Gong, Shiaoching

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selected publications

Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model. Neuron. 2024 Academic Article GET IT
Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties. Proceedings of the National Academy of Sciences of the United States of America. 2024 Academic Article GET IT
APOE3 - R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition. 2024 GET IT
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation. Cell. 2024 Academic Article GET IT
Times cited: 3
Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties. 2024 GET IT
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model. 2024 GET IT
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation. 2023 GET IT
Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience. Nature neuroscience. 2023 Academic Article GET IT
Times cited: 32
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration. Cell. 2022 Academic Article GET IT
Times cited: 119
The Purkinje-myocardial junction is the anatomical origin of ventricular arrhythmia in CPVT. JCI insight. 2022 Academic Article GET IT
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation. Science translational medicine. 2021 Academic Article GET IT
Times cited: 55
Parallel ascending spinal pathways for affective touch and pain. Nature. 2020 Academic Article GET IT
Times cited: 119
Growth of Saccharomyces cerevisiae and Preparation of DNA. Cold Spring Harbor protocols. 2020 Academic Article GET IT
Times cited: 2
Small-Scale Preparations of Yeast DNA. Cold Spring Harbor protocols. 2020 Academic Article GET IT
Times cited: 3
One-Step Bacterial Artificial Chromosome (BAC) Modification: Cloning of the A Homology Arm into Reporter-Shuttle Vector. Cold Spring Harbor protocols. 2020 Academic Article GET IT
Times cited: 4
One-Step Bacterial Artificial Chromosome (BAC) Modification: Preparation of Plasmids. Cold Spring Harbor protocols. 2020 Academic Article GET IT
Times cited: 4
One-Step Bacterial Artificial Chromosome (BAC) Modification: Preparation of the A Homology Arm (A-Box). Cold Spring Harbor protocols. 2020 Academic Article GET IT
Times cited: 5
One-Step Bacterial Artificial Chromosome (BAC) Modification: Transfer of the Reporter Vector into BAC/RecA Cells and Selection of Co-Integrates. Cold Spring Harbor protocols. 2020 Academic Article GET IT
One-Step Bacterial Artificial Chromosome (BAC) Modification: Transformation of the BAC Host with the RecA Vector. Cold Spring Harbor protocols. 2020 Academic Article GET IT
Times cited: 2
Two-Step Bacterial Artificial Chromosome (BAC) Engineering: Cloning of the A and B Homology Arms into the Shuttle Vector. Cold Spring Harbor protocols. 2020 Academic Article GET IT
Times cited: 4
Two-Step Bacterial Artificial Chromosome (BAC) Engineering: Electroporation of Competent BAC Host Cells with the Recombinant Shuttle Vector. Cold Spring Harbor protocols. 2020 Academic Article GET IT
Times cited: 3
Two-Step Bacterial Artificial Chromosome (BAC) Engineering: Preparation and Verification of the Recombinant Shuttle Vector. Cold Spring Harbor protocols. 2020 Academic Article GET IT
Times cited: 5
Two-Step Bacterial Artificial Chromosome (BAC) Engineering: Preparation of Shuttle Vector DNA. Cold Spring Harbor protocols. 2020 Academic Article GET IT
Times cited: 6
Two-Step Bacterial Artificial Chromosome (BAC) Engineering: Preparation of the A Homology Arm (A-Box) and B Homology Arm (B-Box). Cold Spring Harbor protocols. 2020 Academic Article GET IT
Times cited: 3
Two-Step Bacterial Artificial Chromosome (BAC) Engineering: Verification of Co-Integrates and Selection of Resolved BAC Clones. Cold Spring Harbor protocols. 2020 Academic Article GET IT
Times cited: 4
Examination of Bacterial Artificial Chromosome (BAC) DNA Quality and Quantity by Pulsed-Field Gel Electrophoresis. Cold Spring Harbor protocols. 2019 Article GET IT
Times cited: 8
Large-Scale Preparation and Linearization of Bacterial Artificial Chromosome (BAC) DNA. Cold Spring Harbor protocols. 2019 Academic Article GET IT
Small-Scale Isolation of Bacterial Artificial Chromosome (BAC) DNA and Verification by Polymerase Chain Reaction (PCR). Cold Spring Harbor protocols. 2019 Academic Article GET IT
Times cited: 6
Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis. Neuron. 2019 Academic Article GET IT
Times cited: 84
Bone protection by inhibition of microRNA-182. Nature communications. 2018 Academic Article GET IT
Times cited: 75
Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models. Nature communications. 2018 Academic Article GET IT
Times cited: 27
Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex. PLoS genetics. 2014 Academic Article GET IT
Times cited: 102
Signaling role of prokineticin 2 on the estrous cycle of female mice. PloS one. 2014 Academic Article GET IT
Times cited: 16
Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling. Immunity. 2013 Academic Article GET IT
Times cited: 233
Current mouse and cell models in prostate cancer research. Endocrine-related cancer. 2013 Information Resource GET IT
Times cited: 96
