Schwer, Beate

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selected publications

Identification, characterization, and structure of a tRNA splicing enzyme RNA 5'-OH kinase from the pathogenic fungi Mucorales. RNA (New York, N.Y.). 2024 Academic Article GET IT
Activities and genetic interactions of fission yeast Aps1, a Nudix-type inositol pyrophosphatase and inorganic polyphosphatase. mBio. 2024 Academic Article GET IT
Suppression of inositol pyrophosphate toxicosis and hyper-repression of the fission yeast PHO regulon by loss-of-function mutations in chromatin remodelers Snf22 and Sol1. mBio. 2024 Academic Article GET IT
Factors governing the transcriptome changes and chronological lifespan of fission yeast during phosphate starvation. The Journal of biological chemistry. 2024 Academic Article GET IT
Characterization of tRNA splicing enzymes RNA ligase and tRNA 2'-phosphotransferase from the pathogenic fungi Mucorales. RNA (New York, N.Y.). 2024 Academic Article GET IT
Genetic suppressor screen identifies Tgp1 (glycerophosphocholine transporter), Kcs1 (IP₆ kinase), and Plc1 (phospholipase C) as determinants of inositol pyrophosphate toxicosis in fission yeast. mBio. 2023 Academic Article GET IT
Activities, substrate specificity, and genetic interactions of fission yeast Siw14, a cysteinyl-phosphatase-type inositol pyrophosphatase. mBio. 2023 Academic Article GET IT
Fission yeast poly(A) polymerase active site mutation Y86D alleviates the rad24∆ asp1-H397A synthetic growth defect and upregulates mRNAs targeted by MTREC and Mmi1. RNA (New York, N.Y.). 2023 Academic Article GET IT
Duf89 abets lncRNA control of fission yeast phosphate homeostasis via its antagonism of precocious lncRNA transcription termination. RNA (New York, N.Y.). 2023 Academic Article GET IT
Cellular responses to long-term phosphate starvation of fission yeast: Maf1 determines fate choice between quiescence and death associated with aberrant tRNA biogenesis. Nucleic acids research. 2023 Academic Article GET IT
Inorganic polyphosphate abets silencing of a sub-telomeric gene cluster in fission yeast. microPublication biology. 2023 Academic Article GET IT
Structures of Fission Yeast Inositol Pyrophosphate Kinase Asp1 in Ligand-Free, Substrate-Bound, and Product-Bound States. mBio. 2022 Academic Article GET IT
Activities and Structure-Function Analysis of Fission Yeast Inositol Pyrophosphate (IPP) Kinase-Pyrophosphatase Asp1 and Its Impact on Regulation of pho1 Gene Expression. mBio. 2022 Academic Article GET IT
Cleavage-Polyadenylation Factor Cft1 and SPX Domain Proteins Are Agents of Inositol Pyrophosphate Toxicosis in Fission Yeast. mBio. 2022 Academic Article GET IT
Genetic screen for suppression of transcriptional interference reveals fission yeast 14-3-3 protein Rad24 as an antagonist of precocious Pol2 transcription termination. Nucleic acids research. 2021 Academic Article GET IT
Genetic screen for suppression of transcriptional interference identifies a gain-of-function mutation in Pol2 termination factor Seb1. Proceedings of the National Academy of Sciences of the United States of America. 2021 Academic Article GET IT
Structure-function analysis of fission yeast cleavage and polyadenylation factor (CPF) subunit Ppn1 and its interactions with Dis2 and Swd22. PLoS genetics. 2021 Academic Article GET IT
Times cited: 4
Activity and substrate specificity of Candida, Aspergillus, and Coccidioides Tpt1: essential tRNA splicing enzymes and potential anti-fungal targets. RNA (New York, N.Y.). 2021 Academic Article GET IT
A genetic screen for suppressors of hyper-repression of the fission yeast PHO regulon by Pol2 CTD mutation T4A implicates inositol 1-pyrophosphates as agonists of precocious lncRNA transcription termination. Nucleic acids research. 2020 Academic Article GET IT
Times cited: 11
Inactivation of fission yeast Erh1 de-represses pho1 expression: evidence that Erh1 is a negative regulator of prt lncRNA termination. RNA (New York, N.Y.). 2020 Academic Article GET IT
Times cited: 6
Genetic interactions and transcriptomics implicate fission yeast CTD prolyl isomerase Pin1 as an agent of RNA 3' processing and transcription termination that functions via its effects on CTD phosphatase Ssu72. Nucleic acids research. 2020 Academic Article GET IT
Times cited: 13
