Gregory F Sonnenberg Professor of Microbiology and Immunology in Medicine

Professor of Microbiology and Immunology in Medicine, Medicine , Weill Cornell Medical College 2024 -
Henry R. Erle, M.D.-Roberts Family Professor of Medicine, Medicine , Weill Cornell Medical College 2024 -
Professor of Microbiology and Immunology, Microbiology and Immunology , Weill Cornell Medical College 2024 -
Associate Professor of Microbiology and Immunology, Microbiology and Immunology , Weill Cornell Medical College 2022 -
The Henry R. Erle, M.D.-Roberts Family Associate Professor of Medicine, Medicine , Weill Cornell Medical College 2022 - 2024
Associate Professor of Microbiology and Immunology in Medicine, Medicine , Weill Cornell Medical College 2018 - 2024
Assistant Professor of Microbiology and Immunology, Microbiology and Immunology , Weill Cornell Medical College 2015 - 2022
Assistant Professor of Microbiology and Immunology in Medicine, Medicine , Weill Cornell Medical College 2014 - 2018

The focus and long-term research goals of the Sonnenberg Laboratory are to interrogate the mechanisms by which the mammalian immune system controls tissue homeostasis, immunity, inflammation and cancer at mucosal barrier surfaces of the body. This is a considerable challenge given the enormous surface area of these sites, such as the gastrointestinal tract, which is home to an estimated 10 trillion microbes (termed the microbiota) and a majority of our body’s total immune system. While interactions between mammalian hosts and microbiota are normally beneficial, these interactions must be tightly regulated to prevent chronic inflammation. Studies in patient populations indicate that abnormal host immune responses to microbiota are causally-linked to the pathogenesis and progression of numerous chronic disorders, including inflammatory bowel disease (IBD), HIV/AIDS, viral hepatitis, cardiovascular disease, multiple sclerosis, Alzheimer’s diseases, autism, obesity, diabetes and cancer. Further, these interactions can influence the success or failure of multiple clinical therapies. Ongoing research in the Sonnenberg Laboratory aims to (1) interrogate the pathways that regulate normally beneficial host interactions with microbiota; (2) determine how these pathways become disrupted in multiple chronic human diseases; and (3) identify novel preventative, therapeutic or curative approaches to target the immune system and/or microbiota to benefit human health.

To better understand host-commensal bacteria interactions we have been studying the recently identified populations of intestinal-resident innate lymphoid cells (ILCs). ILCs are an emerging family of immune cells that differentiate, independent of somatic recombination, from IL-7Rα+ Id2-dependent lymphoid progenitors. ILCs share striking similarities to heterogeneous populations of effector T cells. As such, ILCs can currently be broadly classified into 3 groups based on their developmental requirements for specific transcription factors, common activating receptors and expression of effector cytokines. Group 1 ILCs are T-bet+, activated by IL-18 and IL-12, and express IFNγ. Group 2 ILCs are GATA-3-hi, activated by IL-25, IL-33 and TSLP, and express IL-4, IL-5, IL-9, IL-13 and amphiregulin. Group 3 ILCs are RORγt-dependent, activated by IL-1β and IL-23, and express IL-22 and IL-17. Importantly, group 3 ILCs have been found to be critical regulators of cytokine-mediated intestinal epithelial cell responses that promote immunity to extracellular bacteria, inflammation and tissue repair in the intestine.

We have also recently launched a pioneering translational research effort involving clinical collaborators at Weill Cornell Medicine and other research institutions to examine primary human samples from both healthy individuals and defined patient populations. Our ongoing research will further interrogate mucosal immune responses and interactions with microbiota in healthy and diseased primary human tissue samples. We anticipate that these studies will allow us to directly translate our findings in mouse models to clinically relevant information.

Talented graduate students and postdoctoral researchers are encouraged to directly contact Dr. Sonnenberg to discuss potential rotation projects and open positions in the laboratory.

Selected Publications

Ahmed A, Joseph AM, Zhou J, Horn V, Uddin J, Lyu M, Joc J, JRI Live Cell Bank, Sockolow RE, Wing JB, Vivier E, Sakaguchi S, Sonnenberg GF. CTLA-4 expressing ILC3s restrain interleukin-23-mediated inflammation. Nature. 2024. https://doi.org/10.1038/s41586-024-07537-3

Joseph AM, Ahmed A, Goc J, Horn V, Fiedler B, Garone D, Grigg JB, Uddin J, Teng F, Fritsch M, Vivier E, Sonnenberg GF. RIPK3 and caspase-8 interpret cytokine signals to regulate ILC3 survival in the gut. Mucosal Immunology 2024 Aug 11:S1933-0219(24)00085-0. doi: 10.1016/j.mucimm.2024.08.004. Epub ahead of print. PMID: 39137882.