BAC transgenic mice and the GENSAT database of engineered mouse strains. Cold Spring Harbor protocols. 2013 Academic Article GET IT
Times cited: 43
Mouse transgenesis in a single locus with independent regulation for multiple fluorophores. PloS one. 2012 Academic Article GET IT
Times cited: 9
The functional organization of cutaneous low-threshold mechanosensory neurons. Cell. 2011 Academic Article GET IT
Times cited: 543
Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement. Neuron. 2011 Academic Article GET IT
Times cited: 509
Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature. 2010 Academic Article GET IT
Times cited: 925
Rapid bacterial artificial chromosome modification for large-scale mouse transgenesis. Nature protocols. 2010 Academic Article GET IT
Times cited: 60
A translational profiling approach for the molecular characterization of CNS cell types. Cell. 2008 Academic Article GET IT
Times cited: 884
Application of a translational profiling approach for the comparative analysis of CNS cell types. Cell. 2008 Academic Article GET IT
Times cited: 709
Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs. Nature neuroscience. 2008 Academic Article GET IT
Times cited: 202
Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice. Autism research : official journal of the International Society for Autism Research. 2008 Academic Article GET IT
Times cited: 245
Defining the expression pattern of the LGI1 gene in BAC transgenic mice. Mammalian genome : official journal of the International Mammalian Genome Society. 2007 Academic Article GET IT
Times cited: 47
Production of green fluorescent protein transgenic embryonic stem cells using the GENSAT bacterial artificial chromosome library. Stem cells (Dayton, Ohio). 2006 Academic Article GET IT
Times cited: 32
Modified bacterial artificial chromosomes for zebrafish transgenesis. Methods (San Diego, Calif.). 2006 Academic Article GET IT
Times cited: 38
Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice. Neuron. 2005 Academic Article GET IT
Times cited: 189
An overview on the generation of BAC transgenic mice for neuroscience research. Current protocols in neuroscience. 2005 Information Resource GET IT
Times cited: 44
Modification of bacterial artificial chromosomes (BACs) and preparation of intact BAC DNA for generation of transgenic mice. Current protocols in neuroscience. 2005 Academic Article GET IT
Times cited: 15
General method for the modification of different BAC types and the rapid generation of BAC transgenic mice. Genesis (New York, N.Y. : 2000). 2004 Academic Article GET IT
Times cited: 51
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes. Nature. 2003 Academic Article GET IT
Times cited: 1493
B cell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin beta. The Journal of experimental medicine. 2001 Academic Article GET IT
Times cited: 97
A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells. Human immunology. 2000 Academic Article GET IT
Times cited: 105
DEC-205 as a marker of dendritic cells with regulatory effects on CD8 T cell responses. International immunology. 2000 Academic Article GET IT
Times cited: 55
Counterselection against D mu is mediated through immunoglobulin (Ig)alpha-Igbeta. The Journal of experimental medicine. 1996 Academic Article GET IT
Times cited: 20
The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes. Nature. 1996 Academic Article GET IT
Times cited: 203
Regulation of an early developmental checkpoint in the B cell pathway by Ig beta. Science (New York, N.Y.). 1996 Academic Article GET IT
Times cited: 236
The 32-kilodalton envelope protein of vaccinia virus synthesized in Escherichia coli binds with specificity to cell surfaces. Journal of virology. 1991 Academic Article GET IT
Times cited: 17
Structural and functional properties of the 14-kDa envelope protein of vaccinia virus synthesized in Escherichia coli. The Journal of biological chemistry. 1990 Academic Article GET IT
Times cited: 32
Vaccinia virus induces cell fusion at acid pH and this activity is mediated by the N-terminus of the 14-kDa virus envelope protein. Virology. 1990 Academic Article GET IT
Times cited: 89
A single point mutation of Ala-25 to Asp in the 14,000-Mr envelope protein of vaccinia virus induces a size change that leads to the small plaque size phenotype of the virus. Journal of virology. 1989 Academic Article GET IT
Times cited: 22

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Research

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Funding awarded

Elucidate the Roles of Alzheimer''s Disease Variants in Gene Expression and AD Phenotypes awarded by National Institute on Aging Co-Investigator 2022 - 2027

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Background

education and training

B.S., Xiamen University (China) 83
Ph.D., State University of New York Health Science Center at Brooklyn 1990

Contact

full name

Shiaoching Gong

primary email

shg3006@med.cornell.edu

VIVO Weill Cornell Medical College

Shiaoching Gong Associate Professor of Research in Neuroscience

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email