Moore, John P

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Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies. The Journal of experimental medicine. 2024 Academic Article GET IT
Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site. Science immunology. 2024 Academic Article GET IT
Immunization with germ line-targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques. Science immunology. 2024 Academic Article GET IT
The harms of promoting the lab leak hypothesis for SARS-CoV-2 origins without evidence. Journal of virology. 2024 Academic Article GET IT
Progress on priming HIV-1 immunity. Science (New York, N.Y.). 2024 Comment GET IT
Times cited: 1
HIV BG505 SOSIP.664 trimer with 3M-052-AF/alum induces human autologous tier-2 neutralizing antibodies. 2024 GET IT
Germline-targeting SOSIP trimer immunization elicits precursor CD4 binding-site targeting broadly neutralizing antibodies in infant macaques. 2023 GET IT
Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization. PLoS pathogens. 2023 Academic Article GET IT
Correction: HIV-1-neutralizing antibody induced by simian adenovirus- and poxvirus MVA-vectored BG505 native-like envelope trimers. 2023 GET IT
Conformational antigenic heterogeneity as a cause of the persistent fraction in HIV-1 neutralization. Retrovirology. 2023 Academic Article GET IT
Times cited: 2
Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions. Cell reports. Medicine. 2023 Academic Article GET IT
Longitudinal antibody response kinetics following SARS-CoV-2 mRNA vaccination in pregnant and non-pregnant persons. American journal of obstetrics & gynecology MFM. 2022 Academic Article GET IT
Asthma 17q21 polymorphism associates with decreased risk of COVID-19 in children. Pediatric pulmonology. 2022 Letter GET IT
Times cited: 2
Structural dynamics reveal isolate-specific differences at neutralization epitopes on HIV Env. iScience. 2022 Academic Article GET IT
Broad and ultra-potent cross-clade neutralization of HIV-1 by a vaccine-induced CD4 binding site bovine antibody. Cell reports. Medicine. 2022 Academic Article GET IT
The glycan hole area of HIV-1 envelope trimers contributes prominently to the induction of autologous neutralization. Journal of virology. 2021 Academic Article GET IT
Beta testing the monkey model. Nature immunology. 2021 Comment GET IT
Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination. Science advances. 2021 Academic Article GET IT
Antibody responses induced by SHIV infection are more focused than those induced by soluble native HIV-1 envelope trimers in non-human primates. PLoS pathogens. 2021 Academic Article GET IT
Serologic response to mRNA COVID-19 vaccination in lymphoma patients. American journal of hematology. 2021 Letter GET IT
Times cited: 24
Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers. NPJ vaccines. 2021 Academic Article GET IT
Antibodies from Rabbits Immunized with HIV-1 Clade B SOSIP Trimers Can Neutralize Multiple Clade B Viruses by Destabilizing the Envelope Glycoprotein. Journal of virology. 2021 Academic Article GET IT
Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM. Nature communications. 2021 Academic Article GET IT
Times cited: 35
Predictors of Nonseroconversion after SARS-CoV-2 Infection. Emerging infectious diseases. 2021 Academic Article GET IT
Antibody Responses to SARS-CoV-2 mRNA Vaccines Are Detectable in Saliva. Pathogens & immunity. 2021 Academic Article GET IT
Times cited: 83
Postconvalescent SARS-CoV-2 IgG and Neutralizing Antibodies are Elevated in Individuals with Poor Metabolic Health. The Journal of clinical endocrinology and metabolism. 2021 Academic Article GET IT
Times cited: 23
Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike. Cell reports. 2021 Academic Article GET IT
Times cited: 3
Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles. NPJ vaccines. 2021 Academic Article GET IT
Times cited: 31
Testing-on-a-probe biosensors reveal association of early SARS-CoV-2 total antibodies and surrogate neutralizing antibodies with mortality in COVID-19 patients. Biosensors & bioelectronics. 2021 Academic Article GET IT
Times cited: 18
