selected publications
- Immune Checkpoint Inhibitor Therapy and Associations with Clonal Hematopoiesis. International journal of molecular sciences. 2024 Academic Article GET IT
- Multiomic profiling identifies predictors of survival in African American patients with acute myeloid leukemia. Nature genetics. 2024 Academic Article GET IT
- Glucocorticoids paradoxically promote steroid resistance in B cell acute lymphoblastic leukemia through CXCR4/PLC signaling. Nature communications. 2024 Academic Article GET IT
- Cancer microenvironment and pharmacological interventions. British journal of pharmacology. 2024 Editorial Article GET IT
- A target discovery pipeline identified ILT3 as a target for immunotherapy of multiple myeloma. Cell reports. Medicine. 2023 Academic Article GET IT
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Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation.
Nature communications.
2023
Academic Article
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Times cited: 17 -
Updates on radiotherapy-immunotherapy combinations: Proceedings of 6th annual ImmunoRad conference.
Oncoimmunology.
2023
Review
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Times cited: 1 - Understanding the interaction between leukemia stem cells and their microenvironment to improve therapeutic approaches. British journal of pharmacology. 2023 Review GET IT
- Editorial: Measurable residual disease in hematologic malignancies. Frontiers in oncology. 2023 Editorial Article GET IT
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Radiation therapy improves CAR T cell activity in acute lymphoblastic leukemia.
Cell death & disease.
2023
Academic Article
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Times cited: 11 - Global representation among journal editors in haematology: are we diverse, equitable, and inclusive?. The Lancet. Haematology. 2023 Academic Article GET IT
- The eukaryotic translation initiation factor eIF4E reprograms alternative splicing. The EMBO journal. 2023 Academic Article GET IT
- Editorial: New immunotherapeutic and pharmacological targets and strategies in haematological malignancies. Frontiers in pharmacology. 2023 Editorial Article GET IT
- Paired bone marrow and peripheral blood samples demonstrate lack of widespread dissemination of some CH clones. Blood advances. 2022 Academic Article GET IT
- Cancer Stem Cells: Biology and Therapeutic Implications. Archives of medical research. 2022 Review GET IT
- CD123-directed allogeneic chimeric-antigen receptor T-cell therapy (CAR-T) in blastic plasmacytoid dendritic cell neoplasm (BPDCN): Clinicopathological insights. Leukemia research. 2022 Academic Article GET IT
- Analysis of Plant-Plant Interactions Reveals the Presence of Potent Antileukemic Compounds. Molecules (Basel, Switzerland). 2022 Academic Article GET IT
- Allogeneic TCRαβ deficient CAR T-cells targeting CD123 in acute myeloid leukemia. Nature communications. 2022 Academic Article GET IT
- Targeting CD123 in blastic plasmacytoid dendritic cell neoplasm using allogeneic anti-CD123 CAR T cells. Nature communications. 2022 Academic Article GET IT
- Mutant PPM1D- and TP53-Driven Hematopoiesis Populates the Hematopoietic Compartment in Response to Peptide Receptor Radionuclide Therapy. JCO precision oncology. 2022 Academic Article GET IT
- Methods to monitor in vivo expansion and efficacy of CAR-T cells in preclinical models. 2021 GET IT
- Technical Aspects of Flow Cytometry-based Measurable Residual Disease Quantification in Acute Myeloid Leukemia: Experience of the European LeukemiaNet MRD Working Party. HemaSphere. 2021 Academic Article GET IT
- 2021 Update Measurable Residual Disease in Acute Myeloid Leukemia: European LeukemiaNet Working Party Consensus Document. Blood. 2021 Academic Article GET IT
- Patient-Derived Bone Marrow Spheroids Reveal Leukemia-Initiating Cells Supported by Mesenchymal Hypoxic Niches in Pediatric B-ALL. Frontiers in immunology. 2021 Academic Article GET IT
- Comparison of Multiple Clinical Testing Modalities for Assessment of NPM1-Mutant AML. Frontiers in oncology. 2021 Academic Article GET IT
- Macrophages in Acute Myeloid Leukaemia: Significant Players in Therapy Resistance and Patient Outcomes. Frontiers in cell and developmental biology. 2021 Information Resource GET IT
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Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain.
Nature chemical biology.
