Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia. Academic Article uri icon

Overview

abstract

  • The protein-protein interaction between menin and mixed lineage leukemia 1 (MLL1) plays a critical role in acute leukemias with translocations of the MLL1 gene or with mutations in the nucleophosmin 1 (NPM1) gene. As a step toward clinical translation of menin-MLL1 inhibitors, we report development of MI-3454, a highly potent and orally bioavailable inhibitor of the menin-MLL1 interaction. MI-3454 profoundly inhibited proliferation and induced differentiation in acute leukemia cells and primary patient samples with MLL1 translocations or NPM1 mutations. When applied as a single agent, MI-3454 induced complete remission or regression of leukemia in mouse models of MLL1-rearranged or NPM1-mutated leukemia, including patient-derived xenograft models, through downregulation of key genes involved in leukemogenesis. We also identified MEIS1 as a potential pharmacodynamic biomarker of treatment response with MI-3454 in leukemia, and demonstrated that this compound is well tolerated and did not impair normal hematopoiesis in mice. Overall, this study demonstrates, for the first time to our knowledge, profound activity of the menin-MLL1 inhibitor as a single agent in clinically relevant PDX models of leukemia. These data provide a strong rationale for clinical translation of MI-3454 or its analogs for leukemia patients with MLL1 rearrangements or NPM1 mutations.

authors

publication date

  • February 3, 2020

Research

keywords

  • Antineoplastic Agents
  • Histone-Lysine N-Methyltransferase
  • Leukemia
  • Mutation
  • Myeloid-Lymphoid Leukemia Protein
  • Neoplasms, Experimental
  • Nuclear Proteins
  • Proto-Oncogene Proteins

Identity

PubMed Central ID

  • PMC6994154

Scopus Document Identifier

  • 85078866486

Digital Object Identifier (DOI)

  • 10.1172/JCI129126

PubMed ID

  • 31855575

Additional Document Info

volume

  • 130

issue

  • 2