High-resolution mapping of the neutralizing and binding specificities of polyclonal sera post-HIV Env trimer vaccination. eLife. 2021 Academic Article GET IT
Times cited: 13
Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers. Journal of virology. 2020 Academic Article GET IT
Times cited: 14
Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates. PLoS pathogens. 2020 Academic Article GET IT
Times cited: 51
COVID-19 Vaccines: "Warp Speed" Needs Mind Melds, Not Warped Minds. Journal of virology. 2020 Information Resource GET IT
Times cited: 67
Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens. PLoS pathogens. 2020 Academic Article GET IT
Times cited: 44
Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens. eLife. 2020 Academic Article GET IT
Times cited: 107
T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers. Nature medicine. 2020 Academic Article GET IT
Times cited: 120
Env Exceptionalism: Why Are HIV-1 Env Glycoproteins Atypical Immunogens?. Cell host & microbe. 2020 Information Resource GET IT
Times cited: 39
Neutralizing Antibody Induction by HIV-1 Envelope Glycoprotein SOSIP Trimers on Iron Oxide Nanoparticles May Be Impaired by Mannose Binding Lectin. Journal of virology. 2020 Academic Article GET IT
Times cited: 26
SOS and IP Modifications Predominantly Affect the Yield but Not Other Properties of SOSIP.664 HIV-1 Env Glycoprotein Trimers. Journal of virology. 2019 Academic Article GET IT
Antibody Responses Elicited by Immunization with BG505 Trimer Immune Complexes. Journal of virology. 2019 Academic Article GET IT
Times cited: 13
Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle. Nature communications. 2019 Academic Article GET IT
Times cited: 133
Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies. Cell host & microbe. 2019 Academic Article GET IT
Times cited: 38
Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence. Nature communications. 2019 Academic Article GET IT
Times cited: 103
Optimizing the production and affinity purification of HIV-1 envelope glycoprotein SOSIP trimers from transiently transfected CHO cells. PloS one. 2019 Academic Article GET IT
Times cited: 16
Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide. Nature communications. 2019 Academic Article GET IT
Times cited: 24
Developability Assessment of Physicochemical Properties and Stability Profiles of HIV-1 BG505 SOSIP.664 and BG505 SOSIP.v4.1-GT1.1 gp140 Envelope Glycoprotein Trimers as Candidate Vaccine Antigens. Journal of pharmaceutical sciences. 2019 Academic Article GET IT
Times cited: 17
Stabilization of the V2 loop improves the presentation of V2 loop-associated broadly neutralizing antibody epitopes on HIV-1 envelope trimers. The Journal of biological chemistry. 2019 Academic Article GET IT
Times cited: 14
Closing and Opening Holes in the Glycan Shield of HIV-1 Envelope Glycoprotein SOSIP Trimers Can Redirect the Neutralizing Antibody Response to the Newly Unmasked Epitopes. Journal of virology. 2019 Academic Article GET IT
Times cited: 55
Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen. Cell reports. 2018 Academic Article GET IT
Times cited: 94
Effects of Adjuvants on HIV-1 Envelope Glycoprotein SOSIP Trimers In Vitro. Journal of virology. 2018 Academic Article GET IT
Times cited: 32
Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins. PLoS pathogens. 2018 Academic Article GET IT
Times cited: 22
Immunogenicity in Rabbits of HIV-1 SOSIP Trimers from Clades A, B, and C, Given Individually, Sequentially, or in Combination. Journal of virology. 2018 Academic Article GET IT
Times cited: 62
Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques. PLoS pathogens. 2018 Academic Article GET IT
Times cited: 82
Integrity of Glycosylation Processing of a Glycan-Depleted Trimeric HIV-1 Immunogen Targeting Key B-Cell Lineages. Journal of proteome research. 2018 Academic Article GET IT
Times cited: 19
cGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV-1 envelope glycoprotein vaccine candidate. Biotechnology and bioengineering. 2017 Academic Article GET IT
Times cited: 59
Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers. The Journal of biological chemistry. 2017 Academic Article GET IT
Times cited: 32
