selected publications
- Interruption of mycothiol synthesis and intracellular redox status impact iron-regulated reporter activation in Mycobacterium smegmatis. Microbiology spectrum. 2024 Academic Article GET IT
- Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin. Nature communications. 2024 Academic Article GET IT
- Synthetic lethality of Mycobacterium tuberculosis NADH dehydrogenases is due to impaired NADH oxidation. mBio. 2023 Academic Article GET IT
- A "suicide" BCG strain provides enhanced immunogenicity and robust protection against Mycobacterium tuberculosis in macaques. 2023 GET IT
- Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model. 2023 GET IT
- Differentiating the roles of Mycobacterium tuberculosis substrate binding proteins, FecB and FecB2, in iron uptake. PLoS pathogens. 2023 Academic Article GET IT
- Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis. mBio. 2023 Academic Article GET IT
- Cyclic AMP is a critical mediator of intrinsic drug resistance and fatty acid metabolism in M. tuberculosis. eLife. 2023 Academic Article GET IT
- A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis. Nature communications. 2022 Academic Article GET IT
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CinA mediates multidrug tolerance in Mycobacterium tuberculosis.
Nature communications.
2022
Academic Article
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Times cited: 22 - Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy. Proceedings of the National Academy of Sciences of the United States of America. 2022 Academic Article GET IT
- Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice. eLife. 2022 Academic Article GET IT
- Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection. Nature communications. 2021 Academic Article GET IT
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Multiform antimicrobial resistance from a metabolic mutation.
Science advances.
2021
Academic Article
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Times cited: 25 -
Growth of Mycobacterium tuberculosis at acidic pH depends on lipid assimilation and is accompanied by reduced GAPDH activity.
Proceedings of the National Academy of Sciences of the United States of America.
2021
Academic Article
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Times cited: 33 -
Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis.
Cell.
2021
Academic Article
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Times cited: 123 -
Genetic models of latent tuberculosis in mice reveal differential influence of adaptive immunity.
The Journal of experimental medicine.
2021
Academic Article
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Times cited: 9 -
Metabolic bifunctionality of Rv0812 couples folate and peptidoglycan biosynthesis in Mycobacterium tuberculosis.
The Journal of experimental medicine.
2021
Academic Article
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Times cited: 4 -
Rv0954 Is a Member of the Mycobacterial Cell Division Complex.
Frontiers in microbiology.
2021
Academic Article
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Times cited: 3 -
Nonredundant functions of Mycobacterium tuberculosis chaperones promote survival under stress.
Molecular microbiology.
2020
Academic Article
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Times cited: 4 - Mycobacterium tuberculosis infection is exacerbated in mice lacking lecithin:retinol acyltransferase. Biochimica et biophysica acta. Molecular basis of disease. 2020 Academic Article GET IT
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Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA-damage response and leads to cell death.
Molecular microbiology.
2020
Academic Article
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Times cited: 22 -
Two interacting ATPases protect Mycobacterium tuberculosis from glycerol and nitric oxide toxicity.
Journal of bacteriology.
2020
Academic Article
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Times cited: 7 -
Tissue Distribution of Doxycycline in Animal Models of Tuberculosis.
Antimicrobial agents and chemotherapy.
2020
Academic Article
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Times cited: 21 -
Peptidoglycan Hydrolases RipA and Ami1 Are Critical for Replication and Persistence of Mycobacterium tuberculosis in the Host.
mBio.
2020
Academic Article
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Times cited: 35 -
Persistent Mycobacterium tuberculosis infection in mice requires PerM for successful cell division.
eLife.
2019
Academic Article
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Times cited: 13 -
Statistical analysis of variability in TnSeq data across conditions using zero-inflated negative binomial regression.
BMC bioinformatics.
2019
Academic Article
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Times cited: 14 -
Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development.
Nature communications.
2019
Academic Article
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Times cited: 72 -
Mycobacterium tuberculosis releases an antacid that remodels phagosomes.
Nature chemical biology.
2019
Academic Article
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Times cited: 47 -
Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis.
Nature communications.
2019
Academic Article
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Times cited: 72 -
Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.
Nature.
2019
Academic Article
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Times cited: 40 -
Identification of Enolase as the Target of 2-Aminothiazoles in Mycobacterium tuberculosis.
