Gross, Steven S.

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selected publications

Untargeted Pixel-by-Pixel Imaging of Metabolite Ratio Pairs as a Novel Tool for Biomedical Discovery in Mass Spectrometry Imaging. 2024 GET IT
Biomolecular condensates create phospholipid-enriched microenvironments. Nature chemical biology. 2023 Academic Article GET IT
Progesterone induces meiosis through two obligate co-receptors with PLA2 activity. 2023 GET IT
Fetal metabolic adaptations to cardiovascular stress in twin-twin transfusion syndrome. iScience. 2023 Academic Article GET IT
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy. EMBO molecular medicine. 2023 Academic Article GET IT
Novel genetically engineered mouse models for clear cell renal cell carcinoma. Scientific reports. 2023 Academic Article GET IT
Times cited: 1
Distinct cAMP signaling microdomains differentially regulate melanosomal pH and pigmentation. The Journal of investigative dermatology. 2023 Academic Article GET IT
Excess folic acid intake increases DNA de novo point mutations. Cell discovery. 2023 Letter GET IT
LKB1-dependent regulation of TPI1 creates a divergent metabolic liability between human and mouse lung adenocarcinoma. Cancer discovery. 2023 Academic Article GET IT
Transcriptional and metabolic remodeling in clear cell renal cell carcinoma caused by ATF4 activation and the integrated stress response (ISR). Molecular carcinogenesis. 2022 Academic Article GET IT
Embryonic Hypotaurine Levels Contribute to Strain-Dependent Susceptibility in Mouse Models of Valproate-Induced Neural Tube Defects. Frontiers in cell and developmental biology. 2022 Academic Article GET IT
Mitochondrial Ndufa4l2 Enhances Deposition of Lipids and Expression of Ca9 in the TRACK Model of Early Clear Cell Renal Cell Carcinoma. Frontiers in oncology. 2021 Academic Article GET IT
A retinoic acid receptor β2 agonist protects against alcohol liver disease and modulates hepatic expression of canonical retinoid metabolism genes. BioFactors (Oxford, England). 2021 Academic Article GET IT
A Retinoic Acid Receptor β2 Agonist Attenuates Transcriptome and Metabolome Changes Underlying Non-Alcohol-Associated Fatty Liver Disease. The Journal of biological chemistry. 2021 Academic Article GET IT
Kidney Allograft Function Is a Confounder of Urine Metabolite Profiles in Kidney Allograft Recipients. Metabolites. 2021 Academic Article GET IT
Measurement of Melanin Metabolism in Live Cells by [U-¹³C]-L-Tyrosine Fate Tracing Using Liquid Chromatography-Mass Spectrometry. The Journal of investigative dermatology. 2021 Academic Article GET IT
Times cited: 1
Exogenous and Endogenous Sources of Serine Contribute to Colon Cancer Metabolism, Growth, and Resistance to 5-Fluorouracil. Cancer research. 2021 Academic Article GET IT
Times cited: 54
MiR-302 Regulates Glycolysis to Control Cell-Cycle during Neural Tube Closure. International journal of molecular sciences. 2020 Academic Article GET IT
Times cited: 14
Accelerated transsulfuration metabolically defines a discrete subclass of amyotrophic lateral sclerosis patients. Neurobiology of disease. 2020 Academic Article GET IT
Times cited: 10
Maternal Programming of Social Dominance via Milk Cytokines. iScience. 2020 Academic Article GET IT
APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice. Scientific reports. 2020 Academic Article GET IT
Times cited: 29
CD73 Blockade Promotes Dendritic Cell Infiltration of Irradiated Tumors and Tumor Rejection. Cancer immunology research. 2020 Academic Article GET IT
Times cited: 85
Combined Metabolomics and Genome-Wide Transcriptomics Analyses Show Multiple HIF1α-Induced Changes in Lipid Metabolism in Early Stage Clear Cell Renal Cell Carcinoma. Translational oncology. 2019 Academic Article GET IT
Times cited: 23
Antibody cross-reactivity accounts for widespread appearance of m¹A in 5'UTRs. Nature communications. 2019 Academic Article GET IT
Times cited: 67
Different Effects of Knockouts in ALDH2 and ACSS2 on Embryonic Stem Cell Differentiation. Alcoholism, clinical and experimental research. 2019 Academic Article GET IT
Times cited: 5
ETHE1 overexpression promotes SIRT1 and PGC1α mediated aerobic glycolysis, oxidative phosphorylation, mitochondrial biogenesis and colorectal cancer. Oncotarget. 2019 Academic Article GET IT
High-fructose corn syrup enhances intestinal tumor growth in mice. Science (New York, N.Y.). 2019 Academic Article GET IT
Times cited: 217
FTO controls reversible m⁶Am RNA methylation during snRNA biogenesis. Nature chemical biology. 2019 Academic Article GET IT
Times cited: 182
Ethanol promotes differentiation of embryonic stem cells through retinoic acid receptor-γ. The Journal of biological chemistry. 2019 Academic Article GET IT