High-Throughput Protein Engineering Improves the Antigenicity and Stability of Soluble HIV-1 Envelope Glycoprotein SOSIP Trimers. Journal of virology. 2017 Academic Article GET IT
Times cited: 21
Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo. The Journal of experimental medicine. 2017 Academic Article GET IT
Times cited: 130
Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization. Cell reports. 2017 Academic Article GET IT
Times cited: 129
HIV-1-neutralizing antibody induced by simian adenovirus- and poxvirus MVA-vectored BG505 native-like envelope trimers. PloS one. 2017 Academic Article GET IT
Times cited: 14
Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike. Nature. 2017 Academic Article GET IT
Times cited: 186
Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP Trimers. Journal of virology. 2017 Academic Article GET IT
Times cited: 39
Improving the Expression and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers by Targeted Sequence Changes. Journal of virology. 2017 Academic Article GET IT
Times cited: 25
Glycosylation Benchmark Profile for HIV-1 Envelope Glycoprotein Production Based on Eleven Env Trimers. Journal of virology. 2017 Academic Article GET IT
Times cited: 72
Recognition of HIV-inactivating peptide triazoles by the recombinant soluble Env trimer, BG505 SOSIP.664. Proteins. 2017 Academic Article GET IT
Times cited: 7
Publishing: Journals, do your own formatting. Nature. 2017 Article GET IT
Times cited: 3
Molecular Architecture of the Cleavage-Dependent Mannose Patch on a Soluble HIV-1 Envelope Glycoprotein Trimer. Journal of virology. 2017 Academic Article GET IT
Times cited: 62
Native-like Env trimers as a platform for HIV-1 vaccine design. Immunological reviews. 2017 Information Resource GET IT
Times cited: 188
Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer. Cell reports. 2016 Academic Article GET IT
Times cited: 133
HIV's Achilles' Heel. Scientific American. 2016 Academic Article GET IT
Times cited: 6
An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability. Nature microbiology. 2016 Academic Article GET IT
Times cited: 120
Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 285
Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C. PLoS pathogens. 2016 Academic Article GET IT
Times cited: 119
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS pathogens. 2016 Academic Article GET IT
Times cited: 223
Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope Glycoprotein. Cell reports. 2016 Academic Article GET IT
Times cited: 212
HIV-1 Envelope Trimer Design and Immunization Strategies To Induce Broadly Neutralizing Antibodies. Trends in immunology. 2016 Information Resource GET IT
Times cited: 82
Native Conformation and Canonical Disulfide Bond Formation Are Interlinked Properties of HIV-1 Env Glycoproteins. Journal of virology. 2015 Academic Article GET IT
Times cited: 26
Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes. Cell. 2015 Academic Article GET IT
Times cited: 280
Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans. Immunity. 2015 Academic Article GET IT
Times cited: 168
A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo. PLoS pathogens. 2015 Academic Article GET IT
Times cited: 42
Chemical Cross-Linking Stabilizes Native-Like HIV-1 Envelope Glycoprotein Trimer Antigens. Journal of virology. 2015 Academic Article GET IT
Times cited: 29
Binding of inferred germline precursors of broadly neutralizing HIV-1 antibodies to native-like envelope trimers. Virology. 2015 Academic Article GET IT
Times cited: 37
Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity. Retrovirology. 2015 Academic Article GET IT
Times cited: 147
Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike. Nature communications. 2015 Academic Article GET IT
Times cited: 74
Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens. Proceedings of the National Academy of Sciences of the United States of America. 2015 Academic Article GET IT
Times cited: 106
Influences on the Design and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers. Journal of virology. 2015 Academic Article GET IT
Times cited: 73
Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity. Journal of virology. 2015 Academic Article GET IT