Frontiers in microbiology.
2018
Academic Article
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Times cited: 8 -
Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis.
Nature reviews. Microbiology.
2018
Review
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Times cited: 149 -
Targeting protein biotinylation enhances tuberculosis chemotherapy.
Science translational medicine.
2018
Academic Article
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Times cited: 23 -
Critical Impact of Peptidoglycan Precursor Amidation on the Activity of l,d-Transpeptidases from Enterococcus faecium and Mycobacterium tuberculosis.
Chemistry (Weinheim an der Bergstrasse, Germany).
2018
Academic Article
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Times cited: 14 -
Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy.
2017
Academic Article
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Times cited: 67 -
Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between Mycobacterium smegmatis and Mycobacterium tuberculosis.
mBio.
2017
Academic Article
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Times cited: 42 -
Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America.
2017
Academic Article
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Times cited: 73 -
Fumarase Deficiency Causes Protein and Metabolite Succination and Intoxicates Mycobacterium tuberculosis.
Cell chemical biology.
2017
Academic Article
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Times cited: 37 -
PPE Surface Proteins Are Required for Heme Utilization by Mycobacterium tuberculosis.
mBio.
2017
Academic Article
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Times cited: 69 -
Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis.
mBio.
2017
Academic Article
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Times cited: 406 -
Mycobacterium tuberculosis protease MarP activates a peptidoglycan hydrolase during acid stress.
The EMBO journal.
2017
Academic Article
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Times cited: 41 -
Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice.
PLoS pathogens.
2016
Academic Article
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Times cited: 30 -
A broader spectrum of tuberculosis.
Nature medicine.
2016
Comment
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Times cited: 8 -
Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis.
ACS infectious diseases.
2016
Academic Article
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Times cited: 60 -
Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense.
PLoS pathogens.
2016
Academic Article
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Times cited: 51 -
Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis.
Nature communications.
2015
Academic Article
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Times cited: 52 -
Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages.
Molecular microbiology.
2015
Academic Article
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Times cited: 59 -
Identification of Rv3852 as an Agrimophol-Binding Protein in Mycobacterium tuberculosis.
PloS one.
2015
Academic Article
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Times cited: 18 -
Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice.
PLoS pathogens.
2015
Academic Article
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Times cited: 27 -
Construction of conditional knockdown mutants in mycobacteria.
Methods in molecular biology (Clifton, N.J.).
2015
Academic Article
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Times cited: 27 -
Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis.
ACS chemical biology.
2014
Academic Article
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Times cited: 28 -
LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis.
PLoS pathogens.
2014
Academic Article
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Times cited: 80 -
Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis.
PLoS pathogens.
2014
Academic Article
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Times cited: 60 -
Triosephosphate isomerase is dispensable in vitro yet essential for Mycobacterium tuberculosis to establish infection.
mBio.
2014
Academic Article
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Times cited: 40 -
An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity.
Proceedings of the National Academy of Sciences of the United States of America.
2014
Academic Article
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Times cited: 106 - Regulated Expression Systems for Mycobacteria and Their Applications. Microbiology spectrum. 2014 Academic Article GET IT
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A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence.
Proceedings of the National Academy of Sciences of the United States of America.
2013
Academic Article
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Times cited: 113 -
Perturbation of cytochrome c maturation reveals adaptability of the respiratory chain in Mycobacterium tuberculosis.
mBio.
2013
Academic Article
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Times cited: 61 -
Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis.
PloS one.
2013
Academic Article
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Times cited: 61 -
Substrate specificity of MarP, a periplasmic protease required for resistance to acid and oxidative stress in Mycobacterium tuberculosis.
The Journal of biological chemistry.
2013
Academic Article
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Times cited: 24 -
Glucose phosphorylation is required for Mycobacterium tuberculosis persistence in mice.
PLoS pathogens.
2013
Academic Article
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Times cited: 89 -
Mycobacterial trehalose dimycolate reprograms macrophage global gene expression and activates matrix metalloproteinases.
Infection and immunity.
2012
Academic Article
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Times cited: 36 -
M. tuberculosis induces potent activation of IDO-1, but this is not essential for the immunological control of infection.
