alex, Vittorio

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selected publications

Deep learning-derived optimal aviation strategies to control pandemics. Scientific reports. 2024 Academic Article GET IT
Measurable imaging-based changes in enhancement of intrahepatic cholangiocarcinoma after radiotherapy reflect physical mechanisms of response. 2024 GET IT
Gradient-induced instability in tumour spheroids unveils the impact of microenvironmental nutrient changes. Scientific reports. 2024 Academic Article GET IT
Hybridizing mechanistic modeling and deep learning for personalized survival prediction after immune checkpoint inhibitor immunotherapy. NPJ systems biology and applications. 2024 Academic Article GET IT
Translational modeling-based evidence for enhanced efficacy of standard-of-care drugs in combination with anti-microRNA-155 in non-small-cell lung cancer. Molecular cancer. 2024 Academic Article GET IT
Clinical Validation of Mathematically Derived Early Tumor Dynamics for Solid Tumors in Response to Durvalumab. JCO clinical cancer informatics. 2024 Academic Article GET IT
Hybridizing mechanistic mathematical modeling with deep learning methods to predict individual cancer patient survival after immune checkpoint inhibitor therapy. 2024 GET IT
Translational modeling-based evidence for enhanced efficacy of standard-of-care drugs in combination with anti-microRNA-155 in non-small-cell lung cancer. 2024 GET IT
Hybrid Cellular Automata Modeling Reveals the Effects of Glucose Gradients on Tumour Spheroid Growth. Cancers. 2023 Academic Article GET IT
Exploring Cell Migration Mechanisms in Cancer: From Wound Healing Assays to Cellular Automata Models. Cancers. 2023 Academic Article GET IT
Ceramide as an endothelial cell surface receptor and a lung-specific lipid vascular target for circulating ligands. Proceedings of the National Academy of Sciences of the United States of America. 2023 Academic Article GET IT
A modeling-based approach to optimize COVID-19 vaccine dosing schedules for improved protection. JCI insight. 2023 Academic Article GET IT
Mechanistic modeling for optimal design of dissolvable microneedle-based patches for transdermal drug delivery. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2023 Academic Article GET IT
Mechanistic modeling of anti-microRNA-155 therapy combinations in lung cancer. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2023 Academic Article GET IT
Prospective Subunit Nanovaccine against Mycobacterium tuberculosis Infection─Cubosome Lipid Nanocarriers of Cord Factor, Trehalose 6,6' Dimycolate. ACS applied materials & interfaces. 2023 Academic Article GET IT
Times cited: 1
A modeling-based approach to optimize COVID-19 vaccine dosing schedules for improved protection. 2023 GET IT
Times cited: 43
Mathematical modeling of cancer immunotherapy for personalized clinical translation. Nature computational science. 2022 Academic Article GET IT
Times cited: 16
Protocol for mathematical prediction of patient response and survival to immune checkpoint inhibitor immunotherapy. STAR protocols. 2022 Academic Article GET IT
Zonal Intratumoral Delivery of Nanoparticles Guided by Surface Functionalization. Langmuir : the ACS journal of surfaces and colloids. 2022 Academic Article GET IT
Times cited: 6
Immune-checkpoint inhibitor therapy response evaluation using oncophysics-based mathematical models. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. 2022 Review GET IT
Times cited: 1
Localization of drug biodistribution in a 3D-bioengineered subcutaneous neovascularized microenvironment. Materials today. Bio. 2022 Academic Article GET IT
Times cited: 5
Mechanistic modeling-guided optimization of microneedle-based skin patch for rapid transdermal delivery of naloxone for opioid overdose treatment. Drug delivery and translational research. 2022 Academic Article GET IT
Times cited: 3
Mass Transport Model of Radiation Response: Calibration and Application to Chemoradiation for Pancreatic Cancer. International journal of radiation oncology, biology, physics. 2022 Academic Article GET IT
Times cited: 1
Dedifferentiation-mediated stem cell niche maintenance in early-stage ductal carcinoma in situ progression: insights from a multiscale modeling study. Cell death & disease. 2022 Academic Article GET IT
Times cited: 4