Times cited: 14
HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons. Nature communications. 2018 Academic Article GET IT
Times cited: 34
Untargeted Metabolite Profiling of Cerebrospinal Fluid Uncovers Biomarkers for Severity of Late Infantile Neuronal Ceroid Lipofuscinosis (CLN2, Batten Disease). Scientific reports. 2018 Academic Article GET IT
Times cited: 20
Accelerated lipid catabolism and autophagy are cancer survival mechanisms under inhibited glutaminolysis. Cancer letters. 2018 Academic Article GET IT
Times cited: 23
Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations. Cell metabolism. 2018 Academic Article GET IT
Times cited: 118
Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure. Cell reports. 2017 Academic Article GET IT
Times cited: 65
Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology. Nature communications. 2017 Academic Article GET IT
Times cited: 99
Fibroblast bioenergetics to classify amyotrophic lateral sclerosis patients. Molecular neurodegeneration. 2017 Academic Article GET IT
Times cited: 44
Blockade of alcohol escalation and "relapse" drinking by pharmacological FAAH inhibition in male and female C57BL/6J mice. Psychopharmacology. 2017 Academic Article GET IT
Times cited: 39
Metabolite profiling of whole murine embryos reveals metabolic perturbations associated with maternal valproate-induced neural tube closure defects. Birth defects research. 2017 Academic Article GET IT
Times cited: 13
Role of RPL39 in Metaplastic Breast Cancer. Journal of the National Cancer Institute. 2016 Academic Article GET IT
Times cited: 55
Reversible methylation of m⁶A_m in the 5' cap controls mRNA stability. Nature. 2016 Academic Article GET IT
Times cited: 752
Metabolomics enables precision medicine: "A White Paper, Community Perspective". Metabolomics : Official journal of the Metabolomic Society. 2016 Academic Article GET IT
Pulmonary Abnormalities in Young, Light-Use Waterpipe (Hookah) Smokers. American journal of respiratory and critical care medicine. 2016 Academic Article GET IT
Times cited: 23
Celecoxib Alters the Intestinal Microbiota and Metabolome in Association with Reducing Polyp Burden. Cancer prevention research (Philadelphia, Pa.). 2016 Academic Article GET IT
Times cited: 33
Behavioural traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanisms. Nature communications. 2016 Academic Article GET IT
Times cited: 27
Smoking-Associated Disordering of the Airway Basal Stem/Progenitor Cell Metabotype. American journal of respiratory cell and molecular biology. 2016 Academic Article GET IT
Times cited: 27
ANSID: A Solid-Phase Proteomic Approach for Identification and Relative Quantification of Aromatic Nitration Sites. Frontiers in chemistry. 2016 Academic Article GET IT
Times cited: 14
Serum Metabolite Biomarkers Discriminate Healthy Smokers from COPD Smokers. PloS one. 2015 Academic Article GET IT
Times cited: 42
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science (New York, N.Y.). 2015 Academic Article GET IT
Times cited: 667
Urine Metabolite Profiles Predictive of Human Kidney Allograft Status. Journal of the American Society of Nephrology : JASN. 2015 Academic Article GET IT
Times cited: 50
Analyses of the transcriptome and metabolome demonstrate that HIF1α mediates altered tumor metabolism in clear cell renal cell carcinoma. PloS one. 2015 Academic Article GET IT
Times cited: 26
Inhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer. Breast cancer research : BCR. 2015 Academic Article GET IT
Times cited: 161
A requirement for Gch1 and tetrahydrobiopterin in embryonic development. Developmental biology. 2014 Academic Article GET IT
Times cited: 30
Untargeted metabolite profiling of murine embryos to reveal metabolic perturbations associated with neural tube closure defects. Birth defects research. Part A, Clinical and molecular teratology. 2014 Academic Article GET IT
Times cited: 12
Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 88
Huntingtin protein is essential for mitochondrial metabolism, bioenergetics and structure in murine embryonic stem cells. Developmental biology. 2014 Academic Article GET IT
Times cited: 55
KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability. Science signaling. 2014 Academic Article GET IT
Times cited: 53
Increases in levels of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids (EETs and DHETs) in liver and heart in vivo by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and in hepatic EET:DHET ratios by cotreatment with TCDD and the soluble epoxide hydrolase inhibitor AUDA. Drug metabolism and disposition: the biological fate of chemicals. 2013 Academic Article GET IT
Times cited: 18
