The Journal of clinical investigation

publication venue for

RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis. 2022
SARS-CoV-2 infection of the placenta. 2020
Autoantibody to the C3b/C4b receptor and absence of this receptor from erythrocytes of a patient with systemic lupus erythematosus. 1985
Lymphatic dysfunction in lupus contributes to cutaneous photosensitivity and lymph node B cell responses. 2025
Clinical evidence for independent regulation of vitamin D by intestinal CYP24A1. Reply.. 135. 2025
Intestinal Cyp24a1 regulates vitamin D locally independent of systemic regulation by renal Cyp24a1 in mice. 2024
Estimation of prevalence of autoimmune diseases in the United States using electronic health record data. 2024
In utero human cytomegalovirus infection expands NK-like FcγRIII+ CD8+ T cells that mediate Fc antibody functions. 2024
Leptin signaling maintains autonomic stability during severe influenza infection in mice. 2024
Itm2a expression marks periosteal skeletal stem cells that contribute to bone fracture healing.. 134. 2024
Pharmacologic LDH inhibition redirects intratumoral glucose uptake and improves antitumor immunity in solid tumor models.. 134. 2024
Pharmacological suppression of the OTUD4/CD73 proteolytic axis revives antitumor immunity against immune-suppressive breast cancers.. 134. 2024
Corticosteroids impair epithelial regeneration in immune-mediated intestinal damage. 2024
KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss.. 134. 2024
A membrane-associated phosphoswitch in Rad controls adrenergic regulation of cardiac calcium channels. 2024
Impaired T cell IRE1α/XBP1 signaling directs inflammation in experimental heart failure with preserved ejection fraction.. 133. 2023
Somatic estrogen receptor α mutations that induce dimerization promote receptor activity and breast cancer proliferation. 2023
Clinical-genomic determinants of immune checkpoint blockade response in head and neck squamous cell carcinoma.. 133. 2023
Hyperphosphorylation of BCL-2 family proteins underlies functional resistance to venetoclax in lymphoid malignancies. 2023
Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting β cell differentiation.. 133. 2023
Inflammatory ER stress responses dictate the immunopathogenic progression of systemic candidiasis.. 133. 2023
IL-18-secreting CAR T cells targeting DLL3 are highly effective in small cell lung cancer models.. 133. 2023
Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody to antigenically distinct Omicron subvariants. 2023
Epsilon toxin-producing Clostridium perfringens colonize the MS gut and epsilon toxin overcomes immune privilege. 2023
A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas.. 132. 2022
TIAM1-mediated synaptic plasticity underlies comorbid depression-like and ketamine antidepressant-like actions in chronic pain.. 132. 2022
Human immunomodulatory ligand B7-1 mediates synaptic remodeling via the p75 neurotrophin receptor.. 132. 2022
Increased p53 expression induced by APR-246 reprograms tumor-associated macrophages to augment immune checkpoint blockade.. 132. 2022
Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert microenvironment and is sensitized by immunogenic viruses.. 132. 2022
An optimized bicistronic chimeric antigen receptor against GPC2 or CD276 overcomes heterogeneous expression in neuroblastoma.. 132. 2022
Tumor associated antigen PRAME exhibits dualistic functions that are targetable in diffuse large B-cell lymphoma. 2022
Protein kinase A drives paracrine crisis and WNT4-dependent testis tumor in Carney complex.. 131. 2021
SARS-CoV-2 vaccine effectiveness in preventing confirmed infection in pregnant women.. 131. 2021
Circular RNA cia-MAF drives self-renewal and metastasis of liver tumor-initiating cells via transcription factor MAFF.. 131. 2021
Tumor subtype defines distinct pathways of molecular and clinical progression in primary prostate cancer.. 131. 2021
Radiotherapy-exposed CD8+ and CD4+ neoantigens enhance tumor control.. 131. 2021
Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity.. 131. 2021
Mutant SF3B1 promotes AKT- and NF-κB-driven mammary tumorigenesis.. 131. 2021
A randomized double-blind controlled trial of convalescent plasma in adults with severe COVID-19. 131. 2021
Favorable outcomes of COVID-19 in recipients of hematopoietic cell transplantation.. 130. 2020
ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming.. 130. 2020
Cyclophilin D-dependent oligodendrocyte mitochondrial ion leak contributes to neonatal white matter injury.. 130. 2020
Taxane resistance in prostate cancer is mediated by decreased drug-target engagement.. 130. 2020
Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood.. 130. 2020
Circulating tumor DNA profile recognizes transformation to castration-resistant neuroendocrine prostate cancer.. 130. 2020
Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases.. 130. 2020
Decreased sphingolipid synthesis in children with 17q21 asthma-risk genotypes.. 130. 2020