Horn V, Sonnenberg GF. Group 3 innate lymphoid cells in intestinal health and disease. Nature Reviews Gastroenterology & Hepatology 2024. https://doi.org/10.1038/s41575-024-00906-3

Abramson J, Dobeš J, Lyu M, Sonnenberg GF. The emerging family of RORγt⁺antigen-presenting cells. Nature Reviews Immunology. 2023 Jul 21. doi: 10.1038/s41577-023-00906-5. Epub ahead of print. PMID: 37479834.

Lyu M, Suzuki H, Kang L, Gaspal F, Zhou W, Goc J, Zhou L, Zhou J, Zhang W, JRI Live Cell Bank, Shen Z, Fox JG, Sockolow RE, Laufer TM, Fan Y, Eberl G, Withers DR, Sonnenberg GF. ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut. Nature. 2022. https://doi.org/10.1038/s41586-022-05141-x

Zhou W, Zhou L, Zhou J; JRI Live Cell Bank, Chu C, Zhang C, Sockolow RE, Eberl G, Sonnenberg GF. ZBTB46 defines and regulates ILC3s that protect the intestine. Nature. 2022 Jul 13. doi: 10.1038/s41586-022-04934-4. Epub ahead of print. PMID: 35831503.

Zhou JZ, Sonnenberg GF. Coordination of Mucosal Immunity by Innate Lymphoid Cells. Adv Exp Med Biol. 2022;1365:113-134. doi: 10.1007/978-981-16-8387-9_8. PMID: 35567744.

Zhou L, Zhou W, Joseph AM, Chu C, Putzel GG, Fang B, Teng F, Lyu M, Yano H, Andreasson KI, Mekada E, Eberl G, Sonnenberg GF. Group 3 innate lymphoid cells produce the growth factor HB-EGF to protect the intestine from TNF-mediated inflammation. Nature Immunology. 2022 Jan 31. doi: 10.1038/s41590-021-01110-0. PMID: 35102343.

Grigg JB, Shanmugavadiv A, Regen T, Parkhurt CN, Ahmed A, Joseph AM, Mazzucco M, Gronke K, Diegenbach A, Eberl G, Vartanian T, Waisman A, Sonnenberg GF. Antigen presenting innate lymphoid cells orchestrate neuroinflammation. Nature. 2021 Dec;600(7890):707-712. doi: 10.1038/s41586-021-04136-4. Epub 2021 Dec 1. PMID: 34853467; PMCID: PMC8702489.

Teng F, Tachó-Piñot R, Sung B, Farber DL, Worgall S, Hammad H, Lambrecht BN, Hepworth MR, Sonnenberg GF. ILC3s control airway inflammation by limiting T cell responses to allergens and microbes. Cell Reports 2021 Nov 23;37(8):110051. doi: 10.1016/j.celrep.2021.110051. PMID: 34818549.

Goc J, Lv M, Bessman NJ, Flamar A, Sahota S, Suzuki H, Teng F, Putzel GG, JRI Live Cell Bank, Eberl G, Withers DR, Arthur JC, Shah MA, Sonnenberg GF. Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer. Cell. 2021. Sep 16;184(19):5015-5030.e16. doi: 10.1016/j.cell.2021.07.029. PubMed PMID: 34407392

Bessman N.J., Mathieu J.R.R., Renassia C., Zhou L., Fung T.C., Fernandez K.C., Austin C., Moeller J.B., Zumerle S., Louis S., Vaulont S., Ajami N.J., Sokol H., Putzel G.G., Arvedson T., Sockolow R.E., Lakhal-Littleon S., Cloonan S.M., Arora M., Peyssonnaux C., Sonnenberg G.F.. Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing. Science. 2020 Apr 10;368(6487):186-189. doi: 10.1126/science.aau6481. PubMed PMID: 32273468

Teng F, Goc J, Zhou L, Chu C, Shah MA, Eberl G, Sonnenberg GF. A circadian clock is essential for homeostasis of group 3 innate lymphoid cells in the gut. Science Immunology. 2019 Oct 4;4(40). pii: eaax1215. doi: 10.1126/sciimmunol.aax1215. PubMed PMID: 31586011.

