Unc13: a multifunctional synaptic marvel. Review uri icon

Overview

abstract

  • Nervous systems are built on synaptic connections, and our understanding of these complex compartments has deepened over the past quarter century as the diverse fields of genetics, molecular biology, physiology, and biochemistry each made significant in-roads into synaptic function. On the presynaptic side, an evolutionarily conserved core fusion apparatus constructed from a handful of proteins has emerged, with Unc13 serving as a hub that coordinates nearly every aspect of synaptic transmission. This review briefly highlights recent studies on diverse aspects of Unc13 function including roles in SNARE assembly and quality control, release site building, calcium channel proximity, and short-term synaptic plasticity.

publication date

  • January 25, 2019

Research

keywords

  • Synaptic Transmission

Identity

PubMed Central ID

  • PMC6629506

Scopus Document Identifier

  • 85060492547

Digital Object Identifier (DOI)

  • 10.1016/j.conb.2018.12.011

PubMed ID

  • 30690332

Additional Document Info

volume

  • 57