Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release. Academic Article uri icon

Overview

abstract

  • A major challenge of targeted molecular imaging and drug delivery in cancer is establishing a functional combination of ligand-directed cargo with a triggered release system. Here we develop a hydrogel-based nanotechnology platform that integrates tumor targeting, photon-to-heat conversion, and triggered drug delivery within a single nanostructure to enable multimodal imaging and controlled release of therapeutic cargo. In proof-of-concept experiments, we show a broad range of ligand peptide-based applications with phage particles, heat-sensitive liposomes, or mesoporous silica nanoparticles that self-assemble into a hydrogel for tumor-targeted drug delivery. Because nanoparticles pack densely within the nanocarrier, their surface plasmon resonance shifts to near-infrared, thereby enabling a laser-mediated photothermal mechanism of cargo release. We demonstrate both noninvasive imaging and targeted drug delivery in preclinical mouse models of breast and prostate cancer. Finally, we applied mathematical modeling to predict and confirm tumor targeting and drug delivery. These results are meaningful steps toward the design and initial translation of an enabling nanotechnology platform with potential for broad clinical applications.

publication date

  • February 2, 2016

Research

keywords

  • Antineoplastic Agents
  • Breast Neoplasms
  • Disease Models, Animal
  • Multimodal Imaging
  • Nanotechnology
  • Prostatic Neoplasms

Identity

PubMed Central ID

  • PMC4763738

Scopus Document Identifier

  • 84959020202

Digital Object Identifier (DOI)

  • 10.1073/pnas.1525796113

PubMed ID

  • 26839407

Additional Document Info

volume

  • 113

issue

  • 7