Linares Rodriguez, Juan Francisco

Publications

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selected publications

Increased translation driven by non-canonical EZH2 creates a synthetic vulnerability in enzalutamide-resistant prostate cancer. Nature communications. 2024 Academic Article GET IT
Opposing regulation of the STING pathway in hepatic stellate cells by NBR1 and p62 determines the progression of hepatocellular carcinoma. Molecular cell. 2024 Academic Article GET IT
Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation. Developmental cell. 2024 Academic Article GET IT
Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis. Nature communications. 2023 Academic Article GET IT
Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer. Cancer cell. 2022 Academic Article GET IT
The lactate-NAD⁺ axis activates cancer-associated fibroblasts by downregulating p62. Cell reports. 2022 Academic Article GET IT
Protein kinase Cλ/ι in cancer: a contextual balance of time and signals. Trends in cell biology. 2022 Review GET IT
PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis. Molecular cell. 2021 Academic Article GET IT
Times cited: 16
NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ. Nature communications. 2021 Academic Article GET IT
Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population. Developmental cell. 2020 Academic Article GET IT
Times cited: 64
PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression. Cancer cell. 2020 Academic Article GET IT
Times cited: 99
Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer. Cancer cell. 2019 Academic Article GET IT
Times cited: 146
Mechanistic insight into the regulation of SQSTM1/p62. Autophagy. 2019 Article GET IT
Times cited: 13
ZZ-dependent regulation of p62/SQSTM1 in autophagy. Nature communications. 2018 Academic Article GET IT
Times cited: 72
ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma. Cell metabolism. 2017 Academic Article GET IT
Times cited: 86
p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells. Cancer cell. 2016 Academic Article GET IT
Times cited: 366
Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade. Cell reports. 2015 Academic Article GET IT
Times cited: 98
Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ. Cell reports. 2015 Academic Article GET IT
Times cited: 71
A macrophage NBR1-MEKK3 complex triggers JNK-mediated adipose tissue inflammation in obesity. Cell metabolism. 2014 Academic Article GET IT
Times cited: 39
K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells. Molecular cell. 2013 Academic Article GET IT
Times cited: 209
c-Myc phosphorylation by PKCζ represses prostate tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 44
p62 is a key regulator of nutrient sensing in the mTORC1 pathway. Molecular cell. 2011 Academic Article GET IT
Times cited: 422
Phosphorylation of p62 by cdk1 controls the timely transit of cells through mitosis and tumor cell proliferation. Molecular and cellular biology. 2010 Academic Article GET IT
Times cited: 44
PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance. Cell metabolism. 2010 Academic Article GET IT
Times cited: 27
A global view of antibiotic resistance. FEMS microbiology reviews. 2008 Information Resource GET IT
Times cited: 208
Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo. Molecular and cellular biology. 2008 Academic Article GET IT
Times cited: 70
Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis. The EMBO journal. 2008 Academic Article GET IT
Times cited: 69
The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis. Cancer cell. 2008 Academic Article GET IT
Times cited: 405
[Antimicrobial resistance and bacterial virulence]. Enfermedades infecciosas y microbiologia clinica. 2005 Information Resource GET IT
Times cited: 14
The Pseudomonas putida Crc global regulator controls the expression of genes from several chromosomal catabolic pathways for aromatic compounds. Journal of bacteriology. 2004 Academic Article GET IT
Times cited: 104
Fitness of in vitro selected Pseudomonas aeruginosa nalB and nfxB multidrug resistant mutants. The Journal of antimicrobial chemotherapy. 2002 Academic Article GET IT
Times cited: 137

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Research

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Co-investigator Network

Funding awarded

Molecular mechanisms driving therapy-induced lineage plasticity awarded by National Cancer Institute Principal Investigator 2023 - 2028

Role of the CD44/Hyaluronan axis in mesenchymal prostate cancer awarded by National Cancer Institute Co-Investigator 2023 - 2028
Novel Pathways in the Control of Lineage Plasticity in Neuroendocrine Prostate Cancer awarded by National Cancer Institute Co-Investigator 2020 - 2025

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Background

education and training

Ph.D., Autonomous University of Madrid (Spain) 2005
B.S., University of Granada (Spain) 2000

Contact

full name

Juan Francisco Linares Rodriguez

primary email

jul4008@med.cornell.edu

VIVO Weill Cornell Medical College

Juan Francisco Linares Rodriguez Instructor in Pathology and Laboratory Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email