Notch inhibition overcomes resistance to tyrosine kinase inhibitors in EGFR-driven lung adenocarcinoma.. 130. 2020
Off-the-shelf EBV-specific T cell immunotherapy for rituximab-refractory EBV-associated lymphoma following transplantation.. 130. 2020
Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling.. 129. 2019
Genetic hallmarks of recurrent/metastatic adenoid cystic carcinoma.. 129. 2019
In situ vaccination with defined factors overcomes T cell exhaustion in distant tumors.. 129. 2019
N-Myc-mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer.. 129. 2019
Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2.. 129. 2019
T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy.. 129. 2019
Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy.. 129. 2019
Cardiac CaV1.2 channels require β subunits for β-adrenergic-mediated modulation but not trafficking.. 129. 2019
An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup.. 129. 2018
CDCA7 and HELLS mutations undermine nonhomologous end joining in centromeric instability syndrome.. 129. 2018
Spec-seq unveils transcriptional subpopulations of antibody-secreting cells following influenza vaccination.. 129. 2018
The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction.. 128. 2018
HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers.. 128. 2018
Hgf/Met activation mediates resistance to BRAF inhibition in murine anaplastic thyroid cancers.. 128. 2018
SNAP23 regulates BAX-dependent adipocyte programmed cell death independently of canonical macroautophagy.. 128. 2018
Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells.. 128. 2018
Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth.. 128. 2018
Blocking IFNAR1 inhibits multiple myeloma-driven Treg expansion and immunosuppression.. 128. 2018
COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors.. 128. 2018
PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy.. 128. 2018
iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling.. 128. 2018
JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition.. 128. 2018
Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma.. 128. 2017
SPOP mutation drives prostate neoplasia without stabilizing oncogenic transcription factor ERG.. 128. 2017
Thioesterase-mediated control of cellular calcium homeostasis enables hepatic ER stress.. 128. 2017
Endothelial jagged-2 sustains hematopoietic stem and progenitor reconstitution after myelosuppression.. 127. 2017
Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling.. 127. 2017
Introduction of Laurie H. Glimcher, MD.. 127. 2017
Anthrax toxin receptor 1 is the cellular receptor for Seneca Valley virus.. 127. 2017
A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigens.. 127. 2017
Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells.. 127. 2017
MYC-dependent oxidative metabolism regulates osteoclastogenesis via nuclear receptor ERRα.. 127. 2017
Identification of a nucleoside analog active against adenosine kinase-expressing plasma cell malignancies.. 127. 2017
TNF superfamily receptor OX40 triggers invariant NKT cell pyroptosis and liver injury.. 127. 2017
A proangiogenic signaling axis in myeloid cells promotes malignant progression of glioma.. 127. 2017
Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine.. 127. 2017
Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder.. 127. 2017
Prolonged red cell storage before transfusion increases extravascular hemolysis.. 127. 2016
Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension.. 126. 2016
Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer.. 126. 2016
Dendritic cells maintain dermal adipose-derived stromal cells in skin fibrosis.. 126. 2016
Sustained ERK inhibition maximizes responses of BrafV600E thyroid cancers to radioiodine.. 126. 2016
Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin.. 126. 2016
Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma.. 126. 2016
Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition.. 126. 2016
CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer.. 126. 2016
c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma.. 126. 2016
Schwann cells induce cancer cell dispersion and invasion.. 126. 2016
Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers.. 126. 2016
PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis.. 126. 2016
Pharmacoproteomics identifies combinatorial therapy targets for diffuse large B cell lymphoma.. 125. 2015
Insulin demand regulates β cell number via the unfolded protein response.. 125. 2015
Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients.. 125. 2015
Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage.. 125. 2015
Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.. 125. 2015
Resetting the transcription factor network reverses terminal chronic hepatic failure.. 125. 2015
Preexisting human antibodies neutralize recently emerged H7N9 influenza strains.. 125. 2015
Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation.. 125. 2015
Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma.. 125. 2015
Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.. 125. 2015
Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription.. 125. 2015
Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells.. 125. 2015
UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis.. 125. 2015
LMP1-deficient Epstein-Barr virus mutant requires T cells for lymphomagenesis.. 125. 2014
mTORC2 regulates renal tubule sodium uptake by promoting ENaC activity.. 125. 2014
RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis.. 124. 2014
Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD.. 124. 2014
Network modulation following sham surgery in Parkinson's disease.. 124. 2014
Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRβ1-governed pathway.. 124. 2014
Melanoma NOS1 expression promotes dysfunctional IFN signaling.. 124. 2014
Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation.. 124. 2014
Transport properties of pancreatic cancer describe gemcitabine delivery and response.. 124. 2014
Taxonomy of breast cancer based on normal cell phenotype predicts outcome.. 124. 2014
Identification of kinase fusion oncogenes in post-Chernobyl radiation-induced thyroid cancers.. 123. 2013
Retinal angiogenesis suppression through small molecule activation of p53.. 123. 2013
Metabolic network as a progression biomarker of premanifest Huntington's disease.. 123. 2013
Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.. 123. 2013
HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma.. 123. 2013
Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia.. 123. 2013
Adoptively transferred TRAIL+ T cells suppress GVHD and augment antitumor activity.. 123. 2013
Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice.. 123. 2013
Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development.. 123. 2013
ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer.. 123. 2013
iRHOM2 is a critical pathogenic mediator of inflammatory arthritis.. 123. 2013
β4 Integrin signaling induces expansion of prostate tumor progenitors.. 123. 2013
p62 links β-adrenergic input to mitochondrial function and thermogenesis.. 123. 2012
Vertical T cell immunodominance and epitope entropy determine HIV-1 escape.. 123. 2012
C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia.. 122. 2012
Extrathymic development of murine T cells after bone marrow transplantation.. 122. 2012
A misplaced lncRNA causes brachydactyly in humans.. 122. 2012
ER stress in the brain subfornical organ mediates angiotensin-dependent hypertension.. 122. 2012
Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.. 122. 2012
Chemokine 25-induced signaling suppresses colon cancer invasion and metastasis.. 122. 2012
Unlicensed NK cells target neuroblastoma following anti-GD2 antibody treatment.. 122. 2012
Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice.. 122. 2012
Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice.. 122. 2011
In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafish.. 121. 2011
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation.. 121. 2011
FGF23 induces left ventricular hypertrophy.. 121. 2011
MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice.. 121. 2011
In vitro differentiation of human macrophages with enhanced antimycobacterial activity.. 121. 2011
Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis.. 121. 2011
Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies.. 121. 2011
Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma.. 121. 2011
Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice.. 121. 2011
Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice.. 121. 2011
Kaposi sarcoma herpesvirus (KSHV) vFLIP oncoprotein induces B cell transdifferentiation and tumorigenesis in mice.. 121. 2011
Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2.. 121. 2010
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice.. 121. 2010
Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans.. 120. 2010
Transplantation of mouse HSCs genetically modified to express a CD4-restricted TCR results in long-term immunity that destroys tumors and initiates spontaneous autoimmunity.. 120. 2010
BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy.. 120. 2010
The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration.. 120. 2010
Replacing adenoviral vector HVR1 with a malaria B cell epitope improves immunogenicity and circumvents preexisting immunity to adenovirus in mice.. 120. 2010
CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations.. 120. 2010
The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice.. 120. 2010
Identification of a B cell signature associated with renal transplant tolerance in humans.. 120. 2010
Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis.. 120. 2010
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.. 120. 2010
Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion.. 120. 2010
FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice.. 120. 2009
The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease.. 120. 2009
