited: 29
Mechanisms underlying the dual-mode regulation of microtubule dynamics by Kip3/kinesin-8. Molecular cell. 2011 Academic Article GET IT
Times cited: 105
Probing the force generation and stepping behavior of cytoplasmic Dynein. Methods in molecular biology (Clifton, N.J.). 2011 Academic Article GET IT
Times cited: 15
Determining single-molecule intensity as a function of power density. Cold Spring Harbor protocols. 2010 Academic Article GET IT
Imaging single molecular motor motility with total internal reflection fluorescence microscopy (TIRFM). Cold Spring Harbor protocols. 2010 Academic Article GET IT
Imaging single molecules using total internal reflection fluorescence microscopy (TIRFM). Cold Spring Harbor protocols. 2010 Review GET IT
Regulation of the processivity and intracellular localization of Saccharomyces cerevisiae dynein by dynactin. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 120
Regulatory ATPase sites of cytoplasmic dynein affect processivity and force generation. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 119
Myo2p, a class V myosin in budding yeast, associates with a large ribonucleic acid-protein complex that contains mRNAs and subunits of the RNA-processing body. RNA (New York, N.Y.). 2008 Academic Article GET IT
Times cited: 25
Force-induced bidirectional stepping of cytoplasmic dynein. Cell. 2007 Academic Article GET IT
Times cited: 332
Single-molecule analysis of dynein processivity and stepping behavior. Cell. 2006 Academic Article GET IT
Times cited: 526
Cell polarity protein Spa2P associates with proteins involved in actin function in Saccharomyces cerevisiae. Molecular biology of the cell. 2005 Academic Article GET IT
Times cited: 29
The affinity of the dynein microtubule-binding domain is modulated by the conformation of its coiled-coil stalk. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 151
Molecular dissection of the roles of nucleotide binding and hydrolysis in dynein's AAA domains in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 2004 Article GET IT
Times cited: 16
Molecular dissection of the roles of nucleotide binding and hydrolysis in dynein's AAA domains in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 72
Nuclear actin and actin-related proteins in chromatin remodeling. Annual review of biochemistry. 2001 Review GET IT
Times cited: 367

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Research

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Funding awarded

Mechanisms of microtubule-based transport awarded by National Institute of General Medical Sciences Principal Investigator 2025 - 2026

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Background

education and training

Ph.D., Yale University 2000
B.A., Carleton College 1993

Contact

full name

Samara Reck-Peterson

primary email

slr4003@med.cornell.edu

VIVO Weill Cornell Medical College

Samara Reck-Peterson Chair of Biochemistry and Biophysics

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email