Li, Yi

Publications

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selected publications

Diagnostic accuracy of phosphorylated tau217 in detecting Alzheimer's disease pathology among cognitively impaired and unimpaired: A systematic review and meta-analysis. Alzheimer's & Dementia. 2024 Review GET IT
High-resolution motion compensation for brain PET imaging using real-time electromagnetic motion tracking. Medical physics. 2024 Academic Article GET IT
Reproducibility of [¹⁸F]MK-6240 kinetics in brain studies with shortened dynamic PET protocol in healthy/cognitively normal subjects. EJNMMI physics. 2024 Academic Article GET IT
Quantitative transport mapping of multi-delay arterial spin labeling MRI detects early blood perfusion alterations in Alzheimer's disease. Alzheimer's research & therapy. 2024 Academic Article GET IT
Hybrid PET/MRI in Neurodegenerative Disorders. Advances in clinical radiology. 2024 Academic Article GET IT
Longitudinal trajectories of Alzheimer's disease CSF biomarkers and blood pressure in cognitively healthy subjects. Alzheimer's & Dementia. 2024 Academic Article GET IT
Evidence of Pericyte Damage in a Cognitively Normal Cohort: Association With CSF and PET Biomarkers of Alzheimer Disease. Alzheimer disease and associated disorders. 2024 Academic Article GET IT
Times cited: 1
Clinical Arterial Spin-Labeling MR Imaging to Screen for Typical and Atypical Neurodegenerative Disease in the New Era of Alzheimer Treatment. AJNR. American journal of neuroradiology. 2024 Academic Article GET IT
Times cited: 1
Brain Fluid Clearance After Traumatic Brain Injury Measured Using Dynamic Positron Emission Tomography. Neurotrauma reports. 2024 Academic Article GET IT
[1-¹¹C]-Butanol Positron Emission Tomography reveals an impaired brain to nasal turbinates pathway in aging amyloid positive subjects. Fluids and barriers of the CNS. 2024 Academic Article GET IT
Quantitative transport mapping of multi-delay arterial spin labeling MRI detects early blood perfusion alteration in Alzheimer's disease. 2024 GET IT
Diffusion Tensor Imaging Along Perivascular Spaces (DTI-ALPS) to Assess Effects of Age, Sex, and Head Size on Interstitial Fluid Dynamics in Healthy Subjects. Journal of Alzheimer's disease reports. 2024 Academic Article GET IT
Times cited: 3
Impaired sleep is associated with tau deposition on ¹⁸F-flortaucipir PET and accelerated cognitive decline, accounting for medications that affect sleep. Journal of the neurological sciences. 2024 Academic Article GET IT
Parenchymal CSF fraction is a measure of brain glymphatic clearance and positively associated with amyloid beta deposition on PET. Alzheimer's & Dementia. 2024 Academic Article GET IT
Times cited: 5
Reduction in Constitutively Activated Auditory Brainstem Microglia in Aging and Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2024 Academic Article GET IT
Remote Associations Between Tau and Cortical Amyloid-β Are Stage-Dependent. Journal of Alzheimer's disease : JAD. 2024 Academic Article GET IT
Times cited: 2
Multimodal assessment of brain fluid clearance is associated with amyloid-beta deposition in humans. Journal of neuroradiology = Journal de neuroradiologie. 2023 Academic Article GET IT
Times cited: 8
Association of brain tissue cerebrospinal fluid fraction with age in healthy cognitively normal adults. Frontiers in aging neuroscience. 2023 Academic Article GET IT
Times cited: 8
Choroid Plexus Calcification Correlates with Cortical Microglial Activation in Humans: A Multimodal PET, CT, MRI Study. AJNR. American journal of neuroradiology. 2023 Academic Article GET IT
Times cited: 6
Peripheral immune cell imbalance is associated with cortical beta-amyloid deposition and longitudinal cognitive decline. Scientific reports. 2023 Academic Article GET IT
Times cited: 13
Glymphatic clearance estimated using diffusion tensor imaging along perivascular spaces is reduced after traumatic brain injury and correlates with plasma neurofilament light, a biomarker of injury severity. Brain communications. 2023 Academic Article GET IT
Times cited: 23
Tau PET following acute TBI: Off-target binding to blood products, tauopathy, or both?. Frontiers in neuroimaging. 2022 Academic Article GET IT
Times cited: 104
Quadratic relationship between systolic blood pressure and white matter lesions in individuals with hypertension. Journal of hypertension. 2022 Academic Article GET IT
Times cited: 1
Higher body mass index is associated with worse hippocampal vasoreactivity to carbon dioxide. Frontiers in aging neuroscience. 2022 Academic Article GET IT
Times cited: 1
Positron Emission Tomography reveals age-associated hypothalamic microglial activation in women. Scientific reports. 2022 Academic Article GET IT
Times cited: 6
Quantifying cerebrospinal fluid dynamics: A review of human neuroimaging contributions to CSF physiology and neurodegenerative disease. Neurobiology of disease. 2022 Review GET IT