Atomic structures of the RNA end-healing 5'-OH kinase and 2',3'-cyclic phosphodiesterase domains of fungal tRNA ligase: conformational switches in the kinase upon binding of the GTP phosphate donor. Nucleic acids research. 2019 Academic Article GET IT
Times cited: 6
Inositol pyrophosphates impact phosphate homeostasis via modulation of RNA 3' processing and transcription termination. Nucleic acids research. 2019 Academic Article GET IT
Times cited: 32
Structure of Fission Yeast Transcription Factor Pho7 Bound to pho1 Promoter DNA and Effect of Pho7 Mutations on DNA Binding and Phosphate Homeostasis. Molecular and cellular biology. 2019 Academic Article GET IT
Times cited: 14
Domain Requirements and Genetic Interactions of the Mud1 Subunit of the Saccharomyces cerevisiae U1 snRNP. G3 (Bethesda, Md.). 2019 Academic Article GET IT
Times cited: 1
Distinctive structural basis for DNA recognition by the fission yeast Zn2Cys6 transcription factor Pho7 and its role in phosphate homeostasis. Nucleic acids research. 2018 Academic Article GET IT
Times cited: 16
RNA polymerase II CTD interactome with 3' processing and termination factors in fission yeast and its impact on phosphate homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 29
Defining essential elements and genetic interactions of the yeast Lsm2-8 ring and demonstration that essentiality of Lsm2-8 is bypassed via overexpression of U6 snRNA or the U6 snRNP subunit Prp24. RNA (New York, N.Y.). 2018 Academic Article GET IT
Times cited: 8
A long noncoding (lnc)RNA governs expression of the phosphate transporter Pho84 in fission yeast and has cascading effects on the flanking prt lncRNA and pho1 genes. The Journal of biological chemistry. 2018 Academic Article GET IT
Times cited: 29
Poly(A) site choice and Pol2 CTD Serine-5 status govern lncRNA control of phosphate-responsive tgp1 gene expression in fission yeast. RNA (New York, N.Y.). 2017 Academic Article GET IT
Times cited: 25
Defining the DNA Binding Site Recognized by the Fission Yeast Zn₂Cys₆ Transcription Factor Pho7 and Its Role in Phosphate Homeostasis. mBio. 2017 Academic Article GET IT
Times cited: 24
Will the circle be unbroken: specific mutations in the yeast Sm protein ring expose a requirement for assembly factor Brr1, a homolog of Gemin2. RNA (New York, N.Y.). 2016 Academic Article GET IT
Times cited: 6
Mechanistic insights into the manganese-dependent phosphodiesterase activity of yeast Dbr1 with bis-p-nitrophenylphosphate and branched RNA substrates. RNA (New York, N.Y.). 2016 Academic Article GET IT
Times cited: 12
Characterization of the tRNA ligases of pathogenic fungi Aspergillus fumigatus and Coccidioides immitis. RNA (New York, N.Y.). 2016 Academic Article GET IT
Times cited: 10
Structure-function analysis and genetic interactions of the SmG, SmE, and SmF subunits of the yeast Sm protein ring. RNA (New York, N.Y.). 2016 Academic Article GET IT
Times cited: 7
Phospho-site mutants of the RNA Polymerase II C-terminal domain alter subtelomeric gene expression and chromatin modification state in fission yeast. Nucleic acids research. 2016 Academic Article GET IT
Times cited: 7
Structure-function analysis and genetic interactions of the Luc7 subunit of the Saccharomyces cerevisiae U1 snRNP. RNA (New York, N.Y.). 2016 Academic Article GET IT
Times cited: 15
Transcription of lncRNA prt, clustered prt RNA sites for Mmi1 binding, and RNA polymerase II CTD phospho-sites govern the repression of pho1 gene expression under phosphate-replete conditions in fission yeast. RNA (New York, N.Y.). 2016 Academic Article GET IT
Times cited: 44
Functional interaction of Rpb1 and Spt5 C-terminal domains in co-transcriptional histone modification. Nucleic acids research. 2015 Academic Article GET IT
Times cited: 19
RNA polymerase II CTD phospho-sites Ser5 and Ser7 govern phosphate homeostasis in fission yeast. RNA (New York, N.Y.). 2015 Academic Article GET IT
Times cited: 27
Two Routes to Genetic Suppression of RNA Trimethylguanosine Cap Deficiency via C-Terminal Truncation of U1 snRNP Subunit Snp1 or Overexpression of RNA Polymerase Subunit Rpo26. G3 (Bethesda, Md.). 2015 Academic Article GET IT
Times cited: 6
Structure-function analysis and genetic interactions of the Yhc1, SmD3, SmB, and Snp1 subunits of yeast U1 snRNP and genetic interactions of SmD3 with U2 snRNP subunit Lea1. RNA (New York, N.Y.). 2015 Academic Article GET IT