Genetic and Structural Analysis of SARS-CoV-2 Spike Protein for Universal Epitope Selection. Molecular biology and evolution. 2022 Academic Article GET IT
Times cited: 7
Translational Modeling Identifies Synergy between Nanoparticle-Delivered miRNA-22 and Standard-of-Care Drugs in Triple-Negative Breast Cancer. Pharmaceutical research. 2022 Academic Article GET IT
Times cited: 13
Perioperative nivolumab monotherapy versus nivolumab plus ipilimumab in resectable hepatocellular carcinoma: a randomised, open-label, phase 2 trial. The lancet. Gastroenterology & hepatology. 2022 Academic Article GET IT
Times cited: 125
Early prediction of clinical response to checkpoint inhibitor therapy in human solid tumors through mathematical modeling. eLife. 2021 Academic Article GET IT
Times cited: 10
Current Landscape and Future Directions of Biomarkers for Immunotherapy in Hepatocellular Carcinoma. Journal of hepatocellular carcinoma. 2021 Review GET IT
Times cited: 5104
Apropos of Universal Epitope Discovery for COVID-19 Vaccines: A Framework for Targeted Phage Display-Based Delivery and Integration of New Evaluation Tools. 2021 GET IT
Times cited: 7
Targeting a cell surface vitamin D receptor on tumor-associated macrophages in triple-negative breast cancer. eLife. 2021 Academic Article GET IT
Times cited: 20
Is the worst of the COVID-19 global pandemic yet to come? Application of financial mathematics as candidate predictive tools. Translational psychiatry. 2021 Academic Article GET IT
Times cited: 6
Conversion of RNA Aptamer into Modified DNA Aptamers Provides for Prolonged Stability and Enhanced Antitumor Activity. Journal of the American Chemical Society. 2021 Academic Article GET IT
Times cited: 22
Amphibian regeneration and mammalian cancer: Similarities and contrasts from an evolutionary biology perspective: Comparing the regenerative potential of mammalian embryos and urodeles to develop effective strategies against human cancer. BioEssays : news and reviews in molecular, cellular and developmental biology. 2021 Review GET IT
Times cited: 5
Corrections to "A multiscale Agent-Based Model of Ductal Carcinoma in Situ". 2021 GET IT
A Mathematical Model to Estimate Chemotherapy Concentration at the Tumor-Site and Predict Therapy Response in Colorectal Cancer Patients with Liver Metastases. Cancers. 2021 Academic Article GET IT
Times cited: 15
Do Pandemics Obey the Elliott Wave Principle of Financial Markets? 2021 GET IT
ncRNA therapy with miRNA-22-3p suppresses the growth of triple-negative breast cancer. Molecular therapy. Nucleic acids. 2021 Academic Article GET IT
Times cited: 31
A mathematical model for the quantification of a patient's sensitivity to checkpoint inhibitors and long-term tumour burden. Nature biomedical engineering. 2021 Academic Article GET IT
Times cited: 29
Innate Immunity Plays a Key Role in Controlling Viral Load in COVID-19: Mechanistic Insights from a Whole-Body Infection Dynamics Model. ACS pharmacology & translational science. 2020 Academic Article GET IT
Times cited: 28
Targeted Phage Display-based Pulmonary Vaccination in Mice and Non-human Primates. Med (New York, N.Y.). 2020 Academic Article GET IT
Times cited: 18
Intratumoral injection of hydrogel-embedded nanoparticles enhances retention in glioblastoma. Nanoscale. 2020 Academic Article GET IT
Times cited: 50
Imaging-Based Subtypes of Pancreatic Ductal Adenocarcinoma Exhibit Differential Growth and Metabolic Patterns in the Pre-Diagnostic Period: Implications for Early Detection. Frontiers in oncology. 2020 Academic Article GET IT
Times cited: 10
Innate immunity plays a key role in controlling viral load in COVID-19: mechanistic insights from a whole-body infection dynamics model. 2020 GET IT
Resolving the Disproportionate Left Ventricular Enlargement in Mitral Valve Prolapse Due to Barlow Disease: Insights From Cardiovascular Magnetic Resonance. JACC. Cardiovascular imaging. 2020 Academic Article GET IT
Times cited: 4
Investigating the Effect of Aging on the Pharmacokinetics and Tumor Delivery of Nanomaterials using Mathematical Modeling. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2020 Academic Article GET IT
Times cited: 2
Sequential deconstruction of composite drug transport in metastatic breast cancer. Science advances. 2020 Academic Article GET IT
Times cited: 14
Mathematical prediction of clinical outcomes in advanced cancer patients treated with checkpoint inhibitor immunotherapy. Science advances. 2020 Academic Article GET IT