Sonnenberg GF, Hepworth MR. Functional interactions between innate lymphoid cells and adaptive immunity. Nature Reviews Immunology. 2019 Jul 26. doi: 10.1038/s41577-019-0194-8. Review.PubMed PMID: 31350531.

Zhou L, Chu C, Teng F, Bessman NJ, Goc J, Santosa EK, Putzel GG, Kabata H, Kelsen JR, Baldassano RN, Shah MA, Sockolow RE, Vivier E, Eberl G, Smith KA, Sonnenberg GF. Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2. Nature. 2019 Apr;568(7752):405-409. doi: 10.1038/s41586-019-1082-x. Epub 2019 Apr 3. PubMed PMID: 30944470; PubMed Central PMCID: PMC6481643.

Joseph AM, Monticelli LA, Sonnenberg GF. Metabolic regulation of innate and adaptive lymphocyte effector responses. Immunological Reviews. 2018 Nov;286(1):137-147. doi: 10.1111/imr.12703. Review. PubMed PMID: 30294971; PubMed Central PMCID: PMC6195227.

Zhou L, Sonnenberg GF. Essential immunologic orchestrators of intestinal homeostasis. Science Immunology. 2018 Feb 9;3(20). pii: eaao1605. doi: 10.1126/sciimmunol.aao1605. Review. PubMed PMID: 29440266; PubMed Central PMCID: PMC6352895.

Grigg JB, Sonnenberg GF. Host-Microbiota Interactions Shape Local and Systemic Inflammatory Diseases. Journal of Immunology. 2017 Jan 15;198(2):564-571. doi: 10.4049/jimmunol.1601621. Review. PubMed PMID: 28069751; PubMed Central PMCID: PMC5228396.

Fung TC, Bessman NJ, Hepworth MR, Kumar N, Shibata N, Kobuley D, Wang K, Ziegler CGK, Goc J, Shima T, Umesaki Y, Sartor RB, Sullivan KV, Lawley TD, Kunisawa J, Kiyono H, Sonnenberg GF. Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish Mutualism. Immunity. 2016 Mar 15;44(3):634-646. doi: 10.1016/j.immuni.2016.02.019. PubMed PMID: 26982365; PubMed Central PMCID: PMC4845739.

Withers DR, Hepworth MR, Wang X, Mackley EC, Halford EE, Dutton EE, Marriott CL, Brucklacher-Waldert V, Veldhoen M, Kelsen J, Baldassano RN, Sonnenberg GF. Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells. Nature Medicine. 2016 Mar;22(3):319-23. doi: 10.1038/nm.4046. Epub 2016 Feb 15. PubMed PMID: 26878233; PubMed Central PMCID: PMC4948756.

Goc J., Hepworth M.R., Sonnenberg G.F., (2015) Group 3 innate lymphoid cells: regulating host-commensal bacteria interactions in inflammation and cancer. International Immunology. 2016 Jan;28(1):43-52. doi: 10.1093/intimm/dxv056. Epub 2015 Oct 7. Review. PubMed PMID: 26451009; PubMed Central PMCID: PMC5891988.

Kelsen JR, Baldassano RN, Artis D, Sonnenberg GF. Maintaining intestinal health: the genetics and immunology of very early onset inflammatory bowel disease. Cellular Molecular Gastroenterology Hepatology. 2015 Sep 1;1(5):462-476. PubMed PMID: 26393237; PubMed Central PMCID: PMC4574301.

Sonnenberg G.F., Artis D. (2015) Innate lymphoid cells in the initiation, regulation and resolution of inflammation Nature Medicine. 2015 Jul;21(7):698-708. doi: 10.1038/nm.3892. Epub 2015 Jun 29. Review. PubMed PMID: 26121198; PubMed Central PMCID: PMC4869856.

Hepworth MR, Fung TC, Masur SH, Kelsen JR, McConnell FM, Dubrot J, Withers DR, Hugues S, Farrar MA, Reith W, Eberl G, Baldassano RN, Laufer TM, Elson CO, Sonnenberg GF. Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells. Science. 2015 May 29;348(6238):1031-5. doi: 10.1126/science.aaa4812. Epub 2015 Apr 23. PubMed PMID: 25908663; PubMed Central PMCID: PMC4449822.

Fung TC, Artis D, Sonnenberg GF. Anatomical localization of commensal bacteria in immune cell homeostasis and disease. Immunological Reviews. 2014 Jul;260(1):35-49. doi: 10.1111/imr.12186. Review. PubMed PMID: 24942680; PubMed Central PMCID: PMC4216679.

