Holloman, William K.

Publications

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selected publications

DNA polymerase ζ has robust reverse transcriptase activity relative to other cellular DNA polymerases. The Journal of biological chemistry. 2024 Academic Article GET IT
DNA polymerase ζ is a robust reverse transcriptase. 2024 GET IT
Determinants governing BRC function evaluated by mutational analysis of Brh2 in Ustilago maydis. DNA repair. 2023 Academic Article GET IT
Ustilago maydis telomere protein Pot1 harbors an extra N-terminal OB fold and regulates homology-directed DNA repair factors in a dichotomous and context-dependent manner. PLoS genetics. 2022 Academic Article GET IT
Structurally distinct telomere-binding proteins in Ustilago maydis execute non-overlapping functions in telomere replication, recombination, and protection. Communications biology. 2020 Academic Article GET IT
Times cited: 5
Characterization of a potent dominant negative mutant variant of Rad51 in Ustilago maydis. DNA repair. 2019 Academic Article GET IT
Loss of Cohesin Subunit Rec8 Switches Rad51 Mediator Dependence in Resistance to Formaldehyde Toxicity in Ustilago maydis. Genetics. 2018 Academic Article GET IT
Times cited: 3
Collaboration in the actions of Brh2 with resolving functions during DNA repair and replication stress in Ustilago maydis. DNA repair. 2018 Academic Article GET IT
Approaches to Understanding the Mediator Function of Brh2 in Ustilago maydis. Methods in enzymology. 2018 Article GET IT
Times cited: 1
Contributions of recombination and repair proteins to telomere maintenance in telomerase-positive and negative Ustilago maydis. Molecular microbiology. 2017 Academic Article GET IT
Times cited: 4
Dss1 Regulates Association of Brh2 with Rad51. Biochemistry. 2017 Academic Article GET IT
Times cited: 6
Mre11 and Blm-Dependent Formation of ALT-Like Telomeres in Ku-Deficient Ustilago maydis. PLoS genetics. 2015 Academic Article GET IT
Times cited: 20
LAMMER kinase contributes to genome stability in Ustilago maydis. DNA repair. 2015 Academic Article GET IT
Times cited: 10
Fungal Ku prevents permanent cell cycle arrest by suppressing DNA damage signaling at telomeres. Nucleic acids research. 2015 Academic Article GET IT
Times cited: 17
Dual DNA-binding domains shape the interaction of Brh2 with DNA. DNA repair. 2014 Academic Article GET IT
Times cited: 7
Initiation of meiotic recombination in Ustilago maydis. Genetics. 2013 Academic Article GET IT
Times cited: 8
Brh2 and Rad51 promote telomere maintenance in Ustilago maydis, a new model system of DNA repair proteins at telomeres. DNA repair. 2013 Academic Article GET IT
Times cited: 16
Dss1 release activates DNA binding potential in Brh2. Biochemistry. 2012 Academic Article GET IT
Times cited: 9
Brh2 domain function distinguished by differential cellular responses to DNA damage and replication stress. Molecular microbiology. 2011 Academic Article GET IT
Times cited: 7
Unraveling the mechanism of BRCA2 in homologous recombination. Nature structural & molecular biology. 2011 Information Resource GET IT
Times cited: 160
The DNA damage response signaling cascade regulates proliferation of the phytopathogenic fungus Ustilago maydis in planta. The Plant cell. 2011 Academic Article GET IT
Times cited: 21
Mutational analysis of Brh2 reveals requirements for compensating mediator functions. Molecular microbiology. 2010 Academic Article GET IT
Times cited: 15
Dss1 regulates interaction of Brh2 with DNA. Biochemistry. 2009 Academic Article GET IT
Times cited: 17
Brh2 promotes a template-switching reaction enabling recombinational bypass of lesions during DNA synthesis. Molecular cell. 2009 Academic Article GET IT
Times cited: 12
Role of Blm and collaborating factors in recombination and survival following replication stress in Ustilago maydis. DNA repair. 2009 Academic Article GET IT
Times cited: 16
DNA-binding Domain within the Brh2 N Terminus Is the Primary Interaction Site for Association with DNA. The Journal of biological chemistry. 2009 Academic Article GET IT
Times cited: 22