Times cited: 16
Genetic and structural analysis of the essential fission yeast RNA polymerase II CTD phosphatase Fcp1. RNA (New York, N.Y.). 2015 Academic Article GET IT
Times cited: 12
Structural basis for recognition of intron branchpoint RNA by yeast Msl5 and selective effects of interfacial mutations on splicing of yeast pre-mRNAs. RNA (New York, N.Y.). 2015 Academic Article GET IT
Times cited: 17
Fission yeast RNA triphosphatase reads an Spt5 CTD code. RNA (New York, N.Y.). 2014 Academic Article GET IT
Times cited: 11
Crystal structure, mutational analysis and RNA-dependent ATPase activity of the yeast DEAD-box pre-mRNA splicing factor Prp28. Nucleic acids research. 2014 Academic Article GET IT
Times cited: 23
How an mRNA capping enzyme reads distinct RNA polymerase II and Spt5 CTD phosphorylation codes. Genes & development. 2014 Academic Article GET IT
Times cited: 36
Individual letters of the RNA polymerase II CTD code govern distinct gene expression programs in fission yeast. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 44
Structure-function analysis of the Yhc1 subunit of yeast U1 snRNP and genetic interactions of Yhc1 with Mud2, Nam8, Mud1, Tgs1, U1 snRNA, SmD3 and Prp28. Nucleic acids research. 2014 Academic Article GET IT
Times cited: 17
The PAF complex and Prf1/Rtf1 delineate distinct Cdk9-dependent pathways regulating transcription elongation in fission yeast. PLoS genetics. 2013 Academic Article GET IT
Times cited: 38
Structure-function analysis of the 5' end of yeast U1 snRNA highlights genetic interactions with the Msl5*Mud2 branchpoint-binding complex and other spliceosome assembly factors. Nucleic acids research. 2013 Academic Article GET IT
Times cited: 14
Punctuation and syntax of the RNA polymerase II CTD code in fission yeast. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 39
Genetic interactions of hypomorphic mutations in the m7G cap-binding pocket of yeast nuclear cap binding complex: an essential role for Cbc2 in meiosis via splicing of MER3 pre-mRNA. RNA (New York, N.Y.). 2012 Academic Article GET IT
Times cited: 22
A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast. PLoS genetics. 2012 Academic Article GET IT
Times cited: 44
A fungal anticodon nuclease ribotoxin exploits a secondary cleavage site to evade tRNA repair. RNA (New York, N.Y.). 2012 Academic Article GET IT
Times cited: 13
Structure-function analysis and genetic interactions of the yeast branchpoint binding protein Msl5. Nucleic acids research. 2012 Academic Article GET IT
Times cited: 19
Defining the Mer1 and Nam8 meiotic splicing regulons by cDNA rescue. RNA (New York, N.Y.). 2011 Academic Article GET IT
Times cited: 8
Deciphering the RNA polymerase II CTD code in fission yeast. Molecular cell. 2011 Academic Article GET IT
Times cited: 104
Composition of yeast snRNPs and snoRNPs in the absence of trimethylguanosine caps reveals nuclear cap binding protein as a gained U1 component implicated in the cold-sensitivity of tgs1Δ cells. Nucleic acids research. 2011 Academic Article GET IT
Times cited: 28
An essential role for trimethylguanosine RNA caps in Saccharomyces cerevisiae meiosis and their requirement for splicing of SAE3 and PCH2 meiotic pre-mRNAs. Nucleic acids research. 2011 Academic Article GET IT
Times cited: 21
Determinants of Nam8-dependent splicing of meiotic pre-mRNAs. Nucleic acids research. 2011 Academic Article GET IT
Times cited: 23
Determinants of eukaryal cell killing by the bacterial ribotoxin PrrC. Nucleic acids research. 2010 Academic Article GET IT
Times cited: 15
Mutational analyses of trimethylguanosine synthase (Tgs1) and Mud2: proteins implicated in pre-mRNA splicing. RNA (New York, N.Y.). 2010 Academic Article GET IT
Times cited: 21
Separable functions of the fission yeast Spt5 carboxyl-terminal domain (CTD) in capping enzyme binding and transcription elongation overlap with those of the RNA polymerase II CTD. Molecular and cellular biology. 2010 Academic Article GET IT
Times cited: 52
Characterization of the Schizosaccharomyces pombe Spt5-Spt4 complex. RNA (New York, N.Y.). 2009 Academic Article GET IT
Times cited: 14
TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast. Molecular cell. 2009 Academic Article GET IT