2021
Academic Article
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Times cited: 37 -
Targeting the epichaperome as an effective precision medicine approach in a novel PML-SYK fusion acute myeloid leukemia.
NPJ precision oncology.
2021
Academic Article
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Times cited: 21 -
Inhibiting autophagy targets human leukemic stem cells and hypoxic AML blasts by disrupting mitochondrial homeostasis.
Blood advances.
2021
Academic Article
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Times cited: 27 -
BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells.
Blood.
2021
Academic Article
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Times cited: 20 -
Clonal Hematopoiesis Before, During, and After Human Spaceflight.
Cell reports.
2020
Academic Article
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Times cited: 4 -
Synthesis, Crystallography, and Anti-Leukemic Activity of the Amino Adducts of Dehydroleucodine.
Molecules (Basel, Switzerland).
2020
Academic Article
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Times cited: 3 -
Chemical probes and methods for single-cell detection and quantification of epichaperomes in hematologic malignancies.
Methods in enzymology.
2020
Academic Article
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Times cited: 10 -
Applicability and reproducibility of acute myeloid leukaemia stem cell assessment in a multi-centre setting.
British journal of haematology.
2020
Academic Article
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Times cited: 11 -
Clonal Hematopoiesis and Premalignant Diseases.
Cold Spring Harbor perspectives in medicine.
2020
Review
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Times cited: 12 -
CD123 as a Therapeutic Target Against Malignant Stem Cells.
Hematology/oncology clinics of North America.
2020
Information Resource
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Times cited: 6 -
Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.
The Journal of clinical investigation.
2020
Academic Article
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Times cited: 156 -
The therapeutic landscape for cells engineered with chimeric antigen receptors.
Nature biotechnology.
2020
Academic Article
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Times cited: 43 -
Chaperome Networks - Redundancy and Implications for Cancer Treatment.
Advances in experimental medicine and biology.
2020
Article
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Times cited: 2 -
Cranberry A-type proanthocyanidins selectively target acute myeloid leukemia cells.
Blood advances.
2019
Academic Article
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Times cited: 5 -
Paradigms for Precision Medicine in Epichaperome Cancer Therapy.
Cancer cell.
2019
Academic Article
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Times cited: 44 -
Telomere Trimming and DNA Damage as Signatures of High Risk Neuroblastoma.
Neoplasia (New York, N.Y.).
2019
Academic Article
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Times cited: 12 -
Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML.
Cancer discovery.
2019
Academic Article
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Times cited: 35 -
FDA-approved ferumoxytol displays anti-leukaemia efficacy against cells with low ferroportin levels.
Nature nanotechnology.
2019
Academic Article
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Times cited: 225 -
A novel tetrazole analogue of resveratrol is a potent anticancer agent.
Bioorganic & medicinal chemistry letters.
2018
Academic Article
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Times cited: 32 -
Chaperome heterogeneity and its implications for cancer study and treatment.
The Journal of biological chemistry.
2018
Information Resource
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Times cited: 35 -
Parthenolide and DMAPT induce cell death in primitive CML cells through reactive oxygen species.
Journal of cellular and molecular medicine.
2018
Academic Article
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Times cited: 21 -
Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia.
Nature medicine.
2018
Academic Article
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Times cited: 61 -
Somatic mutations precede acute myeloid leukemia years before diagnosis.
Nature medicine.
2018
Academic Article
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Times cited: 428 -
Phase I trial of plerixafor combined with decitabine in newly diagnosed older patients with acute myeloid leukemia.
Haematologica.
2018
Academic Article
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Times cited: 32 -
Minimal Residual Disease in Acute Myeloid Leukemia.
Advances in experimental medicine and biology.
2018
Article
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Times cited: 5 -
Synthesis and Evaluation of 2-Naphthaleno trans-Stilbenes and Cyanostilbenes as Anticancer Agents.
Anti-cancer agents in medicinal chemistry.
2018
Academic Article
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Times cited: 7 -
Potential for subsets of wt-NPM1 primary AML blasts to respond to retinoic acid treatment.
Oncotarget.
2017
Academic Article
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Times cited: 9 -
Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites.
Nature.
2017
Academic Article
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Times cited: 149 -
Prostaglandin E1 and Its Analog Misoprostol Inhibit Human CML Stem Cell Self-Renewal via EP4 Receptor Activation and Repression of AP-1.