Sonnenberg GF. Regulation of intestinal health and disease by innate lymphoid cells. International Immunology. 2014 Sep;26(9):501-7. doi: 10.1093/intimm/dxu052. Epub 2014 May 12. PubMed PMID: 24821261; PubMed Central PMCID: PMC4142604.

Hepworth MR, Sonnenberg GF. Regulation of the adaptive immune system by innate lymphoid cells. Current Opinions in Immunology. 2014 Apr;27:75-82. doi: 10.1016/j.coi.2014.01.013. Epub 2014 Mar 3. Review. PubMed PMID: 24594491; PubMed Central PMCID: PMC3979357.

Hepworth MR, Monticelli LA, Fung TC, Ziegler CG, Grunberg S, Sinha R, Mantegazza AR, Ma HL, Crawford A, Angelosanto JM, Wherry EJ, Koni PA, Bushman FD, Elson CO, Eberl G, Artis D, Sonnenberg GF. Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria. Nature. 2013 Jun 6;498(7452):113-7. doi: 10.1038/nature12240. Epub 2013 May 22. PubMed PMID: 23698371; PubMed Central PMCID: PMC3699860.

Sonnenberg GF, Artis D. Innate lymphoid cell interactions with microbiota: implications for intestinal health and disease. Immunity. 2012 Oct 19;37(4):601-10. doi: 10.1016/j.immuni.2012.10.003. Review. PubMed PMID: 23084357; PubMed Central PMCID: PMC3495160.