Times cited: 94
Characterization of a mimivirus RNA cap guanine-N2 methyltransferase. RNA (New York, N.Y.). 2009 Academic Article GET IT
Times cited: 22
Genetic and biochemical analysis of yeast and human cap trimethylguanosine synthase: functional overlap of 2,2,7-trimethylguanosine caps, small nuclear ribonucleoprotein components, pre-mRNA splicing factors, and RNA decay pathways. The Journal of biological chemistry. 2008 Academic Article GET IT
Times cited: 55
RNA repair: an antidote to cytotoxic eukaryal RNA damage. Molecular cell. 2008 Academic Article GET IT
Times cited: 67
Human RNA 5'-kinase (hClp1) can function as a tRNA splicing enzyme in vivo. RNA (New York, N.Y.). 2008 Academic Article GET IT
Times cited: 50
A conformational rearrangement in the spliceosome sets the stage for Prp22-dependent mRNA release. Molecular cell. 2008 Academic Article GET IT
Times cited: 105
Sinefungin resistance of Saccharomyces cerevisiae arising from Sam3 mutations that inactivate the AdoMet transporter or from increased expression of AdoMet synthase plus mRNA cap guanine-N7 methyltransferase. Nucleic acids research. 2007 Academic Article GET IT
Ntr1 activates the Prp43 helicase to trigger release of lariat-intron from the spliceosome. Genes & development. 2007 Academic Article GET IT
Times cited: 127
Functional interactions between Prp8, Prp18, Slu7, and U5 snRNA during the second step of pre-mRNA splicing. RNA (New York, N.Y.). 2007 Academic Article GET IT
Times cited: 31
The C-terminal domain of T4 RNA ligase 1 confers specificity for tRNA repair. RNA (New York, N.Y.). 2007 Academic Article GET IT
Times cited: 24
Biochemical and genetic analysis of RNA cap guanine-N2 methyltransferases from Giardia lamblia and Schizosaccharomyces pombe. Nucleic acids research. 2007 Academic Article GET IT
Structure-guided mutational analysis of T4 RNA ligase 1. RNA (New York, N.Y.). 2006 Academic Article GET IT
Times cited: 20
Mutational analysis of Encephalitozoon cuniculi mRNA cap (guanine-N7) methyltransferase, structure of the enzyme bound to sinefungin, and evidence that cap methyltransferase is the target of sinefungin's antifungal activity. The Journal of biological chemistry. 2006 Academic Article GET IT
Times cited: 25
Genetic analysis of poxvirus mRNA cap methyltransferase: suppression of conditional mutations in the stimulatory D12 subunit by second-site mutations in the catalytic D1 subunit. Virology. 2006 Academic Article GET IT
Times cited: 11
Mutations in PRP43 that uncouple RNA-dependent NTPase activity and pre-mRNA splicing function. Biochemistry. 2006 Academic Article GET IT
Times cited: 64
Poxvirus mRNA cap methyltransferase. Bypass of the requirement for the stimulatory subunit by mutations in the catalytic subunit and evidence for intersubunit allostery. The Journal of biological chemistry. 2006 Academic Article GET IT
Times cited: 14
Structure-function analysis of the kinase-CPD domain of yeast tRNA ligase (Trl1) and requirements for complementation of tRNA splicing by a plant Trl1 homolog. Nucleic acids research. 2006 Academic Article GET IT
Times cited: 51
Structure-function analysis of yeast RNA debranching enzyme (Dbr1), a manganese-dependent phosphodiesterase. Nucleic acids research. 2005 Academic Article GET IT
Times cited: 47
Characterization of the NTPase, RNA-binding, and RNA helicase activities of the DEAH-box splicing factor Prp22. Biochemistry. 2005 Academic Article GET IT
Times cited: 58
Structure-function analysis of the yeast NAD+-dependent tRNA 2'-phosphotransferase Tpt1. RNA (New York, N.Y.). 2005 Academic Article GET IT
Times cited: 30
An encephalitozoon cuniculi ortholog of the RNA polymerase II carboxyl-terminal domain (CTD) serine phosphatase Fcp1. Biochemistry. 2004 Academic Article GET IT
Times cited: 15
Portability and fidelity of RNA-repair systems. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 61
A function of yeast mRNA cap methyltransferase, Abd1, in transcription by RNA polymerase II. Molecular cell. 2004 Academic Article GET IT
Times cited: 54
Motifs IV and V in the DEAH box splicing factor Prp22 are important for RNA unwinding, and helicase-defective Prp22 mutants are suppressed by Prp8. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 47