Times cited: 124
Short Communication: Virion Aggregation by Neutralizing and Nonneutralizing Antibodies to the HIV-1 Envelope Glycoprotein. AIDS research and human retroviruses. 2015 Academic Article GET IT
Times cited: 12
HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers. Science (New York, N.Y.). 2015 Academic Article GET IT
Times cited: 425
Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice. Cell. 2015 Academic Article GET IT
Times cited: 215
Structural Constraints Determine the Glycosylation of HIV-1 Envelope Trimers. Cell reports. 2015 Academic Article GET IT
Times cited: 110
Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer. PLoS pathogens. 2015 Academic Article GET IT
Times cited: 86
What Do Chaotrope-Based Avidity Assays for Antibodies to HIV-1 Envelope Glycoproteins Measure?. Journal of virology. 2015 Academic Article GET IT
Times cited: 24
Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env. Nature communications. 2015 Academic Article GET IT
Times cited: 113
A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene. Journal of virology. 2015 Academic Article GET IT
Times cited: 202
Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 284
HIV: A stamp on the envelope. Nature. 2014 Article GET IT
Times cited: 26
Structural evolution of glycan recognition by a family of potent HIV antibodies. Cell. 2014 Academic Article GET IT
Times cited: 147
Independent evolution of Fc- and Fab-mediated HIV-1-specific antiviral antibody activity following acute infection. European journal of immunology. 2014 Academic Article GET IT
Times cited: 45
Structure of 2G12 Fab2 in complex with soluble and fully glycosylated HIV-1 Env by negative-stain single-particle electron microscopy. Journal of virology. 2014 Academic Article GET IT
Times cited: 55
CD4-induced activation in a soluble HIV-1 Env trimer. Structure (London, England : 1993). 2014 Academic Article GET IT
Times cited: 104
Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits. Retrovirology. 2014 Academic Article GET IT
Times cited: 131
Stable 293 T and CHO cell lines expressing cleaved, stable HIV-1 envelope glycoprotein trimers for structural and vaccine studies. Retrovirology. 2014 Academic Article GET IT
Times cited: 45
Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers. Immunity. 2014 Academic Article GET IT
Times cited: 312
Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers. Immunity. 2014 Academic Article GET IT
Times cited: 284
Autoantibodies induced by chimeric cytokine-HIV envelope glycoprotein immunogens. Journal of immunology (Baltimore, Md. : 1950). 2014 Academic Article GET IT
Times cited: 3
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies. Nature. 2014 Academic Article GET IT
Times cited: 601
Modified silicone elastomer vaginal gels for sustained release of antiretroviral HIV microbicides. Journal of pharmaceutical sciences. 2014 Academic Article GET IT
Times cited: 16
Pharmacokinetics of a CCR5 inhibitor in rhesus macaques following vaginal, rectal and oral application. The Journal of antimicrobial chemotherapy. 2013 Academic Article GET IT
Times cited: 13
Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer. Science (New York, N.Y.). 2013 Academic Article GET IT
Times cited: 582
Crystal structure of a soluble cleaved HIV-1 envelope trimer. Science (New York, N.Y.). 2013 Academic Article GET IT
Times cited: 715
Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 154
A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies. PLoS pathogens. 2013 Academic Article GET IT
Times cited: 745
Influences on trimerization and aggregation of soluble, cleaved HIV-1 SOSIP envelope glycoprotein. Journal of virology. 2013 Academic Article GET IT
Times cited: 77
Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers. Journal of virology. 2013 Academic Article GET IT
Times cited: 68
Comparative Immunogenicity of Evolved V1V2-Deleted HIV-1 Envelope Glycoprotein Trimers. PloS one. 2013 Academic Article GET IT
Times cited: 8
An HIV-1 envelope glycoprotein trimer with an embedded IL-21 domain activates human B cells. PloS one. 2013 Academic Article GET IT
Times cited: 5