PloS one.
2012
Academic Article
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Times cited: 76 -
Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression.
PLoS pathogens.
2011
Academic Article
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Times cited: 126 -
Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli.
The Journal of biological chemistry.
2011
Academic Article
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Times cited: 69 -
Mycobacterium tuberculosis gene Rv2136c is dispensable for acid resistance and virulence in mice.
Tuberculosis (Edinburgh, Scotland).
2011
Academic Article
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Times cited: 6 -
Phosphodiesterase 4 inhibition reduces innate immunity and improves isoniazid clearance of Mycobacterium tuberculosis in the lungs of infected mice.
PloS one.
2011
Academic Article
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Times cited: 62 -
Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes.
Cell host & microbe.
2011
Academic Article
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Times cited: 100 -
Simultaneous analysis of multiple Mycobacterium tuberculosis knockdown mutants in vitro and in vivo.
PloS one.
2010
Academic Article
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Times cited: 61 -
Metabolomics of Mycobacterium tuberculosis reveals compartmentalized co-catabolism of carbon substrates.
Chemistry & biology.
2010
Academic Article
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Times cited: 243 -
Nitrate respiration protects hypoxic Mycobacterium tuberculosis against acid- and reactive nitrogen species stresses.
PloS one.
2010
Academic Article
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Times cited: 88 -
Structural insight into serine protease Rv3671c that Protects M. tuberculosis from oxidative and acidic stress.
Structure (London, England : 1993).
2010
Academic Article
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Times cited: 30 -
Induction of ER stress in macrophages of tuberculosis granulomas.
PloS one.
2010
Academic Article
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Times cited: 114 -
The Mycobacterium tuberculosis proteasome active site threonine is essential for persistence yet dispensable for replication and resistance to nitric oxide.
PLoS pathogens.
2010
Academic Article
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Times cited: 78 -
Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection.
Proceedings of the National Academy of Sciences of the United States of America.
2010
Academic Article
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Times cited: 284 -
The spectrum of latent tuberculosis: rethinking the biology and intervention strategies.
Nature reviews. Microbiology.
2009
Review
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Times cited: 1109 -
Improved tetracycline repressors for gene silencing in mycobacteria.
Nucleic acids research.
2009
Academic Article
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Times cited: 80 -
RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteins.
Cell host & microbe.
2009
Academic Article
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Times cited: 50 -
Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment.
Journal of bacteriology.
2008
Academic Article
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Times cited: 126 - Sabine Ehrt: searching for mycobacterial stress points. Interview by Hema Bashyam. The Journal of experimental medicine. 2008 Article GET IT
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A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis.
Nature medicine.
2008
Academic Article
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Times cited: 271 -
Biosynthesis and recycling of nicotinamide cofactors in mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli.
The Journal of biological chemistry.
2008
Academic Article
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Times cited: 142 -
Selective killing of nonreplicating mycobacteria.
Cell host & microbe.
2008
Academic Article
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Times cited: 159 -
In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice.
Nature medicine.
2007
Academic Article
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Times cited: 215 -
Nucleotide-binding oligomerization domain protein 2-deficient mice control infection with Mycobacterium tuberculosis.
Infection and immunity.
2007
Academic Article
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Times cited: 93 -
Mycobacterial nonhomologous end joining mediates mutagenic repair of chromosomal double-strand DNA breaks.
Journal of bacteriology.
2007
Academic Article
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Times cited: 79 -
Silencing Mycobacterium smegmatis by using tetracycline repressors.
Journal of bacteriology.
2007
Academic Article
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Times cited: 99 -
Mycobacterium tuberculosis virulence: lipids inside and out.
Nature medicine.
2007
Article
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Times cited: 41 -
Controlling gene expression in mycobacteria.
Future microbiology.
2006
Review
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Times cited: 22 -
Cytosolic phospholipase A2 enzymes are not required by mouse bone marrow-derived macrophages for the control of Mycobacterium tuberculosis in vitro.
Infection and immunity.
2006
Academic Article
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Times cited: 14 - Introduction: genomic approaches in infectious diseases. Microbes and infection. 2006 Editorial Article GET IT
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Dihydrolipoamide acyltransferase is critical for Mycobacterium tuberculosis pathogenesis.
