eLife Journal

Overview

publication venue for

• Correction: Epigenetic scores for the circulating proteome as tools for disease prediction. 2023
• Unlocking the power of virtual networking for early-career researchers..  13. 2024
• RBP-J regulates homeostasis and function of circulating Ly6C^lo monocytes..  12. 2024
• Iron chelation improves ineffective erythropoiesis and iron overload in myelodysplastic syndrome mice..  12. 2023
• Sensory neurons couple arousal and foraging decisions in Caenorhabditis elegans..  12. 2023
• Structural insights into the career path between pre- and postgraduate physician-scientist training programs..  12. 2023
• Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferases..  12. 2023
• A novel single alpha-helix DNA-binding domain in CAF-1 promotes gene silencing and DNA damage survival through tetrasome-length DNA selectivity and spacer function..  12. 2023
• Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis..  12. 2023
• Roles for mycobacterial DinB2 in frameshift and substitution mutagenesis..  12. 2023
• A genetic variant of fatty acid amide hydrolase (FAAH) exacerbates hormone-mediated orexigenic feeding in mice..  12. 2023
• GABA_BR silencing of nerve terminals..  12. 2023
• Cyclic AMP is a critical mediator of intrinsic drug resistance and fatty acid metabolism in M. tuberculosis..  12. 2023
• Bone marrow Adipoq-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis, and bone mass..  12. 2023
• A coordinated transcriptional switching network mediates antigenic variation of human malaria parasites..  11. 2022
• Defining cellular population dynamics at single-cell resolution during prostate cancer progression..  11. 2022
• DNA damage independent inhibition of NF-kB transcription by anthracyclines..  11. 2022
• Evolution and regulation of microbial secondary metabolism..  11. 2022
• Quantifying the impact of immune history and variant on SARS-CoV-2 viral kinetics and infection rebound: a retrospective cohort study..  11. 2022
• Machine learning-assisted elucidation of CD81-CD44 interactions in promoting cancer stemness and extracellular vesicle integrity..  11. 2022
• Biphasic regulation of osteoblast development via the ERK MAPK-mTOR pathway..  11. 2022
• Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface..  11. 2022
• AR-V7 exhibits non-canonical mechanisms of nuclear import and chromatin engagement in castrate-resistant prostate cancer..  11. 2022
• DNA-PK promotes DNA end resection at DNA double strand breaks in G₀ cells..  11. 2022
• Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry..  11. 2022
• Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis..  11. 2022
• SWI/SNF senses carbon starvation with a pH-sensitive low complexity sequence..  11. 2022
• Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice..  11. 2022
• Human interictal epileptiform discharges are bidirectional traveling waves echoing ictal discharges..  11. 2022
• Lipid kinases VPS34 and PIKfyve coordinate a phosphoinositide cascade to regulate Retriever-mediated recycling on endosomes..  11. 2022
• Epigenetic scores for the circulating proteome as tools for disease prediction..  11. 2022
• Hyaluronic acid fuels pancreatic cancer cell growth..  10. 2021
• Extent, impact, and mitigation of batch effects in tumor biomarker studies using tissue microarrays..  10. 2021
• Glutamine deprivation triggers NAGK-dependent hexosamine salvage..  10. 2021
• Differential adhesion regulates neurite placement via a retrograde zippering mechanism..  10. 2021
• Early prediction of clinical response to checkpoint inhibitor therapy in human solid tumors through mathematical modeling..  10. 2021
• Ssl2/TFIIH function in transcription start site scanning by RNA polymerase II in Saccharomyces cerevisiae..  10. 2021
• HIF1α stabilization in hypoxia is not oxidant-initiated..  10. 2021
• Mutation analysis links angioimmunoblastic T-cell lymphoma to clonal hematopoiesis and smoking..  10. 2021
• LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells..  10. 2021
• Inducible and reversible inhibition of miRNA-mediated gene repression in vivo..  10. 2021
• Linker histone H1.8 inhibits chromatin binding of condensins and DNA topoisomerase II to tune chromosome length and individualization..  10. 2021
• Linking plasmid-based beta-lactamases to their bacterial hosts using single-cell fusion PCR..  10. 2021
• Dynamics of primitive streak regression controls the fate of neuromesodermal progenitors in the chicken embryo..  10. 2021
• Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells..  10. 2021
• Presynaptic NMDA receptors facilitate short-term plasticity and BDNF release at hippocampal mossy fiber synapses..  10. 2021