Second-end capture in DNA double-strand break repair promoted by Brh2 protein of Ustilago maydis. Molecular cell. 2009 Academic Article GET IT
Times cited: 26
Resolving resolvases: the final act?. Molecular cell. 2008 Article GET IT
Times cited: 7
The homologous recombination system of Ustilago maydis. Fungal genetics and biology : FG & B. 2008 Information Resource GET IT
Times cited: 43
Compensatory role for Rad52 during recombinational repair in Ustilago maydis. Molecular microbiology. 2008 Academic Article GET IT
Times cited: 25
D-loop formation by Brh2 protein of Ustilago maydis. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 17
Towards understanding the extreme radiation resistance of Ustilago maydis. Trends in microbiology. 2007 Academic Article GET IT
Times cited: 29
Ortholog of BRCA2-interacting protein BCCIP controls morphogenetic responses during DNA replication stress in Ustilago maydis. DNA repair. 2007 Academic Article GET IT
Times cited: 12
DNA binding, annealing, and strand exchange activities of Brh2 protein from Ustilago maydis. Biochemistry. 2007 Academic Article GET IT
Times cited: 32
Dss1 interaction with Brh2 as a regulatory mechanism for recombinational repair. Molecular and cellular biology. 2007 Academic Article GET IT
Times cited: 40
Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis. Nature. 2006 Academic Article GET IT
Times cited: 791
Rec2 interplay with both Brh2 and Rad51 balances recombinational repair in Ustilago maydis. Molecular and cellular biology. 2006 Academic Article GET IT
Times cited: 20
Brh2-Dss1 interplay enables properly controlled recombination in Ustilago maydis. Molecular and cellular biology. 2005 Academic Article GET IT
Times cited: 54
The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction. Nature. 2005 Academic Article GET IT
Times cited: 231
BRCA2-RAD51-DSS1 interplay examined from a microbial perspective. Cell cycle (Georgetown, Tex.). 2004 Academic Article GET IT
Times cited: 5
The BRCA2-interacting protein DSS1 is vital for DNA repair, recombination, and genome stability in Ustilago maydis. Molecular cell. 2003 Academic Article GET IT
Times cited: 92
AID-dependent generation of resected double-strand DNA breaks and recruitment of Rad52/Rad51 in somatic hypermutation. Immunity. 2003 Academic Article GET IT
Times cited: 82
BRCA2 homolog required for proficiency in DNA repair, recombination, and genome stability in Ustilago maydis. Molecular cell. 2002 Academic Article GET IT
Times cited: 128
Disruptions of the Ustilago maydis REC2 gene identify a protein domain important in directing recombinational repair of DNA. Molecular microbiology. 2001 Academic Article GET IT
Times cited: 9
Cell cycle phase, cellular Ca2+ and development in Dictyostelium discoideum. The International journal of developmental biology. 2001 Academic Article GET IT
Times cited: 27
A RecA homologue in Ustilago maydis that is distinct and evolutionarily distant from Rad51 actively promotes DNA pairing reactions in the absence of auxiliary factors. Biochemistry. 2001 Academic Article GET IT
Times cited: 6
Binding and melting of D-loops by the Bloom syndrome helicase. Biochemistry. 2000 Academic Article GET IT
Times cited: 185
Shuttle vectors for genetic manipulations in Ustilago maydis. Canadian journal of microbiology. 2000 Academic Article GET IT
Times cited: 23
BLM, the Bloom's syndrome protein, varies during the cell cycle in its amount, distribution, and co-localization with other nuclear proteins. Cytogenetics and cell genetics. 2000 Academic Article GET IT
Times cited: 50
DNA hydrolytic activity associated with the Ustilago maydis REC1 gene product analyzed on hairpin oligonucleotide substrates. Biochemistry. 1999 Academic Article GET IT
Times cited: 4
Targeted gene repair directed by the chimeric RNA/DNA oligonucleotide in a mammalian cell-free extract. Nucleic acids research. 1999 Academic Article GET IT
Times cited: 115
Molecular cloning of a gene required for DNA replication in Ustilago maydis. Molecular & general genetics : MGG. 1997 Academic Article GET IT
Times cited: 9
Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide. Science (New York, N.Y.). 1996 Academic Article GET IT
Times cited: 270
Recombinational repair of gaps in DNA is asymmetric in Ustilago maydis and can be explained by a migrating D-loop model. Proceedings of the National Academy of Sciences of the United States of America. 1996 Academic Article GET IT
Times cited: 136
The REC1 gene of Ustilago maydis, which encodes a 3'-->5' exonuclease, couples DNA repair and completion of DNA synthesis to a mitotic checkpoint. Genetics. 1996 Academic Article GET IT
Times cited: 26
Mutation avoidance and DNA repair proficiency in Ustilago maydis are differentially lost with progressive truncation of the REC1 gene product. Molecular and cellular biology. 1995 Academic Article GET IT
Times cited: 26
The REC2 gene encodes the homologous pairing protein of Ustilago maydis. Molecular and cellular biology. 1994 Academic Article GET IT
Times cited: 39
Structure of REC2, a recombinational repair gene of Ustilago maydis, and its function in homologous recombination between plasmid and chromosomal sequences. Molecular and cellular biology. 1994 Academic Article GET IT
Times cited: 29
DNA strand exchange in the absence of homologous pairing. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 13
The LEU1 gene of Ustilago maydis. Gene. 1994 Academic Article GET IT
Times cited: 11
ATP-dependent DNA renaturation and DNA-dependent ATPase reactions catalyzed by the Ustilago maydis homologous pairing protein. European journal of biochemistry. 1994 Academic Article GET IT
Times cited: 2
The REC1 gene of Ustilago maydis involved in the cellular response to DNA damage encodes an exonuclease. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 53
DNA relaxation mediated by Ustilago maydis type I topoisomerase; modulation by chromatin associated proteins. Biochimica et biophysica acta. 1993 Academic Article GET IT
Times cited: 9
Purification and properties of a cruciform DNA binding protein from Ustilago maydis. Chromosoma. 1993 Academic Article GET IT
Times cited: 6
Extrachromosomal recombination is deranged in the rec2 mutant of Ustilago maydis. Genetics. 1991 Academic Article GET IT
Times cited: 12
Isolation of the REC2 gene controlling recombination in Ustilago maydis. Gene. 1990 Academic Article GET IT
Times cited: 15
Pathways of transformation in Ustilago maydis determined by DNA conformation. Genetics. 1990 Academic Article GET IT
Times cited: 37
Isolation of the REC1 gene controlling recombination in Ustilago maydis. Gene. 1989 Academic Article GET IT
Times cited: 23
Cloning and disruption of Ustilago maydis genes. Molecular and cellular biology. 1989 Academic Article GET IT
Times cited: 50
Isolation and characterization of an autonomously replicating sequence from Ustilago maydis. Molecular and cellular biology. 1988 Academic Article GET IT
Times cited: 233
Topoisomerase from Ustilago maydis forms a covalent complex with single-stranded DNA through a phosphodiester bond to tyrosine. Biochemistry. 1986 Academic Article GET IT
Times cited: 6
Homologous pairing of DNA molecules by Ustilago rec1 protein is promoted by sequences of Z-DNA. Cell. 1986 Academic Article GET IT
Times cited: 71
Left-handed DNA and the synaptic pairing reaction promoted by Ustilago rec1 protein. Cell. 1985 Academic Article GET IT
Times cited: 62
Hysteretic regulation of Ustilago rec1 protein during synapsis. The Journal of biological chemistry. 1984 Academic Article GET IT
Times cited: 3
Purification and properties of nuclease gamma from Ustilago maydis. The Journal of biological chemistry. 1984 Academic Article GET IT
Times cited: 10
Synapsis promoted by Ustilago rec1 protein. Cell. 1984 Academic Article GET IT
Times cited: 46
Biochemical characterization of rec1 mutants and the genetic control of recombination in Ustilago maydis. Cold Spring Harbor symposia on quantitative biology. 1984 Academic Article GET IT
Times cited: 11
Homologous pairing promoted by Ustilago RecI protein. Cold Spring Harbor symposia on quantitative biology. 1984 Academic Article GET IT
Times cited: 5