Genetic and biochemical analysis of the functional domains of yeast tRNA ligase. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 63
Yeast-based genetic system for functional analysis of poxvirus mRNA cap methyltransferase. Journal of virology. 2003 Academic Article GET IT
Times cited: 22
Interactions between fission yeast Cdk9, its cyclin partner Pch1, and mRNA capping enzyme Pct1 suggest an elongation checkpoint for mRNA quality control. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 56
Tat stimulates cotranscriptional capping of HIV mRNA. Molecular cell. 2002 Academic Article GET IT
Times cited: 104
How Slu7 and Prp18 cooperate in the second step of yeast pre-mRNA splicing. RNA (New York, N.Y.). 2002 Academic Article GET IT
Times cited: 77
Prp43 is an essential RNA-dependent ATPase required for release of lariat-intron from the spliceosome. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 132
Characterization of dominant-negative mutants of the DEAH-box splicing factors Prp22 and Prp16. The Journal of biological chemistry. 2002 Academic Article GET IT
Times cited: 45
ATP-dependent remodeling of the spliceosome: intragenic suppressors of release-defective mutants of Saccharomyces cerevisiae Prp22. Genetics. 2002 Academic Article GET IT
Times cited: 23
RNA triphosphatase is essential in Schizosaccharomyces pombe and Candida albicans. BMC microbiology. 2001 Academic Article GET IT
Times cited: 16
An essential function of Saccharomyces cerevisiae RNA triphosphatase Cet1 is to stabilize RNA guanylyltransferase Ceg1 against thermal inactivation. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 14
The length, phosphorylation state, and primary structure of the RNA polymerase II carboxyl-terminal domain dictate interactions with mRNA capping enzymes. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 58
Functional domains of the yeast splicing factor Prp22p. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 45
A new twist on RNA helicases: DExH/D box proteins as RNPases. Nature structural biology. 2001 Information Resource GET IT
Times cited: 124
Characterization of Schizosaccharomyces pombe RNA triphosphatase. Nucleic acids research. 2001 Academic Article GET IT
Times cited: 41
RNA helicase dynamics in pre-mRNA splicing. The EMBO journal. 2000 Academic Article GET IT
Times cited: 83
Characterization of the mRNA capping apparatus of Candida albicans. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 30
Dynamic association of capping enzymes with transcribing RNA polymerase II. Genes & development. 2000 Academic Article GET IT
Times cited: 311
Structure-function analysis of yeast mRNA cap methyltransferase and high-copy suppression of conditional mutants by AdoMet synthase and the ubiquitin conjugating enzyme Cdc34p. Genetics. 2000 Academic Article GET IT
Times cited: 45
Interaction of the yeast DExH-box RNA helicase prp22p with the 3' splice site during the second step of nuclear pre-mRNA splicing. Nucleic acids research. 2000 Academic Article GET IT
Times cited: 32
Mutational analysis of Escherichia coli DNA ligase identifies amino acids required for nick-ligation in vitro and for in vivo complementation of the growth of yeast cells deleted for CDC9 and LIG4. Nucleic acids research. 1999 Academic Article GET IT
Times cited: 64
Mutational analyses of yeast RNA triphosphatases highlight a common mechanism of metal-dependent NTP hydrolysis and a means of targeting enzymes to pre-mRNAs in vivo by fusion to the guanylyltransferase component of the capping apparatus. The Journal of biological chemistry. 1999 Academic Article GET IT
Times cited: 41
A conserved domain of yeast RNA triphosphatase flanking the catalytic core regulates self-association and interaction with the guanylyltransferase component of the mRNA capping apparatus. The Journal of biological chemistry. 1999 Academic Article GET IT
Times cited: 36
Trans-complementation of the second step of pre-mRNA splicing by exogenous 5' exons. RNA (New York, N.Y.). 1999 Academic Article GET IT
Times cited: 3
Characterization of human, Schizosaccharomyces pombe, and Candida albicans mRNA cap methyltransferases and complete replacement of the yeast capping apparatus by mammalian enzymes. The Journal of biological chemistry. 1999 Academic Article GET IT
Times cited: 67
