TADsplimer reveals splits and mergers of topologically associating domains for epigenetic regulation of transcription. Academic Article uri icon

Overview

abstract

  • We present TADsplimer, the first computational tool to systematically detect topologically associating domain (TAD) splits and mergers across the genome between Hi-C samples. TADsplimer recaptures splits and mergers of TADs with high accuracy in simulation analyses and defines hundreds of TAD splits and mergers between pairs of different cell types, such as endothelial cells and fibroblasts. Our work reveals a key role for TAD remodeling in epigenetic regulation of transcription and delivers the first tool for the community to perform dynamic analysis of TAD splits and mergers in numerous biological and disease models.

publication date

  • April 2, 2020

Research

keywords

  • Algorithms
  • Chromosomes, Mammalian
  • Epigenesis, Genetic
  • Transcription, Genetic

Identity

PubMed Central ID

  • PMC7114812

Scopus Document Identifier

  • 85082744217

Digital Object Identifier (DOI)

  • 10.1186/s13059-020-01992-7

PubMed ID

  • 32241291

Additional Document Info

volume

  • 21

issue

  • 1