Anxiety-associated alternative polyadenylation of the serotonin transporter mRNA confers translational regulation by hnRNPK. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 35
Characterization of a cellular denitrase activity that reverses nitration of cyclooxygenase. American journal of physiology. Heart and circulatory physiology. 2013 Academic Article GET IT
Times cited: 46
Unbiased metabolite profiling indicates that a diminished thymidine pool is the underlying mechanism of colon cancer chemoprevention by alpha-difluoromethylornithine. Cancer discovery. 2013 Academic Article GET IT
Times cited: 40
Glutamine supplementation alleviates vasculopathy and corrects metabolic profile in an in vivo model of endothelial cell dysfunction. PloS one. 2013 Academic Article GET IT
Times cited: 22
Untargeted plasma metabolite profiling reveals the broad systemic consequences of xanthine oxidoreductase inactivation in mice. PloS one. 2012 Academic Article GET IT
Times cited: 43
Patulin: Mechanism of genotoxicity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 Academic Article GET IT
Times cited: 70
Excretion of anti-angiogenic proteins in patients with chronic allograft dysfunction. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2012 Academic Article GET IT
Times cited: 4
Retraction of: NO suppresses while peroxynitrite sustains NF-κB: a paradigm to rationalize cytoprotective and cytotoxic actions attributed to NO. Cardiovascular research. 2011 Article GET IT
Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90. Nature chemical biology. 2011 Academic Article GET IT
Times cited: 223
Retraction of 'Angiotensin-II-induced oxidative stress elicits hypoadiponectinaemia in rats'. Diabetologia. 2011 Article GET IT
Discovery and biological characterization of 1-(1H-indol-3-yl)-9H-pyrido[3,4-b]indole as an aryl hydrocarbon receptor activator generated by photoactivation of tryptophan by sunlight. Chemico-biological interactions. 2011 Academic Article GET IT
Times cited: 18
Protein nitrotryptophan: formation, significance and identification. Journal of proteomics. 2011 Information Resource GET IT
Times cited: 55
The scavenger receptor CD36 contributes to the neurotoxicity of bone marrow-derived monocytes through peroxynitrite production. Neurobiology of disease. 2011 Academic Article GET IT
Times cited: 11
The N-terminal peptide of mammalian GTP cyclohydrolase I is an autoinhibitory control element and contributes to binding the allosteric regulatory protein GFRP. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 11
Physical evidence for substrate binding in preventing cyclooxygenase inactivation under nitrative stress. Journal of the American Chemical Society. 2010 Academic Article GET IT
Times cited: 12
Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells. Leukemia. 2009 Academic Article GET IT
Times cited: 38
Paradoxical anxiogenic response of juvenile mice to fluoxetine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2009 Academic Article GET IT
Times cited: 62
Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 275
Neutral loss of isocyanic acid in peptide CID spectra: a novel diagnostic marker for mass spectrometric identification of protein citrullination. Journal of the American Society for Mass Spectrometry. 2008 Academic Article GET IT
Times cited: 62
Urinary proteomic analysis of chronic allograft nephropathy. Proteomics. Clinical applications. 2008 Academic Article GET IT
Times cited: 46
Beyond tissueInfo: functional prediction using tissue expression profile similarity searches. Nucleic acids research. 2008 Academic Article GET IT
Times cited: 6
Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS. American journal of physiology. Heart and circulatory physiology. 2008 Academic Article GET IT
Times cited: 178
Protein 3-nitrotyrosine in complex biological samples: quantification by high-pressure liquid chromatography/electrochemical detection and emergence of proteomic approaches for unbiased identification of modification sites. Methods in enzymology. 2008 Article GET IT
Times cited: 41
Maintaining equilibrium by selective targeting of cyclooxygenase pathways: promising offensives against vascular injury. Hypertension (Dallas, Tex. : 1979). 2007 Information Resource GET IT
Times cited: 18
Profound biopterin oxidation and protein tyrosine nitration in tissues of ApoE-null mice on an atherogenic diet: contribution of inducible nitric oxide synthase. American journal of physiology. Heart and circulatory physiology. 2007 Academic Article GET IT
Times cited: 29
Balancing reactivity against selectivity: the evolution of protein S-nitrosylation as an effector of cell signaling by nitric oxide. Cardiovascular research. 2007 Information Resource GET IT
Times cited: 98
Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: a phase II dose-ranging study. European heart journal. 2007 Academic Article GET IT
Times cited: 56
PREMATURE VASCULAR SENESCENCE IN METABOLIC SYNDROME: COULD IT BE PREVENTED AND REVERSED BY A SELENORGANIC ANTIOXIDANT AND PEROXYNITRITE SCAVENGER EBSELEN?. Drug discovery today. Therapeutic strategies. 2007 Academic Article GET IT
Unbiased identification of cysteine S-nitrosylation sites on proteins. Nature protocols. 2007 Academic Article GET IT
Times cited: 77
Electrospray tandem mass spectrometry analysis of S- and N-nitrosopeptides: facile loss of NO and radical-induced fragmentation. Journal of the American Society for Mass Spectrometry. 2006 Academic Article GET IT
Times cited: 81
Technology Insight: renal proteomics--at the crossroads between promise and problems. Nature clinical practice. Nephrology. 2006 Information Resource GET IT
Times cited: 28
Heme catalyzes tyrosine 385 nitration and inactivation of prostaglandin H2 synthase-1 by peroxynitrite. Journal of lipid research. 2006 Academic Article GET IT
Times cited: 43
SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures. Proceedings of the National Academy of Sciences of the United States of America. 2006 Academic Article GET IT
Times cited: 306
Inducible nitric oxide synthase mediates prostaglandin h2 synthase nitration and suppresses eicosanoid production. The American journal of pathology. 2006 Academic Article GET IT
Angiotensin-II-induced oxidative stress elicits hypoadiponectinaemia in rats. Diabetologia. 2005 Academic Article GET IT
Times cited: 96
Nephropathy in Zucker diabetic fat rat is associated with oxidative and nitrosative stress: prevention by chronic therapy with a peroxynitrite scavenger ebselen. Journal of the American Society of Nephrology : JASN. 2004 Academic Article GET IT
Times cited: 133
The mechanism of potent GTP cyclohydrolase I inhibition by 2,4-diamino-6-hydroxypyrimidine: requirement of the GTP cyclohydrolase I feedback regulatory protein. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 44
NO suppresses while peroxynitrite sustains NF-kappaB: a paradigm to rationalize cytoprotective and cytotoxic actions attributed to NO. Cardiovascular research. 2004 Academic Article GET IT
Times cited: 68
Argininosuccinate synthetase is reversibly inactivated by S-nitrosylation in vitro and in vivo. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 69
Docking of endothelial nitric oxide synthase (eNOS) to the mitochondrial outer membrane: a pentabasic amino acid sequence in the autoinhibitory domain of eNOS targets a proteinase K-cleavable peptide on the cytoplasmic face of mitochondria. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 98
Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen. Circulation research. 2003 Academic Article GET IT
Times cited: 167
Inducible nitric oxide synthase promotes pathophysiological consequences of experimental bladder outlet obstruction. The Journal of urology. 2003 Academic Article GET IT
Times cited: 34
Detection of cysteine S-nitrosylation and tyrosine 3-nitration in kidney proteins. Methods in molecular medicine. 2003 Academic Article GET IT
Times cited: 9
Renal hemodynamic and ureteral pressure changes in response to ureteral obstruction: the role of nitric oxide. The Journal of urology. 2003 Academic Article GET IT
Times cited: 36
Glycated collagen I induces premature senescence-like phenotypic changes in endothelial cells. Circulation research. 2002 Academic Article GET IT
Times cited: 124
Disabling a C-terminal autoinhibitory control element in endothelial nitric-oxide synthase by phosphorylation provides a molecular explanation for activation of vascular NO synthesis by diverse physiological stimuli. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 65
Activation and inactivation of neuronal nitric oxide synthase: characterization of Ca(2+)-dependent [125I]Calmodulin binding. European journal of pharmacology. 2002 Academic Article GET IT
Times cited: 31
S-nitrosylation is emerging as a specific and fundamental posttranslational protein modification: head-to-head comparison with O-phosphorylation. Science's STKE : signal transduction knowledge environment. 2001 Information Resource GET IT
Times cited: 136
Measurement of NO and NO synthase. Current protocols in neuroscience. 2001 Academic Article GET IT
Times cited: 34
The ins and outs of endothelial dysfunction: much ado about NO-thing. Drug news & perspectives. 2001 Academic Article GET IT
Glucose scavenging of nitric oxide. American journal of physiology. Renal physiology. 2001 Academic Article GET IT
Times cited: 101
Carbon monoxide induces vasodilation and nitric oxide release but suppresses endothelial NOS. The American journal of physiology. 1999 Academic Article GET IT
