Anrather, Josef

Publications

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selected publications

The immunology of stroke and dementia. Immunity. 2025 Review GET IT
A cell-autonomous role for border-associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury. Nature neuroscience. 2024 Academic Article GET IT
Molecular and functional alterations in the cerebral microvasculature in an optimized mouse model of sepsis-associated cognitive dysfunction. eNeuro. 2024 Academic Article GET IT
Correction: Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress. 2024 GET IT
A minimally invasive thrombotic stroke model to study circadian rhythm in awake mice. 2024 GET IT
Molecular and functional alterations in the cerebral microvasculature in an optimized mouse model of sepsis-associated cognitive dysfunction. 2024 GET IT
Correction: Comparative multi-omic analyses of cardiac mitochondrial stress in three mouse models of frataxin deficiency. 2024 GET IT
Analysis of brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke. Nature immunology. 2024 Academic Article GET IT
Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension. Nature neuroscience. 2023 Academic Article GET IT
Essential Role of Endothelial Sphingolipid Biosynthesis in Cerebrovascular Homeostasis. Circulation research. 2023 Academic Article GET IT
Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress. Molecular neurodegeneration. 2023 Academic Article GET IT
Comparative multi-omics analyses of cardiac mitochondrial stress in three mouse models of frataxin deficiency. Disease models & mechanisms. 2023 Academic Article GET IT
Highlighting a New Potential Target in Stroke: Immunoreceptor NKG2D. Journal of the American Heart Association. 2023 Editorial Article GET IT
Calcium transients in nNOS neurons underlie distinct phases of the neurovascular response to barrel cortex activation in awake mice. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2023 Academic Article GET IT
Immune compartments at the brain's borders in health and neurovascular diseases. Seminars in immunopathology. 2023 Review GET IT
The Neurovasculome: Key Roles in Brain Health and Cognitive Impairment: A Scientific Statement From the American Heart Association/American Stroke Association. Stroke. 2023 Review GET IT
A preclinical randomized controlled multi-centre trial of anti-interleukin-17A treatment for acute ischaemic stroke. Brain communications. 2023 Academic Article GET IT
DNA damage independent inhibition of NF-kB transcription by anthracyclines. eLife. 2022 Academic Article GET IT
Stroke affects intestinal immune cell trafficking to the central nervous system. Brain, behavior, and immunity. 2021 Academic Article GET IT
Role of microglial and endothelial CD36 in post-ischemic inflammasome activation and interleukin-1β-induced endothelial activation. Brain, behavior, and immunity. 2021 Academic Article GET IT
Times cited: 16
tPA Deficiency Underlies Neurovascular Coupling Dysfunction by Amyloid-β. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2020 Academic Article GET IT
Times cited: 35
Effects of COVID-19 on the Nervous System. Cell. 2020 Information Resource GET IT
Times cited: 478
Tau induces PSD95-neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration. Nature neuroscience. 2020 Academic Article GET IT
Times cited: 79
Endothelium-Macrophage Crosstalk Mediates Blood-Brain Barrier Dysfunction in Hypertension. Hypertension (Dallas, Tex. : 1979). 2020 Academic Article GET IT
Times cited: 127
Immune responses to stroke: mechanisms, modulation, and therapeutic potential. The Journal of clinical investigation. 2020 Information Resource GET IT
Times cited: 483
Distinct Commensal Bacterial Signature in the Gut Is Associated With Acute and Long-Term Protection From Ischemic Stroke. Stroke. 2020 Academic Article GET IT
Times cited: 76
Th17 and Cognitive Impairment: Possible Mechanisms of Action. Frontiers in neuroanatomy. 2019 Information Resource GET IT
Times cited: 86
Dietary salt promotes cognitive impairment through tau phosphorylation. Nature. 2019 Academic Article GET IT
Times cited: 169
AGO CLIP Reveals an Activated Network for Acute Regulation of Brain Glutamate Homeostasis in Ischemic Stroke. Cell reports. 2019 Academic Article GET IT
Times cited: 19
Ablation of nasal-associated lymphoid tissue does not affect focal ischemic brain injury in mice. PloS one. 2018 Academic Article GET IT
Times cited: 7