Affiliation

head of

Medicine-Gastroenterology and Hepatology Head of Basic Research 2022 -

member of

Mucosal Immunology Deputy Editor 2021 -

Publications

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Co-Author Network

selected publications

RIPK3 and Caspase-8 interpret cytokine signals to regulate ILC3 survival in the gut. Mucosal immunology. 2024 Academic Article GET IT
Chlamydia muridarum Causes Persistent Subclinical Infection and Elicits Innate and Adaptive Immune Responses in C57BL/6J, BALB/cJ and J:ARC(S) Mice Following Exposure to Shedding Mice. 2024 GET IT
CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation. Nature. 2024 Academic Article GET IT
Group 3 innate lymphoid cells in intestinal health and disease. Nature reviews. Gastroenterology & hepatology. 2024 Review GET IT
The emerging family of RORγt⁺ antigen-presenting cells. Nature reviews. Immunology. 2023 Review GET IT
Times cited: 523
Epsilon toxin-producing Clostridium perfringens colonize the MS gut and epsilon toxin overcomes immune privilege. The Journal of clinical investigation. 2023 Academic Article GET IT
Metabolic control of innate lymphoid cells in health and disease. Nature metabolism. 2022 Review GET IT
Harnessing Microbiota to Improve Immunotherapy for Gastrointestinal Cancers. Cancer immunology research. 2022 Academic Article GET IT
ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut. Nature. 2022 Academic Article GET IT
ZBTB46 defines and regulates ILC3s that protect the intestine. Nature. 2022 Academic Article GET IT
Joint Disease Activity in Inflammatory Bowel Disease-associated Peripheral Spondyloarthritis Stratifies Therapeutic Response. Gastro hep advances. 2022 Academic Article GET IT
Group 3 innate lymphoid cells produce the growth factor HB-EGF to protect the intestine from TNF-mediated inflammation. Nature immunology. 2022 Academic Article GET IT
Antigen-presenting innate lymphoid cells orchestrate neuroinflammation. Nature. 2021 Academic Article GET IT
ILC3s control airway inflammation by limiting T cell responses to allergens and microbes. Cell reports. 2021 Academic Article GET IT
Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer. Cell. 2021 Academic Article GET IT
Impact of Use of Antibiotics on Response to Immune Checkpoint Inhibitors and Tumor Microenvironment. American journal of clinical oncology. 2021 Academic Article GET IT
Activation and Suppression of Group 3 Innate Lymphoid Cells in the Gut. Trends in immunology. 2020 Information Resource GET IT
Times cited: 45
Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing. Science (New York, N.Y.). 2020 Academic Article GET IT
Times cited: 86
A circadian clock is essential for homeostasis of group 3 innate lymphoid cells in the gut. Science immunology. 2019 Academic Article GET IT
Times cited: 76
Functional interactions between innate lymphoid cells and adaptive immunity. Nature reviews. Immunology. 2019 Review GET IT
Times cited: 186
Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2. Nature. 2019 Academic Article GET IT
Times cited: 212
Mice with epidermal filaggrin deficiency show increased immune reactivity to nickel. Contact dermatitis. 2018 Academic Article GET IT
Times cited: 8
Metabolic regulation of innate and adaptive lymphocyte effector responses. Immunological reviews. 2018 Information Resource GET IT
Times cited: 19
Anti-microbial Functions of Group 3 Innate Lymphoid Cells in Gut-Associated Lymphoid Tissues Are Regulated by G-Protein-Coupled Receptor 183. Cell reports. 2018 Academic Article GET IT
Times cited: 70
Regulation of inflammation by microbiota interactions with the host. Nature immunology. 2017 Information Resource GET IT
Times cited: 466
Single Delivery of High-Diversity Fecal Microbiota Preparation by Colonoscopy Is Safe and Effective in Increasing Microbial Diversity in Active Ulcerative Colitis. Inflammatory bowel diseases. 2017 Academic Article GET IT
Times cited: 94
Host-Microbiota Interactions Shape Local and Systemic Inflammatory Diseases. Journal of immunology (Baltimore, Md. : 1950). 2017 Review GET IT
Times cited: 98
Emerging roles for antigen presentation in establishing host-microbiome symbiosis. Immunological reviews. 2016 Review GET IT
Times cited: 18
Cross-protective mucosal immunity mediated by memory Th17 cells against Streptococcus pneumoniae lung infection. Mucosal immunology. 2016 Academic Article GET IT
Times cited: 52
Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish Mutualism. Immunity. 2016 Academic Article GET IT
Times cited: 119
Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells. Nature medicine. 2016 Academic Article GET IT
Times cited: 197
Epithelial-intrinsic IKKα expression regulates group 3 innate lymphoid cell responses and antibacterial immunity. The Journal of experimental medicine. 2015 Academic Article GET IT
Times cited: 73
Maintaining intestinal health: the genetics and immunology of very early onset inflammatory bowel disease. Cellular and molecular gastroenterology and hepatology. 2015 Academic Article GET IT
Exome sequencing analysis reveals variants in primary immunodeficiency genes in patients with very early onset inflammatory bowel disease. Gastroenterology. 2015 Academic Article GET IT
Times cited: 93
Innate lymphoid cells in the initiation, regulation and resolution of inflammation. Nature medicine. 2015 Information Resource GET IT
Times cited: 422
The Group 3 Innate Lymphoid Cell Defect in Aryl Hydrocarbon Receptor Deficient Mice Is Associated with T Cell Hyperactivation during Intestinal Infection. PloS one. 2015 Academic Article GET IT
Times cited: 37
Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells. Science (New York, N.Y.). 2015 Academic Article GET IT
Times cited: 411
CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes. Nature communications. 2015 Academic Article GET IT
Times cited: 175
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature. 2014 Academic Article GET IT
Times cited: 773
Anatomical localization of commensal bacteria in immune cell homeostasis and disease. Immunological reviews. 2014 Information Resource GET IT
Times cited: 55
Regulation of the adaptive immune system by innate lymphoid cells. Current opinion in immunology. 2014 Review GET IT
Times cited: 39
Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis. Nature. 2013 Academic Article GET IT
Times cited: 196
Editorial: New tricks for innate lymphoid cells. Journal of leukocyte biology. 2013 Editorial Article GET IT
Times cited: 1
SnapShot: innate lymphoid cells. Immunity. 2013 Article GET IT
Times cited: 47
Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora. Immunity. 2013 Academic Article GET IT
Times cited: 352
Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria. Nature. 2013 Academic Article GET IT
Times cited: 629
T cell factor 1 is required for group 2 innate lymphoid cell generation. Immunity. 2013 Academic Article GET IT
Times cited: 209
Persistent enteric murine norovirus infection is associated with functionally suboptimal virus-specific CD8 T cell responses. Journal of virology. 2013 Academic Article GET IT
Times cited: 74
TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation. Science translational medicine. 2013 Academic Article GET IT
Times cited: 615
Resistin-like molecule α promotes pathogenic Th17 cell responses and bacterial-induced intestinal inflammation. Journal of immunology (Baltimore, Md. : 1950). 2013 Academic Article GET IT
Times cited: 30
Innate lymphoid cell interactions with microbiota: implications for intestinal health and disease. Immunity. 2012 Information Resource GET IT
Times cited: 227
Commensal bacteria calibrate the activation threshold of innate antiviral immunity. Immunity. 2012 Academic Article GET IT
Times cited: 790
Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science (New York, N.Y.). 2012 Academic Article GET IT
Times cited: 619
Innate lymphoid cells: critical regulators of allergic inflammation and tissue repair in the lung. Current opinion in immunology. 2012 Information Resource GET IT
Times cited: 92
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nature immunology. 2011 Academic Article GET IT
Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22. Nature immunology. 2011 Information Resource GET IT
Times cited: 693
CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut. Immunity. 2010 Academic Article GET IT
Times cited: 499
Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A. The Journal of experimental medicine. 2010 Academic Article GET IT
Times cited: 320
Functional biology of the IL-22-IL-22R pathway in regulating immunity and inflammation at barrier surfaces. Advances in immunology. 2010 Article GET IT
Times cited: 116
Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production. Blood. 2009 Academic Article GET IT
Times cited: 9
Manipulation of T(H)17 responses in pulmonary immunity and disease through vaccination. Human vaccines. 2009 Review GET IT
Times cited: 8
Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice. Journal of immunology (Baltimore, Md. : 1950). 2008 Academic Article GET IT
Times cited: 78