• Targeting a cell surface vitamin D receptor on tumor-associated macrophages in triple-negative breast cancer..  10. 2021
• Integrated sensing of host stresses by inhibition of a cytoplasmic two-component system controls M. tuberculosis acute lung infection..  10. 2021
• The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry..  10. 2021
• Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors..  10. 2021
• Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice..  10. 2021
• Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia..  10. 2021
• High-resolution mapping of the neutralizing and binding specificities of polyclonal sera post-HIV Env trimer vaccination..  10. 2021
• Def6 regulates endogenous type-I interferon responses in osteoblasts and suppresses osteogenesis..  9. 2020
• Mechanistic insights into volatile anesthetic modulation of K2P channels..  9. 2020
• Translation in amino-acid-poor environments is limited by tRNA^Gln charging..  9. 2020
• Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement..  9. 2020
• Sepsis impedes EAE disease development and diminishes autoantigen-specific naive CD4 T cells..  9. 2020
• Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops..  9. 2020
• Large domain movements through the lipid bilayer mediate substrate release and inhibition of glutamate transporters..  9. 2020
• Emergence of non-canonical parvalbumin-containing interneurons in hippocampus of a murine model of type I lissencephaly..  9. 2020
• The S-phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway..  9. 2020
• A MAC2-positive progenitor-like microglial population is resistant to CSF1R inhibition in adult mouse brain..  9. 2020
• Cadherin preserves cohesion across involuting tissues during C. elegans neurulation..  9. 2020
• A single-cell atlas of the mouse and human prostate reveals heterogeneity and conservation of epithelial progenitors..  9. 2020
• A limbic circuit selectively links active escape to food suppression..  9. 2020
• m6A RNA methylation impacts fate choices during skin morphogenesis..  9. 2020
• Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens..  9. 2020
• Efficient coding of natural scene statistics predicts discrimination thresholds for grayscale textures..  9. 2020
• Transposase-assisted tagmentation of RNA/DNA hybrid duplexes..  9. 2020
• Early life adversity decreases pre-adolescent fear expression by accelerating amygdala PV cell development..  9. 2020
• Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531..  9. 2020
• Apolipoprotein L-1 renal risk variants form active channels at the plasma membrane driving cytotoxicity..  9. 2020
• A role for CIM6P/IGF2 receptor in memory consolidation and enhancement..  9. 2020
• Divergent Cl^- and H⁺ pathways underlie transport coupling and gating in CLC exchangers and channels..  9. 2020
• Stress-mediated exit to quiescence restricted by increasing persistence in CDK4/6 activation..  9. 2020
• A model for focal seizure onset, propagation, evolution, and progression..  9. 2020
• Framework for advancing rigorous research..  9. 2020
• Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism..  9. 2020
• Career choices of underrepresented and female postdocs in the biomedical sciences..  9. 2020
• PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis..  8. 2019
• Exchange of water for sterol underlies sterol egress from a StARkin domain..  8. 2019
• Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex..  8. 2019
• Real time dynamics of Gating-Related conformational changes in CorA..  8. 2019
• Persistent Mycobacterium tuberculosis infection in mice requires PerM for successful cell division..  8. 2019
• Cerebellar nuclei excitatory neurons regulate developmental scaling of presynaptic Purkinje cell number and organ growth..  8. 2019
• Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel..  8. 2019
• Late developing cardiac lymphatic vasculature supports adult zebrafish heart function and regeneration..  8. 2019
• A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion..  8. 2019
• A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS..  8. 2019
• Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin..  8. 2019
• Electrostatic lateral interactions drive ESCRT-III heteropolymer assembly..  8. 2019
• Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor..  8. 2019
• IFNγ induces epigenetic programming of human T-bet^hi B cells and promotes TLR7/8 and IL-21 induced differentiation..  8. 2019
• Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration..  8. 2019
• Mutant huntingtin enhances activation of dendritic Kv4 K⁺ channels in striatal spiny projection neurons..  8. 2019
• Cerebellar folding is initiated by mechanical constraints on a fluid-like layer without a cellular pre-pattern..  8. 2019