Times cited: 31
Statistical Parametric Mapping in Amyloid Positron Emission Tomography. Frontiers in aging neuroscience. 2022 Academic Article GET IT
Times cited: 5
Overview of tau PET molecular imaging. Current opinion in neurology. 2022 Review GET IT
Times cited: 35
Decreased CSF clearance and increased brain amyloid in Alzheimer's disease. Fluids and barriers of the CNS. 2022 Academic Article GET IT
Times cited: 53
The Brain-Nose Interface: A Potential Cerebrospinal Fluid Clearance Site in Humans. Frontiers in physiology. 2022 Review GET IT
Times cited: 24
Neuromodulation Effect of Very Low Intensity Transcranial Ultrasound Stimulation on Multiple Nuclei in Rat Brain. Frontiers in aging neuroscience. 2021 Academic Article GET IT
Times cited: 6
Periodontal dysbiosis associates with reduced CSF Aβ42 in cognitively normal elderly. Alzheimer's & dementia (Amsterdam, Netherlands). 2021 Academic Article GET IT
Times cited: 29
Quantitative transport mapping (QTM) of the kidney with an approximate microvascular network. Magnetic resonance in medicine. 2020 Academic Article GET IT
Times cited: 12
Plasma tau complements CSF tau and P-tau in the diagnosis of Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). 2019 Academic Article GET IT
Times cited: 101
Precisely-Measured Hydration Status Correlates with Hippocampal Volume in Healthy Older Adults. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2019 Letter GET IT
Times cited: 4
Different Relationship Between Systolic Blood Pressure and Cerebral Perfusion in Subjects With and Without Hypertension. Hypertension (Dallas, Tex. : 1979). 2019 Academic Article GET IT
Times cited: 46
Quantitative evaluation of tau PET tracers ¹⁸F-THK5351 and ¹⁸F-AV-1451 in Alzheimer's disease with standardized uptake value peak-alignment (SUVP) normalization. European journal of nuclear medicine and molecular imaging. 2018 Academic Article GET IT
Times cited: 16
Obstructive Sleep Apnea Severity Affects Amyloid Burden in Cognitively Normal Elderly. A Longitudinal Study. American journal of respiratory and critical care medicine. 2018 Academic Article GET IT
Times cited: 186
Reply: Cerebrospinal Fluid, Hyposmia, and Dementia in Alzheimer Disease: Insights from Dynamic PET and a Hypothesis. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2018 Letter GET IT
The nonlinear relationship between cerebrospinal fluid Aβ42 and tau in preclinical Alzheimer's disease. PloS one. 2018 Academic Article GET IT
Times cited: 44
Basal forebrain septal nuclei are enlarged in healthy subjects prior to the development of Alzheimer's disease. Neurobiology of aging. 2018 Academic Article GET IT
Times cited: 27
Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. 2017 Review GET IT
Times cited: 208
Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2017 Academic Article GET IT
Times cited: 174
Transient and chronic seizure-induced inflammation in human focal epilepsy. 2016 GET IT
Times cited: 39
Effects of vascular risk factors, statins, and antihypertensive drugs on PiB deposition in cognitively normal subjects. Alzheimer's & dementia (Amsterdam, Netherlands). 2016 Academic Article GET IT
Times cited: 28
Greater specificity for cerebrospinal fluid P-tau231 over P-tau181 in the differentiation of healthy controls from Alzheimer's disease. Journal of Alzheimer's disease : JAD. 2016 Academic Article GET IT
Times cited: 36
Nutrient patterns and brain biomarkers of Alzheimer's disease in cognitively normal individuals. The journal of nutrition, health & aging. 2015 Academic Article GET IT
Times cited: 122
Cortical laminar binding of PET amyloid and tau tracers in Alzheimer disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2015 Academic Article GET IT
Times cited: 21
Reduced retention of Pittsburgh compound B in white matter lesions. European journal of nuclear medicine and molecular imaging. 2014 Academic Article GET IT
Times cited: 27
Physical Activity, Mediterranean Diet and Biomarkers-Assessed Risk of Alzheimer's: A Multi-Modality Brain Imaging Study. Advances in molecular imaging. 2014 Academic Article GET IT
Times cited: 30
Insulin sensitizers improve learning and attenuate tau hyperphosphorylation and neuroinflammation in 3xTg-AD mice. Journal of neural transmission (Vienna, Austria : 1996). 2014 Academic Article GET IT
Times cited: 31
Reduced glucose uptake and Aβ in brain regions with hyperintensities in connected white matter. NeuroImage. 2014 Academic Article GET IT
Times cited: 22
Nutrient intake and brain biomarkers of Alzheimer's disease in at-risk cognitively normal individuals: a cross-sectional neuroimaging pilot study. BMJ open. 2014 Academic Article GET IT
Times cited: 71
Mediterranean Diet and Magnetic Resonance Imaging-Assessed Brain Atrophy in Cognitively Normal Individuals at Risk for Alzheimer's Disease. The journal of prevention of Alzheimer's disease. 2014 Academic Article GET IT