Infection and immunity.
2006
Academic Article
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Times cited: 82 -
Induction of macrophage-derived SLPI by Mycobacterium tuberculosis depends on TLR2 but not MyD88.
Immunology.
2005
Academic Article
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Times cited: 28 -
Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase.
The Journal of experimental medicine.
2005
Academic Article
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Times cited: 184 -
Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1.
Journal of immunology (Baltimore, Md. : 1950).
2005
Academic Article
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Times cited: 75 -
Ancestral antibiotic resistance in Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America.
2005
Academic Article
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Times cited: 260 -
A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP.
Molecular microbiology.
2005
Academic Article
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Times cited: 112 -
Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor.
Nucleic acids research.
2005
Academic Article
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Times cited: 289 -
The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide.
Science (New York, N.Y.).
2003
Academic Article
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Times cited: 395 -
Hypervirulent mutant of Mycobacterium tuberculosis resulting from disruption of the mce1 operon.
Proceedings of the National Academy of Sciences of the United States of America.
2003
Academic Article
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Times cited: 184 -
MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis.
The Journal of experimental medicine.
2003
Academic Article
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Times cited: 127 -
Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment.
The Journal of experimental medicine.
2003
Academic Article
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Times cited: 1202 -
Isolation of plasmids from E. coli by alkaline lysis.
Methods in molecular biology (Clifton, N.J.).
2003
Academic Article
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Times cited: 17 -
Isolation of plasmids from E. coli by boiling lysis.
Methods in molecular biology (Clifton, N.J.).
2003
Academic Article
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Times cited: 1 -
Energy transfer between fluorescent proteins using a co-expression system in Mycobacterium smegmatis.
Gene.
2001
Academic Article
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Times cited: 52 -
Reprogramming of the macrophage transcriptome in response to interferon-gamma and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase.
The Journal of experimental medicine.
2001
Academic Article
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Times cited: 405 -
Recombinant Mycobacterium tuberculosis protein associated with mammalian cell entry.
Cellular microbiology.
2001
Academic Article
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Times cited: 123 - Plasmid vectors. Methods in molecular medicine. 2001 Academic Article GET IT
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A parallel intraphagosomal survival strategy shared by mycobacterium tuberculosis and Salmonella enterica.
Molecular microbiology.
2000
Academic Article
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Times cited: 118 -
Deletion of the putative antioxidant noxR1 does not alter the virulence of Mycobacterium tuberculosis H37Rv.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.
2000
Academic Article
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Times cited: 8 -
Cloning of the mspA gene encoding a porin from Mycobacterium smegmatis.
Molecular microbiology.
1999
Academic Article
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Times cited: 116 -
noxR3, a novel gene from Mycobacterium tuberculosis, protects Salmonella typhimurium from nitrosative and oxidative stress.
Infection and immunity.
1999
Academic Article
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Times cited: 53 -
A novel antioxidant gene from Mycobacterium tuberculosis.
The Journal of experimental medicine.
1997
Academic Article
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Times cited: 91 -
Expression, inducer spectrum, domain structure, and function of MopR, the regulator of phenol degradation in Acinetobacter calcoaceticus NCIB8250.
Journal of bacteriology.
1997
Academic Article
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Times cited: 108 -
Genetic organization, nucleotide sequence and regulation of expression of genes encoding phenol hydroxylase and catechol 1,2-dioxygenase in Acinetobacter calcoaceticus NCIB8250.
Molecular microbiology.
1995
Academic Article
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Times cited: 83 -
Two genes encoding proteins with similarities to rubredoxin and rubredoxin reductase are required for conversion of dodecane to lauric acid in Acinetobacter calcoaceticus ADP1.
Microbiology (Reading, England).
1995
Academic Article
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Times cited: 31 -
RpoN (sigma 54) is required for conversion of phenol to catechol in Acinetobacter calcoaceticus.
Journal of bacteriology.
1994
Academic Article
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Times cited: 23 -
UDP-N-acetylglucosamine 1-carboxyvinyl-transferase from Acinetobacter calcoaceticus.
FEMS microbiology letters.
1994
Academic Article
GET IT
Times cited: 3