Times cited: 216
Adrenomedullin augments nitric oxide and tetrahydrobioptein synthesis in cytokine-stimulated vascular smooth muscle cells. Cardiovascular research. 1999 Academic Article GET IT
Times cited: 24
Physiological reactions of nitric oxide and hemoglobin: a radical rethink. Proceedings of the National Academy of Sciences of the United States of America. 1999 Article GET IT
Times cited: 93
Cationic amino acid transporter gene expression in cultured vascular smooth muscle cells and in rats. The American journal of physiology. 1999 Academic Article GET IT
Times cited: 73
Glycated serum albumin-induced nitric oxide production in vascular smooth muscle cells by nuclear factor kappaB-dependent transcriptional activation of inducible nitric oxide synthase. Biochemical and biophysical research communications. 1999 Academic Article GET IT
Times cited: 36
Cell signaling by nitric oxide. Seminars in nephrology. 1999 Information Resource GET IT
Times cited: 98
The C331A mutant of neuronal nitric-oxide synthase is defective in arginine binding. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 50
GTP cyclohydrolase I inhibition by the prototypic inhibitor 2, 4-diamino-6-hydroxypyrimidine. Mechanisms and unanticipated role of GTP cyclohydrolase I feedback regulatory protein. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 42
Induction of nitric oxide and tetrahydrobiopterin synthesis by lipoteichoic acid from Staphylococcus aureus in vascular smooth muscle cells. Journal of vascular research. 1998 Academic Article GET IT
Times cited: 10
Tetrahydrobiopterin synthesis in rat cardiac myocytes; an event required for cytokine-induced NO generation. Pteridines. 1998 Article
Localization of GTP cyclohydrolase in monoaminergic but not nitric oxide-producing cells. Synapse (New York, N.Y.). 1998 Academic Article GET IT
Times cited: 55
Leptin regulates proinflammatory immune responses. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1998 Academic Article GET IT
Times cited: 1052
A control element in calcium-dependent nitric oxide synthases. FASEB Journal. 1997 Article
CYS 331 of neuronal nitric oxide synthase is involved in L-arg binding rather than direct BH4 binding. FASEB Journal. 1997 Article
GTP cyclohydrolase limits the magnitude and onset of no synthesis by immunostimulant-activated vascular smooth muscle cells. FASEB Journal. 1997 Article
Molecular aspects of the three isoforms of nitric oxide synthase that uniquely suit them for no. production. FASEB Journal. 1997 Article
Structural aspects of the isoforms of nitric oxide synthase which influence function. FASEB Journal. 1997 Article
An autoinhibitory control element defines calcium-regulated isoforms of nitric oxide synthase. The Journal of biological chemistry. 1997 Academic Article GET IT
Times cited: 204
Induction of tetrahydrobiopterin synthesis in rat cardiac myocytes: impact on cytokine-induced NO generation. The American journal of physiology. 1997 Academic Article GET IT
Times cited: 27
Argininosuccinate synthetase overexpression in vascular smooth muscle cells potentiates immunostimulant-induced NO production. The Journal of biological chemistry. 1997 Academic Article GET IT
Times cited: 63
Nitric oxide, an autocrine regulator of wound fibroblast synthetic function. Journal of immunology (Baltimore, Md. : 1950). 1997 Academic Article GET IT
Times cited: 207
Evidence for nitric oxide participation in down-regulation of CYP2B1/2 gene expression at the pretranslational level. Toxicology letters. 1997 Academic Article GET IT
Times cited: 36
Overexpression of argininosuccinate synthetase in vascular smooth muscle enhances immunostimulant-evoked nitric oxide production. FASEB Journal. 1996 Article
Neuronal nitric oxide synthase, a modular enzyme formed by convergent evolution: structure studies of a cysteine thiolate-liganded heme protein that hydroxylates L-arginine to produce NO. as a cellular signal. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1996 Information Resource GET IT
Times cited: 193
Characterization of bovine endothelial nitric oxide synthase expressed in E. coli. Biochemical and biophysical research communications. 1996 Academic Article GET IT
Times cited: 141
Pyrrolidine dithiocarbamate inhibits immunostimulant-induced tetrahydrobiopterin synthesis in rat vascular smooth muscle. European journal of pharmacology. 1996 Academic Article GET IT
Times cited: 20
Binding sites of nitric oxide synthases. Methods in enzymology. 1996 Academic Article GET IT
Times cited: 45
Microtiter plate assay for determining kinetics of nitric oxide synthesis. Methods in enzymology. 1996 Academic Article GET IT
Times cited: 22
Up-regulation of rat adrenomedullin gene expression by endotoxin: relation to nitric oxide synthesis. Life sciences. 1996 Academic Article GET IT
