Paradigms for Precision Medicine in Epichaperome Cancer Therapy. Academic Article uri icon

Overview

abstract

  • Alterations in protein-protein interaction networks are at the core of malignant transformation but have yet to be translated into appropriate diagnostic tools. We make use of the kinetic selectivity properties of an imaging probe to visualize and measure the epichaperome, a pathologic protein-protein interaction network. We are able to assay and image epichaperome networks in cancer and their engagement by inhibitor in patients' tumors at single-lesion resolution in real time, and demonstrate that quantitative evaluation at the level of individual tumors can be used to optimize dose and schedule selection. We thus provide preclinical and clinical evidence in the use of this theranostic platform for precision medicine targeting of the aberrant properties of protein networks.

authors

publication date

  • October 24, 2019

Research

keywords

  • Antineoplastic Agents
  • Molecular Chaperones
  • Neoplasms
  • Protein Interaction Maps

Identity

PubMed Central ID

  • PMC6996250

Scopus Document Identifier

  • 85074398844

Digital Object Identifier (DOI)

  • 10.1016/j.ccell.2019.09.007

PubMed ID

  • 31668946

Additional Document Info

volume

  • 36

issue

  • 5