Tregs control the development of symptomatic West Nile virus infection in humans and mice.. 119. 2009
Extracellular K+ concentration controls cell surface density of IKr in rabbit hearts and of the HERG channel in human cell lines.. 119. 2009
Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity.. 119. 2009
Endothelial NOS, estrogen receptor beta, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer.. 119. 2009
Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling.. 119. 2009
CD4+ T cells mediate cytotoxicity in neurodegenerative diseases.. 119. 2009
Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease.. 118. 2008
CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors.. 118. 2008
Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas.. 117. 2007
Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway.. 117. 2007
Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk.. 117. 2007
Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina.. 117. 2007
Improved tumor imaging and therapy via i.v. IgG-mediated time-sequential modulation of neonatal Fc receptor.. 117. 2007
Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease.. 117. 2007
Improved prediction of prostate cancer recurrence through systems pathology.. 117. 2007
Mature B cells class switched to IgD are autoreactive in healthy individuals.. 117. 2007
Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization.. 116. 2006
Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes.. 116. 2006
NF-kappaB2 is required for the establishment of central tolerance through an Aire-dependent pathway.. 116. 2006
Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection.. 116. 2006
Possible axonal regrowth in late recovery from the minimally conscious state.. 116. 2006
Trans-cyclopropanation of mycolic acids on trehalose dimycolate suppresses Mycobacterium tuberculosis -induced inflammation and virulence.. 116. 2006
Optimization of a self antigen for presentation of multiple epitopes in cancer immunity.. 116. 2006
Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion.. 116. 2006
Differential exoprotease activities confer tumor-specific serum peptidome patterns.. 116. 2006
Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients.. 116. 2005
Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling.. 115. 2005
Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions.. 115. 2005
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease.. 115. 2005
Protection against P. aeruginosa with an adenovirus vector containing an OprF epitope in the capsid.. 115. 2005
Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors.. 115. 2005
The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses.. 115. 2005
Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer.. 115. 2005
Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics.. 114. 2004
Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference.. 114. 2004
Structural and functional impairment of endocytic pathways by retinitis pigmentosa mutant rhodopsin-arrestin complexes.. 114. 2004
Human immunoglobulin selection associated with class switch and possible tolerogenic origins for C delta class-switched B cells.. 113. 2004
Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection.. 113. 2004
Site and mechanism of leptin action in a rodent form of congenital lipodystrophy.. 113. 2004
Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo.. 113. 2004
Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome.. 112. 2003
Differential regulation of CCL21 in lymphoid/nonlymphoid tissues for effectively attracting T cells to peripheral tissues.. 112. 2003
Collecting duct-specific gene inactivation of alphaENaC in the mouse kidney does not impair sodium and potassium balance.. 112. 2003
Altered cutaneous immune parameters in transgenic mice overexpressing viral IL-10 in the epidermis.. 111. 2003
PPARgamma ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis.. 110. 2002
Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer.. 110. 2002
Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy.. 109. 2002
Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells.. 109. 2002
Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain.. 109. 2002
Multiple immuno-regulatory defects in type-1 diabetes.. 109. 2002
The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT.. 108. 2001
Selective deletion of leptin receptor in neurons leads to obesity.. 108. 2001
Discordant effects of anti-VLA-4 treatment before and after onset of relapsing experimental autoimmune encephalomyelitis.. 107. 2001
Neutral endopeptidase inhibits prostate cancer cell migration by blocking focal adhesion kinase signaling.. 106. 2000
Role of the Cdc25A phosphatase in human breast cancer.. 106. 2000
Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration.. 106. 2000
Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms.. 105. 2000
Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species.. 105. 2000
Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice.. 105. 2000
Chemotaxis of primitive hematopoietic cells in response to stromal cell-derived factor-1.. 105. 2000
Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury.. 104. 1999
Airway epithelial CFTR mRNA expression in cystic fibrosis patients after repetitive administration of a recombinant adenovirus.. 104. 1999
Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog.. 104. 1999
HIV-1-specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy.. 104. 1999
Augmentation of pulmonary host defense against Pseudomonas by FcgammaRIIA cDNA transfer to the respiratory epithelium.. 104. 1999
Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF.. 104. 1999
Endogenous IL-1alpha from systemic sclerosis fibroblasts induces IL-6 and PDGF-A.. 103. 1999
CAR-dependent and CAR-independent pathways of adenovirus vector-mediated gene transfer and expression in human fibroblasts.. 103. 1999
Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice.. 103. 1999
Functional activation of lymphocyte CD44 in peripheral blood is a marker of autoimmune disease activity.. 102. 1998
In vivo human carboxylesterase cDNA gene transfer to activate the prodrug CPT-11 for local treatment of solid tumors.. 101. 1998
Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase.. 101. 1998
Interleukin-10 promotes activation-induced cell death of SLE lymphocytes mediated by Fas ligand.. 100. 1997
Genomic instability in the type II TGF-beta1 receptor gene in atherosclerotic and restenotic vascular cells.. 100. 1997
Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice.. 100. 1997
A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease.. 100. 1997
The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39.. 99. 1997
Prevention of hepatic tumor metastases in rats with herpes viral vaccines and gamma-interferon.. 99. 1997
Bacterial infection induces nitric oxide synthase in human neutrophils.. 99. 1997
Acute lung injury fibroblast migration and invasion of a fibrin matrix is mediated by CD44.. 98. 1996
Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes.. 98. 1996
1H-NMR detectable fatty acyl chain unsaturation in excised leiomyosarcoma correlate with grade and mitotic activity.. 98. 1996
Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans.. 97. 1996
Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression.. 97. 1996
Decreased type II/type I TGF-beta receptor ratio in cells derived from human atherosclerotic lesions. Conversion from an antiproliferative to profibrotic response to TGF-beta1.. 96. 1995
Activation of cultured vascular endothelial cells by antiphospholipid antibodies.. 96. 1995
Induction of cyclooxygenase-2 in human umbilical vein endothelial cells by lysophosphatidylcholine.. 96. 1995
Nitric oxide suppression of human hematopoiesis in vitro. Contribution to inhibitory action of interferon-gamma and tumor necrosis factor-alpha.. 96. 1995
Somatic mutation and CDR3 lengths of immunoglobulin kappa light chains expressed in patients with rheumatoid arthritis and in normal individuals.. 96. 1995
Tumor necrosis factor-alpha gene and protein expression in adult feline myocardium after endotoxin administration.. 96. 1995
Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation.. 96. 1995
T cell proliferative response induced by DNA topoisomerase I in patients with systemic sclerosis and healthy donors.. 96. 1995
Adenoviral-mediated gene transfer to fetal pulmonary epithelia in vitro and in vivo.. 95. 1995
Fc gamma receptor IIIb enhances Fc gamma receptor IIa function in an oxidant-dependent and allele-sensitive manner.. 95. 1995
Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin.. 95. 1995
Effect of granulocyte-macrophage colony-stimulating factor in experimental visceral leishmaniasis.. 95. 1995
Specific inhibition of eIF-5A and collagen hydroxylation by a single agent. Antiproliferative and fibrosuppressive effects on smooth muscle cells from human coronary arteries.. 95. 1995
Interleukin-1 beta-modulated gene expression in immortalized human chondrocytes.. 94. 1994
Intracellular ionic consequences of dietary salt loading in essential hypertension. Relation to blood pressure and effects of calcium channel blockade.. 94. 1994
Autoantigen-specific T cell proliferation induced by the ribosomal P2 protein in patients with systemic lupus erythematosus.. 94. 1994
Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model.. 93. 1994
Vasodilation of rat retinal microvessels induced by monobutyrin. Dysregulation in diabetes.. 92. 1993
Distinct patterns of expression of fibroblast growth factors and their receptors in human atheroma and nonatherosclerotic arteries. Association of acidic FGF with plaque microvessels and macrophages.. 92. 1993
Plasma triglycerides determine low density lipoprotein composition, physical properties, and cell-specific binding in cultured cells.. 91. 1993
High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas.. 91. 1993
Mesenchymal cells isolated after acute lung injury manifest an enhanced proliferative phenotype.. 90. 1992
Novel Fc gamma receptor I family gene products in human mononuclear cells.. 90. 1992