Cell stem cell.
2017
Academic Article
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Times cited: 31 -
Selection and characterization of antibody clones are critical for accurate flow cytometry-based monitoring of CD123 in acute myeloid leukemia.
Leukemia & lymphoma.
2017
Letter
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Times cited: 12 -
CD25 expression and outcomes in older patients with acute myelogenous leukemia treated with plerixafor and decitabine.
Leukemia & lymphoma.
2017
Academic Article
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Times cited: 11 -
Minimal Residual Disease Monitoring of Acute Myeloid Leukemia by Massively Multiplex Digital PCR in Patients with NPM1 Mutations.
The Journal of molecular diagnostics : JMD.
2017
Academic Article
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Times cited: 72 -
GLI3 repressor determines Hedgehog pathway activation and is required for response to SMO antagonist glasdegib in AML.
Blood.
2017
Academic Article
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Times cited: 58 -
Minimal residual disease in acute myelogenous leukemia.
International journal of laboratory hematology.
2017
Information Resource
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Times cited: 40 -
Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers.
Cancer discovery.
2017
Academic Article
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Times cited: 97 -
Pro-inflammatory-Related Loss of CXCL12 Niche Promotes Acute Lymphoblastic Leukemic Progression at the Expense of Normal Lymphopoiesis.
Frontiers in immunology.
2017
Academic Article
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Times cited: 41 -
The epichaperome: the power of many as the power of one.
Oncoscience.
2016
Editorial Article
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Times cited: 6 -
The epichaperome is an integrated chaperome network that facilitates tumour survival.
Nature.
2016
Academic Article
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Times cited: 201 -
Novel strategies for targeting leukemia stem cells: sounding the death knell for blood cancer.
Cellular oncology (Dordrecht).
2016
Information Resource
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Times cited: 19 -
Evolution of acute myelogenous leukemia stem cell properties after treatment and progression.
Blood.
2016
Academic Article
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Times cited: 170 -
Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia.
Nature medicine.
2016
Academic Article
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Times cited: 287 -
Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers.
EBioMedicine.
2016
Academic Article
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Times cited: 79 -
Dehydroleucodine, a Sesquiterpene Lactone from Gynoxys verrucosa, Demonstrates Cytotoxic Activity against Human Leukemia Cells.
Journal of natural products.
2016
Academic Article
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Times cited: 12 -
MSI2 is required for maintaining activated myelodysplastic syndrome stem cells.
Nature communications.
2016
Academic Article
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Times cited: 27 -
In vivo targeting of leukemia stem cells by directing parthenolide-loaded nanoparticles to the bone marrow niche.
Leukemia.
2015
Article
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Times cited: 51 -
A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species.
Cell reports.
2015
Academic Article
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Times cited: 53 -
Pharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat) in FLT3-ITD acute myeloid leukemia.
Leukemia.
2015
Academic Article
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Times cited: 66 - Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin. MedChemComm. 2015 Academic Article GET IT
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Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.
Cancer cell.
2015
Academic Article
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Times cited: 287 -
Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice.
Science (New York, N.Y.).
2015
Academic Article
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Times cited: 98 -
Single-cell mass cytometry reveals intracellular survival/proliferative signaling in FLT3-ITD-mutated AML stem/progenitor cells.
Cytometry. Part A : the journal of the International Society for Analytical Cytology.
2015
Academic Article
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Times cited: 79 -
Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents.
European journal of medicinal chemistry.
2014
Academic Article
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Times cited: 20 -
Affinity purification probes of potential use to investigate the endogenous Hsp70 interactome in cancer.
ACS chemical biology.
2014
Academic Article
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Times cited: 21 -
Selective activity of the histone deacetylase inhibitor AR-42 against leukemia stem cells: a novel potential strategy in acute myelogenous leukemia.
Molecular cancer therapeutics.
2014
Academic Article
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Times cited: 51 -
Concise review: Leukemia stem cells in personalized medicine.
Stem cells (Dayton, Ohio).
2014
Review
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Times cited: 47 -
Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity.
The Journal of clinical investigation.
2013
Academic Article
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Times cited: 61 -
A phase I study using bortezomib with weekly idarubicin for treatment of elderly patients with acute myeloid leukemia.
