Drug metabolism by the human hepatoma cell, Hep G2. Academic Article uri icon

Overview

abstract

  • The human liver-derived cell line, Hep G2, has aryl hydrocarbon hydroxylase and 7-ethoxycoumarin o-de-ethylase activities. Partial purification of cytochrome P-450 from Hep G2 cells provided spectral evidence of this hemeprotein in the purified fraction. These results suggest that Hep G2 cells will be useful for the study of cytochrome P-450 and the regulation of mixed function oxidase activities in liver cells of human origin.

publication date

  • February 27, 1987

Research

keywords

  • Aryl Hydrocarbon Hydroxylases
  • Carcinoma, Hepatocellular
  • Cytochrome P-450 Enzyme System
  • Liver Neoplasms
  • Oxygenases

Identity

Scopus Document Identifier

  • 0023124661

PubMed ID

  • 3030322

Additional Document Info

volume

  • 143

issue

  • 1