ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23. Academic Article uri icon

Overview

abstract

  • CD23, the low-affinity immunoglobulin E receptor, is an important modulator of the allergic response and of diseases such as rheumatoid arthritis. The proteolytic release of CD23 from cells is considered a key event in the allergic response. Here we used loss-of-function and gain-of-function experiments with cells lacking or overexpressing candidate CD23-releasing enzymes (ADAM8, ADAM9, ADAM10, ADAM12, ADAM15, ADAM17, ADAM19 and ADAM33), ADAM-knockout mice and a selective inhibitor to identify ADAM10 as the main CD23-releasing enzyme in vivo. Our findings provide a likely target for the treatment of allergic reactions and set the stage for further studies of the involvement of ADAM10 in CD23-dependent pathologies.

publication date

  • October 29, 2006

Research

keywords

  • ADAM Proteins
  • Amyloid Precursor Protein Secretases
  • Membrane Proteins
  • Receptors, IgE

Identity

Scopus Document Identifier

  • 33846285347

PubMed ID

  • 17072319

Additional Document Info

volume

  • 7

issue

  • 12