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120. Nature structural & molecular biology. 2013 Academic Article GET IT
Times cited: 289
Clinical adjuvant combinations stimulate potent B-cell responses in vitro by activating dermal dendritic cells. PloS one. 2013 Academic Article GET IT
Times cited: 14
Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans. PLoS pathogens. 2013 Academic Article GET IT
Times cited: 250
Use of G-protein-coupled and -uncoupled CCR5 receptors by CCR5 inhibitor-resistant and -sensitive human immunodeficiency virus type 1 variants. Journal of virology. 2013 Academic Article GET IT
Times cited: 32
Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 217
Transmitted/founder and chronic HIV-1 envelope proteins are distinguished by differential utilization of CCR5. Journal of virology. 2012 Academic Article GET IT
Times cited: 63
Potent induction of antibody-secreting B cells by human dermal-derived CD14+ dendritic cells triggered by dual TLR ligation. Journal of immunology (Baltimore, Md. : 1950). 2012 Academic Article GET IT
Times cited: 33
Pharmacokinetics and efficacy of a vaginally administered maraviroc gel in rhesus macaques. The Journal of antimicrobial chemotherapy. 2012 Academic Article GET IT
Times cited: 54
Partial protection against multiple RT-SHIV162P3 vaginal challenge of rhesus macaques by a silicone elastomer vaginal ring releasing the NNRTI MC1220. The Journal of antimicrobial chemotherapy. 2012 Academic Article GET IT
Times cited: 29
HIV-1 gp120 impairs the induction of B cell responses by TLR9-activated plasmacytoid dendritic cells. Journal of immunology (Baltimore, Md. : 1950). 2012 Academic Article GET IT
Times cited: 25
Good CoP, bad CoP? Interrogating the immune responses to primate lentiviral vaccines. Retrovirology. 2012 Information Resource GET IT
Times cited: 12
Glycan-dependent immunogenicity of recombinant soluble trimeric hemagglutinin. Journal of virology. 2012 Academic Article GET IT
Times cited: 59
Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers. The Journal of biological chemistry. 2012 Academic Article GET IT
Times cited: 43
Macaque studies of vaccine and microbicide combinations for preventing HIV-1 sexual transmission. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 39
Enhancement of α-helix mimicry by an α/β-peptide foldamer via incorporation of a dense ionic side-chain array. Journal of the American Chemical Society. 2012 Academic Article GET IT
Times cited: 62
Effects of sequence changes in the HIV-1 gp41 fusion peptide on CCR5 inhibitor resistance. Virology. 2012 Academic Article GET IT
Times cited: 15
V3 determinants of HIV-1 escape from the CCR5 inhibitors Maraviroc and Vicriviroc. Virology. 2012 Academic Article GET IT
Times cited: 31
HIV-1 Env antibodies: are we in a bind or going blind?. Nature medicine. 2012 Article GET IT
Times cited: 7
Sustained release of the CCR5 inhibitors CMPD167 and maraviroc from vaginal rings in rhesus macaques. Antimicrobial agents and chemotherapy. 2012 Academic Article GET IT
Times cited: 61
Differential use of CCR5 by HIV-1 clinical isolates resistant to small-molecule CCR5 antagonists. Antimicrobial agents and chemotherapy. 2012 Academic Article GET IT
Times cited: 8
Targeting HIV-1 envelope glycoprotein trimers to B cells by using APRIL improves antibody responses. Journal of virology. 2011 Academic Article GET IT
Times cited: 38
SHIV-162P3 infection of rhesus macaques given maraviroc gel vaginally does not involve resistant viruses. PloS one. 2011 Academic Article GET IT
Times cited: 13
Env-glycoprotein heterogeneity as a source of apparent synergy and enhanced cooperativity in inhibition of HIV-1 infection by neutralizing antibodies and entry inhibitors. Virology. 2011 Academic Article GET IT
Times cited: 18
A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield. Science (New York, N.Y.). 2011 Academic Article GET IT
Times cited: 605
Non-aqueous silicone elastomer gels as a vaginal microbicide delivery system for the HIV-1 entry inhibitor maraviroc. Journal of controlled release : official journal of the Controlled Release Society. 2011 Academic Article GET IT
Times cited: 49