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Research

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Funding awarded

Immune regulation of intestinal health and disease awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2023 - 2028
Novel mechanisms protecting the gut from TNF awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2023 - 2028
Innate-like lymphocyte regulation of host-microbiota interactions in cancer awarded by National Cancer Institute Principal Investigator 2023 - 2027
Innate lymphoid cell regulation of the host-microbiota interactions in cancer awarded by National Cancer Institute Principal Investigator 2022 - 2027
Innate immune regulation of neuroinflammation awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2021 - 2026
Defining a novel mechanism of mucosal healing awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2019 - 2025
Innate immune regulation of host-microbe interactions awarded by Burroughs Wellcome Fund Principal Investigator 2018 - 2025
Defining host-microbe interactions in cancer and immunotherapy awarded by Cancer Research Institute, Inc. Principal Investigator 2019 - 2024
Interleukin-2 regulation of mucosal inflammation awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2019 - 2024
Biopharma Agreement Principal Investigator 2020 - 2023
EA Pharma Research Collaboration Agreement Principal Investigator 2020 - 2023

Immune Privilege, CNS Autoimmunity, and Clostridium perfringens Epsilon Toxin awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2023 - 2028

Immune Privilege, CNS Autoimmunity, and Clostridium perfringens Epsilon Toxin awarded by National Institute of Allergy & Infectious Diseases Co-Principal Investigator 2023 - 2028
MIST Early Career Scholar Awards in Mucosal Immunology awarded by National Institute of Allergy & Infectious Diseases Co-Principal Investigator 2024 - 2026
Regulation of mucosal immunity by neuronal pathways awarded by National Institute on Aging Co-Principal Investigator 2021 - 2026

Defining novel mechanisms of microbiota in regulating anti-tumor responses awarded by National Cancer Institute Key Personnel 2024 - 2026
[2021] National Science Foundation (NSF) Graduate Research Fellowship (GRF) awarded by National Science Foundation Key Personnel 2023 - 2026
Regulation of Enteric Nervous System Function by Group 3 Innate Lymphoid Cells awarded by National Institute of Diabetes & Digestive & Kidney Diseases Key Personnel 2023 - 2026
ILC3 Syndecan-4 in the Regulation of Intestinal Health and Inflammation awarded by National Institute of Diabetes & Digestive & Kidney Diseases Key Personnel 2023 - 2026
Defining mechanisms of immune tolerance to the intestinal microbiota Key Personnel 2023 - 2025
Investigating molecular mechanisms behind gut bacterial transamination and IBD awarded by Kenneth Rainin Foundation Key Personnel 2022 - 2025
CTLA-4 regulation of intestinal health and inflammation Key Personnel 2022 - 2024
Defining a novel regulator of innate lymphoid cells and intestinal health awarded by Crohn''s & Colitis Foundation of America, Inc. Key Personnel 2021 - 2024

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Background

education and training

Ph.D., University of Pennsylvania 2011
B.S., State University of New York at Buffalo 2007

Contact

full name

Gregory F Sonnenberg

primary email

gfsonnenberg@med.cornell.edu

webpage

https://sonnenberglab.weill.cornell.edu

Phone