Properties of a purified nuclear topoisomerase from L1210 cells. Biochimica et biophysica acta. 1983 Academic Article GET IT
Times cited: 12
Topological linkage of circular DNA molecules promoted by Ustilago rec 1 protein and topoisomerase. Cell. 1983 Academic Article GET IT
Times cited: 12
Heteroduplex formation and polarity during strand transfer promoted by Ustilago rec 1 protein. Cell. 1983 Academic Article GET IT
Times cited: 20
A DNA-binding protein from Ustilago maydis prefers duplex DNA without chain interruptions. Molecular and cellular biology. 1983 Academic Article GET IT
Times cited: 2
Homologous pairing of DNA molecules promoted by a protein from Ustilago. Cell. 1982 Academic Article GET IT
Times cited: 56
Beta protein of bacteriophage lambda promotes renaturation of DNA. The Journal of biological chemistry. 1981 Academic Article GET IT
Times cited: 100
Purification and properties of a topoisomerase from Ustilago maydis. The Journal of biological chemistry. 1981 Academic Article GET IT
Times cited: 45
Studies on nuclease alpha from Ustilago maydis. The Journal of biological chemistry. 1981 Academic Article GET IT
Times cited: 22
Purification and characterization of nuclease beta from Ustilago maydis. The Journal of biological chemistry. 1980 Academic Article GET IT
Times cited: 19
Uptake of homologous single-stranded fragments by superhelical DNA. III. The product and its enzymic conversion to a recombinant molecule. Journal of molecular biology. 1977 Academic Article GET IT
Times cited: 32
Uptake of homologous single-stranded fragments by superhelical DNA. IV. Branch migration. Journal of molecular biology. 1977 Academic Article GET IT
Times cited: 88
Recombination promoted by superhelical DNA and the recA gene of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 1976 Academic Article GET IT
Times cited: 35
A DNA polymerase from Ustilago maydis. 1. Purification and properties of the polymerase activity. European journal of biochemistry. 1976 Academic Article GET IT
Times cited: 26
Nuclease that preferentially inactivates DNA containing mismatched bases. Nature. 1975 Academic Article GET IT
Times cited: 22
Uptake of homologous single-stranded fragments by superhelical DNA: a possible mechanism for initiation of genetic recombination. Proceedings of the National Academy of Sciences of the United States of America. 1975 Academic Article GET IT
Times cited: 74
A protein from Ustilago which forms an acid-soluble complex with deoxyribonucleic acid. The Journal of biological chemistry. 1975 Academic Article GET IT
Times cited: 4
Studies on a nuclease from Ustilago maydis. I. Purification, properties, and implication in recombination of the enzyme. The Journal of biological chemistry. 1973 Academic Article GET IT
Times cited: 53
Studies on a nuclease from Ustilago maydis. II. Substrate specificity and mode of action of the enzyme. The Journal of biological chemistry. 1973 Academic Article GET IT
Times cited: 23
The possible role of deoxyribonucleases in recombination in eukaryotes: hypotheses and observations. Biochemical Society Transactions. 1973 Article
Control by cesium and intermediates of the citric acid cycle of extracellular ribonuclease and other enzymes involved in the assimilation of nitrogen. Proceedings of the National Academy of Sciences of the United States of America. 1971 Academic Article GET IT
Times cited: 12

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Research

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Funding awarded

Identifying synthetically lethal compounds for therapy of homologous recombination deficient (HRD) breast cancers awarded by National Cancer Institute Principal Investigator Subaward 2022 - 2024

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Background

education and training

Ph.D., University of California, Berkeley 1971
B.S., University of Texas, Austin 1967

Contact

full name

William K. Holloman

primary email

wkhollo@med.cornell.edu

VIVO Weill Cornell Medical College

William K. Holloman Professor of Microbiology and Immunology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email