Guo, Chun-Jun

Publications

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selected publications

Gut bacteria-derived succinate induces enteric nervous system regeneration. 2024 GET IT
Genetic manipulations of nonmodel gut microbes. iMeta. 2024 Academic Article GET IT
Functional characterization of helminth-associated Clostridiales reveals covariates of Treg differentiation. Microbiome. 2024 Academic Article GET IT
Microbiota metabolism of intestinal amino acids impacts host nutrient homeostasis and physiology. Cell host & microbe. 2024 Academic Article GET IT
Dietary fiber is a critical determinant of pathologic ILC2 responses and intestinal inflammation. The Journal of experimental medicine. 2024 Academic Article GET IT
Gut bacteria-derived serotonin promotes immune tolerance in early life. Science immunology. 2024 Academic Article GET IT
Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8⁺ T cell effector functions. Immunity. 2024 Academic Article GET IT
The gut microbiome regulates the clinical efficacy of sulfasalazine therapy for IBD-associated spondyloarthritis. Cell reports. Medicine. 2024 Academic Article GET IT
Nutritional regulation of microbiota-derived metabolites: Implications for immunity and inflammation. Immunity. 2024 Review GET IT
Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19. Nature immunology. 2023 Academic Article GET IT
Increased Primary Bile Acids with Ileocolonic Resection Impact Ileal Inflammation and Gut Microbiota in Inflammatory Bowel Disease. Journal of Crohn's & colitis. 2022 Academic Article GET IT
Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation. Nature. 2022 Academic Article GET IT
Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression. Nature communications. 2022 Academic Article GET IT
Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection. Cell. 2022 Academic Article GET IT
Times cited: 58
Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome. Cell. 2022 Academic Article GET IT
Gut microbiota-derived metabolites confer protection against SARS-CoV-2 infection. Gut microbes. 2022 Academic Article GET IT
Transferable Immunoglobulin A-Coated Odoribacter splanchnicus in Responders to Fecal Microbiota Transplantation for Ulcerative Colitis Limits Colonic Inflammation. Gastroenterology. 2021 Academic Article GET IT
Times cited: 71
Adherent-invasive E. coli metabolism of propanediol in Crohn's disease regulates phagocytes to drive intestinal inflammation. Cell host & microbe. 2021 Academic Article GET IT
A metabolic pathway for bile acid dehydroxylation by the gut microbiome. Nature. 2020 Academic Article GET IT
Times cited: 307
Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells. Nature. 2020 Academic Article GET IT
Times cited: 497
Depletion of microbiome-derived molecules in the host using Clostridium genetics. Science (New York, N.Y.). 2019 Academic Article GET IT
Times cited: 104
Microbial Transplantation With Human Gut Commensals Containing CutC Is Sufficient to Transmit Enhanced Platelet Reactivity and Thrombosis Potential. Circulation research. 2018 Academic Article GET IT
Times cited: 130
Genome-based deletion analysis in Aspergillus terreus reveals the acetylaranotin bis-thiomethyltransferase gene. Fungal genetics and biology : FG & B. 2018 Academic Article GET IT
Times cited: 1
Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases. Cell. 2017 Academic Article GET IT
Times cited: 170
Engineering Fungal Nonribosomal Peptide Synthetase-like Enzymes by Heterologous Expression and Domain Swapping. Organic letters. 2016 Academic Article GET IT
Times cited: 13
Discovery of McrA, a master regulator of Aspergillus secondary metabolism. Molecular microbiology. 2016 Academic Article GET IT
Times cited: 64
Microbial metabolomics in open microscale platforms. Nature communications. 2016 Academic Article GET IT
Times cited: 88
Characterization of the product of a nonribosomal peptide synthetase-like (NRPS-like) gene using the doxycycline dependent Tet-on system in Aspergillus terreus. Fungal genetics and biology : FG & B. 2016 Academic Article GET IT
Times cited: 18
Spatial regulation of a common precursor from two distinct genes generates metabolite diversity. Chemical science. 2015 Academic Article GET IT
Times cited: 32
Asperaculanes A and B, two sesquiterpenoids from the fungus Aspergillus aculeatus. Molecules (Basel, Switzerland). 2014 Academic Article GET IT
Times cited: 17
Recent advances in genome mining of secondary metabolites in Aspergillus terreus. Frontiers in microbiology. 2014 Review GET IT
Times cited: 60
Molecular genetic characterization of terreic acid pathway in Aspergillus terreus. Organic letters. 2014 Academic Article GET IT
Times cited: 29
Prototype of an intertwined secondary-metabolite supercluster. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 154
Application of an efficient gene targeting system linking secondary metabolites to their biosynthetic genes in Aspergillus terreus. Organic letters. 2013 Academic Article GET IT
Times cited: 51
Biosynthetic pathway for the epipolythiodioxopiperazine acetylaranotin in Aspergillus terreus revealed by genome-based deletion analysis. Journal of the American Chemical Society. 2013 Academic Article GET IT
Times cited: 83
Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites. PLoS pathogens. 2013 Academic Article GET IT
Times cited: 60
Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin. Organic letters. 2012 Academic Article GET IT
Times cited: 72
Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids austinol and dehydroaustinol in Aspergillus nidulans. Journal of the American Chemical Society. 2012 Academic Article GET IT
Times cited: 211
The synthesis and biological evaluation of 10-O-dialkylaminoethyl ginkgolide B as platelet-activating factor antagonist. Journal of Asian natural products research. 2008 Academic Article GET IT
Times cited: 3

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Research

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Funding awarded

Molecular Mechanisms behind microbiota regulation of host amino acid and glucose homeostasis awarded by National Institute of Diabetes & Digestive & Kidney Diseases Principal Investigator 2023 - 2028
Investigating molecular mechanisms behind gut bacterial transamination and IBD awarded by Kenneth Rainin Foundation Principal Investigator 2022 - 2025
missing activity Principal Investigator 2023 - 2024
An integrative and generalizable approach to modulate microbiota small molecules in the host Principal Investigator 2019 - 2024

Microbiota-derived metabolites and the regulation of host immunity and inflammation awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2022 - 2027
A randomized, placebo-controlled clinical trial examining the efficacy of Fecal Microbiota Transplantation (FMT) and subsequent dietary fiber in patients with moderate ulcerative colitis (MINDFUL) awarded by National Institute of Diabetes & Digestive & Kidney Diseases Co-Investigator 2021 - 2024

Activity Probes to Guide Precision Microbiome Therapy awarded by National Center for Complementary and Integrative Health/NIH/DHHS Co-Principal Investigator 2024 - 2029
Investigation of gut microbiota metabolite-mediated transkingdom interactions with fungi awarded by National Institute of Allergy & Infectious Diseases Co-Principal Investigator 2024 - 2029
Microbiota-derived metabolites and the regulation of host immunity and inflammation awarded by National Institute of Allergy & Infectious Diseases Co-Principal Investigator 2022 - 2027
Dietary Regulation of Intestinal Inflammation and Repair awarded by National Institute of Diabetes & Digestive & Kidney Diseases Co-Principal Investigator 2022 - 2026

missing activity Principal Investigator Subaward 2020 - 2024

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Background

education and training

Ph.D., University of Southern California 2014
B.A., Fudan University (China) 2009

Contact

full name

Chun-Jun Guo

primary email

chg4001@med.cornell.edu

VIVO Weill Cornell Medical College

Chun-Jun Guo Associate Professor of Immunology in Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email