Impact of amyloid β25-35 on membrane stability, energy metabolism, and antioxidant enzymes in erythrocytes. American journal of Alzheimer's disease and other dementias. 2014 Academic Article GET IT
Times cited: 14
Comparison of human septal nuclei MRI measurements using automated segmentation and a new manual protocol based on histology. NeuroImage. 2014 Academic Article GET IT
Times cited: 25
FDG and Amyloid PET in Cognitively Normal Individuals at Risk for Late-Onset Alzheimer's Disease. Advances in molecular imaging. 2014 Academic Article GET IT
Times cited: 83
Brain imaging of cognitively normal individuals with 2 parents affected by late-onset AD. Neurology. 2014 Academic Article GET IT
Times cited: 50
Blood pressure decrease correlates with tau pathology and memory decline in hypertensive elderly. Neurobiology of aging. 2013 Academic Article GET IT
Times cited: 65
Amyloid and metabolic positron emission tomography imaging of cognitively normal adults with Alzheimer's parents. Neurobiology of aging. 2012 Academic Article GET IT
Times cited: 52
Surgery and brain atrophy in cognitively normal elderly subjects and subjects diagnosed with mild cognitive impairment. Anesthesiology. 2012 Academic Article GET IT
Times cited: 86
Alzheimer's disease markers, hypertension, and gray matter damage in normal elderly. Neurobiology of aging. 2011 Academic Article GET IT
Times cited: 60
Maternal age affects brain metabolism in adult children of mothers affected by Alzheimer's disease. Neurobiology of aging. 2011 Academic Article GET IT
Times cited: 9
Resting-state glucose metabolism level is associated with the regional pattern of amyloid pathology in Alzheimer's disease. International journal of Alzheimer's disease. 2011 Academic Article GET IT
Times cited: 13
Structural brain changes in normal individuals with a maternal history of Alzheimer's. Neurobiology of aging. 2011 Academic Article GET IT
Times cited: 50
Framingham cardiovascular risk profile correlates with impaired hippocampal and cortical vasoreactivity to hypercapnia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2010 Academic Article GET IT
Times cited: 62
Evaluation of Early Dementia (Mild Cognitive Impairment). PET clinics. 2010 Review GET IT
Times cited: 4
Increased fibrillar amyloid-{beta} burden in normal individuals with a family history of late-onset Alzheimer's. Proceedings of the National Academy of Sciences of the United States of America. 2010 Academic Article GET IT
Times cited: 123
Early detection of Alzheimer's disease with PET imaging. Neuro-degenerative diseases. 2010 Review GET IT
Times cited: 47
Phosphorylated tau 231, memory decline and medial temporal atrophy in normal elders. Neurobiology of aging. 2010 Academic Article GET IT
Times cited: 39
Current Challenges for the Early Detection of Alzheimer's Disease: Brain Imaging and CSF Studies. Journal of clinical neurology (Seoul, Korea). 2009 Academic Article GET IT
Times cited: 75
An entorhinal cortex sulcal pattern is associated with Alzheimer's disease. Human brain mapping. 2009 Academic Article GET IT
Times cited: 13
FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease. European journal of nuclear medicine and molecular imaging. 2009 Academic Article GET IT
Times cited: 391
Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer's disease. European journal of nuclear medicine and molecular imaging. 2008 Academic Article GET IT
Times cited: 249
Quantitation, regional vulnerability, and kinetic modeling of brain glucose metabolism in mild Alzheimer's disease. European journal of nuclear medicine and molecular imaging. 2007 Academic Article GET IT
Times cited: 38
Imaging and CSF studies in the preclinical diagnosis of Alzheimer's disease. Annals of the New York Academy of Sciences. 2007 Review GET IT
Times cited: 170
Hippocampal hypometabolism predicts cognitive decline from normal aging. Neurobiology of aging. 2007 Academic Article GET IT
Times cited: 294
Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2006 Academic Article GET IT
Times cited: 225
Hippocampal cerebrospinal fluid spaces on MR imaging: Relationship to aging and Alzheimer disease. AJNR. American journal of neuroradiology. 2006 Academic Article GET IT
Times cited: 31
Visual rating of medial temporal lobe metabolism in mild cognitive impairment and Alzheimer's disease using FDG-PET. European journal of nuclear medicine and molecular imaging. 2005 Academic Article GET IT
Times cited: 68
The role of quantitative structural imaging in the early diagnosis of Alzheimer's disease. Neuroimaging clinics of North America. 2005 Review GET IT
Times cited: 33
Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment. Neurobiology of aging. 2005 Academic Article GET IT
Times cited: 227
Reduced hippocampal metabolism in MCI and AD: automated FDG-PET image analysis. Neurology. 2005 Academic Article GET IT
Times cited: 280

