JCI insight
Journal
Overview
publication venue for
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ROCK1 promotes B-cell differentiation and proteostasis under stress through the heme-regulated proteins, BACH2 and HRI.
2025
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BPDCN MYB fusions regulate cell cycle genes, impair differentiation, and induce myeloid-dendritic cell leukemia..
9.
2024
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Cellular signatures in human blood track bone mineral density in postmenopausal women..
9.
2024
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STARD7 maintains intestinal epithelial mitochondria architecture, barrier integrity, and protection from colitis..
9.
2024
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Diversity of the immune microenvironment and response to checkpoint inhibitor immunotherapy in mucosal melanoma..
9.
2024
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Inhibition of Bruton's tyrosine kinase with PD-1 blockade modulates T cell activation in solid tumors..
9.
2024
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Longitudinal lipidomic profiles of left ventricular mass and hypertrophy in American Indians.
2024
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The HIV latency reversing agent HODHBt inhibits the phosphatases PTPN1 and PTPN2.
2024
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Endothelial cell sphingosine 1-phosphate receptor 1 restrains VE-cadherin cleavage and attenuates experimental inflammatory arthritis..
9.
2024
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Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder..
9.
2024
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Is it time to reduce the length of postgraduate training for physician-scientists in internal medicine?.
9.
2024
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Adipsin and Adipocyte-derived C3aR1 Regulate Thermogenic Fat in a Sex-dependent Fashion.
2024
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HIV-1-infected T cell clones are shared across cerebrospinal fluid and blood during ART..
9.
2024
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Plasma cells in human pancreatic ductal adenocarcinoma secrete antibodies to self-antigens.
2023
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The latency-reversing agent HODHBt synergizes with IL-15 to enhance cytotoxic function of HIV-specific T cells..
8.
2023
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Alveolar type II epithelial cell FASN maintains lipid homeostasis in experimental COPD..
8.
2023
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Distinct mucosal and systemic immunological characteristics in transgender women potentially relating to HIV acquisition..
8.
2023
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A modeling-based approach to optimize COVID-19 vaccine dosing schedules for improved protection..
8.
2023
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ADCC-activating antibodies correlate with decreased risk of congenital human cytomegalovirus transmission..
8.
2023
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Nucleolin promotes angiogenesis and endothelial metabolism along the onco-fetal axis in the human brain vasculature.
2023
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KIBRA upregulation increases susceptibility to glomerular injury and correlates with kidney function decline.
2023
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Reversible epigenetic alterations mediate PSMA expression heterogeneity in advanced metastatic prostate cancer.
2023
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SETD2 regulates chromatin accessibility and transcription to suppress lung tumorigenesis..
8.
2023
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Acute high-fat diet impairs macrophage-supported intestinal damage resolution..
8.
2023
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Association of self-identified race and genetic ancestry with the immunogenomic landscape of primary prostate cancer..
8.
2023
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Late gene expression-deficient cytomegalovirus vectors elicit conventional T cells that do not protect against SIV.
2023
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Origin, prospective identification, and function of circulating endothelial colony forming cells in mouse and man.
2023
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Iron therapy mitigates chronic kidney disease progression by regulating intracellular iron status of kidney macrophages..
8.
2023
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Metastatic pancreatic neuroendocrine tumors feature elevated T cell infiltration..
7.
2022
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The effect of induction immunosuppression for kidney transplant on the latent HIV reservoir..
7.
2022
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Targeting BCL-XL in fibrolamellar hepatocellular carcinoma..
7.
2022
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Somatic gene mutations expose cytoplasmic DNA to co-opt the cGAS/STING/NLRP3 axis in myelodysplastic syndromes..
7.
2022
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HIV viral transcription and immune perturbations in the CNS of people with HIV despite ART..
7.
2022
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Protein expression of the gp78 E3 ligase predicts poor breast cancer outcome based on race..
7.
2022
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Specific human endogenous retroviruses predict metastatic potential in uveal melanoma..
7.
2022
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Mucosal metabolites fuel the growth and virulence of E. coli linked to Crohn's disease.
2022
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Plasma metabolomics reveals disrupted response and recovery following maximal exercise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
2022
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Notch-mediated Ephrin signaling disrupts islet architecture and β cell function..