Regulation of insulin-like growth factor-I and its receptor in rat aorta after balloon denudation. Evidence for local bioactivity.. 90. 1992
Molecular genetics of steroid 5 alpha-reductase 2 deficiency.. 90. 1992
The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro.. 90. 1992
Allelic polymorphisms of human Fc gamma receptor IIA and Fc gamma receptor IIIB. Independent mechanisms for differences in human phagocyte function.. 89. 1992
Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase.. 89. 1992
Abundant expression of parathyroid hormone-related protein in primary rat aortic smooth muscle cells accompanies serum-induced proliferation.. 88. 1991
150-kD von Willebrand factor binding protein extracted from human vascular subendothelium is type VI collagen.. 88. 1991
Preferential expression of human Fc gamma RIIIPMN (CD16) in paroxysmal nocturnal hemoglobinuria. Discordant expression of glycosyl phosphatidylinositol-linked proteins.. 87. 1991
Insulin-like growth factor I expression by tumors of neuroectodermal origin with the t(11;22) chromosomal translocation. A potential autocrine growth factor.. 86. 1990
Metabolic effects of cachectin/tumor necrosis factor are modified by site of production. Cachectin/tumor necrosis factor-secreting tumor in skeletal muscle induces chronic cachexia, while implantation in brain induces predominantly acute anorexia.. 86. 1990
The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. Further evidence that some autoantibodies are unmutated copies of germ line genes.. 86. 1990
Cytokine-dependent long-term culture of highly enriched precursors of hematopoietic progenitor cells from human bone marrow.. 86. 1990
Clonal composition of benign and malignant human thyroid tumors.. 86. 1990
Fc gamma receptor III on human neutrophils. Allelic variants have functionally distinct capacities.. 85. 1990
Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties.. 85. 1990
Role of thyroid hormones in apolipoprotein A-I gene expression in rat liver.. 85. 1990
Biochemical basis of synergy between antigen and T-helper (Th) cell-mediated activation of resting human B cells.. 84. 1989
Human immunodeficiency virus infection of helper T cell clones. Early proliferative defects despite intact antigen-specific recognition and interleukin 4 secretion.. 83. 1989
Presence of a non-HLA B cell antigen in rheumatic fever patients and their families as defined by a monoclonal antibody.. 83. 1989
Expression of class I and class II major histocompatibility antigens on human hepatocellular carcinoma.. 83. 1989
Antiadrenergic effects of adenosine on His-Purkinje automaticity. Evidence for accentuated antagonism.. 82. 1988
Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes.. 82. 1988
Amplification of altered self-reactive cytolytic T lymphocyte responses by cloned, allospecific human Th cells.. 82. 1988
Phase I study of granulocyte colony-stimulating factor in patients with transitional cell carcinoma of the urothelium.. 82. 1988
Identification of transcripts encoding a parathyroid hormone-like peptide in messenger RNAs from a variety of human and animal tumors associated with humoral hypercalcemia of malignancy.. 81. 1988
Decay-accelerating factor protects human tumor cells from complement-mediated cytotoxicity in vitro.. 81. 1988
In vitro adenylate cyclase-stimulating activity predicts the occurrence of humoral hypercalcemia of malignancy in nude mice.. 81. 1988
Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes.. 80. 1987
PolyI.polyC12U-mediated inhibition of loss of alloantigen responsiveness viral replication in human CD4+ T cell clones exposed to human immunodeficiency virus in vitro.. 80. 1987
Herpes simplex virus infection in human arterial cells. Implications in arteriosclerosis.. 80. 1987
Relationship between canine transthoracic impedance and defibrillation threshold. Evidence for current-based defibrillation.. 80. 1987
High density lipoprotein2. Relationship of the plasma levels of this lipoprotein species to its composition, to the magnitude of postprandial lipemia, and to the activities of lipoprotein lipase and hepatic lipase.. 80. 1987
Hydrogen peroxide release by alveolar macrophages from sarcoid patients and by alveolar macrophages from normals after exposure to recombinant interferons alpha A, beta, and gamma and 1,25-dihydroxyvitamin D3.. 80. 1987
Sn-protoporphyrin inhibition of fetal and neonatal brain heme oxygenase. Transplacental passage of the metalloporphyrin and prenatal suppression of hyperbilirubinemia in the newborn animal.. 77. 1986
In vivo interaction of synthetic acylated apopeptides with high density lipoproteins in rat.. 77. 1986
Sn-protoporphyrin suppresses chemically induced experimental hepatic porphyria. Potential clinical implications.. 76. 1985
Mechanoelectrical feedback: independent role of preload and contractility in modulation of canine ventricular excitability.. 76. 1985
Production of and in vitro response to interleukin 2 in the acquired immunodeficiency syndrome.. 76. 1985
