Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier. Review uri icon

Overview

abstract

  • Recent advances in liquid chromatography and mass spectrometry have enabled the highly parallel, quantitative measurement of metabolites within a cell and the ability to trace their biochemical fates. In Mycobacterium tuberculosis (Mtb), these advances have highlighted major gaps in our understanding of central carbon metabolism (CCM) that have prompted fresh interpretations of the composition and structure of its metabolic pathways and the phenotypes of Mtb strains in which CCM genes have been deleted. High-throughput screens have demonstrated that small chemical compounds can selectively inhibit some enzymes of Mtb's CCM while sparing homologs in the host. Mtb's CCM has thus emerged as a frontier for both fundamental and translational research.

publication date

  • May 10, 2011

Research

keywords

  • Carbon
  • Genes, Bacterial
  • Mycobacterium tuberculosis

Identity

PubMed Central ID

  • PMC3601588

Scopus Document Identifier

  • 79959913123

Digital Object Identifier (DOI)

  • 10.1016/j.tim.2011.03.008

PubMed ID

  • 21561773

Additional Document Info

volume

  • 19

issue

  • 7