Occluding the mannose moieties on human immunodeficiency virus type 1 gp120 with griffithsin improves the antibody responses to both proteins in mice. AIDS research and human retroviruses. 2011 Academic Article GET IT
Times cited: 28
Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 137
A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cells. Retrovirology. 2011 Academic Article GET IT
Times cited: 26
Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 228
Multiple CCR5 conformations on the cell surface are used differentially by human immunodeficiency viruses resistant or sensitive to CCR5 inhibitors. Journal of virology. 2011 Academic Article GET IT
Times cited: 54
How can HIV-type-1-Env immunogenicity be improved to facilitate antibody-based vaccine development?. AIDS research and human retroviruses. 2011 Information Resource GET IT
Times cited: 61
A chimeric HIV-1 envelope glycoprotein trimer with an embedded granulocyte-macrophage colony-stimulating factor (GM-CSF) domain induces enhanced antibody and T cell responses. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 15
Resistance of a human immunodeficiency virus type 1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41. Virology. 2011 Academic Article GET IT
Times cited: 21
Stabilized HIV-1 envelope glycoprotein trimers lacking the V1V2 domain, obtained by virus evolution. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 22
Protection of rhesus macaques from vaginal infection by vaginally delivered maraviroc, an inhibitor of HIV-1 entry via the CCR5 co-receptor. The Journal of infectious diseases. 2010 Academic Article GET IT
Times cited: 126
Misconduct: don't penalize the honest majority of scientists. Nature. 2010 Article GET IT
Times cited: 1
IgG subclass profiles in infected HIV type 1 controllers and chronic progressors and in uninfected recipients of Env vaccines. AIDS research and human retroviruses. 2010 Academic Article GET IT
Times cited: 97
Lack of complex N-glycans on HIV-1 envelope glycoproteins preserves protein conformation and entry function. Virology. 2010 Academic Article GET IT
Times cited: 64
Role of a putative gp41 dimerization domain in human immunodeficiency virus type 1 membrane fusion. Journal of virology. 2010 Academic Article GET IT
Times cited: 16
Adenovirus vectors block human immunodeficiency virus-1 replication in human alveolar macrophages by inhibition of the long terminal repeat. American journal of respiratory cell and molecular biology. 2009 Academic Article GET IT
Times cited: 4
Structural and biological mimicry of protein surface recognition by alpha/beta-peptide foldamers. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 232
Two HIV-1 variants resistant to small molecule CCR5 inhibitors differ in how they use CCR5 for entry. PLoS pathogens. 2009 Academic Article GET IT
Times cited: 62
Structural and immunogenicity studies of a cleaved, stabilized envelope trimer derived from subtype A HIV-1. Vaccine. 2009 Academic Article GET IT
Times cited: 54
Enzymatic removal of mannose moieties can increase the immune response to HIV-1 gp120 in vivo. Virology. 2009 Academic Article GET IT
Times cited: 45
Structure of the HIV-1 gp41 membrane-proximal ectodomain region in a putative prefusion conformation. Biochemistry. 2009 Academic Article GET IT
Times cited: 51
Inefficient entry of vicriviroc-resistant HIV-1 via the inhibitor-CCR5 complex at low cell surface CCR5 densities. Virology. 2009 Academic Article GET IT
Times cited: 37
Addition of a cholesterol group to an HIV-1 peptide fusion inhibitor dramatically increases its antiviral potency. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 191
Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 86
A pièce de resistance: how HIV-1 escapes small molecule CCR5 inhibitors. Current opinion in HIV and AIDS. 2009 Information Resource GET IT
Times cited: 86
Biochemical and biophysical comparison of cleaved and uncleaved soluble, trimeric HIV-1 envelope glycoproteins. Virology. 2009 Academic Article GET IT
Times cited: 29
Whither or wither microbicides?. Science (New York, N.Y.). 2008 Article GET IT
Times cited: 117
Tropism-independent protection of macaques against vaginal transmission of three SHIVs by the HIV-1 fusion inhibitor T-1249. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 41