7.
2022
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A TCR mimic monoclonal antibody reactive with the "public" phospho-neoantigen pIRS2/HLA-A*02:01 complex..
7.
2022
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Disruption of the crypt niche promotes outgrowth of mutated colorectal tumor stem cells..
7.
2022
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Increased Ca2+ influx through CaV1.2 drives aortic valve calcification.
2022
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Clinico-histopathologic and single-nuclei RNA-sequencing insights into cardiac injury and microthrombi in critical COVID-19..
7.
2022
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Collision tumors revealed by prospectively assessing subtype-defining molecular alterations in 904 individual prostate cancer foci.
2022
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Customization of a DADA2-based pipeline for fungal internal transcribed spacer 1 (ITS1) amplicon data sets..
7.
2022
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The Purkinje-myocardial junction is the anatomical origin of ventricular arrhythmia in CPVT.
2022
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Circulating autoreactive proteinase 3+ B cells and tolerance checkpoints in ANCA-associated vasculitis..
6.
2021
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Therapeutic radiation exposure of the abdomen during childhood induces chronic adipose tissue dysfunction..
6.
2021
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SARS-CoV-2 infection mediates differential expression of human endogenous retroviruses and long interspersed nuclear elements.
2021
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Dynamics and origin of rebound viremia in SHIV-infected infant macaques following interruption of long-term ART.
2021
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Adrenal-permissive HSD3B1 genetic inheritance and risk of estrogen-driven postmenopausal breast cancer..
6.
2021
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Cyclophosphamide enhances the antitumor potency of GITR engagement by increasing oligoclonal cytotoxic T cell fitness..
6.
2021
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Rapid, robust, and sustainable antibody responses to mRNA COVID-19 vaccine in convalescent COVID-19 individuals..
6.
2021
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Asymptomatic or mild symptomatic SARS-CoV-2 infection elicits durable neutralizing antibody responses in children and adolescents..
6.
2021
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Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors..
6.
2021
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Taspase1 orchestrates fetal liver hematopoietic stem cell and vertebrae fates by cleaving TFIIA..
6.
2021
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L-SIGN is a receptor on liver sinusoidal endothelial cells for SARS-CoV-2 virus..
6.
2021
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Leveraging copper import by yersiniabactin siderophore system for targeted PET imaging of bacteria..
6.
2021
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Restoration of proximal tubule flow-activated transport prevents cyst growth in polycystic kidney disease..
6.
2021
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Dromedary camels as a natural source of neutralizing nanobodies against SARS-CoV-2..
6.
2021
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GLP-1 receptor signaling increases PCSK1 and β cell features in human α cells..
6.
2021
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HIV-specific T cell responses reflect substantive in vivo interactions with antigen despite long-term therapy..
6.
2021
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Evolution of ocular defects in infant macaques following in utero Zika virus infection..
5.
2020
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PDX-derived organoids model in vivo drug response and secrete biomarkers..
5.
2020
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Fibroblast growth factor homologous factors tune arrhythmogenic late NaV1.5 current in calmodulin binding-deficient channels..
5.
2020
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Solving an MHC allele-specific bias in the reported immunopeptidome..
5.
2020
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Fc receptor-like 5 and anti-CD20 treatment response in granulomatosis with polyangiitis and microscopic polyangiitis..
5.
2020
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Urinary biomarkers of mycobacterial load and treatment response in pulmonary tuberculosis..
5.
2020
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Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regeneration..
5.
2020
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Gene therapy for alpha 1-antitrypsin deficiency with an oxidant-resistant human alpha 1-antitrypsin..
5.
2020
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Streptococcus pyogenes genes that promote pharyngitis in primates..
5.
2020
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Age-dependent regulation of cell-mediated collagen turnover..
5.
2020
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CIC is a critical regulator of neuronal differentiation..
5.
2020
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Neoantigen-based EpiGVAX vaccine initiates antitumor immunity in colorectal cancer..
5.
2020
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Signaling pathways predisposing to chronic kidney disease progression..
5.
2020
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Biological sex influences susceptibility to Acinetobacter baumannii pneumonia in mice..