• Shank3 modulates sleep and expression of circadian transcription factors..  8. 2019
• Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma..  8. 2019
• Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization..  8. 2019
• Complementary networks of cortical somatostatin interneurons enforce layer specific control..  8. 2019
• Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition..  8. 2019
• Structural basis of Ca²⁺-dependent activation and lipid transport by a TMEM16 scramblase..  8. 2019
• GREB1 amplifies androgen receptor output in human prostate cancer and contributes to antiandrogen resistance..  8. 2019
• Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons..  8. 2019
• Contrast sensitivity reveals an oculomotor strategy for temporally encoding space..  8. 2019
• Rejection of immunogenic tumor clones is limited by clonal fraction..  7. 2018
• The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells..  7. 2018
• Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells..  7. 2018
• Kinetic mechanism of coupled binding in sodium-aspartate symporter GltPh..  7. 2018
• Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death..  7. 2018
• Elementary sensory-motor transformations underlying olfactory navigation in walking fruit-flies..  7. 2018
• Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan..  7. 2018
• VivosX, a disulfide crosslinking method to capture site-specific, protein-protein interactions in yeast and human cells..  7. 2018
• Pooled genome-wide CRISPR screening for basal and context-specific fitness gene essentiality in Drosophila cells..  7. 2018
• Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures..  7. 2018
• A facile approach for the in vitro assembly of multimeric membrane transport proteins..  7. 2018
• ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity..  7. 2018
• Distinct chromatin functional states correlate with HIV latency reactivation in infected primary CD4⁺ T cells..  7. 2018
• HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations..  7. 2018
• Gene-specific mechanisms direct glucocorticoid-receptor-driven repression of inflammatory response genes in macrophages..  7. 2018
• Challenges in validating candidate therapeutic targets in cancer..  7. 2018
• ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2..  7. 2018
• Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2..  6. 2017
• Dnmt3a is an epigenetic mediator of adipose insulin resistance..  6. 2017
• Defining the location of promoter-associated R-loops at near-nucleotide resolution using bisDRIP-seq..  6. 2017
• Mechanism of activation at the selectivity filter of the KcsA K⁺ channel..  6. 2017
• Ligand modulation of sidechain dynamics in a wild-type human GPCR..  6. 2017
• The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis..  6. 2017
• Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer..  6. 2017
• Sexual dimorphism in striatal dopaminergic responses promotes monogamy in social songbirds..  6. 2017
• Estrogen receptor coregulator binding modulators (ERXs) effectively target estrogen receptor positive human breast cancers..  6. 2017
• ESCRTs function directly on the lysosome membrane to downregulate ubiquitinated lysosomal membrane proteins..  6. 2017
• Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition..  6. 2017
• Distinct Akt phosphorylation states are required for insulin regulated Glut4 and Glut1-mediated glucose uptake..  6. 2017
• Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3..  6. 2017
• Efficacy of β-lactam/β-lactamase inhibitor combination is linked to WhiB4-mediated changes in redox physiology of Mycobacterium tuberculosis..  6. 2017
• Shank is a dose-dependent regulator of Ca_v1 calcium current and CREB target expression..  6. 2017
• The Sec14-like phosphatidylinositol transfer proteins Sec14l3/SEC14L2 act as GTPase proteins to mediate Wnt/Ca²⁺ signaling..  6. 2017
• SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation..  6. 2017
• Oncogenic BRAF disrupts thyroid morphogenesis and function via twist expression..  6. 2017
• Discovery of novel determinants of endothelial lineage using chimeric heterokaryons..  6. 2017
• Identification of a pre-active conformation of a pentameric channel receptor..  6. 2017
• Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA..  6. 2017
• A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory..  5. 2016
• DNA methylation directs genomic localization of Mbd2 and Mbd3 in embryonic stem cells..  5. 2016
• The Cac1 subunit of histone chaperone CAF-1 organizes CAF-1-H3/H4 architecture and tetramerizes histones..  5. 2016
• Upregulation of neurovascular communication through filamin abrogation promotes ectopic periventricular neurogenesis..  5. 2016
• TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants..  5. 2016
• A circuit motif in the zebrafish hindbrain for a two alternative behavioral choice to turn left or right..  5. 2016
• Nucleosome disassembly during human non-homologous end joining followed by concerted HIRA- and CAF-1-dependent reassembly..  5. 2016
• Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate..  5. 2016
• α8β1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism..  5. 2016
• A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division..  5. 2016
• ESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis..  5. 2016
• Mitochondrial DNA copy number variation across human cancers..  5. 2016
• Aurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis..  5. 2016
• Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation..  5. 2016
• Waves of actin and microtubule polymerization drive microtubule-based transport and neurite growth before single axon formation..  5. 2016
• Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments..  4. 2015
• Frequency-selective control of cortical and subcortical networks by central thalamus..  4. 2015
• Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing..  4. 2015
• Genetic and epigenetic variation in the lineage specification of regulatory T cells..  4. 2015
• A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome..  4. 2015
• Genomic DNA transposition induced by human PGBD5..  4. 2015
• SPOP mutation leads to genomic instability in prostate cancer..  4. 2015
• Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma..  4. 2015
• Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits..  4. 2015
• Perturbation biology nominates upstream-downstream drug combinations in RAF inhibitor resistant melanoma cells..  4. 2015
• The active-zone protein Munc13 controls the use-dependence of presynaptic voltage-gated calcium channels..  4. 2015
• Dynamic regulation of transcription factors by nucleosome remodeling..  4. 2015
• Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma..  4. 2015
• A new family of StART domain proteins at membrane contact sites has a role in ER-PM sterol transport..  4. 2015
• Visual processing of informative multipoint correlations arises primarily in V2..  4. 2015
• Global biogeographic sampling of bacterial secondary metabolism..  4. 2015
• A kinase-independent function of AKT promotes cancer cell survival..  3. 2014
• Dynamic recruitment of the curvature-sensitive protein ArhGAP44 to nanoscale membrane deformations limits exploratory filopodia initiation in neurons..  3. 2014
• Variance predicts salience in central sensory processing..  3. 2014
• The accessory helix of complexin functions by stabilizing central helix secondary structure..  3. 2014
• FGF14 modulates resurgent sodium current in mouse cerebellar Purkinje neurons..  3. 2014
• The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation..  3. 2014
• Cannabinoid-induced actomyosin contractility shapes neuronal morphology and growth..  3. 2014
• Coupled ion binding and structural transitions along the transport cycle of glutamate transporters..  3. 2014
• MOF-associated complexes ensure stem cell identity and Xist repression..  3. 2014
• T cells translate individual, quantal activation into collective, analog cytokine responses via time-integrated feedbacks..  3. 2014
• In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes..  3. 2014
• Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1..  2. 2013
• Common resting brain dynamics indicate a possible mechanism underlying zolpidem response in severe brain injury..  2. 2013
• Essential yet limited role for CCR2⁺ inflammatory monocytes during Mycobacterium tuberculosis-specific T cell priming..  2. 2013
• Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis..  2. 2013
• Global cellular response to chemotherapy-induced apoptosis..  2. 2013
• Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice..  2. 2013
• Dynamin phosphorylation controls optimization of endocytosis for brief action potential bursts..  2. 2013
• Evolutionary dynamics of cancer in response to targeted combination therapy..  2. 2013
• Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2..  2. 2013
• The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress..  2. 2013
• Overcoming mutation-based resistance to antiandrogens with rational drug design..  2. 2013
• Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo..  2. 2013
• Proteins acting out of (dis)order..  6. 2017
• Aquaporin-4-dependent glymphatic solute transport in the rodent brain. 2018

Identity

ISO Abbreviation

• Elife

Linking ISSN

• 2050-084X

International Standard Serial Number (ISSN)

• 2050-084X

Electronic International Standard Serial Number (EISSN)

• 2050-084X