Times cited: 48
Cytokine-stimulated expression of inducible nitric oxide synthase by mouse, rat, and human osteoblast-like cells and its functional role in osteoblast metabolic activity. Endocrinology. 1995 Academic Article GET IT
Times cited: 156
Lipid A and the lipid A analogue anti-tumour compound ONO-4007 induce nitric oxide synthase in vitro and in vivo. European journal of pharmacology. 1995 Academic Article GET IT
Times cited: 25
Effect of lipopolysaccharide treatment in vivo on tissue expression of argininosuccinate synthetase and argininosuccinate lyase mRNAs: relationship to nitric oxide synthase. Biochemical and biophysical research communications. 1995 Academic Article GET IT
Times cited: 26
Cycloheximide induces nitric oxide synthase mRNA in vascular smooth muscle cells by prolonging mRNA lifetime. Biochemistry and molecular biology international. 1995 Academic Article GET IT
Times cited: 18
High-level expression of functional rat neuronal nitric oxide synthase in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 1995 Academic Article GET IT
Times cited: 244
Modular structure of neuronal nitric oxide synthase: localization of the arginine binding site and modulation by pterin. Biochemical and biophysical research communications. 1995 Academic Article GET IT
Times cited: 51
Bidirectional regulation of osteoclast function by nitric oxide synthase isoforms. Proceedings of the National Academy of Sciences of the United States of America. 1995 Academic Article GET IT
Times cited: 202
Nitric oxide: pathophysiological mechanisms. Annual review of physiology. 1995 Information Resource GET IT
Times cited: 805
L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 99
Argininosuccinate synthetase mRNA and activity are induced by immunostimulants in vascular smooth muscle. Role in the regeneration or arginine for nitric oxide synthesis. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 137
NG-methyl-L-arginine, an inhibitor of nitric oxide formation, reverses IL-2-mediated hypotension in dogs. Journal of applied physiology (Bethesda, Md. : 1985). 1994 Academic Article GET IT
Times cited: 40
Immunocytochemical localization of distinct isoforms of nitric oxide synthase in the juxtaglomerular apparatus of normal rat kidney. Journal of the American Society of Nephrology : JASN. 1994 Academic Article GET IT
Times cited: 162
Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants. Proceedings of the National Academy of Sciences of the United States of America. 1993 Academic Article GET IT
Times cited: 290
Platelet-activating factor contributes to the induction of nitric oxide synthase by bacterial lipopolysaccharide. Circulation research. 1993 Academic Article GET IT
Times cited: 141
Interleukin-1 contributes to the induction of nitric oxide synthase by endotoxin in vivo. European journal of pharmacology. 1993 Academic Article GET IT
Times cited: 80
Pathogenetic mechanisms of septic shock. The New England journal of medicine. 1993 Article GET IT
Times cited: 14
GTP cyclohydrolase I mRNA is induced by LPS in vascular smooth muscle: characterization, sequence and relationship to nitric oxide synthase. Biochemical and biophysical research communications. 1993 Academic Article GET IT
Nifedipine inhibits the induction of nitric oxide synthase by bacterial lipopolysaccharide. The Journal of pharmacology and experimental therapeutics. 1993 Academic Article GET IT
Times cited: 88
Cholesterol enrichment of arterial smooth muscle cells upregulates cytokine-induced nitric oxide synthesis. Biochemical and biophysical research communications. 1993 Academic Article GET IT
Times cited: 23
Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle. The Journal of biological chemistry. 1992 Academic Article GET IT
Times cited: 439
Nitric oxide synthase in macula densa regulates glomerular capillary pressure. Proceedings of the National Academy of Sciences of the United States of America. 1992 Academic Article GET IT
Times cited: 512
Nitric oxide is a mediator of hypoxic coronary vasodilatation. Relation to adenosine and cyclooxygenase-derived metabolites. Circulation research. 1992 Academic Article GET IT
Times cited: 157
A central nervous system action of nitric oxide in blood pressure regulation. The Journal of pharmacology and experimental therapeutics. 1992 Academic Article GET IT
Times cited: 262
Inhibition of interleukin-1-alpha-induced nitric oxide synthase in vascular smooth muscle and full reversal of interleukin-1-alpha-induced hypotension by N omega-amino-L-arginine. Journal of the National Cancer Institute. 1992 Academic Article GET IT
Times cited: 66
Nitric oxide and the cardiovascular actions of histamine. Agents and Actions. 1992 Article GET IT