5.
2020
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Differences in inducibility of the latent HIV reservoir in perinatal and adult infection..
5.
2020
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Urinary cell transcriptomics and acute rejection in human kidney allografts..
5.
2020
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Association of persistent wild-type measles virus RNA with long-term humoral immunity in rhesus macaques..
5.
2020
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Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort..
5.
2020
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Lupus-associated endogenous retroviral LTR polymorphism and epigenetic imprinting promote HRES-1/RAB4 expression and mTOR activation..
5.
2020
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Mitophagy-dependent macrophage reprogramming protects against kidney fibrosis..
4.
2019
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YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinoma..
4.
2019
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Prohibitin is a prognostic marker and therapeutic target to block chemotherapy resistance in Wilms' tumor..
4.
2019
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Glucagon lowers glycemia when β-cells are active..
5.
2019
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Landscape of innate immune system transcriptome and acute T cell-mediated rejection of human kidney allografts..
4.
2019
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Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity..
5.
2019
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Racial differences in the association of NT-proBNP with risk of incident heart failure in REGARDS..
5.
2019
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Circulating cell death biomarker TRAIL is associated with increased organ dysfunction in sepsis..
4.
2019
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Endothelial senescence is induced by phosphorylation and nuclear export of telomeric repeat binding factor 2-interacting protein..
4.
2019
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Pressure overload leads to coronary plaque formation, progression, and myocardial events in ApoE-/- mice..
4.
2019
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Heterogeneity of the action potential duration is required for sustained atrial fibrillation..
5.
2019
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Prohibitin promotes de-differentiation and is a potential therapeutic target in neuroblastoma..
5.
2019
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MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis..
4.
2019
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Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers..
4.
2019
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Deficiency of Socs3 leads to brain-targeted EAE via enhanced neutrophil activation and ROS production..
5.
2019
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Safety and tolerability of conditioning chemotherapy followed by CD19-targeted CAR T cells for relapsed/refractory CLL..
5.
2019
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Cancer stem cell-associated miRNAs serve as prognostic biomarkers in colorectal cancer..
4.
2019
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Blood-retina barrier failure and vision loss in neuron-specific degeneration..
5.
2019
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BAFF-driven B cell hyperplasia underlies lung disease in common variable immunodeficiency..
4.
2019
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β Cell tone is defined by proglucagon peptides through cAMP signaling..
4.
2019
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Predicting breast cancer response to neoadjuvant chemotherapy based on tumor vascular features in needle biopsies..
5.
2019
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Targeting protein disulfide isomerase with the flavonoid isoquercetin to improve hypercoagulability in advanced cancer..
4.
2019
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Metabolic and microstructural alterations in the SLE brain correlate with cognitive impairment..
4.
2019
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OX40L/OX40 axis impairs follicular and natural Treg function in human SLE..
3.
2018
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A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS..
3.
2018
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Randomized trial of intravenous iron-induced hypophosphatemia..
3.
2018
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Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene..
3.
2018
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Functional heterogeneity of human tissue-resident memory T cells based on dye efflux capacities..
3.
2018
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Targeting the CALR interactome in myeloproliferative neoplasms..
3.
2018
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Transcriptomic heterogeneity in multifocal prostate cancer..
3.
2018
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Dual TLR2 and TLR7 agonists as HIV latency-reversing agents..
3.
2018
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Mucosal-associated invariant and γδ T cell subsets respond to initial Mycobacterium tuberculosis infection..
3.
2018
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Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies..
3.
2018
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Beclin-1 regulates cigarette smoke-induced kidney injury in a murine model of chronic obstructive pulmonary disease..
3.
2018
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Laminin α1 is a genetic modifier of TGF-β1-stimulated pulmonary fibrosis..
3.
2018
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Necroptosis of infiltrated macrophages drives Yersinia pestis dispersal within buboes..
3.
2018
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AIBP augments cholesterol efflux from alveolar macrophages to surfactant and reduces acute lung inflammation..
3.
2018
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FGFR1 underlies obesity-associated progression of estrogen receptor-positive breast cancer after estrogen deprivation..
3.