Degradation of heparan sulfate in the subendothelial extracellular matrix by a readily released heparanase from human neutrophils. Possible role in invasion through basement membranes.. 76. 1985
Enhancement of the impaired autologous mixed leukocyte reaction in patients with systemic lupus erythematosus.. 76. 1985
Hydrogen peroxide from cellular metabolism of cystine. A requirement for lysis of murine tumor cells by vernolepin, a glutathione-depleting antineoplastic.. 76. 1985
Resistance of human tumor cells in vitro to oxidative cytolysis.. 76. 1985
Nifedipine increases cholesteryl ester hydrolytic activity in lipid-laden rabbit arterial smooth muscle cells. A possible mechanism for its antiatherogenic effect.. 75. 1985
Studies on the mechanism of Sn-protoporphyrin suppression of hyperbilirubinemia. Inhibition of heme oxidation and bilirubin production.. 75. 1985
Sn-protoporphyrin rapidly and markedly enhances the heme saturation of hepatic tryptophan pyrrolase. Evidence that this synthetic metalloporphyrin increases the functional content of heme in the liver.. 75. 1985
Induction of cytolytic activity by anti-T3 monoclonal antibody. Activation of alloimmune memory cells and natural killer cells from normal and immunodeficient individuals.. 74. 1984
Metabolism of apolipoprotein B in large triglyceride-rich very low density lipoproteins of normal and hypertriglyceridemic subjects.. 74. 1984
Modulation of the immune response by gangliosides. Inhibition of adherent monocyte accessory function in vitro.. 74. 1984
Postprandial lipemia. A key for the conversion of high density lipoprotein2 into high density lipoprotein3 by hepatic lipase.. 74. 1984
Degradation of sulfated proteoglycans in the subendothelial extracellular matrix by human platelet heparitinase.. 74. 1984
Interaction between the legionnaires' disease bacterium (Legionella pneumophila) and human alveolar macrophages. Influence of antibody, lymphokines, and hydrocortisone.. 74. 1984
Porphyrin-heme biosynthesis in organotypic cultures of mouse dorsal root ganglia. Effects of heme and lead on porphyrin synthesis and peripheral myelin.. 74. 1984
An experimental model of postnatal jaundice in the suckling rat. Suppression of induced hyperbilirubinemia by Sn-protoporphyrin.. 74. 1984
Gallium nitrate inhibits calcium resorption from bone and is effective treatment for cancer-related hypercalcemia.. 73. 1984
Interferon enhances prostacyclin production by cultured vascular endothelial cells.. 73. 1984
Localization of 131I-labeled p97-specific Fab fragments in human melanoma as a basis for radiotherapy.. 72. 1983
Metabolism of estradiol in liver cell culture. Differential responses of C-2 and C-16 oxidations to drugs and other chemicals that induce selective species of cytochrome P-450.. 72. 1983
Genetic regulation of a structural polymorphism of human C3b receptor.. 72. 1983
Delineation of four cell types comprising the giant cell tumor of bone. Expression of Ia and monocyte-macrophage lineage antigens.. 71. 1983
Hereditary tyrosinemia and the heme biosynthetic pathway. Profound inhibition of delta-aminolevulinic acid dehydratase activity by succinylacetone.. 71. 1983
Inhibition of glutathione synthesis augments lysis of murine tumor cells by sulfhydryl-reactive antineoplastics.. 71. 1983
Lymphokines enhance the capacity of human monocytes to secret reactive oxygen intermediates.. 70. 1982
Prostacyclin modulates cholesteryl ester hydrolytic activity by its effect on cyclic adenosine monophosphate in rabbit aortic smooth muscle cells.. 70. 1982
Hypertriglyceridemic very low density lipoproteins induce triglyceride synthesis and accumulation in mouse peritoneal macrophages.. 70. 1982
Immunohistochemical study of the human glomerular C3b receptor in normal kidney and in seventy-five cases of renal diseases: loss of C3b receptor antigen in focal hyalinosis and in proliferative nephritis of systemic lupus erythematosus.. 69. 1982
Studies in porphyria: functional evidence for a partial deficiency of ferrochelatase activity in mitogen-stimulated lymphocytes from patients with erythropoietic protoporphyria.. 69. 1982
Hydrogen peroxide metabolism in human monocytes during differentiation in vitro.. 68. 1981
Platelet Fc receptor. Increased expression in myeloproliferative disease.. 67. 1981
Recovery of prostacyclin production by de-endothelialized rabbit aorta. Critical role of neointimal smooth muscle cells.. 67. 1981
Structural determinants of the capacity of heparin to inhibit the formation of the human amplification C3 convertase.. 67. 1981
Synthesis of prostacyclin from platelet-derived endoperoxides by cultured human endothelial cells.. 66. 1980
Spectrum of immunodeficiencies with Hodgkin's disease.. 66. 1980
Stage-dependent reduction in T colony formation in Hodgkin's disease. Coincidence with monocyte synthesis of prostaglandins.. 66. 1980
Prostaglandin E inhibition of T-lymphocyte colony formation: a possible mechanism of monocyte modulation of clonal expansion.. 64. 1979
Association of HLA-DRw2 with autoimmune thrombocytopenic purpura.. 63. 1979