Endogenous Protection from Ischemic Brain Injury by Preconditioned Monocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2018 Academic Article GET IT
Times cited: 58
Diverse Inflammatory Response After Cerebral Microbleeds Includes Coordinated Microglial Migration and Proliferation. Stroke. 2018 Academic Article GET IT
Times cited: 61
Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response. Nature neuroscience. 2018 Academic Article GET IT
Times cited: 257
Brain perivascular macrophages: characterization and functional roles in health and disease. Journal of molecular medicine (Berlin, Germany). 2017 Information Resource GET IT
Times cited: 152
Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides. Circulation research. 2017 Academic Article GET IT
Times cited: 177
Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 163
Microbiota differences between commercial breeders impacts the post-stroke immune response. Brain, behavior, and immunity. 2017 Academic Article GET IT
Times cited: 24
Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension. The Journal of clinical investigation. 2016 Academic Article GET IT
Times cited: 262
Spatio-temporal profile, phenotypic diversity, and fate of recruited monocytes into the post-ischemic brain. Journal of neuroinflammation. 2016 Academic Article GET IT
Times cited: 91
Inflammation and Stroke: An Overview. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2016 Information Resource GET IT
Times cited: 702
Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells. Nature medicine. 2016 Academic Article GET IT
Times cited: 841
Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2016 Academic Article GET IT
Times cited: 141
Endothelial CD36 Contributes to Postischemic Brain Injury by Promoting Neutrophil Activation via CSF3. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015 Academic Article GET IT
Times cited: 49
The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation. Nucleic acids research. 2015 Academic Article GET IT
Times cited: 24
Immune interventions in stroke. Nature reviews. Neurology. 2015 Information Resource GET IT
Times cited: 321
The Myelin and Lymphocyte Protein MAL Is Required for Binding and Activity of Clostridium perfringens ε-Toxin. PLoS pathogens. 2015 Academic Article GET IT
Times cited: 71
The role of microglia and myeloid immune cells in acute cerebral ischemia. Frontiers in cellular neuroscience. 2015 Review GET IT
Times cited: 220
SUMO2/3 is associated with ubiquitinated protein aggregates in the mouse neocortex after middle cerebral artery occlusion. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2014 Academic Article GET IT
Times cited: 25
The key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction. Nature communications. 2014 Academic Article GET IT
Times cited: 110
Inducible nitric oxide synthase in neutrophils and endothelium contributes to ischemic brain injury in mice. Journal of immunology (Baltimore, Md. : 1950). 2014 Academic Article GET IT
Times cited: 111
Immune mechanisms in cerebral ischemic tolerance. Frontiers in neuroscience. 2014 Review GET IT
Times cited: 61
Water deprivation induces neurovascular and cognitive dysfunction through vasopressin-induced oxidative stress. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2014 Academic Article GET IT
Times cited: 48
Progranulin deficiency promotes post-ischemic blood-brain barrier disruption. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Academic Article GET IT
Times cited: 77
COX-1-derived PGE2 and PGE2 type 1 receptors are vital for angiotensin II-induced formation of reactive oxygen species and Ca(2+) influx in the subfornical organ. American journal of physiology. Heart and circulatory physiology. 2013 Academic Article GET IT
Times cited: 31
Circulating endothelin-1 alters critical mechanisms regulating cerebral microcirculation. Hypertension (Dallas, Tex. : 1979). 2013 Academic Article GET IT
Times cited: 48
Lipoprotein receptor-related protein-6 protects the brain from ischemic injury. Stroke. 2013 Academic Article GET IT
Times cited: 21
Prostaglandin E2 type 1 receptors contribute to neuronal apoptosis after transient forebrain ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2013 Academic Article GET IT
Times cited: 31
Angiotensin II slow-pressor hypertension enhances NMDA currents and NOX2-dependent superoxide production in hypothalamic paraventricular neurons. American journal of physiology. Regulatory, integrative and comparative physiology. 2013 Academic Article GET IT