Genetic, physical, and functional interactions between the triphosphatase and guanylyltransferase components of the yeast mRNA capping apparatus. Molecular and cellular biology. 1998 Academic Article GET IT
Times cited: 59
Mutational analysis of the yeast DEAH-box splicing factor Prp16. Genetics. 1998 Academic Article GET IT
Times cited: 44
Accelerated mRNA decay in conditional mutants of yeast mRNA capping enzyme. Nucleic acids research. 1998 Academic Article GET IT
Times cited: 88
The guanylyltransferase domain of mammalian mRNA capping enzyme binds to the phosphorylated carboxyl-terminal domain of RNA polymerase II. The Journal of biological chemistry. 1998 Academic Article GET IT
Times cited: 115
Prp22, a DExH-box RNA helicase, plays two distinct roles in yeast pre-mRNA splicing. The EMBO journal. 1998 Academic Article GET IT
Times cited: 195
Effects of deletion mutations in the yeast Ces1 protein on cell growth and morphology and on high copy suppression of mutations in mRNA capping enzyme and translation initiation factor 4A. Nucleic acids research. 1998 Academic Article GET IT
Times cited: 17
Functional and physical interaction between the yeast splicing factors Slu7 and Prp18. Nucleic acids research. 1997 Academic Article GET IT
Times cited: 59
Requirement for SLU7 in yeast pre-mRNA splicing is dictated by the distance between the branchpoint and the 3' splice site. RNA (New York, N.Y.). 1996 Academic Article GET IT
Times cited: 75
Conditional inactivation of mRNA capping enzyme affects yeast pre-mRNA splicing in vivo. RNA (New York, N.Y.). 1996 Academic Article GET IT
Times cited: 53
Mutational analysis of the Saccharomyces cerevisiae ABD1 gene: cap methyltransferase activity is essential for cell growth. Molecular and cellular biology. 1996 Academic Article GET IT
Times cited: 62
Multicopy suppressors of temperature-sensitive mutations of yeast mRNA capping enzyme. Gene expression. 1996 Academic Article GET IT
Times cited: 17
SLU7 and a novel activity, SSF1, act during the PRP16-dependent step of yeast pre-mRNA splicing. The EMBO journal. 1995 Academic Article GET IT
Times cited: 116
RNA capping enzyme and DNA ligase: a superfamily of covalent nucleotidyl transferases. Molecular microbiology. 1995 Information Resource GET IT
Times cited: 184
Yeast mRNA cap methyltransferase is a 50-kilodalton protein encoded by an essential gene. Molecular and cellular biology. 1995 Academic Article GET IT
Times cited: 95
Covalent catalysis in nucleotidyl transfer reactions: essential motifs in Saccharomyces cerevisiae RNA capping enzyme are conserved in Schizosaccharomyces pombe and viral capping enzymes and among polynucleotide ligases. Proceedings of the National Academy of Sciences of the United States of America. 1994 Academic Article GET IT
Times cited: 97
Mutational analysis of yeast mRNA capping enzyme. Proceedings of the National Academy of Sciences of the United States of America. 1994 Academic Article GET IT
Times cited: 64
A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis. The EMBO journal. 1992 Academic Article GET IT
Times cited: 175
A dominant negative mutation in a spliceosomal ATPase affects ATP hydrolysis but not binding to the spliceosome. Molecular and cellular biology. 1992 Academic Article GET IT
Times cited: 42
PRP16 is an RNA-dependent ATPase that interacts transiently with the spliceosome. Nature. 1991 Academic Article GET IT
Times cited: 243
Vaccinia virus late transcripts generated in vitro have a poly(A) head. The EMBO journal. 1988 Academic Article GET IT
Times cited: 43
Discontinuous transcription or RNA processing of vaccinia virus late messengers results in a 5' poly(A) leader. Cell. 1987 Academic Article GET IT
Times cited: 103

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Funding awarded

Inositol pyrophosphate dynamics affect RNA 3''-processing/transcription termination awarded by National Institute of General Medical Sciences Principal Investigator 2023 - 2027

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Background

education and training

Ph.D., University of Heidelberg (Germany) 1989

Contact

full name

Beate Schwer

primary email

bschwer@med.cornell.edu

VIVO Weill Cornell Medical College

Beate Schwer Professor of Microbiology and Immunology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email