Effects of nicotinic acid therapy on plasma high density lipoprotein subfraction distribution and composition and on apolipoprotein A metabolism.. 63. 1979
Human skin aryl hydrocarbon hydroxylase. Induction by coal tar.. 62. 1978
Interaction of platelet membrane receptors with von Willebrand factor, ristocetin, and the Fc region of immunoglobulin G.. 62. 1978
Effects of dietary polyunsaturated and saturated fat on the properties of high density lipoproteins and the metabolism of apolipoprotein A-I.. 61. 1978
Deoxyguanosine triphosphate as a possible toxic metabolite in the immunodeficiency associated with purine nucleoside phosphorylase deficiency.. 61. 1978
Control of 3-hydroxy-3-methylglutaryl-CoA reductase activity in cultured human fibroblasts by very low density lipoproteins of subjects with hypertriglyceridemia.. 61. 1978
Studies in porphyria. VII. Induction of uroporphyrinogen-I synthase and expression of the gene defect of acute intermittent porphyria in mitogen-stimulated human lymphocytes.. 61. 1978
Effects of acetazolamide on proximal tubule C1, Na, and HCO3 transport in normal and acidotic dogs during distal blockade.. 60. 1977
Immunoinhibition of ristocetin-induced platelet aggregation.. 59. 1977
Induction of a deficiency of steroid delta 4-5 alpha-reductase activity in liver by a porphyrinogenic drug.. 59. 1977
Long term effects of radiation of T and B lymphocytes in peripheral blood of patients with Hodgkin's disease.. 58. 1976
Stimulators and inhibitors of hepatic porphyrin formation in human sera.. 53. 1974
In vitro antibody-enzyme conjugates with specific bactericidal activity.. 52. 1973
Coproporphyrin I and 3 excretion in bile and urine.. 51. 1972
Studies on the protein defect in Tangier disease. Isolation and characterization of an abnormal high density lipoprotein.. 51. 1972
Evidence for the identity of the major apoprotein in low density and very low density lipoproteins in normal subjects and patients with familial hyperlipoproteinemia.. 51. 1972
Characterization of human platelet vascular permeability-enhancing activity.. 51. 1972
Diphenylhydantoin and potassium transport in isolated nerve terminals.. 50. 1971
Increased vascular permeability produced by human platelet granule cationic extract.. 49. 1970
Effect of diphenylhydantoin on synaptosome sodium-potassium-ATPase.. 47. 1968
The effects of estradiol and estriol on plasma levels of cortisol and thyroid hormone-binding globulins and on aldosterone and cortisol secretion rates in man.. 46. 1967
Studies of cellular proliferation in human leukemia. I. Estimation of growth rates of leukemic and normal hematopoietic cells in two adults with acute leukemia given single injections of tritiated thymidine.. 46. 1967
Secretory products of macrophages: twenty-five years on.. 122. 2012
Finding a needle in a haystack: whole genome sequencing and mutation discovery in murine models.. 121. 2011
Upper urinary tract pacemaker cells join the GLI club.. 121. 2011
Resisting arrest: a switch from angiogenesis to vasculogenesis in recurrent malignant gliomas.. 120. 2010
Predicting response to hepatitis C therapy.. 119. 2009
Azathioprine: old drug, new actions.. 111. 2003
Can SOCS make arthritis better?. 111. 2003
Renal interstitial fibrosis: remembrance of things past?. 110. 2002
Circulating endothelial precursors: mystery, reality, and promise.. 105. 2000
Renal proximal tubule cells: power and finesse. 2023
Kidney to bone via bedside to bench…and back? 2020
Open the gates: vascular neurocrine signaling mobilizes hematopoietic stem and progenitor cells. 2017
Pruning the ricket thicket. 2016
αKlotho: FGF23 coreceptor and FGF23-regulating hormone. 2012
New horizons for studying human hepatotropic infections. 2010
The future of the ASCI (American Society for Clinical Investigation) : a lesson from 2000 presidential election. 2001
Tolerance to factor VIII inhibitors in hemophilia A patients: a French twist.. 97. 1996
Nitric oxide and biopterin: a study in Chiaroscuro.. 93. 1994
Preventing antiphospholipid antibody-induced fetal loss: a new idea.. 91. 1993
Immune responses to stroke: mechanisms, modulation, and therapeutic potential. 2020
Brain networks in Huntington disease. 2011
The legacy of the Philadelphia chromosome. 2007
Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling. 2003
Neuronal degeneration and mitochondrial dysfunction. 2003
Intracellular cholesterol transport. 2002
The therapeutic potential of modulating the ceramide/sphingomyelin pathway. 2002
Stat proteins and oncogenesis. 2002
Recent developments in lymphocyte activation: linking kinases to downstream signaling events. 1999
Inducible nitric oxide synthase: what difference does it make? 1997
Secretory products of macrophages. 1987
Control of heme metabolism with synthetic metalloporphyrins. 1986
Control of inflammation by integration of environmental cues by regulatory T cells. 2013
CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism. 2001

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