Times cited: 36
Image-guided mathematical modeling for pharmacological evaluation of nanomaterials and monoclonal antibodies. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. 2020 Review GET IT
Times cited: 21
A mathematical model to predict nanomedicine pharmacokinetics and tumor delivery. Computational and structural biotechnology journal. 2020 Academic Article GET IT
Times cited: 63
Therapeutic potential of FLANC, a novel primate-specific long non-coding RNA in colorectal cancer. Gut. 2020 Academic Article GET IT
Times cited: 81
Mathematical Modeling to Address Challenges in Pancreatic Cancer. Current topics in medicinal chemistry. 2020 Academic Article GET IT
Times cited: 10
Tumor core biopsies adequately represent immune microenvironment of high-grade serous carcinoma. Scientific reports. 2019 Academic Article GET IT
Times cited: 13
A Multiscale Agent-Based Model of Ductal Carcinoma In Situ. IEEE transactions on bio-medical engineering. 2019 Academic Article GET IT
Times cited: 13
Size-Optimized Ultrasmall Porous Silica Nanoparticles Depict Vasculature-Based Differential Targeting in Triple Negative Breast Cancer. Small (Weinheim an der Bergstrasse, Germany). 2019 Academic Article GET IT
Times cited: 36
Development of a Physiologically-Based Mathematical Model for Quantifying Nanoparticle Distribution in Tumors. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2019 Academic Article GET IT
Times cited: 1
Mathematical modeling in cancer nanomedicine: a review. Biomedical microdevices. 2019 Review GET IT
Times cited: 116
Predicting breast cancer response to neoadjuvant chemotherapy based on tumor vascular features in needle biopsies. JCI insight. 2019 Academic Article GET IT
Times cited: 18
Establishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics. Nature communications. 2018 Academic Article GET IT
Times cited: 195
A Visually Apparent and Quantifiable CT Imaging Feature Identifies Biophysical Subtypes of Pancreatic Ductal Adenocarcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018 Academic Article GET IT
Times cited: 80
Understanding the Connection between Nanoparticle Uptake and Cancer Treatment Efficacy using Mathematical Modeling. Scientific reports. 2018 Academic Article GET IT
Times cited: 45
Development of a three dimensional, multiscale agent-based model of ductal carcinoma in situ. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2017 Academic Article GET IT
Times cited: 9
Development of a three dimensional, lattice-free multiscale model of the mammary terminal end bud. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2016 Academic Article GET IT
Times cited: 2
A hybrid agent-based model of the developing mammary terminal end bud. Journal of theoretical biology. 2016 Academic Article GET IT
Times cited: 13
Theory and Experimental Validation of a Spatio-temporal Model of Chemotherapy Transport to Enhance Tumor Cell Kill. PLoS computational biology. 2016 Academic Article GET IT
Times cited: 56
A Geometrically-Constrained Mathematical Model of Mammary Gland Ductal Elongation Reveals Novel Cellular Dynamics within the Terminal End Bud. PLoS computational biology. 2016 Academic Article GET IT
Times cited: 42
Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 56
A modeling approach to study the normal mammary gland growth process. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2015 Academic Article GET IT
Times cited: 2
Predictive Modeling of Drug Response in Non-Hodgkin's Lymphoma. PloS one. 2015 Academic Article GET IT
Times cited: 23
Integrated PK-PD and agent-based modeling in oncology. Journal of pharmacokinetics and pharmacodynamics. 2015 Review GET IT
Times cited: 57
Intra-tumoral heterogeneity of gemcitabine delivery and mass transport in human pancreatic cancer. Physical biology. 2014 Academic Article GET IT
Times cited: 31
Development of a sampling-based global sensitivity analysis workflow for multiscale computational cancer models. IET systems biology. 2014 Academic Article GET IT
Times cited: 25
Understanding Drug Resistance in Breast Cancer with Mathematical Oncology. Current breast cancer reports. 2014 Academic Article GET IT
Times cited: 30
Simulating cancer growth with multiscale agent-based modeling. Seminars in cancer biology. 2014 Review GET IT
Times cited: 170