2018
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Circulating RIPK3 levels are associated with mortality and organ failure during critical illness..
3.
2018
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Immune reprogramming via PD-1 inhibition enhances early-stage lung cancer survival..
3.
2018
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RIPK3 promotes sepsis-induced acute kidney injury via mitochondrial dysfunction..
3.
2018
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RIPK3 mediates pathogenesis of experimental ventilator-induced lung injury..
3.
2018
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Targeting the gut microbiome to treat the osteoarthritis of obesity..
3.
2018
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TCR-mimic bispecific antibodies targeting LMP2A show potent activity against EBV malignancies..
3.
2018
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RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase..
3.
2018
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Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss..
2.
2017
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T cells presenting viral antigens or autoantigens induce cytotoxic T cell anergy..
2.
2017
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Increased putamen hypercapnic vasoreactivity in levodopa-induced dyskinesia..
2.
2017
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MTG16 is a tumor suppressor in colitis-associated carcinoma..
2.
2017
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Rilonacept maintains long-term inflammatory remission in patients with deficiency of the IL-1 receptor antagonist..
2.
2017
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Sustained immune tolerance induction in enzyme replacement therapy-treated CRIM-negative patients with infantile Pompe disease..
2.
2017
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A CCR2+ myeloid cell niche required for pancreatic β cell growth..
2.
2017
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Increased de novo ceramide synthesis and accumulation in failing myocardium..
2.
2017
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Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys..
2.
2017
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Genomic landscape and evolution of metastatic chromophobe renal cell carcinoma..
2.
2017
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Increased de novo ceramide synthesis and accumulation in failing myocardium..
2.
2017
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SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease..
2.
2017
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Efficacy of ALK5 inhibition in myelofibrosis..
2.
2017
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Long-term follow-up of a randomized AAV2-GAD gene therapy trial for Parkinson's disease..
2.
2017
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Panobinostat acts synergistically with ibrutinib in diffuse large B cell lymphoma cells with MyD88 L265P mutations..
2.
2017
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Enhanced FCGR2A and FCGR3A signaling by HIV viremic controller IgG..
2.
2017
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IFITM1 targets HIV-1 latently infected cells for antibody-dependent cytolysis..
2.
2017
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Kappa opioid receptor signaling protects cartilage tissue against posttraumatic degeneration..
2.
2017
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HDL activation of endothelial sphingosine-1-phosphate receptor-1 (S1P1) promotes regeneration and suppresses fibrosis in the liver..
1.
2016
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Integrated, multicohort analysis of systemic sclerosis identifies robust transcriptional signature of disease severity..
1.
2016
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Institutional implementation of clinical tumor profiling on an unselected cancer population..
1.
2016
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Longitudinal PET imaging demonstrates biphasic CAR T cell responses in survivors..
1.
2016
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Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis..
1.
2016
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Mfge8 regulates enterocyte lipid storage by promoting enterocyte triglyceride hydrolase activity..
1.
2016
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The head and neck cancer immune landscape and its immunotherapeutic implications..
1.
2016
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Flow-metabolism dissociation in the pathogenesis of levodopa-induced dyskinesia..
1.
2016
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Prohibitin/annexin 2 interaction regulates fatty acid transport in adipose tissue..
1.
2016
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A clinical measure of DNA methylation predicts outcome in de novo acute myeloid leukemia..
1.
2016
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Cyclosporine A immunosuppression drives catastrophic squamous cell carcinoma through IL-22..
1.
2016
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Multiplexed immunofluorescence delineates proteomic cancer cell states associated with metabolism..
1.
2016
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Endothelial Nogo-B regulates sphingolipid biosynthesis to promote pathological cardiac hypertrophy during chronic pressure overload..
1.
2016
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Autoimmune response to transthyretin in juvenile idiopathic arthritis..
1.
2016
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Blocking MHC class II on human endothelium mitigates acute rejection..
1.
2016
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Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort.
2024
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Emerging functions of DNA transposases and oncogenic mutators in childhood cancer development.
2018
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Fat fibrosis: friend or foe?
2018
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Immunity against fungi.
2017
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Necroptosis: a crucial pathogenic mediator of human disease.
2019
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