Times cited: 55
Innate immunity receptor CD36 promotes cerebral amyloid angiopathy. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 109
Biological networks in ischemic tolerance - rethinking the approach to clinical conditioning. Translational stroke research. 2013 Information Resource GET IT
Times cited: 17
Site-specific phosphorylation of the p65 protein subunit mediates selective gene expression by differential NF-κB and RNA polymerase II promoter recruitment. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 59
Regulation of nuclear factor κB (NF-κB) transcriptional activity via p65 acetylation by the chaperonin containing TCP1 (CCT). PloS one. 2012 Academic Article GET IT
Times cited: 32
Reperfusion rather than ischemia drives the formation of ubiquitin aggregates after middle cerebral artery occlusion. Stroke. 2012 Academic Article GET IT
Times cited: 49
Endothelin 1-dependent neurovascular dysfunction in chronic intermittent hypoxia. Hypertension (Dallas, Tex. : 1979). 2012 Academic Article GET IT
Times cited: 61
Central cardiovascular circuits contribute to the neurovascular dysfunction in angiotensin II hypertension. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Academic Article GET IT
Times cited: 87
Angiotensin II type 2 receptor-coupled nitric oxide production modulates free radical availability and voltage-gated Ca2+ currents in NTS neurons. American journal of physiology. Regulatory, integrative and comparative physiology. 2012 Academic Article GET IT
Times cited: 24
Angiotensin II-dependent hypertension requires cyclooxygenase 1-derived prostaglandin E2 and EP1 receptor signaling in the subfornical organ of the brain. Hypertension (Dallas, Tex. : 1979). 2012 Academic Article GET IT
Times cited: 50
Monoubiquitination of nuclear RelA negatively regulates NF-κB activity independent of proteasomal degradation. Cellular and molecular life sciences : CMLS. 2012 Academic Article GET IT
Times cited: 23
Stroke research at a crossroad: asking the brain for directions. Nature neuroscience. 2011 Academic Article GET IT
Times cited: 345
Purinergic signaling induces cyclooxygenase-1-dependent prostanoid synthesis in microglia: roles in the outcome of excitotoxic brain injury. PloS one. 2011 Academic Article GET IT
Times cited: 30
The immunology of stroke: from mechanisms to translation. Nature medicine. 2011 Information Resource GET IT
Times cited: 2020
Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-beta. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 141
The scavenger receptor CD36 contributes to the neurotoxicity of bone marrow-derived monocytes through peroxynitrite production. Neurobiology of disease. 2011 Academic Article GET IT
Times cited: 11
Chronic intermittent hypoxia induces NMDA receptor-dependent plasticity and suppresses nitric oxide signaling in the mouse hypothalamic paraventricular nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 Academic Article GET IT
Times cited: 62
Key role of CD36 in Toll-like receptor 2 signaling in cerebral ischemia. Stroke. 2010 Academic Article GET IT
Times cited: 112
Cyclooxygenase 1-derived prostaglandin E2 and EP1 receptors are required for the cerebrovascular dysfunction induced by angiotensin II. Hypertension (Dallas, Tex. : 1979). 2010 Academic Article GET IT
Times cited: 57
Angiotensin II type 2 receptors have a major somatodendritic distribution in vasopressin-containing neurons in the mouse hypothalamic paraventricular nucleus. Neuroscience. 2009 Academic Article GET IT
Times cited: 28
Estrous cycle-dependent neurovascular dysfunction induced by angiotensin II in the mouse neocortex. Hypertension (Dallas, Tex. : 1979). 2009 Academic Article GET IT
Times cited: 41
Termination of NF-kappaB activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligase. The EMBO journal. 2009 Academic Article GET IT
Times cited: 54
NMDA receptor activation increases free radical production through nitric oxide and NOX2. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Academic Article GET IT
Times cited: 216
The neuroprotective effect of prostaglandin E2 EP1 receptor inhibition has a wide therapeutic window, is sustained in time and is not sexually dimorphic. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2008 Academic Article GET IT
Times cited: 73