The effect of interstitial pressure on therapeutic agent transport: coupling with the tumor blood and lymphatic vascular systems. Journal of theoretical biology. 2014 Academic Article GET IT
Times cited: 88
Transport properties of pancreatic cancer describe gemcitabine delivery and response. The Journal of clinical investigation. 2014 Academic Article GET IT
Times cited: 151
Computational modeling of 3D tumor growth and angiogenesis for chemotherapy evaluation. PloS one. 2014 Academic Article GET IT
Times cited: 80
Development of a diffusion-based mathematical model for predicting chemotherapy effects. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2014 Academic Article GET IT
Tumor vascular permeabilization using localized mild hyperthermia to improve macromolecule transport. Nanomedicine : nanotechnology, biology, and medicine. 2013 Academic Article GET IT
Times cited: 60
Mechanistic modeling identifies drug-uptake history as predictor of tumor drug resistance and nano-carrier-mediated response. ACS nano. 2013 Academic Article GET IT
Times cited: 62
Mechanistic patient-specific predictive correlation of tumor drug response with microenvironment and perfusion measurements. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 63
Impact of diffusion barriers to small cytotoxic molecules on the efficacy of immunotherapy in breast cancer. PloS one. 2013 Academic Article GET IT
Times cited: 31
An integrated computational/experimental model of lymphoma growth. PLoS computational biology. 2013 Academic Article GET IT
Times cited: 30
A computational model for predicting nanoparticle accumulation in tumor vasculature. PloS one. 2013 Academic Article GET IT
Times cited: 87
The effect of interstitial pressure on tumor growth: coupling with the blood and lymphatic vascular systems. Journal of theoretical biology. 2012 Academic Article GET IT
Times cited: 180
Quantitative measurements and modeling of cargo-motor interactions during fast transport in the living axon. Physical biology. 2012 Academic Article GET IT
Times cited: 14
Dynamic density functional theory of solid tumor growth: Preliminary models. AIP advances. 2012 Academic Article GET IT
Times cited: 32
Integrated intravital microscopy and mathematical modeling to optimize nanotherapeutics delivery to tumors. AIP advances. 2012 Academic Article GET IT
Times cited: 82
Patient-calibrated agent-based modelling of ductal carcinoma in situ (DCIS): from microscopic measurements to macroscopic predictions of clinical progression. Journal of theoretical biology. 2012 Academic Article GET IT
Times cited: 174
Integrative physical oncology. Wiley interdisciplinary reviews. Systems biology and medicine. 2011 Review GET IT
Times cited: 23
Multiscale cancer modeling. Annual review of biomedical engineering. 2011 Review GET IT
Times cited: 313
Density-dependent quiescence in glioma invasion: instability in a simple reaction-diffusion model for the migration/proliferation dichotomy. Journal of biological dynamics. 2011 Academic Article GET IT
Times cited: 55
Physical oncology: a bench-to-bedside quantitative and predictive approach. Cancer research. 2011 Review GET IT
Times cited: 38
A novel, patient-specific mathematical pathology approach for assessment of surgical volume: application to ductal carcinoma in situ of the breast. Analytical cellular pathology (Amsterdam). 2011 Academic Article GET IT
Times cited: 42
An Adaptive Multigrid Algorithm for Simulating Solid Tumor Growth Using Mixture Models. Mathematical and computer modelling. 2011 Academic Article GET IT
Times cited: 86
Mathematical Oncology: How Are the Mathematical and Physical Sciences Contributing to the War on Breast Cancer?. Current breast cancer reports. 2010 Academic Article GET IT
Times cited: 30
Predictions of tumour morphological stability and evaluation against experimental observations. Journal of the Royal Society, Interface. 2010 Academic Article GET IT
Times cited: 33
Three-dimensional multispecies nonlinear tumor growth-II: Tumor invasion and angiogenesis. Journal of theoretical biology. 2010 Academic Article GET IT
Times cited: 191
Applications of a new In vivo tumor spheroid based shell-less chorioallantoic membrane 3-D model in bioengineering research. Journal of biomedical science and engineering. 2010 Academic Article GET IT
Nonlinear modelling of cancer: bridging the gap between cells and tumours. Nonlinearity. 2010 Academic Article GET IT
Times cited: 435
