Hirschhorn, Daniel

Publications

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selected publications

Having the cake and eating it? Clofazimine boosts immunotherapy while limiting side effects. Cancer cell. 2024 Academic Article GET IT
T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants. Cell. 2023 Academic Article GET IT
Times cited: 1
The ectonucleotidase CD39 identifies tumor-reactive CD8⁺ T cells predictive of immune checkpoint blockade efficacy in human lung cancer. Immunity. 2022 Academic Article GET IT
Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions. The Journal of experimental medicine. 2022 Academic Article GET IT
Cyclophosphamide enhances the antitumor potency of GITR engagement by increasing oligoclonal cytotoxic T cell fitness. JCI insight. 2021 Academic Article GET IT
Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma. Cell reports. 2021 Academic Article GET IT
In situ vaccination with defined factors overcomes T cell exhaustion in distant tumors. The Journal of clinical investigation. 2019 Academic Article GET IT
Times cited: 32
Non-conventional Inhibitory CD4⁺Foxp3^-PD-1^hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity. Cancer cell. 2018 Academic Article GET IT
Times cited: 109
Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells. Nature. 2016 Academic Article GET IT
Times cited: 619
The New Era of Cancer Immunotherapy: Manipulating T-Cell Activity to Overcome Malignancy. Advances in cancer research. 2015 Article GET IT
Times cited: 31
Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy. Journal for immunotherapy of cancer. 2014 Information Resource GET IT
Times cited: 102
Combination of alphavirus replicon particle-based vaccination with immunomodulatory antibodies: therapeutic activity in the B16 melanoma mouse model and immune correlates. Cancer immunology research. 2014 Academic Article GET IT
Times cited: 35
Agonist antibodies to TNFR molecules that costimulate T and NK cells. Clinical cancer research : an official journal of the American Association for Cancer Research. 2013 Academic Article GET IT
Times cited: 134
Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype. The Journal of experimental medicine. 2012 Academic Article GET IT
Times cited: 118
Monocytic CCR2(+) myeloid-derived suppressor cells promote immune escape by limiting activated CD8 T-cell infiltration into the tumor microenvironment. Cancer research. 2011 Academic Article GET IT
Times cited: 288
Alphavirus replicon particles expressing TRP-2 provide potent therapeutic effect on melanoma through activation of humoral and cellular immunity. PloS one. 2010 Academic Article GET IT
Times cited: 61
Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs. Blood. 2010 Academic Article GET IT
Times cited: 97
Cytokine-FC fusion genes as molecular adjuvants for DNA vaccines. Methods in molecular biology (Clifton, N.J.). 2010 Academic Article GET IT
Times cited: 3
The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease. The Journal of clinical investigation. 2009 Academic Article GET IT
Times cited: 62
Cutting Edge: OX40 agonists can drive regulatory T cell expansion if the cytokine milieu is right. Journal of immunology (Baltimore, Md. : 1950). 2009 Academic Article GET IT
Times cited: 130
OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis. The Journal of experimental medicine. 2009 Academic Article GET IT
Times cited: 182
Self-antigen-specific CD8+ T cell precursor frequency determines the quality of the antitumor immune response. The Journal of experimental medicine. 2009 Academic Article GET IT
Times cited: 89
Mechanisms of immunization against cancer using chimeric antigens. Molecular therapy : the journal of the American Society of Gene Therapy. 2008 Academic Article GET IT
Times cited: 13
Adjuvanticity of plasmid DNA encoding cytokines fused to immunoglobulin Fc domains. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006 Academic Article GET IT
Times cited: 41
Glucocorticoid-induced TNF receptor family related gene activation overcomes tolerance/ignorance to melanoma differentiation antigens and enhances antitumor immunity. Journal of immunology (Baltimore, Md. : 1950). 2006 Academic Article GET IT
Times cited: 147

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Research

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Funding awarded

Sponsored Research Agreement - Merghoub Lab awarded by ReAlta Life Sciences, Inc. Key Personnel 2023 - 2025

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Background

education and training

B.S., University of Texas 96
Ph.D., University of Texas 2003

Contact

full name

Daniel Hirschhorn

primary email

dah4023@med.cornell.edu

VIVO Weill Cornell Medical College

Daniel Hirschhorn Assistant Professor of Research in Pharmacology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email