Leukemia research.
2013
Academic Article
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Times cited: 19 -
Novel mTOR inhibitory activity of ciclopirox enhances parthenolide antileukemia activity.
Experimental hematology.
2013
Academic Article
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Times cited: 33 -
Iron and reactive oxygen species: friends or foes of cancer cells?.
Antioxidants & redox signaling.
2013
Information Resource
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Times cited: 157 -
Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia.
Cancer discovery.
2012
Academic Article
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Times cited: 78 -
Acute myelogenous leukemia stem cells: from Bench to Bedside.
Cancer letters.
2012
Information Resource
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Times cited: 42 -
Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90.
Nature chemical biology.
2011
Academic Article
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Times cited: 231 -
Synthesis of purine-scaffold fluorescent probes for heat shock protein 90 with use in flow cytometry and fluorescence microscopy.
Bioorganic & medicinal chemistry letters.
2011
Academic Article
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Times cited: 20 -
Discovery of 1,2,4-thiadiazolidine-3,5-dione analogs that exhibit unusual and selective rapid cell death kinetics against acute myelogenous leukemia cells in culture.
Bioorganic & medicinal chemistry letters.
2011
Academic Article
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Times cited: 9 -
Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways.
Blood.
2010
Academic Article
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Times cited: 64 -
The NF (Nuclear factor)-κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1-dependent apoptosis in human acute myeloid leukaemia cells.
British journal of haematology.
2010
Academic Article
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Times cited: 63 -
Modulation of cell surface protein free thiols: a potential novel mechanism of action of the sesquiterpene lactone parthenolide.
PloS one.
2009
Academic Article
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Times cited: 61 -
Acute myeloid leukemia stem cells: seek and destroy.
Expert review of hematology.
2009
Information Resource
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Times cited: 45 -
Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1).
Bioorganic & medicinal chemistry letters.
2009
Academic Article
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Times cited: 149 -
Monoclonal antibodies against IREM-1: potential for targeted therapy of AML.
Leukemia.
2009
Academic Article
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Times cited: 19 -
Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data.
Blood.
2008
Academic Article
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Times cited: 167 -
The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target.
Blood.
2008
Academic Article
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Times cited: 132 -
An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells.
Blood.
2007
Academic Article
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Times cited: 353 -
Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8).
Blood.
2007
Academic Article
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Times cited: 102 -
Cancer stem cells.
The New England journal of medicine.
2006
Information Resource
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Times cited: 1255 -
Parathyroid hormone stimulates expression of the Notch ligand Jagged1 in osteoblastic cells.
Bone.
2006
Academic Article
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Times cited: 76 -
Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels.
Molecular and cellular biology.
2005
Academic Article
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Times cited: 85 -
The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells.
Blood.
2005
Academic Article
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Times cited: 615 -
Mechanisms controlling pathogenesis and survival of leukemic stem cells.
Oncogene.
2004
Information Resource
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Times cited: 111 -
Considerations for targeting malignant stem cells in leukemia.
Cancer control : journal of the Moffitt Cancer Center.
2004
Information Resource
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Times cited: 67 -
Aberrant eukaryotic translation initiation factor 4E-dependent mRNA transport impedes hematopoietic differentiation and contributes to leukemogenesis.
Molecular and cellular biology.
2003
Academic Article
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Times cited: 182 -
Preferential induction of apoptosis for primary human leukemic stem cells.
Proceedings of the National Academy of Sciences of the United States of America.
2002
Academic Article
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Times cited: 400 -
Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells.
Blood.
2001
Academic Article
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Times cited: 631 -
Expression of tumor-suppressor genes interferon regulatory factor 1 and death-associated protein kinase in primitive acute myelogenous leukemia cells.
Blood.
2001
Academic Article
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Times cited: 46 -
The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells.
Leukemia.
2000
Academic Article
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Times cited: 573 -
Wild-type HFE protein normalizes transferrin iron accumulation in macrophages from subjects with hereditary hemochromatosis.
Blood.
2000
Academic Article
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Times cited: 128 -
Pharmacological studies with SK&F 93944 (temelastine), a novel histamine H1-receptor antagonist with negligible ability to penetrate the central nervous system.
British journal of pharmacology.
1986
Academic Article
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Times cited: 63