Immune responses to stroke: mechanisms, modulation, and therapeutic potential. Review uri icon

Overview

abstract

  • Stroke is the second leading cause of death worldwide and a leading cause of disability. Most strokes are caused by occlusion of a major cerebral artery, and substantial advances have been made in elucidating how ischemia damages the brain. In particular, increasing evidence points to a double-edged role of the immune system in stroke pathophysiology. In the acute phase, innate immune cells invade brain and meninges and contribute to ischemic damage, but may also be protective. At the same time, danger signals released into the circulation by damaged brain cells lead to activation of systemic immunity, followed by profound immunodepression that promotes life-threatening infections. In the chronic phase, antigen presentation initiates an adaptive immune response targeted to the brain, which may underlie neuropsychiatric sequelae, a considerable cause of poststroke morbidity. Here, we briefly review these pathogenic processes and assess the potential therapeutic value of targeting immunity in human stroke.

publication date

  • June 1, 2020

Research

keywords

  • Adaptive Immunity
  • Brain Ischemia
  • Stroke

Identity

PubMed Central ID

  • PMC7260029

Scopus Document Identifier

  • 85085904956

Digital Object Identifier (DOI)

  • 10.1172/JCI135530

PubMed ID

  • 32391806

Additional Document Info

volume

  • 130

issue

  • 6