NG-methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo. A role for nitric oxide in the central regulation of sympathetic tone?. Circulation research. 1992 Academic Article GET IT
Times cited: 385
Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages. Biochemical and biophysical research communications. 1991 Academic Article GET IT
Times cited: 364
Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1991 Academic Article GET IT
Times cited: 392
L-arginine, but not N alpha-benzoyl-L-arginine ethyl ester, is a precursor of endothelium-derived relaxing factor. The Journal of pharmacology and experimental therapeutics. 1990 Academic Article GET IT
Times cited: 7
Arachidonic acid metabolism by dioxin-induced cytochrome P-450: a new hypothesis on the role of P-450 in dioxin toxicity. Biochemical and biophysical research communications. 1990 Academic Article GET IT
Times cited: 53
Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis. Biochemical and biophysical research communications. 1990 Academic Article GET IT
Times cited: 545
Vasopressor effects of N(G)-substituted arginine analogs in the anesthetized guinea pig. European Journal of Pharmacology. 1990 Article GET IT
Macrophage and endothelial cell nitric oxide synthesis: cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine. Biochemical and biophysical research communications. 1990 Academic Article GET IT
Times cited: 257
NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide. Proceedings of the National Academy of Sciences of the United States of America. 1990 Academic Article GET IT
Times cited: 643
Glutathione protects cardiac and skeletal muscle from cyclophosphamide-induced toxicity. Cancer research. 1990 Academic Article GET IT
Times cited: 56
N(G)-monomethyl-L-arginine, an inhibitor of endothelium-derived nitric oxide synthesis, abbreviates acetylcholine-induced vasodilatation in the guinea-pig. Nitric oxide from L-arginine: a bioregulatory system: proceedings of a Symposium on Biological Importance of Nitric Oxide. ICS897. 1990 Article
L-arginine availability determines the duration of acetylcholine-induced systemic vasodilation in vivo. Biochemical and biophysical research communications. 1989 Academic Article GET IT
Times cited: 113
Positive inotropic effect of the thromboxane analog U-46619 on guinea pig left atrium: mediation by specific receptors and association with increased phosphoinositide turnover. Canadian journal of physiology and pharmacology. 1989 Academic Article GET IT
Times cited: 21
Synthesis of nitrogen oxides from L-arginine by macrophage cytosol: requirement for inducible and constitutive components. Biochemical and biophysical research communications. 1989 Academic Article GET IT
Times cited: 116
NG-methylarginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: does nitric oxide regulate blood pressure in vivo?. Biochemical and biophysical research communications. 1989 Academic Article GET IT
Times cited: 368
Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide. The Journal of experimental medicine. 1989 Academic Article GET IT
Times cited: 408
Adenosine promotes histamine H1-mediated negative chronotropic and inotropic effects on human atrial myocardium. The Journal of pharmacology and experimental therapeutics. 1988 Academic Article GET IT
Times cited: 14
Identification of arginine as a precursor of endothelium-derived relaxing factor. Proceedings of the National Academy of Sciences of the United States of America. 1988 Academic Article GET IT
Times cited: 404
Positive inotropic effect of histamine on guinea pig left atrium: H1-receptor-induced stimulation of phosphoinositide turnover. The Journal of pharmacology and experimental therapeutics. 1988 Academic Article GET IT
Times cited: 43
Histamine and cardiac dysfunction. Discussion about a protocol of a controlled clinical trial: Induction of anaesthesia and perioperative risk [Theor Surg (1988) 3:55-77]. Theoretical Surgery. 1988 Article
Peptidoleukotrienes induce an endothelium-dependent relaxation of guinea pig main pulmonary artery and thoracic aorta. Prostaglandins. 1987 Academic Article GET IT
Times cited: 29
Release of histamine by sympathetic nerve stimulation in the guinea pig heart and modulation of adrenergic responses. A physiological role for cardiac histamine?. Circulation research. 1984 Academic Article GET IT
Clinical application of a high-resolution electrophoresis system: a review of electrophoretic patterns in disease. Annals of clinical and laboratory science. 1978 Academic Article GET IT
Times cited: 10
Acid-catalyzed deuterium exchange of the indole ring protons in tryptamine derivatives. The Journal of organic chemistry. 1977 Academic Article GET IT
Times cited: 5