Gene expression meta-analysis supports existence of molecular apocrine breast cancer with a role for androgen receptor and implies interactions with ErbB family. BMC medical genomics. 2009 Academic Article GET IT
Times cited: 50
Multiparameter computational modeling of tumor invasion. Cancer research. 2009 Academic Article GET IT
Times cited: 116
Prediction of drug response in breast cancer using integrative experimental/computational modeling. Cancer research. 2009 Academic Article GET IT
Times cited: 110
Nonlinear simulations of solid tumor growth using a mixture model: invasion and branching. Journal of mathematical biology. 2008 Academic Article GET IT
Times cited: 231
Multiscale modelling and nonlinear simulation of vascular tumour growth. Journal of mathematical biology. 2008 Academic Article GET IT
Times cited: 296
Predicting drug pharmacokinetics and effect in vascularized tumors using computer simulation. Journal of mathematical biology. 2008 Academic Article GET IT
Times cited: 69
Three-dimensional multispecies nonlinear tumor growth--I Model and numerical method. Journal of theoretical biology. 2008 Academic Article GET IT
Times cited: 393
Brain mapping in stereotactic surgery: a brief overview from the probabilistic targeting to the patient-based anatomic mapping. NeuroImage. 2007 Review GET IT
Times cited: 48
Predictive oncology: a review of multidisciplinary, multiscale in silico modeling linking phenotype, morphology and growth. NeuroImage. 2007 Review GET IT
Times cited: 116
Computer simulation of glioma growth and morphology. NeuroImage. 2007 Academic Article GET IT
Times cited: 198
Mathematical modeling of cancer progression and response to chemotherapy. Expert review of anticancer therapy. 2006 Review GET IT
Times cited: 102
Drop deformation in microconfined shear flow. Physical review letters. 2006 Academic Article GET IT
Times cited: 153
Multicell tumor spheroids in photodynamic therapy. Lasers in surgery and medicine. 2006 Review GET IT
Times cited: 47
Analysis of cell growth in three-dimensional scaffolds. Tissue engineering. 2006 Academic Article GET IT
Times cited: 107
An integrated computational/experimental model of tumor invasion. Cancer research. 2006 Academic Article GET IT
Times cited: 243
Prototyping virtual cancer therapist (VCT): a software engineering approach. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2006 Academic Article GET IT
Times cited: 2
Computer modeling of red blood cell rheology in the microcirculation: a brief overview. Annals of biomedical engineering. 2005 Academic Article GET IT
Times cited: 42
Morphologic instability and cancer invasion. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005 Academic Article GET IT
Times cited: 134
Nonlinear simulation of tumor necrosis, neo-vascularization and tissue invasion via an adaptive finite-element/level-set method. Bulletin of mathematical biology. 2005 Academic Article GET IT
Times cited: 199
Two-dimensional chemotherapy simulations demonstrate fundamental transport and tumor response limitations involving nanoparticles. Biomedical microdevices. 2004 Academic Article GET IT
Times cited: 86
Design of microfluidic channel geometries for the control of droplet volume, chemical concentration, and sorting. Lab on a chip. 2004 Academic Article GET IT
Times cited: 450
Theory and numerical simulation of droplet dynamics in complex flows--a review. Lab on a chip. 2004 Review GET IT
Times cited: 282
Nonlinear simulation of tumor growth. Journal of mathematical biology. 2003 Academic Article GET IT
Times cited: 244
Near-Contact Motion of Surfactant-Covered Spherical Drops: Ionic Surfactant. Journal of colloid and interface science. 1999 Academic Article GET IT
Times cited: 20
[Is mammography useful in the detection of breast cancer in women 35 years of age or younger?]. La Radiologia medica. 1998 Academic Article GET IT
Times cited: 7

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Background

education and training

M.S., Yale University 96
Ph.D., Yale University 2000
M.Phil., Yale University 1998
Laurea, University of Rome I "La Sapienza" (Italy) 1994

Contact

full name

Vittorio Cristini

primary email

vcristini@houstonmethodist.org

VIVO Weill Cornell Medical College

Vittorio Cristini Professor of Population Health Sciences

Publications

selected publications

Background

education and training

Contact

full name

primary email