Nuclear factor-kappaB activation and postischemic inflammation are suppressed in CD36-null mice after middle cerebral artery occlusion. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Academic Article GET IT
Times cited: 101
Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 282
Key role of tissue plasminogen activator in neurovascular coupling. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 83
Heme oxygenase-1 inhibits the expression of adhesion molecules associated with endothelial cell activation via inhibition of NF-kappaB RelA phosphorylation at serine 276. Journal of immunology (Baltimore, Md. : 1950). 2007 Academic Article GET IT
Times cited: 106
Farnesyl transferase inhibitors induce neuroprotection by inhibiting Ha-Ras signalling pathway. The European journal of neuroscience. 2007 Academic Article GET IT
Times cited: 23
Hypo-phosphorylation leads to nuclear retention of NF-kappaB p65 due to impaired IkappaBalpha gene synthesis. FEBS letters. 2007 Academic Article GET IT
Times cited: 18
Lipopolysaccharide induces early tolerance to excitotoxicity via nitric oxide and cGMP. Stroke. 2007 Academic Article GET IT
Times cited: 34
Neurovascular protection by ischemic tolerance: role of nitric oxide and reactive oxygen species. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007 Academic Article GET IT
Times cited: 126
Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2007 Academic Article GET IT
Times cited: 195
iNOS-derived NO and nox2-derived superoxide confer tolerance to excitotoxic brain injury through peroxynitrite. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2007 Academic Article GET IT
Times cited: 39
Cerebrovascular nitrosative stress mediates neurovascular and endothelial dysfunction induced by angiotensin II. Arteriosclerosis, thrombosis, and vascular biology. 2006 Academic Article GET IT
Times cited: 106
Nox2, Ca2+, and protein kinase C play a role in angiotensin II-induced free radical production in nucleus tractus solitarius. Hypertension (Dallas, Tex. : 1979). 2006 Academic Article GET IT
Times cited: 92
Cyclooxygenase-2 does not contribute to postischemic production of reactive oxygen species. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2006 Academic Article GET IT
Times cited: 70
Inducible nitric oxide synthase contributes to gender differences in ischemic brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2006 Academic Article GET IT
Times cited: 102
Angiotensin II attenuates endothelium-dependent responses in the cerebral microcirculation through nox-2-derived radicals. Arteriosclerosis, thrombosis, and vascular biology. 2006 Academic Article GET IT
Times cited: 118
Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity. Nature medicine. 2006 Academic Article GET IT
Times cited: 313
NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox. The Journal of biological chemistry. 2006 Academic Article GET IT
Times cited: 265
The class B scavenger receptor CD36 mediates free radical production and tissue injury in cerebral ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Academic Article GET IT
Times cited: 189
NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Academic Article GET IT
Times cited: 225
cis-acting, element-specific transcriptional activity of differentially phosphorylated nuclear factor-kappa B. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 75
Interaction between inducible nitric oxide synthase and poly(ADP-ribose) polymerase in focal ischemic brain injury. Stroke. 2004 Academic Article GET IT
Times cited: 65
Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals. Circulation research. 2004 Academic Article GET IT
Times cited: 187
Exogenous NADPH increases cerebral blood flow through NADPH oxidase-dependent and -independent mechanisms. Arteriosclerosis, thrombosis, and vascular biology. 2004 Academic Article GET IT
Times cited: 50
NADPH oxidase contributes to angiotensin II signaling in the nucleus tractus solitarius. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Academic Article GET IT
Times cited: 163
Prostanoids, not reactive oxygen species, mediate COX-2-dependent neurotoxicity. Annals of neurology. 2004 Academic Article GET IT
Times cited: 127
Abeta-induced vascular oxidative stress and attenuation of functional hyperemia in mouse somatosensory cortex. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2004 Academic Article GET IT
Times cited: 109