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Funding awarded

Predoctoral Training in Pharmacological Sciences awarded by National Institute of General Medical Sciences Principal Investigator 2021 - 2026
Microbiome-derived Hydrogen Sulfide as a Trigger for CIMP Colorectal Cancer awarded by Starr Cancer Consortium Principal Investigator 2020 - 2023

Dissecting the Cellular and Molecular Links Between Atrial Fibrillation and Obesity awarded by American Heart Association Co-Investigator 2022 - 2025
Metabolic remodeling of skeletal muscle in mitochondrial myopathies awarded by National Inst of Arthritis & Musculoskeletal & Skin Diseases Co-Investigator 2020 - 2025
missing activity Co-Investigator 2017 - 2022

Metabolic landscape and mitochondrial ROS balance in brain ischemia/reperfusion awarded by National Institute of Neurological Disorders & Stroke Co-Principal Investigator 2024 - 2028
Mechanisms Of Camp-Dependent Regulation Of Melanosome Ph awarded by National Inst of Arthritis & Musculoskeletal & Skin Diseases Co-Principal Investigator 2021 - 2026
Pre-malignant mutation landscape and risk factors for progression to hematologic cancers awarded by National Cancer Institute Co-Principal Investigator 2021 - 2026
Metabolic origin of oxidative stress injury in brain ischemia/reperfusion awarded by National Institute of Neurological Disorders & Stroke Co-Principal Investigator 2022 - 2024

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Background

education and training

M.P.H., City University of New York 79
Ph.D., Mount Sinai School of Medicine 1982
B.S., Brooklyn College, City University of New York 1974

Contact

full name

Steven S. Gross

primary email

ssgross@med.cornell.edu

VIVO Weill Cornell Medical College

Steven S. Gross Professor of Pharmacology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email