Following a brief review of brain neurofluid pathways and the general PET technique, we introduce PET imaging of cerebrospinal fluid and interstitial fluid dynamics. Our summary includes both our published and unpublished observations on the modeling of PET imaging for neurofluid quantification in aging, Alzheimer's disease, and in the presence of amyloid lesions. We identify the limitations of PET imaging and point to validations and potential future directions.