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Research

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Funding awarded

CSF Clearance in Sporadic Alzheimer''s Disease awarded by National Institute on Aging Principal Investigator 2019 - 2025

Prism-PET/EMMT: High resolution, cost effective, portable, and upright brain PET scanner for early diagnosis of Alzheimer''s disease awarded by National Institute on Aging Co-Investigator 2024 - 2029
Brain fluid clearance and misfolded protein dynamics following traumatic brain injury awarded by National Institute on Aging Co-Investigator 2023 - 2028
Quantitative MRI-based cerebral oxygen metabolism in Alzheimer''s disease awarded by National Institute on Aging Co-Investigator 2023 - 2028
Ultra-High Performance Brain-dedicated PET scanner for Neurology and Neuro-oncology imaging awarded by National Cancer Institute Co-Investigator 2023 - 2028
Anatomy of the circle of Willis, cerebral blood flow, and Alzheimer''s disease biomarkers in hypertension awarded by National Heart, Lung, & Blood Institute Co-Investigator 2022 - 2026
Quantitative Susceptibility Mapping (QSM) as a Non-Invasive Imaging Biomarker for Predicting Neurodegeneration in Alzheimer''s Disease awarded by National Institute on Aging Co-Investigator 2020 - 2025
Hypertension, brain clearance and markers of neurodegeneration awarded by National Institute of Neurological Disorders & Stroke Co-Investigator 2019 - 2025

New PET/CT System for Human and Non-human Primate Imaging awarded by National Institutes of Health, Office of the Director Key Personnel 2023 - 2025
7T Magnetic Resonance Imaging System for Basic, Translational and Clinical Research awarded by National Institutes of Health, Office of the Director Key Personnel 2021 - 2025

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Background

education and training

Ph.D., Shandong University (China) 2015
M.D., Shandong University School of Medicine (China) 2000
B.M., Shandong University School of Medicine (China) 1997

Contact

full name

Yi Li

primary email

yil4008@med.cornell.edu

VIVO Weill Cornell Medical College

Yi Li Associate Professor of Radiology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email