Neutralizing antibody and anti-retroviral drug sensitivities of HIV-1 isolates resistant to small molecule CCR5 inhibitors. Virology. 2008 Academic Article GET IT
Times cited: 52
AIDS/HIV. A STEP into darkness or light?. Science (New York, N.Y.). 2008 Article GET IT
Times cited: 42
Antiretroviral drug-based microbicides to prevent HIV-1 sexual transmission. Annual review of medicine. 2008 Information Resource GET IT
Times cited: 156
N-terminal substitutions in HIV-1 gp41 reduce the expression of non-trimeric envelope glycoproteins on the virus. Virology. 2007 Academic Article GET IT
Times cited: 24
Speaking out about U.S. science output. Science (New York, N.Y.). 2007 Article GET IT
HIV-1 gp120 mannoses induce immunosuppressive responses from dendritic cells. PLoS pathogens. 2007 Academic Article GET IT
Escape of HIV-1 from a small molecule CCR5 inhibitor is not associated with a fitness loss. PLoS pathogens. 2007 Academic Article GET IT
Purified, proteolytically mature HIV type 1 SOSIP gp140 envelope trimers. AIDS research and human retroviruses. 2007 Academic Article GET IT
Times cited: 23
Cell surface expression of CCR5 and other host factors influence the inhibition of HIV-1 infection of human lymphocytes by CCR5 ligands. Virology. 2007 Academic Article GET IT
Times cited: 46
Entry inhibitor-based microbicides are active in vitro against HIV-1 isolates from multiple genetic subtypes. Virology. 2007 Academic Article GET IT
Times cited: 31
Protein design of a bacterially expressed HIV-1 gp41 fusion inhibitor. Biochemistry. 2007 Academic Article GET IT
Times cited: 44
Changes in the V3 region of gp120 contribute to unusually broad coreceptor usage of an HIV-1 isolate from a CCR5 Delta32 heterozygote. Virology. 2007 Academic Article GET IT
Times cited: 37
HIV-1 clones resistant to a small molecule CCR5 inhibitor use the inhibitor-bound form of CCR5 for entry. Virology. 2006 Academic Article GET IT
Times cited: 162
A comparative immunogenicity study in rabbits of disulfide-stabilized, proteolytically cleaved, soluble trimeric human immunodeficiency virus type 1 gp140, trimeric cleavage-defective gp140 and monomeric gp120. Virology. 2006 Academic Article GET IT
Times cited: 85
Specific amino acids in the N-terminus of the gp41 ectodomain contribute to the stabilization of a soluble, cleaved gp140 envelope glycoprotein from human immunodeficiency virus type 1. Virology. 2006 Academic Article GET IT
Times cited: 39
A plea for justice for jailed medical workers. Science (New York, N.Y.). 2006 Article GET IT
Times cited: 4
Construction and characterization of soluble, cleaved, and stabilized trimeric Env proteins based on HIV type 1 Env subtype A. AIDS research and human retroviruses. 2006 Academic Article GET IT
Times cited: 21
Dominant-negative effect of hetero-oligomerization on the function of the human immunodeficiency virus type 1 envelope glycoprotein complex. Virology. 2006 Academic Article GET IT
Times cited: 19
HIV-1 envelope triggers polyclonal Ig class switch recombination through a CD40-independent mechanism involving BAFF and C-type lectin receptors. Journal of immunology (Baltimore, Md. : 1950). 2006 Academic Article GET IT
Times cited: 173
The production of cleaved, trimeric human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein vaccine antigens and infectious pseudoviruses using linear polyethylenimine as a transfection reagent. Protein expression and purification. 2006 Academic Article GET IT
Times cited: 40
Interaction of small molecule inhibitors of HIV-1 entry with CCR5. Virology. 2006 Academic Article GET IT
Times cited: 110
Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor. Nature medicine. 2005 Academic Article GET IT
Times cited: 82
Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion. Nature. 2005 Academic Article GET IT
Times cited: 270
Ternary complex formation of human immunodeficiency virus type 1 Env, CD4, and chemokine receptor captured as an intermediate of membrane fusion. Journal of virology. 2005 Academic Article GET IT
Times cited: 47
Use of alternate coreceptors on primary cells by two HIV-1 isolates. Virology. 2005 Academic Article GET IT
