Bryk, Ruslana

Publications

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selected publications

Indazole to 2-cyanoindole scaffold progression for mycobacterial lipoamide dehydrogenase inhibitors achieves extended target residence time and improved antibacterial activity. Angewandte Chemie (International ed. in English). 2024 Academic Article GET IT
Shape-Based Virtual Screening of a Billion-Compound Library Identifies Mycobacterial Lipoamide Dehydrogenase Inhibitors. ACS bio & med chem Au. 2023 Academic Article GET IT
Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions. ACS infectious diseases. 2021 Academic Article GET IT
Potentiation of rifampin activity in a mouse model of tuberculosis by activation of host transcription factor EB. PLoS pathogens. 2020 Academic Article GET IT
Times cited: 9
Fatal Cytomegalovirus Infection in an Adult with Inherited NOS2 Deficiency. 2020 GET IT
Times cited: 23
Evidence for dispensability of protein kinase R in host control of tuberculosis. European journal of immunology. 2018 Academic Article GET IT
Times cited: 8
Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase. Tuberculosis (Edinburgh, Scotland). 2015 Academic Article GET IT
Times cited: 6
E1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 2015 Academic Article GET IT
Times cited: 46
Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. Biochemistry. 2013 Academic Article GET IT
Times cited: 16
Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorganic & medicinal chemistry letters. 2011 Academic Article GET IT
Times cited: 18
Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes. Cell host & microbe. 2011 Academic Article GET IT
Times cited: 101
Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase . Biochemistry. 2010 Academic Article GET IT
Times cited: 24
Identification of a copper-binding metallothionein in pathogenic mycobacteria. Nature chemical biology. 2008 Academic Article GET IT
Times cited: 174
A philosophy of anti-infectives as a guide in the search for new drugs for tuberculosis. Tuberculosis (Edinburgh, Scotland). 2008 Review GET IT
Times cited: 51
Selective killing of nonreplicating mycobacteria. Cell host & microbe. 2008 Academic Article GET IT
Times cited: 159
Crystal structure and functional analysis of lipoamide dehydrogenase from Mycobacterium tuberculosis. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 27
Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Molecular microbiology. 2005 Academic Article GET IT
Times cited: 70
Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase. Proceedings of the National Academy of Sciences of the United States of America. 2005 Academic Article GET IT
Times cited: 167
Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein. Science (New York, N.Y.). 2002 Academic Article GET IT
Times cited: 297
Peroxynitrite reductase activity of bacterial peroxiredoxins. Nature. 2000 Academic Article GET IT
Times cited: 546
Pharmacological modulation of nitric oxide synthesis by mechanism-based inactivators and related inhibitors. Pharmacology & therapeutics. 1999 Information Resource GET IT
Times cited: 45
Studies of neuronal nitric oxide synthase inactivation by diverse suicide inhibitors. Archives of biochemistry and biophysics. 1999 Academic Article GET IT
Times cited: 13
Mechanism of inducible nitric oxide synthase inactivation by aminoguanidine and L-N6-(1-iminoethyl)lysine. Biochemistry. 1998 Academic Article GET IT
Times cited: 73
Pharmacological characterization of guanidinoethyldisulphide (GED), a novel inhibitor of nitric oxide synthase with selectivity towards the inducible isoform. British journal of pharmacology. 1996 Academic Article GET IT
Times cited: 54

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Research

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Funding awarded

Studies of lipoamide dehydrogenase tight binding inhibition in tuberculous and non-tuberculous mycobacteria awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2023 - 2028

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Background

education and training

Ph.D., Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey 1999
B.S., Lviv State University (Ukraine) 1990

VIVO Weill Cornell Medical College

Ruslana Bryk Associate Professor of Research in Microbiology and Immunology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email