Angiotensin II attenuates functional hyperemia in the mouse somatosensory cortex. American journal of physiology. Heart and circulatory physiology. 2003 Academic Article GET IT
Times cited: 73
Angiotensin II subtype 1A (AT1A) receptors in the rat sensory vagal complex: subcellular localization and association with endogenous angiotensin. Neuroscience. 2003 Academic Article GET IT
Times cited: 54
Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis. The Journal of experimental medicine. 2000 Academic Article GET IT
Times cited: 912
TNF-alpha gene expression in macrophages: regulation by NF-kappa B is independent of c-Jun or C/EBP beta. Journal of immunology (Baltimore, Md. : 1950). 2000 Academic Article GET IT
Times cited: 171
Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells. The Journal of biological chemistry. 1999 Academic Article GET IT
Times cited: 178
Rejection of cardiac xenografts by CD4+ or CD8+ T cells. Journal of immunology (Baltimore, Md. : 1950). 1999 Academic Article GET IT
Times cited: 24
Regulated and endothelial cell-specific expression of Fas ligand: an in vitro model for a strategy aiming at inhibiting xenograft rejection. Transplantation. 1998 Academic Article GET IT
Times cited: 16
Adenovirus-mediated expression of a dominant negative mutant of p65/RelA inhibits proinflammatory gene expression in endothelial cells without sensitizing to apoptosis. Journal of immunology (Baltimore, Md. : 1950). 1998 Academic Article GET IT
Times cited: 71
Expression of heme oxygenase-1 can determine cardiac xenograft survival. Nature medicine. 1998 Academic Article GET IT
Times cited: 547
Regulation of monocyte tissue factor activity by allogeneic and xenogeneic endothelial cells. Thrombosis and haemostasis. 1998 Academic Article GET IT
Times cited: 36
Activation of human platelets by the membrane-expressed A1 domain of von Willebrand factor. Blood. 1997 Academic Article GET IT
Times cited: 69
Glucocorticoids inhibit E-selectin expression by targeting NF-kappaB and not ATF/c-Jun. Journal of immunology (Baltimore, Md. : 1950). 1997 Academic Article GET IT
Times cited: 124
Effect of porcine endothelial tissue factor pathway inhibitor on human coagulation factors. Transplantation. 1997 Academic Article GET IT
Times cited: 95
Inhibition of bovine endothelial cell activation in vitro by regulated expression of a transdominant inhibitor of NF-kappa B. The Journal of clinical investigation. 1997 Academic Article GET IT
Times cited: 69
Identification and characterization of CD39/vascular ATP diphosphohydrolase. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 443
The intron-exon structure of the porcine E-selectin-encoding gene. Gene. 1996 Academic Article GET IT
Times cited: 8
Glucocorticoid-mediated repression of NFkappaB activity in endothelial cells does not involve induction of IkappaBalpha synthesis. The Journal of biological chemistry. 1996 Academic Article GET IT
Times cited: 190
Characterisation of dog allergens by means of immunoblotting. International archives of allergy and immunology. 1993 Academic Article GET IT
Times cited: 37
Allergen profiles of dog hair and dander, body fluids and tissues as defined by immunoblotting. International archives of allergy and applied immunology. 1991 Academic Article GET IT
Times cited: 14

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Research

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Co-investigator Network

Funding awarded

The role of dendritic cells in regulating the gut-brain immune axis in ischemic stroke awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2023 - 2028
missing activity Principal Investigator 2020 - 2024
missing activity Principal Investigator 2018 - 2024

Gut Immunity, Neurovascular dysregulation and Cognitive Impairment awarded by National Institute of Neurological Disorders & Stroke Co-Investigator 2022 - 2027
missing activity Co-Investigator 2022 - 2025

Intestinal microbiota affect stroke outcome by modulating the dendritic cell-regulatory T cell axis awarded by National Institute of Neurological Disorders & Stroke Key Personnel 2023 - 2026

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Background

education and training

V.M.D., University of Vienna (Austria) 91
M.S., University of Vienna (Austria) 1987

Contact

full name

Josef Anrather

primary email

joa2006@med.cornell.edu

VIVO Weill Cornell Medical College

Josef Anrather Professor of Neuroscience

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email