Times cited: 32
Generation and properties of a human immunodeficiency virus type 1 isolate resistant to the small molecule CCR5 inhibitor, SCH-417690 (SCH-D). Virology. 2005 Academic Article GET IT
Times cited: 139
The impact of envelope glycoprotein cleavage on the antigenicity, infectivity, and neutralization sensitivity of Env-pseudotyped human immunodeficiency virus type 1 particles. Virology. 2005 Academic Article GET IT
Times cited: 61
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Times cited: 4
Differential induction of c-fos and c-myc by cyclic AMP in Swiss 3T3 cells: significance for the mitogenic response. Oncogene research. 1988 Academic Article GET IT
Times cited: 18
Immunological probes in the analysis of myc protein expression. Current topics in microbiology and immunology. 1988 Academic Article GET IT
Times cited: 10
Synergistic signals in the mechanism of antigen-induced exocytosis in 2H3 cells: evidence for an unidentified signal required for histamine release. The Journal of cell biology. 1987 Academic Article GET IT
Times cited: 84
Extraction and recovery of inositol phosphates from tissues. The Biochemical journal. 1987 Article GET IT
Times cited: 76
Calcium regulates inositol 1,3,4,5-tetrakisphosphate production in lysed thymocytes and in intact cells stimulated with concanavalin A. The EMBO journal. 1987 Academic Article GET IT
Times cited: 36
The early mitogenic pathway in mouse thymocytes: an analysis of the dual signal hypothesis. Advances in experimental medicine and biology. 1987 Academic Article GET IT
Times cited: 1
c-fos and c-myc gene activation, ionic signals, and DNA synthesis in thymocytes. The Journal of biological chemistry. 1986 Academic Article GET IT
Times cited: 66
A common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cells. Nature. 1985 Academic Article GET IT
Times cited: 279
Mitogens increase phosphorylation of phosphoinositides in thymocytes. Nature. 1984 Academic Article GET IT
Times cited: 129
Calcium signals and phospholipid methylation in eukaryotic cells. The Biochemical journal. 1984 Academic Article GET IT
The calcium signal and phosphatidylinositol breakdown in 2H3 cells. The Journal of biological chemistry. 1984 Academic Article GET IT
Times cited: 151
The mechanism of the calcium signal and correlation with histamine release in 2H3 cells. The Journal of biological chemistry. 1984 Academic Article GET IT
Times cited: 263
Large effects of preparative techniques on lymphocyte cyclic AMP content. The Biochemical journal. 1983 Academic Article GET IT
Times cited: 10
The bivalent-cation dependence of phosphatidylinositol synthesis in a cell-free system from lymphocytes. The Biochemical journal. 1983 Academic Article GET IT
Times cited: 4
Free cytoplasmic calcium concentration and the mitogenic stimulation of lymphocytes. The Journal of biological chemistry. 1983 Academic Article GET IT
Times cited: 322
Early increases in phospholipid methylation are not necessary for the mitogenic stimulation of lymphocytes. The Journal of biological chemistry. 1982 Academic Article GET IT
Times cited: 20

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Research

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Funding awarded

Neutralization of primary HIV-1 viruses awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2023 - 2028
Cleaved, stabilized HIV-1 Env trimers for structural and vaccine studies awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2020 - 2025
Cleaved, stabilized HIV-1 Env trimers for structural and vaccine studies awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2021 - 2022

missing activity Principal Investigator Subaward 2019 - 2024
missing activity Principal Investigator Subaward 2019 - 2023

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Background

education and training

Ph.D., Cambridge University (United Kingdom) 1982
M.A., Cambridge University (United Kingdom) 1981
B.A., Downing College (United Kingdom) 1978

Contact

full name

John P Moore

primary email

jpm2003@med.cornell.edu

VIVO Weill Cornell Medical College

John P Moore Professor of Microbiology and Immunology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email